Linshang Chemical
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1-Chloro-3-Iodo-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
791985 |
| Chemical Formula | C7H3ClF3I |
| Molar Mass | 322.45 g/mol |
| Solubility In Water | expected to be low due to its non - polar nature (hydrophobic groups like trifluoromethyl, chloro, and iodo) |
| Solubility In Organic Solvents | should be soluble in common organic solvents such as dichloromethane, toluene, etc. due to its non - polar structure |
As an accredited 1-Chloro-3-Iodo-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 3 - iodo - 5 - (trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 1 - Chloro - 3 - iodo - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions. Ensure the storage location is locked and inaccessible to unauthorized personnel. |
| Shipping | 1 - chloro - 3 - iodo - 5 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical shipping regulations, ensuring proper labeling and handling to prevent any risks during transit. |
Competitive 1-Chloro-3-Iodo-5-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-3-Iodo-5-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-3-iodo-5- (trifluoromethyl) benzene?
1-Chloro-3-iodine-5- (trifluoromethyl) benzene is also an organic compound. Its chemical properties are unique, with the commonalities of halogenated aromatics.
Chlorine atoms and iodine atoms are both representatives of halogen elements, giving this compound specific reactivity. Chlorine atoms are highly active and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents such as alkoxides and amines can attack the benzene ring carbon atoms connected to chlorine, and the chlorine atoms leave to form new organic compounds.
Although iodine atoms are less active than chlorine, they can also play unique roles in specific reactions due to their large atomic radius. In some metal-catalyzed reactions, iodine atoms can form intermediates with metals to promote the reaction. For example, the coupling reaction catalyzed by palladium can connect the benzene ring with other organic fragments and expand the structure of the molecule. The introduction of
trifluoromethyl greatly changes the physical and chemical properties of this compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reactions on the benzene ring. At the same time, because of its fluorine content, it can improve the stability, fat solubility and biological activity of the compound. In the field of medicinal chemistry, compounds containing trifluoromethyl often have good biological activity and metabolic stability.
This compound has a certain solubility in organic solvents and can be soluble in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., which is conducive to its participation in various organic reactions. Due to its active chemical properties, care should be taken to avoid contact with strong oxidants, strong bases and other substances during storage to prevent violent reactions. In short, the unique structure of 1-chloro-3-iodine-5 - (trifluoromethyl) benzene has important application value and research significance in organic synthesis, drug research and development and other fields.
Chlorine atoms and iodine atoms are both representatives of halogen elements, giving this compound specific reactivity. Chlorine atoms are highly active and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents such as alkoxides and amines can attack the benzene ring carbon atoms connected to chlorine, and the chlorine atoms leave to form new organic compounds.
Although iodine atoms are less active than chlorine, they can also play unique roles in specific reactions due to their large atomic radius. In some metal-catalyzed reactions, iodine atoms can form intermediates with metals to promote the reaction. For example, the coupling reaction catalyzed by palladium can connect the benzene ring with other organic fragments and expand the structure of the molecule. The introduction of
trifluoromethyl greatly changes the physical and chemical properties of this compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reactions on the benzene ring. At the same time, because of its fluorine content, it can improve the stability, fat solubility and biological activity of the compound. In the field of medicinal chemistry, compounds containing trifluoromethyl often have good biological activity and metabolic stability.
This compound has a certain solubility in organic solvents and can be soluble in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., which is conducive to its participation in various organic reactions. Due to its active chemical properties, care should be taken to avoid contact with strong oxidants, strong bases and other substances during storage to prevent violent reactions. In short, the unique structure of 1-chloro-3-iodine-5 - (trifluoromethyl) benzene has important application value and research significance in organic synthesis, drug research and development and other fields.
What are the common uses of 1-chloro-3-iodo-5- (trifluoromethyl) benzene?
1-Chloro-3-iodine-5- (trifluoromethyl) benzene is an organic chemical. It has a wide range of common uses and is of great significance in the field of organic synthesis.
First, as a key intermediate, it often appears in the process of pharmaceutical chemical synthesis. Through a series of chemical reactions, other functional groups can be ingeniously introduced to build complex and diverse drug molecules. For example, specific groups can be connected to the benzene ring through nucleophilic substitution reactions, laying the foundation for the development of new drugs with unique biological activities.
Second, in the field of materials science, it also has its uses. It can be used to prepare polymer materials with special properties. For example, through polymerization, combined with other monomers, the material is endowed with unique properties such as excellent corrosion resistance and thermal stability, so as to meet the strict needs of special materials in high-end fields such as aerospace and electronics.
Third, in the field of pesticide synthesis, it plays an indispensable role. With the help of appropriate chemical transformation, high-efficiency, low-toxicity and environmentally friendly new pesticides can be synthesized, which can help the control of agricultural pests while reducing the negative impact on the ecological environment.
Furthermore, it is also an extremely important raw material in the synthesis of fine chemicals. It can synthesize fine chemicals such as special dyes and fragrances to meet the needs of people for high-quality, functional fine chemicals in daily life and industrial production.
First, as a key intermediate, it often appears in the process of pharmaceutical chemical synthesis. Through a series of chemical reactions, other functional groups can be ingeniously introduced to build complex and diverse drug molecules. For example, specific groups can be connected to the benzene ring through nucleophilic substitution reactions, laying the foundation for the development of new drugs with unique biological activities.
Second, in the field of materials science, it also has its uses. It can be used to prepare polymer materials with special properties. For example, through polymerization, combined with other monomers, the material is endowed with unique properties such as excellent corrosion resistance and thermal stability, so as to meet the strict needs of special materials in high-end fields such as aerospace and electronics.
Third, in the field of pesticide synthesis, it plays an indispensable role. With the help of appropriate chemical transformation, high-efficiency, low-toxicity and environmentally friendly new pesticides can be synthesized, which can help the control of agricultural pests while reducing the negative impact on the ecological environment.
Furthermore, it is also an extremely important raw material in the synthesis of fine chemicals. It can synthesize fine chemicals such as special dyes and fragrances to meet the needs of people for high-quality, functional fine chemicals in daily life and industrial production.
What is the synthesis method of 1-chloro-3-iodo-5- (trifluoromethyl) benzene?
The synthesis of 1-chloro-3-iodine-5- (trifluoromethyl) benzene is an important topic in the field of organic synthesis. The synthesis path is diverse, and the following is one of the common methods.
The starting material is 3-trifluoromethylaniline. It is first diazotized with hydrochloric acid and sodium nitrite at low temperature. This reaction requires strict temperature control, usually at 0-5 ° C, so that 3-trifluoromethylaniline can be converted into diazonium salts.
Then, the diazonium salt is mixed with potassium iodide solution, and an iodine substitution reaction occurs. The diazonium group is replaced by an iodine atom to generate 3-iodine-5- (trifluoromethyl) aniline.
Next, 3-iodine-5- (trifluoromethyl) aniline is chlorinated. Suitable chlorination reagents, such as chlorine gas or thionyl chloride, can be selected. Under suitable reaction conditions, the amino group is replaced by a chlorine atom, and 1-chloro-3-iodine-5- (trifluoromethyl) benzene is successfully prepared.
During the synthesis process, it is crucial to control the conditions of each step of the reaction, such as temperature, ratio of reactants, reaction time, etc., which will affect the yield and purity of the product. And safety should be paid attention to during the reaction process. Some reagents are toxic or corrosive, and relevant safety procedures should be followed during operation. In this way, the synthesis of 1-chloro-3-iodine-5- (trifluoromethyl) benzene can be achieved efficiently and safely.
The starting material is 3-trifluoromethylaniline. It is first diazotized with hydrochloric acid and sodium nitrite at low temperature. This reaction requires strict temperature control, usually at 0-5 ° C, so that 3-trifluoromethylaniline can be converted into diazonium salts.
Then, the diazonium salt is mixed with potassium iodide solution, and an iodine substitution reaction occurs. The diazonium group is replaced by an iodine atom to generate 3-iodine-5- (trifluoromethyl) aniline.
Next, 3-iodine-5- (trifluoromethyl) aniline is chlorinated. Suitable chlorination reagents, such as chlorine gas or thionyl chloride, can be selected. Under suitable reaction conditions, the amino group is replaced by a chlorine atom, and 1-chloro-3-iodine-5- (trifluoromethyl) benzene is successfully prepared.
During the synthesis process, it is crucial to control the conditions of each step of the reaction, such as temperature, ratio of reactants, reaction time, etc., which will affect the yield and purity of the product. And safety should be paid attention to during the reaction process. Some reagents are toxic or corrosive, and relevant safety procedures should be followed during operation. In this way, the synthesis of 1-chloro-3-iodine-5- (trifluoromethyl) benzene can be achieved efficiently and safely.
What are the physical properties of 1-chloro-3-iodo-5- (trifluoromethyl) benzene
1 - chloro - 3 - iodo - 5 - (trifluoromethyl) benzene is an organic compound with unique physical properties, which are described as follows:
1. ** Appearance properties **: Under normal conditions, this compound is mostly colorless to light yellow liquid state, but due to the purity and preparation conditions, the appearance may change. If it contains impurities, or causes a slightly darker color, or has an oily texture, it can be felt that its chemical structure is complex.
2. ** Melting boiling point **: The melting point is about -30 ° C, and the boiling point is between 190-200 ° C. Such melting boiling point characteristics are determined by intermolecular forces and structures. Its molecules contain chlorine, iodine, trifluoromethyl and other functional groups, which increase the intermolecular force and cause a high boiling point; however, the spatial distribution of the molecular structure makes the melting point not too high.
3. ** Solubility **: In organic solvents, such as common ether, dichloromethane, chloroform, etc., it exhibits good solubility. Due to the principle of "similar phase solubility", its organic structure and organic solvent molecules can form a weak interaction, which helps it disperse and dissolve. However, in water, the solubility is very small. Due to the strong hydrogen bond between water molecules, the compound forms an effective interaction with water difficulty, and its hydrophobic group affects it, making it difficult to dissolve in water.
4. ** Density **: The density is greater than that of water, about 1.9 g/cm ³. Due to the large atomic weight of halogen atoms (chlorine, iodine) and trifluoromethyl in the molecule, the mass per unit volume increases, so the density is greater than that of water. In the stratification experiment, it will sink underwater.
5. ** Volatility and odor **: It has a certain volatility and can evaporate slowly in the air. The odor is pungent and uncomfortable to smell. This odor is related to its chemical structure. The presence of halogen atoms and trifluoromethyl makes the odor special, and the volatility makes the odor easy to diffuse and perceive.
1. ** Appearance properties **: Under normal conditions, this compound is mostly colorless to light yellow liquid state, but due to the purity and preparation conditions, the appearance may change. If it contains impurities, or causes a slightly darker color, or has an oily texture, it can be felt that its chemical structure is complex.
2. ** Melting boiling point **: The melting point is about -30 ° C, and the boiling point is between 190-200 ° C. Such melting boiling point characteristics are determined by intermolecular forces and structures. Its molecules contain chlorine, iodine, trifluoromethyl and other functional groups, which increase the intermolecular force and cause a high boiling point; however, the spatial distribution of the molecular structure makes the melting point not too high.
3. ** Solubility **: In organic solvents, such as common ether, dichloromethane, chloroform, etc., it exhibits good solubility. Due to the principle of "similar phase solubility", its organic structure and organic solvent molecules can form a weak interaction, which helps it disperse and dissolve. However, in water, the solubility is very small. Due to the strong hydrogen bond between water molecules, the compound forms an effective interaction with water difficulty, and its hydrophobic group affects it, making it difficult to dissolve in water.
4. ** Density **: The density is greater than that of water, about 1.9 g/cm ³. Due to the large atomic weight of halogen atoms (chlorine, iodine) and trifluoromethyl in the molecule, the mass per unit volume increases, so the density is greater than that of water. In the stratification experiment, it will sink underwater.
5. ** Volatility and odor **: It has a certain volatility and can evaporate slowly in the air. The odor is pungent and uncomfortable to smell. This odor is related to its chemical structure. The presence of halogen atoms and trifluoromethyl makes the odor special, and the volatility makes the odor easy to diffuse and perceive.
What are the precautions for 1-chloro-3-iodo-5- (trifluoromethyl) benzene in storage and transportation?
For 1-chloro-3-iodine-5- (trifluoromethyl) benzene, many matters must be paid attention to during storage and transportation.
This compound is chemically active. When stored, the first environment is dry. Moisture can easily lead to adverse reactions such as hydrolysis, resulting in quality damage. It should be placed in a dry and ventilated warehouse, away from water sources and moisture, to prevent accidents.
Temperature control is also key. Excessive temperature may cause it to decompose, evaporate, or cause dangerous reactions. It should be stored in a cool place, generally not exceeding 30 ° C, and it should be precisely regulated according to its physicochemical properties.
Furthermore, this substance may be toxic and irritating, so the storage place must be well marked to warn people not to approach it. And it should be stored in isolation from oxidizing agents, reducing agents, etc. Because of its active chemical properties, it may come into contact with other substances or react violently.
When transporting, the packaging must be tight. Choose suitable packaging materials to ensure that there is no risk of leakage during transportation. Transportation vehicles should also be clean and dry to avoid mixing with other chemicals to prevent cross-contamination.
Escort personnel should be familiar with the characteristics of this compound and emergency response methods. Pay close attention during transportation. If there is any leakage, immediately dispose of it according to the plan to ensure the safety of personnel and the environment. All of these are essential for the storage and transportation of 1-chloro-3-iodine-5 - (trifluoromethyl) benzene.
This compound is chemically active. When stored, the first environment is dry. Moisture can easily lead to adverse reactions such as hydrolysis, resulting in quality damage. It should be placed in a dry and ventilated warehouse, away from water sources and moisture, to prevent accidents.
Temperature control is also key. Excessive temperature may cause it to decompose, evaporate, or cause dangerous reactions. It should be stored in a cool place, generally not exceeding 30 ° C, and it should be precisely regulated according to its physicochemical properties.
Furthermore, this substance may be toxic and irritating, so the storage place must be well marked to warn people not to approach it. And it should be stored in isolation from oxidizing agents, reducing agents, etc. Because of its active chemical properties, it may come into contact with other substances or react violently.
When transporting, the packaging must be tight. Choose suitable packaging materials to ensure that there is no risk of leakage during transportation. Transportation vehicles should also be clean and dry to avoid mixing with other chemicals to prevent cross-contamination.
Escort personnel should be familiar with the characteristics of this compound and emergency response methods. Pay close attention during transportation. If there is any leakage, immediately dispose of it according to the plan to ensure the safety of personnel and the environment. All of these are essential for the storage and transportation of 1-chloro-3-iodine-5 - (trifluoromethyl) benzene.
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