Linshang Chemical
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1-Chloro-3-Fluoro-5-Nitrobenzene
Linshang Chemical
|
HS Code |
349726 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Solid |
| Color | Yellowish |
| Odor | Pungent |
| Density | 1.514 g/cm³ (estimated) |
| Melting Point | 40 - 42 °C |
| Boiling Point | 235 - 237 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
As an accredited 1-Chloro-3-Fluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluoro - 5 - nitrobenzene: Packed in 500g bottles for chemical storage. |
| Storage | 1 - Chloro - 3 - fluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be stored in a tightly - sealed container to prevent leakage. Keep it separate from oxidizing agents, reducing agents, and bases, as it may react with them. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - Chloro - 3 - fluoro - 5 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under regulated conditions, adhering to safety protocols for hazardous chemicals to prevent leakage and ensure safe transit. |
Competitive 1-Chloro-3-Fluoro-5-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-3-Fluoro-5-Nitrobenzene in China?
As a trusted 1-Chloro-3-Fluoro-5-Nitrobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3-Fluoro-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3-fluoro-5-nitrobenzene?
What are the main uses of 1 + - 3 + - 5 + - aminoquine? "Tiangong Kaiwu" has a saying:
This 1 - 3 - 5 - aminoquine is very useful in the medical way. First, it is an anti-malarial medicine. Malaria disease, throughout the ages, has been a serious disaster, robbing people of health and disturbing people's livelihood. And 1 - 3 - 5 - aminoquine can enter the human body, search for malaria parasites and make them, prevent their reproduction, solve the disease of malaria, and make patients heal.
Second, in the field of chemical industry, it is also useful. It can be used as a raw material, through various chemical changes, to obtain other substances, or as a precursor to dyes, or as a component of special materials, in the chemical industry, adding bricks and mortar to promote its prosperity.
Third, in the process of scientific research, it is an important test drug. Scientists use their properties to explore the secrets of life, study chemical changes, and understand all kinds of things, promote the progress of learning, and pave the way for the development of future generations.
In general, although 1-3-5-aminoquine is small in shape, it is of critical use in medicine, chemical industry, and scientific research.
This 1 - 3 - 5 - aminoquine is very useful in the medical way. First, it is an anti-malarial medicine. Malaria disease, throughout the ages, has been a serious disaster, robbing people of health and disturbing people's livelihood. And 1 - 3 - 5 - aminoquine can enter the human body, search for malaria parasites and make them, prevent their reproduction, solve the disease of malaria, and make patients heal.
Second, in the field of chemical industry, it is also useful. It can be used as a raw material, through various chemical changes, to obtain other substances, or as a precursor to dyes, or as a component of special materials, in the chemical industry, adding bricks and mortar to promote its prosperity.
Third, in the process of scientific research, it is an important test drug. Scientists use their properties to explore the secrets of life, study chemical changes, and understand all kinds of things, promote the progress of learning, and pave the way for the development of future generations.
In general, although 1-3-5-aminoquine is small in shape, it is of critical use in medicine, chemical industry, and scientific research.
What are the physical properties of 1-chloro-3-fluoro-5-nitrobenzene
The physical properties of 1 + -deuterium-3 + -tritium-5 + -aminosilane are related to the characterization of the essence of matter, which is the key to exploring the characteristics of this compound.
Deuterium and tritium are isotopes of hydrogen and have a unique nuclear structure. In deuterium, the nucleus contains a neutron in addition to protons, so its mass is slightly heavier than hydrogen. This property makes deuterium-containing compounds different from ordinary hydrogen-containing compounds in physical properties. In 1 + -deuterium-3 + -tritium-5 + -aminosilane, the presence of deuterium or the increase in molecular mass affects its properties such as density and boiling point. The density may increase due to mass increase, and the boiling point may also change due to changes in intermolecular forces.
As for tritium, its nucleus contains one proton and two neutrons, which are radioactive. This radioactivity in 1 + -deuterium-3 + -tritium-5 + -aminosilane gives the compound special physical properties. On the one hand, its radioactive decay can release energy, which affects the stability of the compound; on the other hand, radioactivity can be used for tracer studies to help researchers understand the behavior of the compound in chemical reactions and biological processes.
5 + -aminosilicon part, silicon atoms affect the overall properties of the compound due to their special electronic structure and bonding ability. Silicon atoms can form stable covalent bonds to build the basic skeleton of compounds. The introduction of amino groups (-NH2O) makes compounds have a certain polarity. Nitrogen atoms in amino groups have lone pairs of electrons and can form hydrogen bonds with other molecules, which significantly affects the solubility and melting point of compounds. In terms of solubility, due to the polarity of amino groups, the compound may have better solubility in polar solvents; the melting point is higher than that without hydrogen bonds due to the action of hydrogen bonds.
Overall, 1 + -deuterium-3 + -tritium-5 + -aminosilane has complex and unique physical properties due to the interaction of deuterium, tritium and amino silicon, covering density, boiling point, radioactivity, solubility, melting point and many other aspects. This is an important entry point for in-depth study of this compound.
Deuterium and tritium are isotopes of hydrogen and have a unique nuclear structure. In deuterium, the nucleus contains a neutron in addition to protons, so its mass is slightly heavier than hydrogen. This property makes deuterium-containing compounds different from ordinary hydrogen-containing compounds in physical properties. In 1 + -deuterium-3 + -tritium-5 + -aminosilane, the presence of deuterium or the increase in molecular mass affects its properties such as density and boiling point. The density may increase due to mass increase, and the boiling point may also change due to changes in intermolecular forces.
As for tritium, its nucleus contains one proton and two neutrons, which are radioactive. This radioactivity in 1 + -deuterium-3 + -tritium-5 + -aminosilane gives the compound special physical properties. On the one hand, its radioactive decay can release energy, which affects the stability of the compound; on the other hand, radioactivity can be used for tracer studies to help researchers understand the behavior of the compound in chemical reactions and biological processes.
5 + -aminosilicon part, silicon atoms affect the overall properties of the compound due to their special electronic structure and bonding ability. Silicon atoms can form stable covalent bonds to build the basic skeleton of compounds. The introduction of amino groups (-NH2O) makes compounds have a certain polarity. Nitrogen atoms in amino groups have lone pairs of electrons and can form hydrogen bonds with other molecules, which significantly affects the solubility and melting point of compounds. In terms of solubility, due to the polarity of amino groups, the compound may have better solubility in polar solvents; the melting point is higher than that without hydrogen bonds due to the action of hydrogen bonds.
Overall, 1 + -deuterium-3 + -tritium-5 + -aminosilane has complex and unique physical properties due to the interaction of deuterium, tritium and amino silicon, covering density, boiling point, radioactivity, solubility, melting point and many other aspects. This is an important entry point for in-depth study of this compound.
What are the chemical properties of 1-chloro-3-fluoro-5-nitrobenzene?
The chemical properties of 1 + -deuterium-3 + -tritium-5 + -aminonaphthalene can be investigated. Deuterium is also an isotope of hydrogen, and its nucleus has more neutrons than hydrogen, and its mass is slightly heavier. Its chemical properties are generally similar to those of hydrogen, but due to the difference in mass, it varies in some reaction rates. In chemical reactions, deuterium participates in the reaction at a slightly slower rate than hydrogen, because the heavier nuclei cause different chemical bond vibration frequencies, which affect the reaction process.
As for tritium, which is also an isotope of hydrogen, the nucleus contains two neutrons and is radioactive. Its chemical properties are also similar to those of hydrogen, but due to radioactivity, the chemical reactions it participates in are even more unique. Its decay can cause changes in the surrounding chemical environment, and it is widely used in biochemical research, tracer technology and other fields. With its radioactivity, the movement and reaction path of substances can be traced.
5 + -Aminonaphthalene, an organic compound containing an amino group and a naphthalene ring. The amino group has electron-giving properties, which can increase the electron cloud density of the naphthalene ring, making it more prone to electrophilic substitution. And the amino group can participate in many reactions, such as salting with acids, acylation with acyl halides, acid anhydrides, etc. The naphthalene ring is an aromatic ring aromatic hydrocarbon, which can undergo typical aromatic electrophilic substitution reactions such as halogenation, nitrification, and sulfonation. Due to the different electron cloud densities at different positions on the naphthalene ring, the substitution reaction Overall, the components of 1 + -deuterium-3 + -tritium-5 + -aminonaphthalene interact with each other to form unique chemical properties, which have potential applications and research value in chemistry, materials, biology and other fields.
As for tritium, which is also an isotope of hydrogen, the nucleus contains two neutrons and is radioactive. Its chemical properties are also similar to those of hydrogen, but due to radioactivity, the chemical reactions it participates in are even more unique. Its decay can cause changes in the surrounding chemical environment, and it is widely used in biochemical research, tracer technology and other fields. With its radioactivity, the movement and reaction path of substances can be traced.
5 + -Aminonaphthalene, an organic compound containing an amino group and a naphthalene ring. The amino group has electron-giving properties, which can increase the electron cloud density of the naphthalene ring, making it more prone to electrophilic substitution. And the amino group can participate in many reactions, such as salting with acids, acylation with acyl halides, acid anhydrides, etc. The naphthalene ring is an aromatic ring aromatic hydrocarbon, which can undergo typical aromatic electrophilic substitution reactions such as halogenation, nitrification, and sulfonation. Due to the different electron cloud densities at different positions on the naphthalene ring, the substitution reaction Overall, the components of 1 + -deuterium-3 + -tritium-5 + -aminonaphthalene interact with each other to form unique chemical properties, which have potential applications and research value in chemistry, materials, biology and other fields.
What are the synthesis methods of 1-chloro-3-fluoro-5-nitrobenzene?
To prepare 1-cyanogen-3-alkyne-5-aminopyridine, there are many methods, and several common ones are described above.
First, pyridine is used as the starting material, and the halogenation method is used to introduce the halogen atom at a specific position of the pyridine, and then interact with the cyanide reagent to introduce the cyanyl group. Then by suitable reaction conditions, the alkynylation reaction occurs and the alkynyl group is added. Finally, the amino group is introduced by means of amination, so as to achieve the synthesis of the target product. In this process, the halogenation reaction requires the selection of suitable halogenating agents and reaction conditions to ensure that the halogen atoms fall precisely in the expected position; the cyanidation step requires attention to the activity and safety of the cyanide reagent; alkynylation and amination also have their own key conditions, which need to be carefully regulated to improve the yield and purity.
Second, the pyridine ring can be constructed by multi-step cyclization from aromatic compounds containing specific substituents. In the cyclization process, cyano, alkynyl and amino groups are introduced synchronously or step by step. For example, some compounds containing benzene rings with specific functional groups can form pyridine structures after molecular cyclization under suitable catalysts and reaction environments, and at the same time, the interaction between functional groups can be cleverly used to achieve the introduction of target substituents. This path requires a high degree of control over the design of the starting material and the reaction conditions. However, if the design is subtle, the synthesis step may be simplified and the overall efficiency can be improved.
Third, the coupling reaction catalyzed by transition metals. First, the active intermediates containing cyanide groups, alkynyl groups and amino groups are prepared, and then the coupling reactions catalyzed by transition metal catalysts, such as palladium and copper, are used to precisely splice the parts to build the target molecule. The advantage of this method is that the reaction selectivity is high and the conditions are relatively mild. However, the choice and dosage of transition metal catalysts, the design of ligands, and other factors have a huge impact on the success or failure of the reaction and the effect, and need to be deeply studied and optimized.
All these synthesis methods have their own advantages and disadvantages. In actual operation, the appropriate method should be weighed according to the availability of raw materials, cost considerations, the difficulty of the reaction, and the requirements for product purity and yield.
First, pyridine is used as the starting material, and the halogenation method is used to introduce the halogen atom at a specific position of the pyridine, and then interact with the cyanide reagent to introduce the cyanyl group. Then by suitable reaction conditions, the alkynylation reaction occurs and the alkynyl group is added. Finally, the amino group is introduced by means of amination, so as to achieve the synthesis of the target product. In this process, the halogenation reaction requires the selection of suitable halogenating agents and reaction conditions to ensure that the halogen atoms fall precisely in the expected position; the cyanidation step requires attention to the activity and safety of the cyanide reagent; alkynylation and amination also have their own key conditions, which need to be carefully regulated to improve the yield and purity.
Second, the pyridine ring can be constructed by multi-step cyclization from aromatic compounds containing specific substituents. In the cyclization process, cyano, alkynyl and amino groups are introduced synchronously or step by step. For example, some compounds containing benzene rings with specific functional groups can form pyridine structures after molecular cyclization under suitable catalysts and reaction environments, and at the same time, the interaction between functional groups can be cleverly used to achieve the introduction of target substituents. This path requires a high degree of control over the design of the starting material and the reaction conditions. However, if the design is subtle, the synthesis step may be simplified and the overall efficiency can be improved.
Third, the coupling reaction catalyzed by transition metals. First, the active intermediates containing cyanide groups, alkynyl groups and amino groups are prepared, and then the coupling reactions catalyzed by transition metal catalysts, such as palladium and copper, are used to precisely splice the parts to build the target molecule. The advantage of this method is that the reaction selectivity is high and the conditions are relatively mild. However, the choice and dosage of transition metal catalysts, the design of ligands, and other factors have a huge impact on the success or failure of the reaction and the effect, and need to be deeply studied and optimized.
All these synthesis methods have their own advantages and disadvantages. In actual operation, the appropriate method should be weighed according to the availability of raw materials, cost considerations, the difficulty of the reaction, and the requirements for product purity and yield.
What should be paid attention to when storing and transporting 1-chloro-3-fluoro-5-nitrobenzene?
For 1-bromo-3-chloro-5-aminopyridine, many things should be paid attention to when storing and transporting.
The first consideration should be environmental factors. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to the characteristics of bromine, chlorine and other elements, it may be dangerous in case of heat or open flame. If the environment is humid, it is easy to cause chemical reactions and affect the quality.
The second is related to the packaging. The packaging must be tightly sealed to prevent leakage. This compound contains bromine, chlorine and other halogen elements and amino groups, and has certain chemical activity. If it comes into contact with outside air, moisture, etc., it is easy to deteriorate. Select suitable packaging materials, such as corrosion-resistant containers, to ensure their stability.
Furthermore, when transporting, relevant regulations and standards must be followed. Because it may be dangerous, the transportation vehicle needs to be equipped with corresponding emergency treatment equipment and protective equipment. Transport personnel should also be familiar with its characteristics and emergency treatment methods to prevent accidents.
And this compound should not be mixed with oxidants, acids, etc. Because the amino group is alkaline, it is easy to react with acids; while the bromine, chlorine-related structures, or react violently with oxidants, causing safety accidents.
During the storage and transportation of 1-bromo-3-chloro-5-aminopyridine, careful attention should be paid to the environment, packaging, regulatory compliance, and avoidance of mixed transportation to ensure safety and quality.
The first consideration should be environmental factors. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to the characteristics of bromine, chlorine and other elements, it may be dangerous in case of heat or open flame. If the environment is humid, it is easy to cause chemical reactions and affect the quality.
The second is related to the packaging. The packaging must be tightly sealed to prevent leakage. This compound contains bromine, chlorine and other halogen elements and amino groups, and has certain chemical activity. If it comes into contact with outside air, moisture, etc., it is easy to deteriorate. Select suitable packaging materials, such as corrosion-resistant containers, to ensure their stability.
Furthermore, when transporting, relevant regulations and standards must be followed. Because it may be dangerous, the transportation vehicle needs to be equipped with corresponding emergency treatment equipment and protective equipment. Transport personnel should also be familiar with its characteristics and emergency treatment methods to prevent accidents.
And this compound should not be mixed with oxidants, acids, etc. Because the amino group is alkaline, it is easy to react with acids; while the bromine, chlorine-related structures, or react violently with oxidants, causing safety accidents.
During the storage and transportation of 1-bromo-3-chloro-5-aminopyridine, careful attention should be paid to the environment, packaging, regulatory compliance, and avoidance of mixed transportation to ensure safety and quality.
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