Linshang Chemical
PRODUCTS
1-Chloro-3-Methoxy-2-Methylbenzene
Linshang Chemical
|
HS Code |
600236 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Liquid (predicted from similar compounds) |
| Solubility In Water | Low solubility (aromatic and chlorinated compounds generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether (due to its organic nature) |
As an accredited 1-Chloro-3-Methoxy-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - methoxy - 2 - methylbenzene in 500 - mL glass bottle for chemical packaging. |
| Storage | 1 - Chloro - 3 - methoxy - 2 - methylbenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames due to its potential flammability. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Label the storage container clearly for easy identification and safety compliance. |
| Shipping | 1 - Chloro - 3 - methoxy - 2 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent spills and maintain product integrity during transit. |
Competitive 1-Chloro-3-Methoxy-2-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-3-Methoxy-2-Methylbenzene in China?
As a trusted 1-Chloro-3-Methoxy-2-Methylbenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3-Methoxy-2-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-chloro-3-methoxy-2-methylbenzene?
1-Chloro-3-methoxy-2-methylbenzene, this is an organic compound. Its physical properties are as follows.
Looking at its properties, it is usually liquid at room temperature and pressure. Its color is mostly colorless or slightly yellowish, clear and transparent, and has a special aromatic odor. The structure of the benzene ring gives it such properties.
When it comes to the boiling point, it is about 190 to 200 degrees Celsius. This value fluctuates slightly due to the measurement environment and accuracy. The boiling point is restricted by intermolecular forces. The compound contains benzene rings, chlorine atoms, methoxy groups and methyl groups. Intermolecular forces include van der Waals forces and weak hydrogen bonds, resulting in its high boiling point.
The number of melting points is roughly in the range of -30 to -20 degrees Celsius. The melting point is also affected by the regularity of molecular arrangement and the interaction force. The molecular structure contains a variety of substituents, resulting in less regular arrangement and relatively low melting point.
The density is about 1.1 to 1.2 grams per cubic centimeter, which is greater than the density of water. The density is related to the molecular weight and the degree of molecular packing. The benzene ring and each substituent increase the molecular weight and the structure causes the molecular packing to be tighter, so the density is higher.
In terms of solubility, the solubility in water is very small. Because it is an organic compound, the molecular polarity is weak, while the water polarity is strong. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in common organic solvents, such as ethanol, ether, acetone, etc., because these organic solvents are close to the polarity of the compound, and the intermolecular forces are compatible and mutually soluble.
Volatility has a certain degree because it has a certain vapor pressure. Vapor pressure is closely related to temperature. When temperature increases, vapor pressure increases and volatility increases.
Refractive index is also an important physical property, about 1.53 to 1.55 range. Refractive index reflects the degree of refraction when light propagates in the substance, and is related to molecular structure, density, etc.
Looking at its properties, it is usually liquid at room temperature and pressure. Its color is mostly colorless or slightly yellowish, clear and transparent, and has a special aromatic odor. The structure of the benzene ring gives it such properties.
When it comes to the boiling point, it is about 190 to 200 degrees Celsius. This value fluctuates slightly due to the measurement environment and accuracy. The boiling point is restricted by intermolecular forces. The compound contains benzene rings, chlorine atoms, methoxy groups and methyl groups. Intermolecular forces include van der Waals forces and weak hydrogen bonds, resulting in its high boiling point.
The number of melting points is roughly in the range of -30 to -20 degrees Celsius. The melting point is also affected by the regularity of molecular arrangement and the interaction force. The molecular structure contains a variety of substituents, resulting in less regular arrangement and relatively low melting point.
The density is about 1.1 to 1.2 grams per cubic centimeter, which is greater than the density of water. The density is related to the molecular weight and the degree of molecular packing. The benzene ring and each substituent increase the molecular weight and the structure causes the molecular packing to be tighter, so the density is higher.
In terms of solubility, the solubility in water is very small. Because it is an organic compound, the molecular polarity is weak, while the water polarity is strong. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in common organic solvents, such as ethanol, ether, acetone, etc., because these organic solvents are close to the polarity of the compound, and the intermolecular forces are compatible and mutually soluble.
Volatility has a certain degree because it has a certain vapor pressure. Vapor pressure is closely related to temperature. When temperature increases, vapor pressure increases and volatility increases.
Refractive index is also an important physical property, about 1.53 to 1.55 range. Refractive index reflects the degree of refraction when light propagates in the substance, and is related to molecular structure, density, etc.
What are the chemical properties of 1-chloro-3-methoxy-2-methylbenzene?
1-chloro-3-methoxy-2-methylbenzene, Chinese name 1-chloro-3-methoxy-2-methylbenzene, is an organic compound with unique chemical properties and is worth exploring.
For its nucleophilic substitution reaction, the chlorine atom is the active check point of the compound. Due to the certain electronegativity of the chlorine atom, the carbon-chlorine bond connected to the benzene ring is polar. When encountering nucleophiles, such as hydroxyl ions ($OH ^ - $), alkoxy ions ($RO ^ - $), etc., the carbon-chlorine bond is easily broken, and the nucleophile will attack the carbon atom, undergo nucleophilic substitution, and then generate the corresponding hydroxyl substitution or alkoxy substitution products.
When it comes to aromaticity, the benzene ring of 1-chloro-3-methoxy-2-methylbenzene satisfies the Shocker rule and is aromatic. This property makes its chemical properties relatively stable, and it is not prone to addition reactions, but more prone to electrophilic substitution reactions. The electron cloud density distribution of the benzene ring is affected by the presence of methoxy groups and methyl groups. Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring ortho and para-site through conjugation effect; methyl group is a weak power supply group, which also increases the electron cloud density of the benzene ring. Therefore, electrophilic reagents are more likely to attack the ortho and para-site of the benzene ring and generate electrophilic substitution products.
Looking at the oxidation reaction, although the benzene ring is relatively stable and not easy to be oxidized, under certain conditions, such as when a strong oxidant acts, the methyl group of the side chain of the benzene ring can be oxidized. If treated with acidic potassium permanganate solution, the methyl group can be gradually oxidized to a carboxyl group to obtain the corresponding benzoic
In addition, the oxygen atom of the methoxy group in 1-chloro-3-methoxy-2-methylbenzene has a lone pair electron, which can form coordination bonds with metal ions, etc. This property may play an important role in some organic synthesis and catalytic reactions. Its chlorine atoms can also participate in metal-catalyzed coupling reactions, such as the Ullman reaction, the Suzuki reaction, etc., to form carbon-carbon bonds or carbon-heteroatom bonds, which have a wide application prospect in the field of organic synthesis.
For its nucleophilic substitution reaction, the chlorine atom is the active check point of the compound. Due to the certain electronegativity of the chlorine atom, the carbon-chlorine bond connected to the benzene ring is polar. When encountering nucleophiles, such as hydroxyl ions ($OH ^ - $), alkoxy ions ($RO ^ - $), etc., the carbon-chlorine bond is easily broken, and the nucleophile will attack the carbon atom, undergo nucleophilic substitution, and then generate the corresponding hydroxyl substitution or alkoxy substitution products.
When it comes to aromaticity, the benzene ring of 1-chloro-3-methoxy-2-methylbenzene satisfies the Shocker rule and is aromatic. This property makes its chemical properties relatively stable, and it is not prone to addition reactions, but more prone to electrophilic substitution reactions. The electron cloud density distribution of the benzene ring is affected by the presence of methoxy groups and methyl groups. Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring ortho and para-site through conjugation effect; methyl group is a weak power supply group, which also increases the electron cloud density of the benzene ring. Therefore, electrophilic reagents are more likely to attack the ortho and para-site of the benzene ring and generate electrophilic substitution products.
Looking at the oxidation reaction, although the benzene ring is relatively stable and not easy to be oxidized, under certain conditions, such as when a strong oxidant acts, the methyl group of the side chain of the benzene ring can be oxidized. If treated with acidic potassium permanganate solution, the methyl group can be gradually oxidized to a carboxyl group to obtain the corresponding benzoic
In addition, the oxygen atom of the methoxy group in 1-chloro-3-methoxy-2-methylbenzene has a lone pair electron, which can form coordination bonds with metal ions, etc. This property may play an important role in some organic synthesis and catalytic reactions. Its chlorine atoms can also participate in metal-catalyzed coupling reactions, such as the Ullman reaction, the Suzuki reaction, etc., to form carbon-carbon bonds or carbon-heteroatom bonds, which have a wide application prospect in the field of organic synthesis.
What are the main uses of 1-chloro-3-methoxy-2-methylbenzene?
1-Chloro-3-methoxy-2-methylbenzene is also an organic compound. It has a wide range of uses and is often used as a raw material for organic synthesis in the chemical industry.
In the process of pharmaceutical synthesis, this compound can be used as a key intermediate. Through specific chemical reactions, it can be converted into biologically active substances, which can then be used to develop new drugs or bring good news to the treatment of diseases.
In the field of materials science, it also has a place. Through appropriate reactions, it can be introduced into polymer materials to give different properties to the materials, such as improving the solubility and thermal stability of the materials, which contribute to the creation of new materials.
In the fragrance industry, the unique molecular structure of 1-chloro-3-methoxy-2-methylbenzene may produce a specific odor. After preparation and treatment, it may become a unique part of the fragrance formula, adding a unique flavor to the fragrance.
In addition, in the preparation of fine chemical products, it can be used as a starting material to generate high-value-added fine chemicals through a series of reactions. It is used in electronics, coatings, inks and other fields to promote technological development and product upgrades in various fields.
In the process of pharmaceutical synthesis, this compound can be used as a key intermediate. Through specific chemical reactions, it can be converted into biologically active substances, which can then be used to develop new drugs or bring good news to the treatment of diseases.
In the field of materials science, it also has a place. Through appropriate reactions, it can be introduced into polymer materials to give different properties to the materials, such as improving the solubility and thermal stability of the materials, which contribute to the creation of new materials.
In the fragrance industry, the unique molecular structure of 1-chloro-3-methoxy-2-methylbenzene may produce a specific odor. After preparation and treatment, it may become a unique part of the fragrance formula, adding a unique flavor to the fragrance.
In addition, in the preparation of fine chemical products, it can be used as a starting material to generate high-value-added fine chemicals through a series of reactions. It is used in electronics, coatings, inks and other fields to promote technological development and product upgrades in various fields.
What are 1-chloro-3-methoxy-2-methylbenzene synthesis methods?
The synthesis of 1-chloro-3-methoxy-2-methylbenzene is an important topic in the field of organic synthesis. To synthesize this substance, there are several common methods as follows.
One is to use o-methylphenol as the starting material. First, o-methylphenol and chloromethane are reacted under basic conditions, so that methoxy groups can be introduced at the para-position of phenolic hydroxyl groups to generate 3-methoxy-2-methylphenol. Subsequently, the product is reacted with chlorinated reagents such as phosphorus trichloride or thionyl chloride, and the hydroxyl group is replaced by a chlorine atom to obtain 1-chloro-3-methoxy-2-methylbenzene. This pathway step is relatively simple, and the raw materials are relatively easy to obtain.
Second, 2-methylbenzoic acid is used as the starting material. First, 2-methylbenzoic acid is converted into the corresponding ester by esterification reaction, and then the ester group is reduced to alcohol by a reducing agent such as lithium aluminum hydride, and then the alcohol hydroxyl group is converted into a chlorine atom by halogenation reaction to obtain 2-methyl-3-chlorobenzyl alcohol. After that, the product is reacted with basic reagents such as sodium methoxide to achieve the introduction of methoxy groups, and the final product 1-chloro-3-methoxy-2-methylbenzene is synthesized. Although this method is a little complicated, the reaction selectivity of each step is higher and the product purity is also good.
Third, m-methoxybenzaldehyde is used as the starting material. The aldehyde group is first protected, and then reacted with methyl Grignard reagent to introduce methyl. After removing the aldehyde group protection, chlorine atoms are introduced at specific positions in the benzene ring through halogenation reaction, and finally 1-chloro-3-methoxy-2-methylbenzene is synthesized. This approach requires attention to the selection of protective groups and removal conditions to ensure the smooth progress of the reaction.
The above synthesis methods have their own advantages and disadvantages. In actual operation, the most suitable method should be selected according to the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
One is to use o-methylphenol as the starting material. First, o-methylphenol and chloromethane are reacted under basic conditions, so that methoxy groups can be introduced at the para-position of phenolic hydroxyl groups to generate 3-methoxy-2-methylphenol. Subsequently, the product is reacted with chlorinated reagents such as phosphorus trichloride or thionyl chloride, and the hydroxyl group is replaced by a chlorine atom to obtain 1-chloro-3-methoxy-2-methylbenzene. This pathway step is relatively simple, and the raw materials are relatively easy to obtain.
Second, 2-methylbenzoic acid is used as the starting material. First, 2-methylbenzoic acid is converted into the corresponding ester by esterification reaction, and then the ester group is reduced to alcohol by a reducing agent such as lithium aluminum hydride, and then the alcohol hydroxyl group is converted into a chlorine atom by halogenation reaction to obtain 2-methyl-3-chlorobenzyl alcohol. After that, the product is reacted with basic reagents such as sodium methoxide to achieve the introduction of methoxy groups, and the final product 1-chloro-3-methoxy-2-methylbenzene is synthesized. Although this method is a little complicated, the reaction selectivity of each step is higher and the product purity is also good.
Third, m-methoxybenzaldehyde is used as the starting material. The aldehyde group is first protected, and then reacted with methyl Grignard reagent to introduce methyl. After removing the aldehyde group protection, chlorine atoms are introduced at specific positions in the benzene ring through halogenation reaction, and finally 1-chloro-3-methoxy-2-methylbenzene is synthesized. This approach requires attention to the selection of protective groups and removal conditions to ensure the smooth progress of the reaction.
The above synthesis methods have their own advantages and disadvantages. In actual operation, the most suitable method should be selected according to the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
1-chloro-3-methoxy-2-methylbenzene What are the precautions in storage and transportation?
1-Chloro-3-methoxy-2-methylbenzene, this is an organic compound. During storage and transportation, many matters need to be paid attention to to to ensure its safety.
First storage environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. Because of its flammability, if heated or exposed to open flames, it may cause the risk of combustion. The warehouse temperature should not be higher than 30 ° C, and the relative humidity should not exceed 80%. This temperature and humidity condition can effectively prevent its deterioration or volatilization. And it should be stored separately from oxidizing agents, acids, and bases, and must not be mixed. Because these substances come into contact with it, or cause violent chemical reactions, causing danger.
The second is the packaging requirements. The packaging must be sealed and cannot leak. The packaging materials used must have good corrosion resistance and sealing to prevent it from interacting with the external environment. Metal or plastic drums are commonly used for packaging, and the name of the chemical, hazard characteristics, emergency treatment methods and other key information should be clearly marked on the outside of the package to facilitate identification and emergency response.
When transporting, there are also many key points. The transportation vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperature and hot sun to prevent it from evaporation due to excessive temperature or danger. During transportation, ensure that the container does not leak, collapse, fall or damage. The speed should not be too fast to prevent package collision damage caused by sudden braking. And the transportation route should avoid densely populated areas and important facilities. If leakage unfortunately occurs, the scope of harm can be reduced.
The loading and unloading process should not be ignored. During operation, it should be handled lightly, and it is strictly forbidden to drop, touch, or collide to prevent package damage. Operators need to wear suitable protective equipment, such as gas masks, chemical protective clothing, etc., to avoid direct contact with the chemical and ensure their own safety.
First storage environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. Because of its flammability, if heated or exposed to open flames, it may cause the risk of combustion. The warehouse temperature should not be higher than 30 ° C, and the relative humidity should not exceed 80%. This temperature and humidity condition can effectively prevent its deterioration or volatilization. And it should be stored separately from oxidizing agents, acids, and bases, and must not be mixed. Because these substances come into contact with it, or cause violent chemical reactions, causing danger.
The second is the packaging requirements. The packaging must be sealed and cannot leak. The packaging materials used must have good corrosion resistance and sealing to prevent it from interacting with the external environment. Metal or plastic drums are commonly used for packaging, and the name of the chemical, hazard characteristics, emergency treatment methods and other key information should be clearly marked on the outside of the package to facilitate identification and emergency response.
When transporting, there are also many key points. The transportation vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperature and hot sun to prevent it from evaporation due to excessive temperature or danger. During transportation, ensure that the container does not leak, collapse, fall or damage. The speed should not be too fast to prevent package collision damage caused by sudden braking. And the transportation route should avoid densely populated areas and important facilities. If leakage unfortunately occurs, the scope of harm can be reduced.
The loading and unloading process should not be ignored. During operation, it should be handled lightly, and it is strictly forbidden to drop, touch, or collide to prevent package damage. Operators need to wear suitable protective equipment, such as gas masks, chemical protective clothing, etc., to avoid direct contact with the chemical and ensure their own safety.
Scan to WhatsApp
