Linshang Chemical
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1-Chloro-3-Fluoro-5-Methoxybenzene
Linshang Chemical
|
HS Code |
963893 |
| Chemical Formula | C7H6ClFO |
| Molar Mass | 160.573 g/mol |
| Appearance | A colorless to light - yellow liquid |
| Boiling Point | Approximately 180 - 185 °C |
| Density | Around 1.2 - 1.3 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
As an accredited 1-Chloro-3-Fluoro-5-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluoro - 5 - methoxybenzene, 500g, packaged in a sealed, chemical - resistant bottle. |
| Storage | 1 - Chloro - 3 - fluoro - 5 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances. Ensure storage facilities comply with safety regulations to avoid potential chemical reactions and hazards. |
| Shipping | 1 - Chloro - 3 - fluoro - 5 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It's transported following strict chemical shipping regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 1-Chloro-3-Fluoro-5-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-3-Fluoro-5-Methoxybenzene in China?
As a trusted 1-Chloro-3-Fluoro-5-Methoxybenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3-Fluoro-5-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-chloro-3-fluoro-5-methoxybenzene?
"Tiangong" Cloud: "1 + - ++ - + 3 + - + River + - + 5 + - + What is the physical property of methoxybenzene?"
Husband 1 + - + Constant flow of liquid, transparent color, cold condensation of ice, chemical vapor, cycle, is very important for the production of materials. It is soluble, soluble in a variety of materials, into a general solution.
and 5 + - + methoxybenzene, this substance has its own characteristics. It is often solid or liquid, and it is difficult to achieve. It has an aromatic taste, because of benzene. Its melting temperature depends on the molecular force. Generally speaking, it is slightly higher than that of small molecules. The presence of methoxy groups gives it a certain degree of solubility, which affects its solubility. It has a certain solubility in the solution, and because of its solubility, it shows a specific activity in the reaction, and can be synthesized.
Well, these three physical properties are different, and they all have their own special functions and positions in the transportation of heaven and earth and the transformation of things.
Husband 1 + - + Constant flow of liquid, transparent color, cold condensation of ice, chemical vapor, cycle, is very important for the production of materials. It is soluble, soluble in a variety of materials, into a general solution.
and 5 + - + methoxybenzene, this substance has its own characteristics. It is often solid or liquid, and it is difficult to achieve. It has an aromatic taste, because of benzene. Its melting temperature depends on the molecular force. Generally speaking, it is slightly higher than that of small molecules. The presence of methoxy groups gives it a certain degree of solubility, which affects its solubility. It has a certain solubility in the solution, and because of its solubility, it shows a specific activity in the reaction, and can be synthesized.
Well, these three physical properties are different, and they all have their own special functions and positions in the transportation of heaven and earth and the transformation of things.
What are the chemical properties of 1-chloro-3-fluoro-5-methoxybenzene?
This is an organic compound called 1-cyanogen-3-ene-5-methoxyphenyl, and its chemical properties are particularly complex and interesting.
First of all, the cyanyl group (-CN) in this compound has high reactivity. In the cyanyl group, the carbon atom and the nitrogen atom are connected by a triple bond, which gives it special chemical properties. Due to the high electronegativity of the nitrogen atom, the cyanyl group is highly electron-absorbing. This makes the cyanyl group easy to react with nucleophiles. For example, under certain conditions, the cyanyl group can be hydrolyzed into a carboxyl group (-COOH). This hydrolysis reaction often requires an acid or base as a catalyst. In alkali catalysis, the cyanyl group first reacts with hydroxide ions to form carboxylic salts through a series of intermediate steps, and then acidifies to obtain carboxylic acids. This property is of great significance in organic synthesis and can be used to prepare many carboxyl-containing compounds.
Furthermore, the alkenyl group (carbon-carbon double bond) is also a key reaction check point. Alkenyl groups are electron-rich and easy to react with electrophilic reagents. Common electrophilic reagents such as halogens (such as bromine and chlorine) can be added to alkenyl groups to form dihalides under appropriate conditions. This reaction mechanism is usually that the electrophilic reagent first attacks the double bond to form a carbon positive ion intermediate, and then halogen ions combine with it. The alkenyl group can also participate in the oxidation reaction. Under the action of strong oxidants, the carbon-carbon double bond can be oxidized and broken to form oxidation products such as alcaldes, ketones or carboxylic acids. The specific products depend on the reaction conditions and the type of oxidant.
The methoxy group (-OCH
) as the power supply group will affect the electron cloud density distribution of the benzene ring. The methoxy group forms a conjugated system with the benzene ring through the lone pair electrons of its oxygen atom, which increases the electron cloud density of the benzene ring, especially in the ortho and para-sites. This makes the ortho and para-sites of the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Compared with benzene itself, the compound is more prone to such electrophilic substitution reactions, and
This 1-cyanogen-3-ene-5-methoxyphenyl group has unique chemical properties and may have important application potential in the fields of organic synthesis, medicinal chemistry, etc. It can provide a rich chemical reaction basis for the synthesis of new compounds and the development of drugs.
First of all, the cyanyl group (-CN) in this compound has high reactivity. In the cyanyl group, the carbon atom and the nitrogen atom are connected by a triple bond, which gives it special chemical properties. Due to the high electronegativity of the nitrogen atom, the cyanyl group is highly electron-absorbing. This makes the cyanyl group easy to react with nucleophiles. For example, under certain conditions, the cyanyl group can be hydrolyzed into a carboxyl group (-COOH). This hydrolysis reaction often requires an acid or base as a catalyst. In alkali catalysis, the cyanyl group first reacts with hydroxide ions to form carboxylic salts through a series of intermediate steps, and then acidifies to obtain carboxylic acids. This property is of great significance in organic synthesis and can be used to prepare many carboxyl-containing compounds.
Furthermore, the alkenyl group (carbon-carbon double bond) is also a key reaction check point. Alkenyl groups are electron-rich and easy to react with electrophilic reagents. Common electrophilic reagents such as halogens (such as bromine and chlorine) can be added to alkenyl groups to form dihalides under appropriate conditions. This reaction mechanism is usually that the electrophilic reagent first attacks the double bond to form a carbon positive ion intermediate, and then halogen ions combine with it. The alkenyl group can also participate in the oxidation reaction. Under the action of strong oxidants, the carbon-carbon double bond can be oxidized and broken to form oxidation products such as alcaldes, ketones or carboxylic acids. The specific products depend on the reaction conditions and the type of oxidant.
The methoxy group (-OCH
) as the power supply group will affect the electron cloud density distribution of the benzene ring. The methoxy group forms a conjugated system with the benzene ring through the lone pair electrons of its oxygen atom, which increases the electron cloud density of the benzene ring, especially in the ortho and para-sites. This makes the ortho and para-sites of the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Compared with benzene itself, the compound is more prone to such electrophilic substitution reactions, and
This 1-cyanogen-3-ene-5-methoxyphenyl group has unique chemical properties and may have important application potential in the fields of organic synthesis, medicinal chemistry, etc. It can provide a rich chemical reaction basis for the synthesis of new compounds and the development of drugs.
What are the main uses of 1-chloro-3-fluoro-5-methoxybenzene?
The main use of 1 + - 3 + - 5 + -methoxybenzene is to develop its effectiveness in various fields such as engineering and chemical engineering.
In this way, this compound is often an important part of the synthesis of general compounds. Due to its specific chemical properties, it can be used to generate compounds with different chemical activities. For example, it can be modified to synthesize compounds for specific diseases, or in the process of chemical research, it can be used as the starting material of the first compound to help researchers to modify many times and seek more phenological compounds to treat diseases such as inflammation and infection.
In the chemical industry, it is also valuable. First, it can be used as a synthetic agent, which is generally inverse, and can be used to modify the molecular properties of the compound. Second, in terms of material science, it may be possible to introduce the compound into the material in a specific way, so as to improve the material's solubility, qualitative or optical properties, etc., which can meet the needs of different applications. Furthermore, in the manufacture of fragrances and fragrances, it may be one of the raw materials used to match certain special fragrances due to its special taste or chemical properties. In addition, 1 + - 3 + - 5 + -methoxylbenzene plays an indispensable role in many important fields due to its characteristics.
In this way, this compound is often an important part of the synthesis of general compounds. Due to its specific chemical properties, it can be used to generate compounds with different chemical activities. For example, it can be modified to synthesize compounds for specific diseases, or in the process of chemical research, it can be used as the starting material of the first compound to help researchers to modify many times and seek more phenological compounds to treat diseases such as inflammation and infection.
In the chemical industry, it is also valuable. First, it can be used as a synthetic agent, which is generally inverse, and can be used to modify the molecular properties of the compound. Second, in terms of material science, it may be possible to introduce the compound into the material in a specific way, so as to improve the material's solubility, qualitative or optical properties, etc., which can meet the needs of different applications. Furthermore, in the manufacture of fragrances and fragrances, it may be one of the raw materials used to match certain special fragrances due to its special taste or chemical properties. In addition, 1 + - 3 + - 5 + -methoxylbenzene plays an indispensable role in many important fields due to its characteristics.
What are the synthesis methods of 1-chloro-3-fluoro-5-methoxybenzene?
To prepare 1-cyanogen-3-alkyne-5-methoxybenzene, the method is as follows:
First, it can be started from the raw material containing the benzene ring. If the anisole is used as the starting point, the appropriate electrophilic substitution reaction is used to introduce the cyanyl group. In the presence of a suitable catalyst, such as anhydrous aluminum trichloride, the anisole can be used to react with cyanide reagents, such as cyanide bromide, and the cyanyl group can be introduced at a specific position in the benzene ring through electrophilic substitution.
Times, the alkynyl group is introduced. The coupling reaction of halogenated aromatics and alkynes can be used. First, the anisole derivatives that already contain cyanide groups are halogenated with halogenated reagents, such as N-bromo Then it is coupled with alkynes in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., and bases, such as potassium carbonate, etc., to introduce alkynyl groups to obtain 1-cyano- 3-alkynyne-5-methoxybenzene.
Or, benzene can be used as the starting material and methoxylated to introduce methoxy groups. Methanol and benzene can be obtained under the action of appropriate acidic catalysts, such as concentrated sulfuric acid. Then, as above, a cyano group is introduced first, and then an alkynyl group is introduced.
There are other methods, which can be reacted by diazonium salts. First, aniline derivatives containing methoxy groups are prepared, and diazonium salts are obtained by diazotization. Then the diazonium salt reacts with the reagent containing cyanide group and alkynyl group under appropriate conditions to construct the target molecular structure, and finally obtains 1-cyanogen-3-alkynyl-5-methoxybenzene.
First, it can be started from the raw material containing the benzene ring. If the anisole is used as the starting point, the appropriate electrophilic substitution reaction is used to introduce the cyanyl group. In the presence of a suitable catalyst, such as anhydrous aluminum trichloride, the anisole can be used to react with cyanide reagents, such as cyanide bromide, and the cyanyl group can be introduced at a specific position in the benzene ring through electrophilic substitution.
Times, the alkynyl group is introduced. The coupling reaction of halogenated aromatics and alkynes can be used. First, the anisole derivatives that already contain cyanide groups are halogenated with halogenated reagents, such as N-bromo Then it is coupled with alkynes in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., and bases, such as potassium carbonate, etc., to introduce alkynyl groups to obtain 1-cyano- 3-alkynyne-5-methoxybenzene.
Or, benzene can be used as the starting material and methoxylated to introduce methoxy groups. Methanol and benzene can be obtained under the action of appropriate acidic catalysts, such as concentrated sulfuric acid. Then, as above, a cyano group is introduced first, and then an alkynyl group is introduced.
There are other methods, which can be reacted by diazonium salts. First, aniline derivatives containing methoxy groups are prepared, and diazonium salts are obtained by diazotization. Then the diazonium salt reacts with the reagent containing cyanide group and alkynyl group under appropriate conditions to construct the target molecular structure, and finally obtains 1-cyanogen-3-alkynyl-5-methoxybenzene.
What are the precautions for storing and transporting 1-chloro-3-fluoro-5-methoxybenzene?
1 + -
First, it is related to the storage environment. This compound should be stored in a cool, dry and well-ventilated place. Because it is cool, it can avoid changes in its properties caused by high temperature, dry can prevent moisture from causing it to deteriorate, and good ventilation can disperse volatile gases that may accumulate and prevent danger. Do not place it in direct sunlight, sunlight exposure or cause photochemical reactions to damage its quality. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., because contact with these substances is likely to cause chemical reactions, and even lead to serious consequences such as combustion and explosion.
Second, it involves packaging materials. The packaging must be tight to ensure that there is no risk of leakage. Appropriate packaging materials should be selected, such as containers with good sealing and corrosion resistance. The packaging containers should be checked regularly. If there are signs of damage or leakage, immediate measures must be taken to prevent the leakage of compounds from causing harm. Whether it is to the environment or personnel safety, leakage may cause serious problems.
Third, about the transportation link. During transportation, ensure that the container is fixed and stable to avoid packaging damage due to bumps and collisions. Transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident, they can respond quickly and correctly. In addition, transport route planning also needs to be cautious, avoiding densely populated areas and environmentally sensitive areas to reduce latent risks.
First, it is related to the storage environment. This compound should be stored in a cool, dry and well-ventilated place. Because it is cool, it can avoid changes in its properties caused by high temperature, dry can prevent moisture from causing it to deteriorate, and good ventilation can disperse volatile gases that may accumulate and prevent danger. Do not place it in direct sunlight, sunlight exposure or cause photochemical reactions to damage its quality. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., because contact with these substances is likely to cause chemical reactions, and even lead to serious consequences such as combustion and explosion.
Second, it involves packaging materials. The packaging must be tight to ensure that there is no risk of leakage. Appropriate packaging materials should be selected, such as containers with good sealing and corrosion resistance. The packaging containers should be checked regularly. If there are signs of damage or leakage, immediate measures must be taken to prevent the leakage of compounds from causing harm. Whether it is to the environment or personnel safety, leakage may cause serious problems.
Third, about the transportation link. During transportation, ensure that the container is fixed and stable to avoid packaging damage due to bumps and collisions. Transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident, they can respond quickly and correctly. In addition, transport route planning also needs to be cautious, avoiding densely populated areas and environmentally sensitive areas to reduce latent risks.
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