Linshang Chemical
PRODUCTS
1-Chloro-3-Fluoro-5-Methylbenzene
Linshang Chemical
|
HS Code |
825833 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 146.57 g/mol |
| Appearance | Liquid (predicted from similar compounds) |
| Solubility In Water | Low solubility, organic halides are generally hydrophobic |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and chloroform |
As an accredited 1-Chloro-3-Fluoro-5-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluoro - 5 - methylbenzene in 500 - mL glass bottles, quantity: 10 bottles. |
| Storage | 1 - Chloro - 3 - fluoro - 5 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, strong acids, and bases. This aromatic compound's storage conditions help maintain its stability and minimize risks associated with its flammability and potential reactivity. |
| Shipping | 1 - chloro - 3 - fluoro - 5 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous material regulations, ensuring safe transportation to prevent leakage and environmental or safety risks. |
Competitive 1-Chloro-3-Fluoro-5-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Chloro-3-Fluoro-5-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-3-fluoro-5-methylbenzene?
1-Chloro-3-fluoro-5-methylbenzene, this is an organic compound. Its chemical properties are unique, due to the functional groups such as chlorine, fluorine and methyl contained in the molecule.
Let's talk about the chlorine atom first, which has electron-absorbing properties and can reduce the electron cloud density of the benzene ring. This property affects the reactivity of the benzene ring, making it difficult for the electrophilic substitution reaction to occur. Taking the halogenation reaction as an example, compared with benzene, when the compound is halogenated, the reaction conditions may be more severe. The electron-withdrawing effect of the chlorine atom weakens the attraction of the benzene ring to the electrophilic reagent.
The fluorine atom also has strong electron-withdrawing properties, and the electroneg This not only further reduces the electron cloud density of the benzene ring, but also affects the spatial structure of the molecule. In some reactions, due to the small radius of the fluorine atom, the spatial steric resistance is small, or it can participate in a specific reaction path, which affects the selectivity of the product.
methyl is the power supply radical, which can increase the electron cloud density of the benzene ring o and para-sites relatively in contrast to the electron-withdrawing action of chlorine and fluorine. In the electrophilic substitution reaction, methyl will guide the electrophilic reagents to attack its o and para-sites. For example, in the nitration reaction, the nitro group is more inclined to enter the adjacent and para-sites of methyl, and the chlorine and fluorine atoms will affect the reaction check point. Various groups interact to jointly determine the main product of the reaction.
In addition, the physical properties of 1-chloro-3-fluoro-5-methylbenzene, such as boiling point and melting point, are also affected by these functional groups. The interaction between functional groups results in the unique chemical behavior of the compound. It may have specific uses in organic synthesis, materials science and other fields, and it is an organic compound worthy of further investigation.
Let's talk about the chlorine atom first, which has electron-absorbing properties and can reduce the electron cloud density of the benzene ring. This property affects the reactivity of the benzene ring, making it difficult for the electrophilic substitution reaction to occur. Taking the halogenation reaction as an example, compared with benzene, when the compound is halogenated, the reaction conditions may be more severe. The electron-withdrawing effect of the chlorine atom weakens the attraction of the benzene ring to the electrophilic reagent.
The fluorine atom also has strong electron-withdrawing properties, and the electroneg This not only further reduces the electron cloud density of the benzene ring, but also affects the spatial structure of the molecule. In some reactions, due to the small radius of the fluorine atom, the spatial steric resistance is small, or it can participate in a specific reaction path, which affects the selectivity of the product.
methyl is the power supply radical, which can increase the electron cloud density of the benzene ring o and para-sites relatively in contrast to the electron-withdrawing action of chlorine and fluorine. In the electrophilic substitution reaction, methyl will guide the electrophilic reagents to attack its o and para-sites. For example, in the nitration reaction, the nitro group is more inclined to enter the adjacent and para-sites of methyl, and the chlorine and fluorine atoms will affect the reaction check point. Various groups interact to jointly determine the main product of the reaction.
In addition, the physical properties of 1-chloro-3-fluoro-5-methylbenzene, such as boiling point and melting point, are also affected by these functional groups. The interaction between functional groups results in the unique chemical behavior of the compound. It may have specific uses in organic synthesis, materials science and other fields, and it is an organic compound worthy of further investigation.
What are the common uses of 1-chloro-3-fluoro-5-methylbenzene?
1-Chloro-3-fluoro-5-methylbenzene, an organic compound, is widely used in chemical and scientific research fields. Its common preparation methods are as follows:
First, halogenation reaction. Using 5-methyl-1,3-difluorobenzene as raw material, with the help of specific reaction conditions and catalysts, it undergoes a substitution reaction with a chlorine source (such as chlorine gas) to obtain 1-chloro-3-fluoro-5-methylbenzene. This process requires precise control of reaction temperature, time and proportion of reactants to ensure product purity and yield.
Second, diazotization reaction. First prepare aniline compounds containing specific substituents, then react with diazotization, then react with fluoroboronic acid or its salts to form fluoride, and finally introduce chlorine atoms through chlorination reaction to achieve the synthesis of 1-chloro-3-fluoro-5-methylbenzene. This route is a bit complicated, but the control of reaction conditions is extremely high, and strict operation is required in each step to obtain the target product.
In practical applications, 1-chloro-3-fluoro-5-methylbenzene is mainly used in organic synthesis. As a key intermediate, it can participate in many organic reactions to synthesize compounds with special structures and properties. In the field of medicinal chemistry, it can be used to prepare new drug molecules, which endow drugs with specific biological activities and pharmacological properties through their unique chemical structure. In the field of materials science, it can be used as a raw material for synthesizing functional materials, such as photoelectric materials, to improve the optical and electrical properties of materials by using their structural properties. In addition, in the field of pesticide chemistry, it can also be used to synthesize pesticide ingredients with high insecticidal and bactericidal activities, providing strong support for agricultural production. In short, 1-chloro-3-fluoro-5-methylbenzene plays an indispensable role in the field of organic synthesis. With the continuous progress of scientific research and chemical technology, its application prospects will become increasingly broad.
First, halogenation reaction. Using 5-methyl-1,3-difluorobenzene as raw material, with the help of specific reaction conditions and catalysts, it undergoes a substitution reaction with a chlorine source (such as chlorine gas) to obtain 1-chloro-3-fluoro-5-methylbenzene. This process requires precise control of reaction temperature, time and proportion of reactants to ensure product purity and yield.
Second, diazotization reaction. First prepare aniline compounds containing specific substituents, then react with diazotization, then react with fluoroboronic acid or its salts to form fluoride, and finally introduce chlorine atoms through chlorination reaction to achieve the synthesis of 1-chloro-3-fluoro-5-methylbenzene. This route is a bit complicated, but the control of reaction conditions is extremely high, and strict operation is required in each step to obtain the target product.
In practical applications, 1-chloro-3-fluoro-5-methylbenzene is mainly used in organic synthesis. As a key intermediate, it can participate in many organic reactions to synthesize compounds with special structures and properties. In the field of medicinal chemistry, it can be used to prepare new drug molecules, which endow drugs with specific biological activities and pharmacological properties through their unique chemical structure. In the field of materials science, it can be used as a raw material for synthesizing functional materials, such as photoelectric materials, to improve the optical and electrical properties of materials by using their structural properties. In addition, in the field of pesticide chemistry, it can also be used to synthesize pesticide ingredients with high insecticidal and bactericidal activities, providing strong support for agricultural production. In short, 1-chloro-3-fluoro-5-methylbenzene plays an indispensable role in the field of organic synthesis. With the continuous progress of scientific research and chemical technology, its application prospects will become increasingly broad.
What is the preparation method of 1-chloro-3-fluoro-5-methylbenzene?
The preparation method of 1-chloro-3-fluoro-5-methylbenzene is a key issue in the field of organic synthesis. Its preparation often follows the following path.
First, m-methylaniline is used as the starting material. Schilling m-methylaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. This reaction requires fine temperature control to prevent the decomposition of diazonium salts. The chemical process involved is quite delicate, and the stability of diazonium salts is crucial. Subsequently, the resulting diazonium salt reacts with a mixed system of cuprous chloride and potassium fluoride to achieve the introduction of chlorine and fluorine atoms. This step requires grasping the appropriate reaction conditions, such as temperature, reactant ratio, etc., in order to efficiently prepare the target product. The advantage of this route is that the raw materials are relatively easy to obtain, the logic of the reaction steps is clear, but the control of the reaction conditions is very high.
Second, it can be started from m-fluorotoluene. First, m-fluorotoluene and chlorine gas are substituted in the presence of light or catalyst, so that chlorine atoms are selectively introduced into the benzene ring. In this substitution reaction, the light intensity, catalyst type and dosage all have a significant impact on the reaction check point and yield. Too strong or too weak light, and differences in catalyst activity can cause the reaction to deviate from expectations. In this way, 1-chloro-3-fluoro-5-methylbenzene can also be obtained after rational regulation. The advantage of this approach is that the starting material is single, the reaction step is relatively simple, but the precise control of the reaction conditions is still indispensable.
Third, m-chlorotoluene is used as the starting material. By interacting with anhydrous hydrogen fluoride and a catalyst, the substitution of fluorine atoms to hydrogen atoms at specific positions on the benzene ring is achieved. The catalyst used for this reaction needs to have high catalytic activity and selectivity to ensure the precise substitution of fluorine atoms. During the reaction process, factors such as temperature, pressure and reactant concentration are interrelated, which jointly affect the reaction process and product purity.
The methods for preparing 1-chloro-3-fluoro-5-methylbenzene have their own advantages and disadvantages. In actual operation, the appropriate preparation route should be carefully selected according to various factors such as raw material availability, cost consideration, controllability of reaction conditions and purity requirements of target products.
First, m-methylaniline is used as the starting material. Schilling m-methylaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. This reaction requires fine temperature control to prevent the decomposition of diazonium salts. The chemical process involved is quite delicate, and the stability of diazonium salts is crucial. Subsequently, the resulting diazonium salt reacts with a mixed system of cuprous chloride and potassium fluoride to achieve the introduction of chlorine and fluorine atoms. This step requires grasping the appropriate reaction conditions, such as temperature, reactant ratio, etc., in order to efficiently prepare the target product. The advantage of this route is that the raw materials are relatively easy to obtain, the logic of the reaction steps is clear, but the control of the reaction conditions is very high.
Second, it can be started from m-fluorotoluene. First, m-fluorotoluene and chlorine gas are substituted in the presence of light or catalyst, so that chlorine atoms are selectively introduced into the benzene ring. In this substitution reaction, the light intensity, catalyst type and dosage all have a significant impact on the reaction check point and yield. Too strong or too weak light, and differences in catalyst activity can cause the reaction to deviate from expectations. In this way, 1-chloro-3-fluoro-5-methylbenzene can also be obtained after rational regulation. The advantage of this approach is that the starting material is single, the reaction step is relatively simple, but the precise control of the reaction conditions is still indispensable.
Third, m-chlorotoluene is used as the starting material. By interacting with anhydrous hydrogen fluoride and a catalyst, the substitution of fluorine atoms to hydrogen atoms at specific positions on the benzene ring is achieved. The catalyst used for this reaction needs to have high catalytic activity and selectivity to ensure the precise substitution of fluorine atoms. During the reaction process, factors such as temperature, pressure and reactant concentration are interrelated, which jointly affect the reaction process and product purity.
The methods for preparing 1-chloro-3-fluoro-5-methylbenzene have their own advantages and disadvantages. In actual operation, the appropriate preparation route should be carefully selected according to various factors such as raw material availability, cost consideration, controllability of reaction conditions and purity requirements of target products.
What impact does 1-chloro-3-fluoro-5-methylbenzene have on the environment?
1-Chloro-3-fluoro-5-methylbenzene is one of the organic compounds. Its impact on the environment is quite complex and multi-faceted, which cannot be ignored.
First of all, its physical properties are affected. This substance is volatile, in the atmosphere, or can participate in photochemical reactions. When volatilized into the atmosphere, it will interact with many free radicals and other chemical substances. It contains chlorine and fluorine atoms. Under light and other conditions, it may release chlorine and fluorine free radicals, both of which have potential damage to the ozone layer. The ozone layer is the protective barrier of the earth. If it is damaged, ultraviolet radiation will increase, endangering the survival of organisms. For example, the incidence of human skin cancer may rise, animals and plants will also be harmed, and the ecological balance will be disturbed.
Furthermore, in terms of its chemical stability. Although 1-chloro-3-fluoro-5-methylbenzene is relatively stable, in certain environments, degradation reactions may occur. Degradation products or more active and toxic than parent compounds. If it enters the water body, it may affect the water quality and be toxic to aquatic organisms. Aquatic organisms have different tolerances to it, and those who are sensitive may die, which in turn affects the food chain structure of the aquatic ecosystem, resulting in an imbalance of the entire ecosystem.
Repeat its bioaccumulation. This substance may have certain lipophilic properties and is easily absorbed by organisms and accumulated in the body. When organisms ingest food or water sources containing 1-chloro-3-fluoro-5-methylbenzene, this substance will gradually accumulate in the organism. With the rise of the food chain, the accumulated concentration in the body of high trophic level organisms is higher, the greater the threat to their health, or affect their physiological functions such as reproduction and immunity.
In addition, if 1-chloro-3-fluoro-5-methylbenzene enters the soil, it may affect the structure and function of soil microbial communities. Soil microorganisms are crucial to soil fertility and material circulation. If they are affected, the normal operation or destruction of soil ecosystems will affect plant growth and development, and further affect terrestrial ecosystems.
In short, 1-chloro-3-fluoro-5-methylbenzene has a wide and far-reaching impact on the environment. From the atmosphere to water bodies, from organisms to soil, many ecological factors are implicated by it, and it needs to be treated with caution and studied in depth to reduce its harm to the environment.
First of all, its physical properties are affected. This substance is volatile, in the atmosphere, or can participate in photochemical reactions. When volatilized into the atmosphere, it will interact with many free radicals and other chemical substances. It contains chlorine and fluorine atoms. Under light and other conditions, it may release chlorine and fluorine free radicals, both of which have potential damage to the ozone layer. The ozone layer is the protective barrier of the earth. If it is damaged, ultraviolet radiation will increase, endangering the survival of organisms. For example, the incidence of human skin cancer may rise, animals and plants will also be harmed, and the ecological balance will be disturbed.
Furthermore, in terms of its chemical stability. Although 1-chloro-3-fluoro-5-methylbenzene is relatively stable, in certain environments, degradation reactions may occur. Degradation products or more active and toxic than parent compounds. If it enters the water body, it may affect the water quality and be toxic to aquatic organisms. Aquatic organisms have different tolerances to it, and those who are sensitive may die, which in turn affects the food chain structure of the aquatic ecosystem, resulting in an imbalance of the entire ecosystem.
Repeat its bioaccumulation. This substance may have certain lipophilic properties and is easily absorbed by organisms and accumulated in the body. When organisms ingest food or water sources containing 1-chloro-3-fluoro-5-methylbenzene, this substance will gradually accumulate in the organism. With the rise of the food chain, the accumulated concentration in the body of high trophic level organisms is higher, the greater the threat to their health, or affect their physiological functions such as reproduction and immunity.
In addition, if 1-chloro-3-fluoro-5-methylbenzene enters the soil, it may affect the structure and function of soil microbial communities. Soil microorganisms are crucial to soil fertility and material circulation. If they are affected, the normal operation or destruction of soil ecosystems will affect plant growth and development, and further affect terrestrial ecosystems.
In short, 1-chloro-3-fluoro-5-methylbenzene has a wide and far-reaching impact on the environment. From the atmosphere to water bodies, from organisms to soil, many ecological factors are implicated by it, and it needs to be treated with caution and studied in depth to reduce its harm to the environment.
What do 1-chloro-3-fluoro-5-methylbenzene need to pay attention to when storing and transporting?
1-Chloro-3-fluoro-5-methylbenzene organic compounds require special attention during storage and transportation.
Let's talk about storage first. This compound has certain chemical activity and potential danger, and the first choice for storage environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Due to high temperature or poor ventilation, it may cause its volatilization to accelerate, and even cause chemical reactions, or there is a risk of combustion or explosion. In addition, it needs to be stored in a special chemical warehouse, separate from oxidants, acids, bases and other substances, and must not be mixed. Due to the chemical activity of this compound, contact with the above substances is likely to cause severe chemical reactions, resulting in serious consequences. At the same time, the storage container must be well sealed to prevent leakage. Use containers of suitable materials, such as corrosion-resistant glass bottles or specific plastic containers, to avoid reactions between the container and the compound. In the warehouse, corresponding fire equipment and leakage emergency treatment equipment should also be equipped to deal with emergencies.
As for transportation, there are also many key points. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. The packaging material must be able to effectively prevent the leakage and volatilization of the compound, and can withstand certain external shocks. During transportation, relevant transportation regulations and operating procedures must be strictly followed, and the transportation vehicle must be equipped with corresponding fire equipment and emergency rescue equipment. Drivers and escorts must be professionally trained to be familiar with the properties, hazards and emergency treatment methods of this compound. During driving, avoid severe bumps and vibrations in vehicles to prevent packaging damage. And do not stay in sensitive areas such as densely populated areas and water sources.
In short, 1-chloro-3-fluoro-5-methylbenzene must be treated with caution when storing and transporting, and strictly follow relevant regulations and operating requirements to ensure personnel safety and the environment is not polluted.
Let's talk about storage first. This compound has certain chemical activity and potential danger, and the first choice for storage environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Due to high temperature or poor ventilation, it may cause its volatilization to accelerate, and even cause chemical reactions, or there is a risk of combustion or explosion. In addition, it needs to be stored in a special chemical warehouse, separate from oxidants, acids, bases and other substances, and must not be mixed. Due to the chemical activity of this compound, contact with the above substances is likely to cause severe chemical reactions, resulting in serious consequences. At the same time, the storage container must be well sealed to prevent leakage. Use containers of suitable materials, such as corrosion-resistant glass bottles or specific plastic containers, to avoid reactions between the container and the compound. In the warehouse, corresponding fire equipment and leakage emergency treatment equipment should also be equipped to deal with emergencies.
As for transportation, there are also many key points. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. The packaging material must be able to effectively prevent the leakage and volatilization of the compound, and can withstand certain external shocks. During transportation, relevant transportation regulations and operating procedures must be strictly followed, and the transportation vehicle must be equipped with corresponding fire equipment and emergency rescue equipment. Drivers and escorts must be professionally trained to be familiar with the properties, hazards and emergency treatment methods of this compound. During driving, avoid severe bumps and vibrations in vehicles to prevent packaging damage. And do not stay in sensitive areas such as densely populated areas and water sources.
In short, 1-chloro-3-fluoro-5-methylbenzene must be treated with caution when storing and transporting, and strictly follow relevant regulations and operating requirements to ensure personnel safety and the environment is not polluted.
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