Linshang Chemical
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1-Chloro-3-Fluoro-4-Nitrobenzene
Linshang Chemical
|
HS Code |
734313 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow solid |
| Melting Point | 51 - 55 °C |
| Boiling Point | 233 - 234 °C |
| Density | 1.482 g/cm³ (calculated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 101.7 °C |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Chloro-3-Fluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluoro - 4 - nitrobenzene: Packed in 1 - kg bottles for chemical storage. |
| Storage | 1 - Chloro - 3 - fluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid storing near incompatible substances to prevent potential reactions. Regularly check storage conditions and containers for integrity. |
| Shipping | 1 - Chloro - 3 - fluoro - 4 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring safety during transit to prevent any leakage or risk. |
Competitive 1-Chloro-3-Fluoro-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-3-Fluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3-fluoro-4-nitrobenzene?
1-Chloro-3-fluoro-4-nitrobenzene is one of the organic compounds. Its main uses are quite extensive.
In the field of organic synthesis, this compound is often an important intermediate. Due to the chlorine, fluorine and nitro functional groups attached to the benzene ring, each has unique reactivity and can participate in a variety of chemical reactions. Such as nucleophilic substitution, chlorine and fluorine atoms can be replaced by other nucleophiles, whereby various groups are introduced to construct more complex organic molecular structures, which is of great significance in drug synthesis. Drug developers can precisely modify molecules by nucleophilic substitution of 1-chloro-3-fluoro-4-nitrobenzene, giving drugs specific biological activities and pharmacological properties.
Furthermore, nitro groups are also an important reaction check point. Nitro groups can be converted into amino groups through reduction reactions to derive amino-containing compounds. Such amino-containing compounds are widely used in the dye industry and can be used as raw materials for the synthesis of various dyes, adding rich color scales to the chromatography of dyes.
In addition, 1-chloro-3-fluoro-4-nitrobenzene has also emerged in the field of materials science due to its special structure and functional group. It can be used as a monomer to participate in polymerization reactions to prepare polymer materials with special properties, such as materials with specific electrical, optical or thermal properties, to meet the needs of special materials in electronic devices, optical instruments and other fields.
In summary, 1-chloro-3-fluoro-4-nitrobenzene, with its unique structure, plays an indispensable role in many fields such as organic synthesis, drug research and development, dye industry and materials science.
In the field of organic synthesis, this compound is often an important intermediate. Due to the chlorine, fluorine and nitro functional groups attached to the benzene ring, each has unique reactivity and can participate in a variety of chemical reactions. Such as nucleophilic substitution, chlorine and fluorine atoms can be replaced by other nucleophiles, whereby various groups are introduced to construct more complex organic molecular structures, which is of great significance in drug synthesis. Drug developers can precisely modify molecules by nucleophilic substitution of 1-chloro-3-fluoro-4-nitrobenzene, giving drugs specific biological activities and pharmacological properties.
Furthermore, nitro groups are also an important reaction check point. Nitro groups can be converted into amino groups through reduction reactions to derive amino-containing compounds. Such amino-containing compounds are widely used in the dye industry and can be used as raw materials for the synthesis of various dyes, adding rich color scales to the chromatography of dyes.
In addition, 1-chloro-3-fluoro-4-nitrobenzene has also emerged in the field of materials science due to its special structure and functional group. It can be used as a monomer to participate in polymerization reactions to prepare polymer materials with special properties, such as materials with specific electrical, optical or thermal properties, to meet the needs of special materials in electronic devices, optical instruments and other fields.
In summary, 1-chloro-3-fluoro-4-nitrobenzene, with its unique structure, plays an indispensable role in many fields such as organic synthesis, drug research and development, dye industry and materials science.
What are the physical properties of 1-chloro-3-fluoro-4-nitrobenzene?
1-Chloro-3-fluoro-4-nitrobenzene is one of the organic compounds. Its physical properties are quite important and have applications in both industrial and scientific fields. Details are as follows.
First of all, its appearance, 1-chloro-3-fluoro-4-nitrobenzene is a solid under normal conditions, and the color is light yellow. This color is a characterization of light absorption caused by the structure of the compound.
Second of all, its melting point is between 36 and 38 degrees Celsius. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This range of melting points indicates that the compound will undergo a phase transition at a specific temperature range slightly above normal temperature. The strength and arrangement of the intermolecular forces in its crystal structure together determine this melting point value.
The boiling point is also a key physical property. The boiling point of 1-chloro-3-fluoro-4-nitrobenzene is about 245-247 degrees Celsius. At this temperature, the liquid will vaporize violently. The higher boiling point of the compound reflects the strong interaction between molecules, such as van der Waals force, dipole-dipole interaction, etc., which requires higher energy to make the molecule break free from the liquid phase and enter the gas phase.
Furthermore, 1-chloro-3-fluoro-4-nitrobenzene is insoluble in water. This is because water molecules are connected by hydrogen bonds to form a relatively tight structure, and the compound molecule is non-polar or weakly polar, and the force between water molecules is weak, making it difficult to break the hydrogen bond between water molecules and dissolve into it. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. The molecular structure and polar characteristics of organic solvents are similar to 1-chloro-3-fluoro-4-nitrobenzene, and the two are miscible according to the principle of "similarity and miscibility".
In addition, the compound has a certain density. Density, the mass per unit volume of the substance. Its density helps to consider the distribution and behavior of the substance when it comes to mixing, separation, etc.
In summary, the physical properties of 1-chloro-3-fluoro-4-nitrobenzene, such as appearance, melting point, boiling point, solubility, and density, each have their own characteristics and are related to each other. They are of great significance for their applications in chemical synthesis, material preparation, and many other fields.
First of all, its appearance, 1-chloro-3-fluoro-4-nitrobenzene is a solid under normal conditions, and the color is light yellow. This color is a characterization of light absorption caused by the structure of the compound.
Second of all, its melting point is between 36 and 38 degrees Celsius. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This range of melting points indicates that the compound will undergo a phase transition at a specific temperature range slightly above normal temperature. The strength and arrangement of the intermolecular forces in its crystal structure together determine this melting point value.
The boiling point is also a key physical property. The boiling point of 1-chloro-3-fluoro-4-nitrobenzene is about 245-247 degrees Celsius. At this temperature, the liquid will vaporize violently. The higher boiling point of the compound reflects the strong interaction between molecules, such as van der Waals force, dipole-dipole interaction, etc., which requires higher energy to make the molecule break free from the liquid phase and enter the gas phase.
Furthermore, 1-chloro-3-fluoro-4-nitrobenzene is insoluble in water. This is because water molecules are connected by hydrogen bonds to form a relatively tight structure, and the compound molecule is non-polar or weakly polar, and the force between water molecules is weak, making it difficult to break the hydrogen bond between water molecules and dissolve into it. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. The molecular structure and polar characteristics of organic solvents are similar to 1-chloro-3-fluoro-4-nitrobenzene, and the two are miscible according to the principle of "similarity and miscibility".
In addition, the compound has a certain density. Density, the mass per unit volume of the substance. Its density helps to consider the distribution and behavior of the substance when it comes to mixing, separation, etc.
In summary, the physical properties of 1-chloro-3-fluoro-4-nitrobenzene, such as appearance, melting point, boiling point, solubility, and density, each have their own characteristics and are related to each other. They are of great significance for their applications in chemical synthesis, material preparation, and many other fields.
What is the chemistry of 1-chloro-3-fluoro-4-nitrobenzene?
1-Chloro-3-fluoro-4-nitrobenzene is also an organic compound. Its activity is very important in the field of organic synthesis.
In this compound, the nitro group has strong electron-absorbing properties, which causes the electron cloud density of the benzene ring to drop, making it difficult for electrophilic substitution reactions to occur. However, because it can reduce the density of the electron cloud in the adjacent and para-sites even more, nucleophilic substitution reactions are easy to occur in the adjacent and para-sites.
Although both chlorine and fluorine dihalides have electron-absorbing induction effects, the electronegativity of fluorine is stronger than that of chlorine, and the electron-absorbing induction effect of fluorine is even worse. These two also affect the reactivity of benzene ring and the selectivity of the reaction
In the nucleophilic substitution reaction, the halogen atom can be replaced by the nucleophilic reagent. Due to the decrease in the electron cloud density of the benzene ring, especially the ortho and para-positions, the nucleophilic reagent is easy to attack the halogen atom of the ortho and para-position of the nitro group. For example, when it encounters the nucleophilic reagent alkoxide or amine, the halogen atom can be substituted for it to produce the corresponding ether or amine compound.
In the reduction reaction, the nitro group can be reduced to an amino group to obtain an amino-containing derivative. This process often requires suitable reducing agents and reaction conditions.
Because of its structure containing halogen atoms and nitro groups, it can participate in many organic reactions. It is a key intermediate for the synthesis of complex organic molecules and is widely used in medicine, pesticides, materials and other industries. Its chemical properties are active and the reactions are diverse. With different reaction conditions and reagents, a variety of valuable products can be obtained.
In this compound, the nitro group has strong electron-absorbing properties, which causes the electron cloud density of the benzene ring to drop, making it difficult for electrophilic substitution reactions to occur. However, because it can reduce the density of the electron cloud in the adjacent and para-sites even more, nucleophilic substitution reactions are easy to occur in the adjacent and para-sites.
Although both chlorine and fluorine dihalides have electron-absorbing induction effects, the electronegativity of fluorine is stronger than that of chlorine, and the electron-absorbing induction effect of fluorine is even worse. These two also affect the reactivity of benzene ring and the selectivity of the reaction
In the nucleophilic substitution reaction, the halogen atom can be replaced by the nucleophilic reagent. Due to the decrease in the electron cloud density of the benzene ring, especially the ortho and para-positions, the nucleophilic reagent is easy to attack the halogen atom of the ortho and para-position of the nitro group. For example, when it encounters the nucleophilic reagent alkoxide or amine, the halogen atom can be substituted for it to produce the corresponding ether or amine compound.
In the reduction reaction, the nitro group can be reduced to an amino group to obtain an amino-containing derivative. This process often requires suitable reducing agents and reaction conditions.
Because of its structure containing halogen atoms and nitro groups, it can participate in many organic reactions. It is a key intermediate for the synthesis of complex organic molecules and is widely used in medicine, pesticides, materials and other industries. Its chemical properties are active and the reactions are diverse. With different reaction conditions and reagents, a variety of valuable products can be obtained.
What are 1-chloro-3-fluoro-4-nitrobenzene synthesis methods?
The synthesis methods of 1-chloro-3-fluoro-4-nitrobenzene are as follows.
First, benzene is used as the initial raw material. First, the benzene is nitrified, and the mixture of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, benzene can be converted into nitrobenzene. This reaction needs to be carefully controlled to prevent side reactions. Then the nitrobenzene is halogenated, and suitable halogenating reagents, such as chlorine and fluorine, can be selected. Under the action of a specific catalyst, chlorine atoms and fluorine atoms can be gradually introduced into specific positions in the benzene ring, and finally 1-chloro-3-fluoro-4-nitrobenzene can be obtained. Although the raw materials are easily available in this path, there are many reaction steps, and the selective control of the halogenation process is quite difficult.
Second, fluorobenzene is used as the starting material. First, fluorobenzene is nitrified, and nitro groups are introduced into the benzene ring with the help of nitrifying reagents. Due to the positioning effect of fluorine atoms, nitro groups will mainly enter specific positions. Subsequent chlorination reactions are carried out, and suitable chlorination reagents and reaction conditions are selected to introduce chlorine atoms to the desired position to achieve the synthesis of 1-chloro-3-fluoro-4-nitrobenzene. This approach is relatively simple, and the positioning effect of fluorobenzene is conducive to the selective generation of products, but the cost of fluorobenzene raw materials is relatively high.
Third Similarly, chlorobenzene is first nitrified and nitro groups are introduced. Then a fluorination reaction is carried out. This fluorination reaction requires the selection of high-efficiency fluorination reagents and specific reaction conditions to prompt fluorine atoms to replace hydrogen atoms at specific positions in the benzene ring to form the target product. In this route, chlorobenzene is relatively inexpensive, but the fluorination reaction conditions are sometimes harsh, and the requirements for reaction equipment are quite high.
Each method for synthesizing 1-chloro-3-fluoro-4-nitrobenzene has its own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider many factors such as raw material cost, reaction conditions, product yield and purity, and reasonably choose the appropriate synthesis path.
First, benzene is used as the initial raw material. First, the benzene is nitrified, and the mixture of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent. At a suitable temperature, benzene can be converted into nitrobenzene. This reaction needs to be carefully controlled to prevent side reactions. Then the nitrobenzene is halogenated, and suitable halogenating reagents, such as chlorine and fluorine, can be selected. Under the action of a specific catalyst, chlorine atoms and fluorine atoms can be gradually introduced into specific positions in the benzene ring, and finally 1-chloro-3-fluoro-4-nitrobenzene can be obtained. Although the raw materials are easily available in this path, there are many reaction steps, and the selective control of the halogenation process is quite difficult.
Second, fluorobenzene is used as the starting material. First, fluorobenzene is nitrified, and nitro groups are introduced into the benzene ring with the help of nitrifying reagents. Due to the positioning effect of fluorine atoms, nitro groups will mainly enter specific positions. Subsequent chlorination reactions are carried out, and suitable chlorination reagents and reaction conditions are selected to introduce chlorine atoms to the desired position to achieve the synthesis of 1-chloro-3-fluoro-4-nitrobenzene. This approach is relatively simple, and the positioning effect of fluorobenzene is conducive to the selective generation of products, but the cost of fluorobenzene raw materials is relatively high.
Third Similarly, chlorobenzene is first nitrified and nitro groups are introduced. Then a fluorination reaction is carried out. This fluorination reaction requires the selection of high-efficiency fluorination reagents and specific reaction conditions to prompt fluorine atoms to replace hydrogen atoms at specific positions in the benzene ring to form the target product. In this route, chlorobenzene is relatively inexpensive, but the fluorination reaction conditions are sometimes harsh, and the requirements for reaction equipment are quite high.
Each method for synthesizing 1-chloro-3-fluoro-4-nitrobenzene has its own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider many factors such as raw material cost, reaction conditions, product yield and purity, and reasonably choose the appropriate synthesis path.
1-chloro-3-fluoro-4-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-3-fluoro-4-nitrobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
Safety first. This compound is toxic and irritating, and the storage place must be well ventilated and kept away from fire and heat sources to prevent fire and explosion. Because of its active chemical nature, it is easy to react with many substances, so it cannot be stored and transported with oxidants, reducing agents, acids, bases, etc., so as not to cause dangerous chemical reactions.
Furthermore, the storage temperature needs to be carefully controlled. It should be stored in a cool place, usually no more than 30 degrees Celsius. If the temperature is too high, it may cause it to decompose or accelerate the reaction, which will damage the quality and increase the safety risk.
Packaging should also not be ignored. A well-sealed packaging container must be used to prevent leakage. If it is liquid, the packaging material should be able to withstand its corrosion and have a leak-proof structure. During transportation, it is also necessary to ensure that the packaging is not damaged and placed firmly to avoid collision and vibration and damage to the packaging.
In addition, the identification must be clear. On the storage container and the means of transportation, its name, nature, hazard warning and other information should be clearly marked so that the relevant personnel can identify it. In case of emergency, appropriate measures can be taken quickly.
The storage and transportation of 1-chloro-3-fluoro-4-nitrobenzene must be carried out in accordance with regulations, and all factors such as safety, temperature, packaging, and labeling must be fully considered to ensure the smooth process and avoid accidents.
Safety first. This compound is toxic and irritating, and the storage place must be well ventilated and kept away from fire and heat sources to prevent fire and explosion. Because of its active chemical nature, it is easy to react with many substances, so it cannot be stored and transported with oxidants, reducing agents, acids, bases, etc., so as not to cause dangerous chemical reactions.
Furthermore, the storage temperature needs to be carefully controlled. It should be stored in a cool place, usually no more than 30 degrees Celsius. If the temperature is too high, it may cause it to decompose or accelerate the reaction, which will damage the quality and increase the safety risk.
Packaging should also not be ignored. A well-sealed packaging container must be used to prevent leakage. If it is liquid, the packaging material should be able to withstand its corrosion and have a leak-proof structure. During transportation, it is also necessary to ensure that the packaging is not damaged and placed firmly to avoid collision and vibration and damage to the packaging.
In addition, the identification must be clear. On the storage container and the means of transportation, its name, nature, hazard warning and other information should be clearly marked so that the relevant personnel can identify it. In case of emergency, appropriate measures can be taken quickly.
The storage and transportation of 1-chloro-3-fluoro-4-nitrobenzene must be carried out in accordance with regulations, and all factors such as safety, temperature, packaging, and labeling must be fully considered to ensure the smooth process and avoid accidents.
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