Linshang Chemical
PRODUCTS
1-Chloro-3-Iodobenzene
Linshang Chemical
|
HS Code |
251842 |
| Chemical Formula | C6H4ClI |
| Molecular Weight | 238.45 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 224 - 226 °C |
| Density | 1.85 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Refractive Index | 1.645 - 1.647 |
As an accredited 1-Chloro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 3 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 3 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of a material resistant to corrosion. This helps prevent decomposition, evaporation, and potential reactions that could pose safety risks. |
| Shipping | 1 - chloro - 3 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It's labeled clearly with hazard warnings. Shipment follows strict regulations for hazardous chemicals, ensuring safe transportation to prevent spills and exposure. |
Competitive 1-Chloro-3-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Chloro-3-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-chloro-3-iodobenzene?
1-chloro-3-iodobenzene is an organic compound. Its physical properties are quite important and are of significance in many fields such as chemical industry and scientific research.
The appearance of this compound is often colorless to light yellow liquid. This color state is easy to observe and distinguish, and its purity can be preliminarily judged in practical applications.
1-chloro-3-iodobenzene has a certain smell. Although its smell is difficult to describe accurately, during operation and use, its smell can provide relevant personnel with preliminary sensory cognition to alert to its existence and possible impact.
When it comes to melting point, this compound has a low melting point and is liquid at room temperature. This property makes it more convenient to participate in the reaction in some chemical reactions that require liquid reactants or solvents, without the need for complicated heating and melting operations.
In terms of boiling point, 1-chloro-3-iodobenzene has a relatively high boiling point, which means that it will boil into a gaseous state at a higher temperature. The higher boiling point allows it to maintain a stable liquid state in some high-temperature reaction systems, providing a continuous and stable environment for the reaction.
In terms of solubility, 1-chloro-3-iodobenzene is insoluble in water, because water is a polar molecule, and the polarity of the compound is weak. According to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in some organic solvents, such as ethanol, ether, etc., which facilitates its application in organic synthesis and other fields. It can be dispersed uniformly with the help of organic solvents, so as to better participate in the reaction.
Density is also one of its important physical properties. 1-chloro-3-iodobenzene has a density greater than that of water. When mixed with water, it will sink to the bottom of the water. This characteristic can be used in operations such as separation and purification according to density differences. Appropriate separation methods can be used to achieve separation from water and other substances with different densities.
The appearance of this compound is often colorless to light yellow liquid. This color state is easy to observe and distinguish, and its purity can be preliminarily judged in practical applications.
1-chloro-3-iodobenzene has a certain smell. Although its smell is difficult to describe accurately, during operation and use, its smell can provide relevant personnel with preliminary sensory cognition to alert to its existence and possible impact.
When it comes to melting point, this compound has a low melting point and is liquid at room temperature. This property makes it more convenient to participate in the reaction in some chemical reactions that require liquid reactants or solvents, without the need for complicated heating and melting operations.
In terms of boiling point, 1-chloro-3-iodobenzene has a relatively high boiling point, which means that it will boil into a gaseous state at a higher temperature. The higher boiling point allows it to maintain a stable liquid state in some high-temperature reaction systems, providing a continuous and stable environment for the reaction.
In terms of solubility, 1-chloro-3-iodobenzene is insoluble in water, because water is a polar molecule, and the polarity of the compound is weak. According to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in some organic solvents, such as ethanol, ether, etc., which facilitates its application in organic synthesis and other fields. It can be dispersed uniformly with the help of organic solvents, so as to better participate in the reaction.
Density is also one of its important physical properties. 1-chloro-3-iodobenzene has a density greater than that of water. When mixed with water, it will sink to the bottom of the water. This characteristic can be used in operations such as separation and purification according to density differences. Appropriate separation methods can be used to achieve separation from water and other substances with different densities.
What are the chemical properties of 1-chloro-3-iodobenzene?
1-chloro-3-iodobenzene is one of the organic halogenated aromatic hydrocarbons. Its molecule contains chlorine atoms and iodine atoms, which give the compound unique chemical properties.
Let's talk about its substitution reaction first. Both chlorine and iodine are halogen atoms and have certain activities. Under appropriate conditions, chlorine atoms or iodine atoms can be replaced by other nucleophiles. For example, when co-heated with sodium alcohol solution, chlorine atoms may be replaced by alkoxy groups to form corresponding aryl ether compounds. This reaction follows a nucleophilic substitution mechanism. The halogen atoms leave, and the nucleophiles attack the carbon atoms attached to the halogen atoms on the benzene ring.
Furthermore, 1-chloro-3-iodobenzene can participate in the metal-catalyzed coupling reaction. Taking palladium catalysis as an example, it can be coupled with nucleophiles containing alkenyl and aryl groups to form carbon-carbon bonds. During this process, palladium metal is first oxidized with halogen atoms, then transmetallized with nucleophiles, and finally eliminated by reduction to form coupling products. This reaction is extremely important in the field of organic synthesis and can be used to construct complex organic molecular structures.
In addition, the electron cloud density of the benzene ring in this compound is affected by chlorine and iodine. Both chlorine and iodine are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, so the electrophilic substitution activity of the benzene ring is lower than that of benzene. If the electrophilic substitution reaction occurs, the newly introduced groups tend to enter the position between chlorine and iodine. Due to the electron-withdrawing induction effect of chlorine and iodine, the electron cloud density of the intermediate position is relatively high, which is conducive to the attack of electrophilic reagents.
In short, 1-chloro-3-iodobenzene has rich and diverse chemical properties and has important applications in organic synthesis and other fields. Through rational utilization of its reactivity, many valuable organic compounds can be prepared.
Let's talk about its substitution reaction first. Both chlorine and iodine are halogen atoms and have certain activities. Under appropriate conditions, chlorine atoms or iodine atoms can be replaced by other nucleophiles. For example, when co-heated with sodium alcohol solution, chlorine atoms may be replaced by alkoxy groups to form corresponding aryl ether compounds. This reaction follows a nucleophilic substitution mechanism. The halogen atoms leave, and the nucleophiles attack the carbon atoms attached to the halogen atoms on the benzene ring.
Furthermore, 1-chloro-3-iodobenzene can participate in the metal-catalyzed coupling reaction. Taking palladium catalysis as an example, it can be coupled with nucleophiles containing alkenyl and aryl groups to form carbon-carbon bonds. During this process, palladium metal is first oxidized with halogen atoms, then transmetallized with nucleophiles, and finally eliminated by reduction to form coupling products. This reaction is extremely important in the field of organic synthesis and can be used to construct complex organic molecular structures.
In addition, the electron cloud density of the benzene ring in this compound is affected by chlorine and iodine. Both chlorine and iodine are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, so the electrophilic substitution activity of the benzene ring is lower than that of benzene. If the electrophilic substitution reaction occurs, the newly introduced groups tend to enter the position between chlorine and iodine. Due to the electron-withdrawing induction effect of chlorine and iodine, the electron cloud density of the intermediate position is relatively high, which is conducive to the attack of electrophilic reagents.
In short, 1-chloro-3-iodobenzene has rich and diverse chemical properties and has important applications in organic synthesis and other fields. Through rational utilization of its reactivity, many valuable organic compounds can be prepared.
What are the common synthetic methods of 1-chloro-3-iodobenzene?
1 - chloro - 3 - iodobenzene is an organic compound, and its synthesis method is quite critical. One of the common synthesis methods is halogenation.
First take benzene as the starting material, and use a chlorinating agent such as chlorine gas. Under the action of a catalyst such as iron trichloride, a chlorination reaction occurs to obtain chlorobenzene. The principle of this reaction is that chlorine atoms replace hydrogen atoms on the benzene ring. The conditions need to be heated or illuminated to promote the splitting of chlorine molecules into chlorine radicals and initiate the reaction.
After chlorobenzene is obtained, the iodization reaction is carried out. In the iodization reaction, iodine elemental substance and chlorobenzene are often used as reactants. Because the electrophilic activity of iodine is weak, a catalyst such as copper powder or Copper powder first reacts with iodine to form cuprous iodide, and cuprous iodide reacts with chlorobenzene, causing iodine atoms to replace hydrogen atoms at specific positions on chlorobenzene to form 1-chloro-3-iodobenzene. This reaction condition requires heating to increase the reaction rate.
Another common synthesis method is by conversion of diazonium salts. Starting from aniline, the diazotization reaction is carried out, and the diazonium salt is formed with sodium nitrite in a hydrochloric acid solution at low temperature. The diazonium salt is unstable, and then it reacts with cuprous chloride, and a Sandmeyer reaction occurs. Chloride ions replace the diazonium group to obtain chlorobenzene derivatives. Then, the chlorobenzene derivative is reacted with an iodizing agent such as potassium iodide under appropriate conditions to replace the hydrogen at a specific position with an iodine atom to obtain 1-chloro-3-iodobenzene.
The method of synthesizing 1-chloro-3-iodobenzene has its own characteristics and application scenarios. The appropriate synthesis path needs to be carefully selected according to actual needs, raw material availability and reaction conditions, so as to achieve the purpose of efficient synthesis.
First take benzene as the starting material, and use a chlorinating agent such as chlorine gas. Under the action of a catalyst such as iron trichloride, a chlorination reaction occurs to obtain chlorobenzene. The principle of this reaction is that chlorine atoms replace hydrogen atoms on the benzene ring. The conditions need to be heated or illuminated to promote the splitting of chlorine molecules into chlorine radicals and initiate the reaction.
After chlorobenzene is obtained, the iodization reaction is carried out. In the iodization reaction, iodine elemental substance and chlorobenzene are often used as reactants. Because the electrophilic activity of iodine is weak, a catalyst such as copper powder or Copper powder first reacts with iodine to form cuprous iodide, and cuprous iodide reacts with chlorobenzene, causing iodine atoms to replace hydrogen atoms at specific positions on chlorobenzene to form 1-chloro-3-iodobenzene. This reaction condition requires heating to increase the reaction rate.
Another common synthesis method is by conversion of diazonium salts. Starting from aniline, the diazotization reaction is carried out, and the diazonium salt is formed with sodium nitrite in a hydrochloric acid solution at low temperature. The diazonium salt is unstable, and then it reacts with cuprous chloride, and a Sandmeyer reaction occurs. Chloride ions replace the diazonium group to obtain chlorobenzene derivatives. Then, the chlorobenzene derivative is reacted with an iodizing agent such as potassium iodide under appropriate conditions to replace the hydrogen at a specific position with an iodine atom to obtain 1-chloro-3-iodobenzene.
The method of synthesizing 1-chloro-3-iodobenzene has its own characteristics and application scenarios. The appropriate synthesis path needs to be carefully selected according to actual needs, raw material availability and reaction conditions, so as to achieve the purpose of efficient synthesis.
1-chloro-3-iodobenzene in what areas
1-chloro-3-iodobenzene is an organic compound that has applications in many fields.
In the field of medicinal chemistry, its role is quite critical. It can be used as an intermediate for the synthesis of a variety of drugs. For example, some compounds with specific biological activities can participate in many chemical reactions with the activity of chlorine atoms and iodine atoms during the synthesis process. Through substitution, coupling and other steps, drug molecules with specific structures and functions can be constructed. The intermediate role of this compound provides a rich structural basis for the research and development of new drugs, helping scientists to create more new drugs with high efficiency and low toxicity.
In the field of materials science, it also has its uses. It can be used to prepare organic materials with special properties. For example, by polymerizing with other organic or inorganic monomers, it is introduced into the polymer structure, and the properties of chlorine atoms and iodine atoms are used to endow the material with unique electrical, optical or thermal properties. The obtained materials may be applied to electronic devices, optical coatings and other fields, injecting new vitality into the development of materials science.
In the field of organic synthetic chemistry, 1-chloro-3-iodobenzene is an extremely important starting material. Due to the different activities of chlorine and iodine atoms, it can selectively react under different reaction conditions, providing a convenient way for the synthesis of complex organic molecules. Chemists can take advantage of this property to precisely construct carbon-carbon bonds or carbon-heteroatomic bonds of target molecules, enabling diverse organic synthesis strategies to synthesize complex and novel organic compounds.
In the field of medicinal chemistry, its role is quite critical. It can be used as an intermediate for the synthesis of a variety of drugs. For example, some compounds with specific biological activities can participate in many chemical reactions with the activity of chlorine atoms and iodine atoms during the synthesis process. Through substitution, coupling and other steps, drug molecules with specific structures and functions can be constructed. The intermediate role of this compound provides a rich structural basis for the research and development of new drugs, helping scientists to create more new drugs with high efficiency and low toxicity.
In the field of materials science, it also has its uses. It can be used to prepare organic materials with special properties. For example, by polymerizing with other organic or inorganic monomers, it is introduced into the polymer structure, and the properties of chlorine atoms and iodine atoms are used to endow the material with unique electrical, optical or thermal properties. The obtained materials may be applied to electronic devices, optical coatings and other fields, injecting new vitality into the development of materials science.
In the field of organic synthetic chemistry, 1-chloro-3-iodobenzene is an extremely important starting material. Due to the different activities of chlorine and iodine atoms, it can selectively react under different reaction conditions, providing a convenient way for the synthesis of complex organic molecules. Chemists can take advantage of this property to precisely construct carbon-carbon bonds or carbon-heteroatomic bonds of target molecules, enabling diverse organic synthesis strategies to synthesize complex and novel organic compounds.
What are 1-chloro-3-iodobenzene storage conditions?
1-chloro-3-iodobenzene is an organic compound. Its storage conditions are quite important, related to the stability and safety of this substance.
When storing, it should be placed in a cool place. Because the temperature is too high, it is easy to cause chemical reactions, or cause adverse changes such as decomposition and polymerization. If it is overheated, its molecular structure may be damaged, resulting in changes in properties and affecting its subsequent use.
And keep the storage place dry. Moisture easily interacts with 1-chloro-3-iodobenzene, or triggers reactions such as hydrolysis. If moisture intrudes, or chlorine atoms and iodine atoms are replaced by hydroxyl groups, other impurities will be formed, which will damage the purity and quality of the substance.
Furthermore, it should be stored in a well-ventilated place. If the ventilation is poor, once the substance evaporates and steam accumulates, it may affect the surrounding environment. Second, it may encounter open flames or hot topics, or there is a risk of explosion. Because it is an organic halide, it has certain flammability and volatility.
In addition, 1-chloro-3-iodobenzene should be kept away from fires, heat sources, and avoid contact with oxidants and other substances. The oxidizing agent has strong oxidizing properties, and encounters with 1-chloro-3-iodobenzene, or triggers a violent oxidation reaction, resulting in danger.
In terms of packaging, it is advisable to use a sealed container to prevent the intrusion of external factors such as air and moisture, and to ensure that 1-chloro-3-iodobenzene remains stable during storage. In this way, the purpose of proper storage can be achieved, so that this material can exert its due effectiveness when used, and to ensure the safety of the storage process.
When storing, it should be placed in a cool place. Because the temperature is too high, it is easy to cause chemical reactions, or cause adverse changes such as decomposition and polymerization. If it is overheated, its molecular structure may be damaged, resulting in changes in properties and affecting its subsequent use.
And keep the storage place dry. Moisture easily interacts with 1-chloro-3-iodobenzene, or triggers reactions such as hydrolysis. If moisture intrudes, or chlorine atoms and iodine atoms are replaced by hydroxyl groups, other impurities will be formed, which will damage the purity and quality of the substance.
Furthermore, it should be stored in a well-ventilated place. If the ventilation is poor, once the substance evaporates and steam accumulates, it may affect the surrounding environment. Second, it may encounter open flames or hot topics, or there is a risk of explosion. Because it is an organic halide, it has certain flammability and volatility.
In addition, 1-chloro-3-iodobenzene should be kept away from fires, heat sources, and avoid contact with oxidants and other substances. The oxidizing agent has strong oxidizing properties, and encounters with 1-chloro-3-iodobenzene, or triggers a violent oxidation reaction, resulting in danger.
In terms of packaging, it is advisable to use a sealed container to prevent the intrusion of external factors such as air and moisture, and to ensure that 1-chloro-3-iodobenzene remains stable during storage. In this way, the purpose of proper storage can be achieved, so that this material can exert its due effectiveness when used, and to ensure the safety of the storage process.
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