Linshang Chemical
PRODUCTS
1-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
803860 |
| Chemical Formula | C6H4ClF |
| Molar Mass | 128.546 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Boiling Point | 136 - 138 °C |
| Melting Point | -46 °C |
| Density | 1.258 g/mL at 25 °C |
| Flash Point | 37 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | 1.5 mmHg at 25 °C |
| Odor | Aromatic odor |
| Refractive Index | 1.502 - 1.504 |
As an accredited 1-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - fluorobenzene packaged in 500 - mL glass bottles, 10 bottles per carton. |
| Storage | 1 - Chloro - 3 - fluorobenzene should be stored in a cool, well - ventilated area away from direct sunlight. It should be kept in a tightly sealed container, preferably made of materials resistant to corrosion. Store it separately from oxidizing agents, strong acids, and bases. This helps prevent potential reactions that could lead to hazardous situations. Ensure proper labeling for easy identification. |
| Shipping | 1 - Chloro - 3 - fluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. Shipment follows strict hazardous material regulations, ensuring proper labeling, handling, and transportation to prevent spills and exposure. |
Competitive 1-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is one of the organic compounds and is widely used in chemical, pharmaceutical, pesticide and other fields.
In the chemical industry, it is often the key raw material for the synthesis of other organic compounds. Due to the presence of chlorine atoms and fluorine atoms on the benzene ring, this compound is endowed with special chemical activity and reactive properties. With these characteristics, many chemical reactions, such as substitution reactions and addition reactions, can be used to produce organic compounds with more complex structures and more specific functions, which play an important role in the synthesis of fine chemical products.
In the field of medicine, 1-chloro-3-fluorobenzene also has important functions. Using it as a starting material, drug molecules with specific pharmacological activities can be synthesized through multi-step chemical reactions. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, this compound may be an indispensable intermediate, contributing greatly to the structure construction and activity regulation of drug molecules.
As for pesticides, 1-chloro-3-fluorobenzene also has extraordinary performance. By modifying and modifying its chemical structure, a variety of high-efficiency and low-toxicity pesticide products can be prepared. Such pesticides have strong toxic effects on pests and are relatively harmless to the environment, contributing to the sustainable development of agriculture.
In summary, 1-chloro-3-fluorobenzene plays a key role in the fields of chemical industry, medicine, pesticides, etc. It is widely used and has a profound impact on the development of related industries.
In the chemical industry, it is often the key raw material for the synthesis of other organic compounds. Due to the presence of chlorine atoms and fluorine atoms on the benzene ring, this compound is endowed with special chemical activity and reactive properties. With these characteristics, many chemical reactions, such as substitution reactions and addition reactions, can be used to produce organic compounds with more complex structures and more specific functions, which play an important role in the synthesis of fine chemical products.
In the field of medicine, 1-chloro-3-fluorobenzene also has important functions. Using it as a starting material, drug molecules with specific pharmacological activities can be synthesized through multi-step chemical reactions. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, this compound may be an indispensable intermediate, contributing greatly to the structure construction and activity regulation of drug molecules.
As for pesticides, 1-chloro-3-fluorobenzene also has extraordinary performance. By modifying and modifying its chemical structure, a variety of high-efficiency and low-toxicity pesticide products can be prepared. Such pesticides have strong toxic effects on pests and are relatively harmless to the environment, contributing to the sustainable development of agriculture.
In summary, 1-chloro-3-fluorobenzene plays a key role in the fields of chemical industry, medicine, pesticides, etc. It is widely used and has a profound impact on the development of related industries.
What are the physical properties of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is a kind of organic compound. Its physical properties are quite important, related to chemical industry, and are used in many fields.
First of all, its appearance, 1-chloro-3-fluorobenzene is a colorless to light yellow transparent liquid under normal conditions, its shape is clear, and it has the characteristics of liquid flow. Smell, there is a special aromatic smell, although this smell is not pungent and intolerable, it is also one of its characteristics, which can be identified to a certain extent.
When it comes to boiling point, it is about 155-157 ° C. For boiling point, the temperature limit of a substance from liquid to gaseous state. 1-Chloro-3-fluorobenzene can achieve phase transformation in this temperature range. This boiling point value allows it to control its state change during heating and other operations, and is particularly critical in the distillation, separation and other steps of chemical production.
In terms of melting point, it is about -48 ° C. The melting point is the critical temperature at which a substance changes from a solid to a liquid state. At this temperature, 1-chloro-3-fluorobenzene is a solid state, and above this temperature, it gradually turns into a liquid state. Knowing the melting point, when storing and transporting, the temperature can be reasonably adjusted to keep its state stable, so as not to change the properties of the substance due to improper temperature.
Its density is about 1.22 g/cm ³. The density is the mass of the substance per unit volume. 1-Chloro-3-fluorobenzene exists at this density. When mixing and proportioning are involved, the density data is the basis for accurate calculation of the dosage, which is related to product quality and reaction process.
In terms of solubility, 1-chloro-3-fluorobenzene is slightly soluble in water, but can be miscible with most organic solvents, such as ethanol, ether, acetone, etc. This solubility property makes it possible to select suitable organic solvents according to the reaction requirements in organic synthesis reactions, establish a good environment for the reaction, promote the reaction, and facilitate the separation and purification of the product.
The vapor pressure of 1-chloro-3-fluorobenzene cannot be ignored. The vapor pressure reflects the ability of the liquid to evaporate at a certain temperature. Its vapor pressure is specific, indicating that in the corresponding temperature environment, a certain amount of substances will evaporate into a gaseous state. In storage and use scenarios, it is necessary to consider the vapor pressure factor, do a good job of protection and operation standards, and avoid safety hazards caused by vapor diffusion or affect the accuracy of experiments and production.
First of all, its appearance, 1-chloro-3-fluorobenzene is a colorless to light yellow transparent liquid under normal conditions, its shape is clear, and it has the characteristics of liquid flow. Smell, there is a special aromatic smell, although this smell is not pungent and intolerable, it is also one of its characteristics, which can be identified to a certain extent.
When it comes to boiling point, it is about 155-157 ° C. For boiling point, the temperature limit of a substance from liquid to gaseous state. 1-Chloro-3-fluorobenzene can achieve phase transformation in this temperature range. This boiling point value allows it to control its state change during heating and other operations, and is particularly critical in the distillation, separation and other steps of chemical production.
In terms of melting point, it is about -48 ° C. The melting point is the critical temperature at which a substance changes from a solid to a liquid state. At this temperature, 1-chloro-3-fluorobenzene is a solid state, and above this temperature, it gradually turns into a liquid state. Knowing the melting point, when storing and transporting, the temperature can be reasonably adjusted to keep its state stable, so as not to change the properties of the substance due to improper temperature.
Its density is about 1.22 g/cm ³. The density is the mass of the substance per unit volume. 1-Chloro-3-fluorobenzene exists at this density. When mixing and proportioning are involved, the density data is the basis for accurate calculation of the dosage, which is related to product quality and reaction process.
In terms of solubility, 1-chloro-3-fluorobenzene is slightly soluble in water, but can be miscible with most organic solvents, such as ethanol, ether, acetone, etc. This solubility property makes it possible to select suitable organic solvents according to the reaction requirements in organic synthesis reactions, establish a good environment for the reaction, promote the reaction, and facilitate the separation and purification of the product.
The vapor pressure of 1-chloro-3-fluorobenzene cannot be ignored. The vapor pressure reflects the ability of the liquid to evaporate at a certain temperature. Its vapor pressure is specific, indicating that in the corresponding temperature environment, a certain amount of substances will evaporate into a gaseous state. In storage and use scenarios, it is necessary to consider the vapor pressure factor, do a good job of protection and operation standards, and avoid safety hazards caused by vapor diffusion or affect the accuracy of experiments and production.
What are the chemical properties of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is also an organic compound. It has the general properties of halogenated aromatics and is quite interesting. It is widely used in the field of organic synthesis.
First of all, its chemical activity. Due to the existence of chlorine and fluorodihalogen atoms, the electron cloud density of the benzene ring changes. Chlorine and fluorine are both electron-absorbing groups, but fluorine is particularly electronegative, so the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than that of benzene. For example, electrophilic substitution such as nitrification, sulfonation, and halogenation requires more severe conditions. When
electrophilic substitution, the positioning effects of chlorine and fluorine also need to be observed. Both are ortho and para-positioning groups, but the positioning effect of fluorine is slightly stronger than Therefore, when electrophilic reagents attack, the products are mainly ortho and para-isomers, and most of them are para-products due to steric hindrance.
In addition, 1-chloro-3-fluorobenzene can be involved in nucleophilic substitution reactions. Under specific conditions, chlorine and fluorine atoms can be replaced by nucleophilic reagents. For example, in the presence of nucleophilic reagents such as sodium alcohol and amine, chlorine and fluorine atoms can be replaced by alkoxy groups and amino groups respectively or at the same time, which is an important path for the construction of new carbon-hetero bonds.
In addition, it can participate in metal-catalyzed reactions. For example, the coupling reaction catalyzed by palladium can be coupled with boron, tin and other reagents to construct more complex organic molecular structures, which is of great significance in the fields of drug synthesis and materials science.
1-chloro-3-fluorobenzene is rich in chemical properties due to its chlorine and fluorine atoms. It is of great value in many aspects of organic synthesis and is a key compound for the research and application of organic chemistry.
First of all, its chemical activity. Due to the existence of chlorine and fluorodihalogen atoms, the electron cloud density of the benzene ring changes. Chlorine and fluorine are both electron-absorbing groups, but fluorine is particularly electronegative, so the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than that of benzene. For example, electrophilic substitution such as nitrification, sulfonation, and halogenation requires more severe conditions. When
electrophilic substitution, the positioning effects of chlorine and fluorine also need to be observed. Both are ortho and para-positioning groups, but the positioning effect of fluorine is slightly stronger than Therefore, when electrophilic reagents attack, the products are mainly ortho and para-isomers, and most of them are para-products due to steric hindrance.
In addition, 1-chloro-3-fluorobenzene can be involved in nucleophilic substitution reactions. Under specific conditions, chlorine and fluorine atoms can be replaced by nucleophilic reagents. For example, in the presence of nucleophilic reagents such as sodium alcohol and amine, chlorine and fluorine atoms can be replaced by alkoxy groups and amino groups respectively or at the same time, which is an important path for the construction of new carbon-hetero bonds.
In addition, it can participate in metal-catalyzed reactions. For example, the coupling reaction catalyzed by palladium can be coupled with boron, tin and other reagents to construct more complex organic molecular structures, which is of great significance in the fields of drug synthesis and materials science.
1-chloro-3-fluorobenzene is rich in chemical properties due to its chlorine and fluorine atoms. It is of great value in many aspects of organic synthesis and is a key compound for the research and application of organic chemistry.
What are the preparation methods of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is also an organic compound, and the method of preparation is slightly lower.
First, m-fluoroaniline is used as the starting material, and can be obtained by diazotization and Sandmeier reaction. First, m-fluoroaniline and sodium nitrite are reacted in an acidic environment at low temperature to obtain diazonium salts. After using cuprous chloride as the catalyst, it is co-heated with concentrated hydrochloric acid, and the diazo group is replaced by a chlorine atom to obtain 1-chloro-3-fluorobenzene. This step is slightly complicated, the yield is acceptable, and the raw material m-fluoroaniline is relatively easy to obtain.
Second, using m-difluorobenzene as a substrate, selective chlorination is carried out with a chlorinating agent. If chlorine is used as a chlorinating agent, the reaction is heated in the presence of a specific catalyst such as Lewis acid (such as aluminum trichloride, etc.). The monofluorine atom in m-difluorobenzene is selectively replaced by a chlorine atom to generate 1-chloro-3-fluorobenzene. The raw material of this route is relatively easy to obtain, and the reaction conditions are not extremely harsh, but the reaction conditions and catalyst dosage need to be controlled to increase the selectivity of the product.
Third, 3-fluorophenylboronic acid is reacted with a chlorinated 3-Fluorophenylboronic acid and suitable chlorinated reagents (such as N-chlorosuccinimide, etc.), in the presence of palladium catalysts and ligands, react in suitable solvents, and the boric acid group can be replaced by chlorine atoms to obtain the target product. This method has mild conditions and is more environmentally friendly. However, the cost of catalysts and ligands may be higher, which affects large-scale preparation.
Or there are other methods, but the above are more commonly used in laboratory and industrial preparation. When preparing, it is necessary to pay attention to the precise control of reaction conditions, such as temperature, pressure, reactant ratio, etc., in order to achieve high yield and excellent purity products.
First, m-fluoroaniline is used as the starting material, and can be obtained by diazotization and Sandmeier reaction. First, m-fluoroaniline and sodium nitrite are reacted in an acidic environment at low temperature to obtain diazonium salts. After using cuprous chloride as the catalyst, it is co-heated with concentrated hydrochloric acid, and the diazo group is replaced by a chlorine atom to obtain 1-chloro-3-fluorobenzene. This step is slightly complicated, the yield is acceptable, and the raw material m-fluoroaniline is relatively easy to obtain.
Second, using m-difluorobenzene as a substrate, selective chlorination is carried out with a chlorinating agent. If chlorine is used as a chlorinating agent, the reaction is heated in the presence of a specific catalyst such as Lewis acid (such as aluminum trichloride, etc.). The monofluorine atom in m-difluorobenzene is selectively replaced by a chlorine atom to generate 1-chloro-3-fluorobenzene. The raw material of this route is relatively easy to obtain, and the reaction conditions are not extremely harsh, but the reaction conditions and catalyst dosage need to be controlled to increase the selectivity of the product.
Third, 3-fluorophenylboronic acid is reacted with a chlorinated 3-Fluorophenylboronic acid and suitable chlorinated reagents (such as N-chlorosuccinimide, etc.), in the presence of palladium catalysts and ligands, react in suitable solvents, and the boric acid group can be replaced by chlorine atoms to obtain the target product. This method has mild conditions and is more environmentally friendly. However, the cost of catalysts and ligands may be higher, which affects large-scale preparation.
Or there are other methods, but the above are more commonly used in laboratory and industrial preparation. When preparing, it is necessary to pay attention to the precise control of reaction conditions, such as temperature, pressure, reactant ratio, etc., in order to achieve high yield and excellent purity products.
What are the precautions in storage and transportation of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage. This substance is toxic and volatile, and should be stored in a cool and ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Because it is flammable, it should be stored separately from oxidants and edible chemicals, and should not be mixed to prevent violent chemical reactions. In the warehouse, lighting, ventilation and other facilities should be explosion-proof, and the switch should be located outside the warehouse. The corresponding variety and quantity of fire equipment and leakage emergency treatment equipment should also be prepared. The storage area should be set up with embankments or pits to contain leaks, and its storage conditions should be regularly checked to prevent material leakage due to damaged packaging.
As for transportation, the tank (tank) car used in the transportation of 1-chloro-3-fluorobenzene should have a grounding chain, and holes can be set in the tank to reduce shock and generate static electricity. During transportation, drive according to the specified route, and do not stop in residential areas and densely populated areas. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer. During transportation, ensure that the container does not leak, collapse, fall, or damage. Mixed transportation with oxidants, edible chemicals, etc. is strictly prohibited.
In short, during the storage and transportation of 1-chloro-3-fluorobenzene, it is necessary to strictly follow relevant safety procedures and operating guidelines, and handle it with caution to prevent harm to personal safety and the environment.
First words storage. This substance is toxic and volatile, and should be stored in a cool and ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Because it is flammable, it should be stored separately from oxidants and edible chemicals, and should not be mixed to prevent violent chemical reactions. In the warehouse, lighting, ventilation and other facilities should be explosion-proof, and the switch should be located outside the warehouse. The corresponding variety and quantity of fire equipment and leakage emergency treatment equipment should also be prepared. The storage area should be set up with embankments or pits to contain leaks, and its storage conditions should be regularly checked to prevent material leakage due to damaged packaging.
As for transportation, the tank (tank) car used in the transportation of 1-chloro-3-fluorobenzene should have a grounding chain, and holes can be set in the tank to reduce shock and generate static electricity. During transportation, drive according to the specified route, and do not stop in residential areas and densely populated areas. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer. During transportation, ensure that the container does not leak, collapse, fall, or damage. Mixed transportation with oxidants, edible chemicals, etc. is strictly prohibited.
In short, during the storage and transportation of 1-chloro-3-fluorobenzene, it is necessary to strictly follow relevant safety procedures and operating guidelines, and handle it with caution to prevent harm to personal safety and the environment.
What are the physical properties of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is an organic compound. It has unique physical properties, which are described in detail by you today.
First of all, its appearance, under room temperature and pressure, 1-chloro-3-fluorobenzene is a colorless and transparent liquid, clear and clear, like the radiance of a mirror, its pure color can be seen.
When it comes to odor, this substance emits a special aromatic smell, but its gas is not pleasant, but has a certain irritation, and the smell is slightly uncomfortable. This also needs to be treated with caution.
As for the boiling point, the boiling point of 1-chloro-3-fluorobenzene is about 147 ° C. When heated up to this point, it gradually changes from a liquid state to a gaseous state, such as cloud rising. This property is very important in chemical operations such as separation and purification.
Then again, the melting point is about -56 ° C. Below this temperature, 1-chloro-3-fluorobenzene will solidify into a solid state, just like the condensation of ice, and the physical properties will also vary between the morphological changes.
The density of 1-chloro-3-fluorobenzene is larger than that of water, about 1.22 g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of the water, like a stone falling into the abyss, which is caused by the difference in density.
In terms of solubility, 1-chloro-3-fluorobenzene is insoluble in water. Water is a polar solvent, and the polarity of this substance is weak, so the two are difficult to dissolve, just like the separation of oil and water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. In such solvents, like a duck to water, they blend with each other. This property makes it widely used in organic synthesis and other fields.
In addition, the vapor pressure of 1-chloro-3-fluorobenzene has a fixed value at a specific temperature, and the vapor density is also greater than that of air. If its vapor diffuses in the air, it will sink below, such as haze, accumulation will not disperse, this should be paid attention to when using and storing to prevent harm.
In summary, the physical properties of 1-chloro-3-fluorobenzene are diverse, each property is interrelated, and it has its unique use in many fields such as chemical industry and medicine. However, because of its irritating properties, it should be used in accordance with regulations and properly disposed of.
First of all, its appearance, under room temperature and pressure, 1-chloro-3-fluorobenzene is a colorless and transparent liquid, clear and clear, like the radiance of a mirror, its pure color can be seen.
When it comes to odor, this substance emits a special aromatic smell, but its gas is not pleasant, but has a certain irritation, and the smell is slightly uncomfortable. This also needs to be treated with caution.
As for the boiling point, the boiling point of 1-chloro-3-fluorobenzene is about 147 ° C. When heated up to this point, it gradually changes from a liquid state to a gaseous state, such as cloud rising. This property is very important in chemical operations such as separation and purification.
Then again, the melting point is about -56 ° C. Below this temperature, 1-chloro-3-fluorobenzene will solidify into a solid state, just like the condensation of ice, and the physical properties will also vary between the morphological changes.
The density of 1-chloro-3-fluorobenzene is larger than that of water, about 1.22 g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of the water, like a stone falling into the abyss, which is caused by the difference in density.
In terms of solubility, 1-chloro-3-fluorobenzene is insoluble in water. Water is a polar solvent, and the polarity of this substance is weak, so the two are difficult to dissolve, just like the separation of oil and water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. In such solvents, like a duck to water, they blend with each other. This property makes it widely used in organic synthesis and other fields.
In addition, the vapor pressure of 1-chloro-3-fluorobenzene has a fixed value at a specific temperature, and the vapor density is also greater than that of air. If its vapor diffuses in the air, it will sink below, such as haze, accumulation will not disperse, this should be paid attention to when using and storing to prevent harm.
In summary, the physical properties of 1-chloro-3-fluorobenzene are diverse, each property is interrelated, and it has its unique use in many fields such as chemical industry and medicine. However, because of its irritating properties, it should be used in accordance with regulations and properly disposed of.
What are the chemical properties of 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is also an organic compound. It has unique chemical properties and is important in many fields.
First of all, its reactivity. Due to the presence of chlorine and fluorine diatoms, the electron cloud density of the benzene ring changes, so it shows a specific electrophilic substitution activity. On the benzene ring, chlorine and fluorine are ortho-para-sites, but the electronic effects of the two are different. Fluorine atoms have a strong electron-absorbing induction effect, while chlorine atoms have a slightly weaker electron-absorbing induction effect. The combined effects of the two make the electrophilic substitution reaction check point tend to a specific position. For example, when nitrification occurs, nitro groups are more likely to enter the ortho-sites of chlorine and fluorine, which is determined by the positioning group effect.
Furthermore, it participates in the nucleophilic substitution reaction. Although the nucleophilic substitution reaction of halogenated atoms on benzene rings is more difficult than that of halogenated alkanes, 1-chloro-3-fluorobenzene can also undergo nucleophilic substitution under specific conditions. When confronted with strong nucleophilic reagents and suitable catalysts and reaction conditions, chlorine or fluorine atoms can be replaced by nucleophilic reagents to generate corresponding replacement products. This reaction mechanism involves the formation of phenyne intermediates, or different paths such as direct nucleophilic attack, depending on the specific reaction conditions.
In addition, the physical properties of 1-chloro-3-fluorobenzene also affect its chemical behavior. It is a colorless liquid with certain volatility and solubility, and has good solubility in organic solvents. This property is conducive to its participation in the chemical reaction of the solution phase, providing a homogeneous environment for the reaction, and promoting the contact and reaction between the reactants.
In the field of organic synthesis, 1-chloro-3-fluorobenzene is often an important intermediate. Through its reaction with different reagents, a variety of organic compound structures can be constructed, providing key starting materials for drug synthesis, materials science and other fields. It plays an important role in the modern chemical industry.
First of all, its reactivity. Due to the presence of chlorine and fluorine diatoms, the electron cloud density of the benzene ring changes, so it shows a specific electrophilic substitution activity. On the benzene ring, chlorine and fluorine are ortho-para-sites, but the electronic effects of the two are different. Fluorine atoms have a strong electron-absorbing induction effect, while chlorine atoms have a slightly weaker electron-absorbing induction effect. The combined effects of the two make the electrophilic substitution reaction check point tend to a specific position. For example, when nitrification occurs, nitro groups are more likely to enter the ortho-sites of chlorine and fluorine, which is determined by the positioning group effect.
Furthermore, it participates in the nucleophilic substitution reaction. Although the nucleophilic substitution reaction of halogenated atoms on benzene rings is more difficult than that of halogenated alkanes, 1-chloro-3-fluorobenzene can also undergo nucleophilic substitution under specific conditions. When confronted with strong nucleophilic reagents and suitable catalysts and reaction conditions, chlorine or fluorine atoms can be replaced by nucleophilic reagents to generate corresponding replacement products. This reaction mechanism involves the formation of phenyne intermediates, or different paths such as direct nucleophilic attack, depending on the specific reaction conditions.
In addition, the physical properties of 1-chloro-3-fluorobenzene also affect its chemical behavior. It is a colorless liquid with certain volatility and solubility, and has good solubility in organic solvents. This property is conducive to its participation in the chemical reaction of the solution phase, providing a homogeneous environment for the reaction, and promoting the contact and reaction between the reactants.
In the field of organic synthesis, 1-chloro-3-fluorobenzene is often an important intermediate. Through its reaction with different reagents, a variety of organic compound structures can be constructed, providing key starting materials for drug synthesis, materials science and other fields. It plays an important role in the modern chemical industry.
1-chloro-3-fluorobenzene in what areas?
1-Chloro-3-fluorobenzene is useful in many fields. In the field of pharmaceutical synthesis, this is an important raw material. Based on it, a variety of specific drugs can be prepared. For example, antibacterial drugs, with their special structure, can play a unique role in bacteria, interfering with the metabolism of bacteria, in order to achieve antibacterial effect. In the development of new antiviral drugs, 1-chloro-3-fluorobenzene can also be used as a key starting material. After multiple steps of delicate reactions, a molecular framework with antiviral activity can be constructed.
In the field of pesticide creation, it is also indispensable. It can be used to prepare insecticides and has high-efficiency killing ability against specific pests. Its structure can precisely act on the physiological system of pests, or damage their nervous system, or interfere with their digestive system, making it difficult for pests to survive and multiply. In the development of herbicides, 1-chloro-3-fluorobenzene also has a place, which can inhibit the growth of weeds, and has little impact on crops, ensuring the harvest of farmland.
In the field of materials science, 1-chloro-3-fluorobenzene can participate in the synthesis of special polymer materials. With this as a monomer, after polymerization, polymers with special properties can be obtained. These polymers may have excellent heat resistance or unique electrical properties, and can be used as key materials in high-end fields such as electronics and aviation.
In addition, in the study of organic synthetic chemistry, 1-chloro-3-fluorobenzene is often an important intermediate. Chemists can modify and transform it through various chemical reactions to synthesize complex organic compounds with diverse structures and functions, opening up a broader field for chemical research.
In the field of pesticide creation, it is also indispensable. It can be used to prepare insecticides and has high-efficiency killing ability against specific pests. Its structure can precisely act on the physiological system of pests, or damage their nervous system, or interfere with their digestive system, making it difficult for pests to survive and multiply. In the development of herbicides, 1-chloro-3-fluorobenzene also has a place, which can inhibit the growth of weeds, and has little impact on crops, ensuring the harvest of farmland.
In the field of materials science, 1-chloro-3-fluorobenzene can participate in the synthesis of special polymer materials. With this as a monomer, after polymerization, polymers with special properties can be obtained. These polymers may have excellent heat resistance or unique electrical properties, and can be used as key materials in high-end fields such as electronics and aviation.
In addition, in the study of organic synthetic chemistry, 1-chloro-3-fluorobenzene is often an important intermediate. Chemists can modify and transform it through various chemical reactions to synthesize complex organic compounds with diverse structures and functions, opening up a broader field for chemical research.
What are 1-chloro-3-fluorobenzene synthesis methods?
1-Chloro-3-fluorobenzene is also a commonly used intermediate in organic synthesis. There are several ways to synthesize it.
First, it can be started from benzene and nitrated to obtain nitrobenzene. Using iron powder and hydrochloric acid as a reducing agent, nitrobenzene is reduced to aniline. Aniline is reacted by diazotization, treated with sodium nitrite and hydrochloric acid to obtain diazonium salt. Then the diazonium salt interacts with cuprous chloride and potassium chloride to introduce chlorine atoms to obtain chlorobenzene. Chlorobenzene is alkylated by Fu-g, using aluminum trichloride as a catalyst and interacting with fluoroalkane to introduce fluorine atoms to obtain 1-chloro-3-fluorobenzene. However, there are many steps in this path, and the reaction conditions of each step need to be carefully controlled.
Second, m-dichlorobenzene is used as the raw material, and under specific conditions, a halogen exchange reaction is carried out with potassium fluoride. This reaction needs to be carried out at high temperature and in the presence of a phase transfer catalyst. The phase transfer catalyst can promote the transfer of ions in the reaction system, increasing the reaction rate and yield. After this reaction, one of the chlorine atoms of m-dichlorobenzene can be replaced by a fluorine atom to obtain 1-chloro-3-fluorobenzene.
Third, starting from m-fluoroaniline, after diazotization, and then reacting with cuprous chloride and hydrochloric acid, chlorine atoms can be directly introduced to obtain 1-chloro-3-fluorobenzene. This method is relatively simple, but it may be difficult to obtain fluoroaniline raw materials.
All this synthesis method has advantages and disadvantages. In practical applications, the appropriate method should be selected according to the availability of raw materials, cost, difficulty in controlling reaction conditions, and purity requirements of target products.
First, it can be started from benzene and nitrated to obtain nitrobenzene. Using iron powder and hydrochloric acid as a reducing agent, nitrobenzene is reduced to aniline. Aniline is reacted by diazotization, treated with sodium nitrite and hydrochloric acid to obtain diazonium salt. Then the diazonium salt interacts with cuprous chloride and potassium chloride to introduce chlorine atoms to obtain chlorobenzene. Chlorobenzene is alkylated by Fu-g, using aluminum trichloride as a catalyst and interacting with fluoroalkane to introduce fluorine atoms to obtain 1-chloro-3-fluorobenzene. However, there are many steps in this path, and the reaction conditions of each step need to be carefully controlled.
Second, m-dichlorobenzene is used as the raw material, and under specific conditions, a halogen exchange reaction is carried out with potassium fluoride. This reaction needs to be carried out at high temperature and in the presence of a phase transfer catalyst. The phase transfer catalyst can promote the transfer of ions in the reaction system, increasing the reaction rate and yield. After this reaction, one of the chlorine atoms of m-dichlorobenzene can be replaced by a fluorine atom to obtain 1-chloro-3-fluorobenzene.
Third, starting from m-fluoroaniline, after diazotization, and then reacting with cuprous chloride and hydrochloric acid, chlorine atoms can be directly introduced to obtain 1-chloro-3-fluorobenzene. This method is relatively simple, but it may be difficult to obtain fluoroaniline raw materials.
All this synthesis method has advantages and disadvantages. In practical applications, the appropriate method should be selected according to the availability of raw materials, cost, difficulty in controlling reaction conditions, and purity requirements of target products.
What is the market outlook for 1-chloro-3-fluorobenzene?
1-Chloro-3-fluorobenzene is also an organic compound. Its market prospect is related to many factors, and now it is your analysis.
Let's talk about its use first. This substance has considerable use in the fields of medicine, pesticides and materials. In medicine, it is a key intermediate for the synthesis of specific drugs, and helps to exert its medicinal power. In pesticides, it can make efficient and low-toxic pesticides, protect the growth of crops, and ensure the hope of a bumper harvest. In the material industry, we can participate in the creation of new materials, develop the uniqueness of materials, and meet the needs of diversity. These various uses expand its market path and increase its demand.
The second discussion on the development of the industry. With the advance of science and technology, the pharmaceutical, pesticide and material industries have all flourished. Medicine seeks new drugs to treat various diseases, pesticides seek high-efficiency products to meet environmental protection regulations, and materials hope to be innovative in quality to meet the needs of the times. 1-Chloro-3-fluorobenzene is not only an important raw material, but it will definitely gain opportunities due to the prosperity of the industry. Demand may rise like a river and continue to rise.
However, there are also challenges. First, the production process must be refined. To obtain high-purity products, the process is complicated and the cost may be high. If it cannot be controlled, market competitiveness will be damaged. Second, environmental protection regulations are becoming stricter. Production processes or pollutants must be disposed of according to regulations, which also increases costs and difficulties. Third, market competition is intense. Congeneric products or substitutes appear from time to time. If they cannot win in quality, price and service, the market may be occupied by others.
In summary, although 1-chloro-3-fluorobenzene has a good prospect due to its wide range of uses and industry prosperity, challenges such as process, environmental protection and competition must also be addressed. Only by meeting the challenges can we be stable in the market, achieve long-term development and develop a brilliant future.
Let's talk about its use first. This substance has considerable use in the fields of medicine, pesticides and materials. In medicine, it is a key intermediate for the synthesis of specific drugs, and helps to exert its medicinal power. In pesticides, it can make efficient and low-toxic pesticides, protect the growth of crops, and ensure the hope of a bumper harvest. In the material industry, we can participate in the creation of new materials, develop the uniqueness of materials, and meet the needs of diversity. These various uses expand its market path and increase its demand.
The second discussion on the development of the industry. With the advance of science and technology, the pharmaceutical, pesticide and material industries have all flourished. Medicine seeks new drugs to treat various diseases, pesticides seek high-efficiency products to meet environmental protection regulations, and materials hope to be innovative in quality to meet the needs of the times. 1-Chloro-3-fluorobenzene is not only an important raw material, but it will definitely gain opportunities due to the prosperity of the industry. Demand may rise like a river and continue to rise.
However, there are also challenges. First, the production process must be refined. To obtain high-purity products, the process is complicated and the cost may be high. If it cannot be controlled, market competitiveness will be damaged. Second, environmental protection regulations are becoming stricter. Production processes or pollutants must be disposed of according to regulations, which also increases costs and difficulties. Third, market competition is intense. Congeneric products or substitutes appear from time to time. If they cannot win in quality, price and service, the market may be occupied by others.
In summary, although 1-chloro-3-fluorobenzene has a good prospect due to its wide range of uses and industry prosperity, challenges such as process, environmental protection and competition must also be addressed. Only by meeting the challenges can we be stable in the market, achieve long-term development and develop a brilliant future.
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