Linshang Chemical
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1-Chloro-3-Methyl-2-Nitrobenzene
Linshang Chemical
|
HS Code |
778985 |
| Chemical Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 |
| Appearance | Solid |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Stability | Stable under normal conditions |
| Hazard Class | Harmful if swallowed, in contact with skin or if inhaled |
As an accredited 1-Chloro-3-Methyl-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - methyl - 2 - nitrobenzene: Packed in 5 - kg drums for safe storage and transport. |
| Storage | 1 - Chloro - 3 - methyl - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - Chloro - 3 - methyl - 2 - nitrobenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage, label clearly, and follow international and domestic shipping guidelines for such substances. |
Competitive 1-Chloro-3-Methyl-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 1-chloro-3-methyl-2-nitrobenzene?
1-Chloro-3-methyl-2-nitrobenzene, this is an organic compound with unique chemical properties, which is quite interesting to explore.
Let's talk about its halogenated hydrocarbon properties first. Because it contains chlorine atoms, it can undergo nucleophilic substitution reaction. In case of nucleophilic reagents, chlorine atoms can be replaced. If treated with sodium hydroxide aqueous solution, hydroxyl groups may replace chlorine atoms to form corresponding phenolic derivatives; if reagents such as sodium alcohol act, alkoxy groups can also replace chlorine atoms to form ether compounds. This is because chlorine atoms are affected by benzene rings and have certain activity, which is easy to be attacked by nucleophilic reagents.
Furthermore, methyl groups on phenyl rings also affect their chemical properties. The electron cloud density of the benzene ring can be increased by methyl as the power supply group, which makes the benzene ring more prone to electrophilic substitution reaction. If it can react with bromine and other electrophilic reagents under appropriate conditions, bromine atoms will mainly replace methyl ortho and para-sites, and the ortho and para-sites electron cloud density is relatively higher due to the methyl power supply effect.
The existence of nitro is of great significance. Nitro is a strong electron-absorbing group, which not only reduces the electron cloud density of the benzene ring, but also reduces the activity of the electrophilic substitution of the benzene ring, and also has a significant impact on the electron cloud density of the ortho and para-sites. Therefore, in some reactions, the choice of the reaction check point may be very different from In addition, nitro groups can undergo reduction reactions, and under specific conditions, they can be reduced to amino groups to derive amino-containing compounds and expand their uses in the field of organic synthesis.
1-chloro-3-methyl-2-nitrobenzene has rich and diverse chemical properties and is of great value in organic synthesis, medicinal chemistry and other fields. Many reaction characteristics are waiting for people of insight to explore and utilize in depth.
Let's talk about its halogenated hydrocarbon properties first. Because it contains chlorine atoms, it can undergo nucleophilic substitution reaction. In case of nucleophilic reagents, chlorine atoms can be replaced. If treated with sodium hydroxide aqueous solution, hydroxyl groups may replace chlorine atoms to form corresponding phenolic derivatives; if reagents such as sodium alcohol act, alkoxy groups can also replace chlorine atoms to form ether compounds. This is because chlorine atoms are affected by benzene rings and have certain activity, which is easy to be attacked by nucleophilic reagents.
Furthermore, methyl groups on phenyl rings also affect their chemical properties. The electron cloud density of the benzene ring can be increased by methyl as the power supply group, which makes the benzene ring more prone to electrophilic substitution reaction. If it can react with bromine and other electrophilic reagents under appropriate conditions, bromine atoms will mainly replace methyl ortho and para-sites, and the ortho and para-sites electron cloud density is relatively higher due to the methyl power supply effect.
The existence of nitro is of great significance. Nitro is a strong electron-absorbing group, which not only reduces the electron cloud density of the benzene ring, but also reduces the activity of the electrophilic substitution of the benzene ring, and also has a significant impact on the electron cloud density of the ortho and para-sites. Therefore, in some reactions, the choice of the reaction check point may be very different from In addition, nitro groups can undergo reduction reactions, and under specific conditions, they can be reduced to amino groups to derive amino-containing compounds and expand their uses in the field of organic synthesis.
1-chloro-3-methyl-2-nitrobenzene has rich and diverse chemical properties and is of great value in organic synthesis, medicinal chemistry and other fields. Many reaction characteristics are waiting for people of insight to explore and utilize in depth.
In what areas is 1-chloro-3-methyl-2-nitrobenzene applied?
1-Chloro-3-methyl-2-nitrobenzene, an organic compound, is used in many fields.
In the field of medicinal chemistry, it is often a key intermediate. It can be converted into specific functional groups through a series of reactions, and then a molecular structure with specific biological activities can be constructed. For example, by nucleophilic substitution of chlorine atoms, groups containing heteroatoms such as nitrogen and oxygen can be introduced. After subsequent modification, it is expected to synthesize drug molecules that are effective on specific disease targets, providing an important starting material for the development of new drugs.
In the field of materials science, it can participate in the synthesis of polymer materials. The presence of methyl, nitro and chlorine atoms in its structure endows the compound with unique electron cloud distribution and steric hindrance. Introducing it into the polymer chain as a monomer can change the physical and chemical properties of the material, such as improving the thermal stability, mechanical properties or endowing it with special optical and electrical properties, thus preparing high-performance materials suitable for electronic devices, aerospace and other fields.
In the field of pesticide chemistry, 1-chloro-3-methyl-2-nitrobenzene also plays an important role. Based on its chemical structure, pesticide compounds with insecticidal, bactericidal or herbicidal activities can be synthesized by chemical modification. Its specific structure may interfere with the physiological process of some pests or pathogens, inhibit their growth and reproduction, and achieve the purpose of controlling pests and diseases and ensuring crop yield and quality.
In the dye industry, this compound can be used as an important raw material for synthesizing dyes. Using the chromophore and chromophore in its structure, through further chemical reactions, dye molecules with different colors and dyeing properties can be constructed to meet the needs of various dyes in textile, printing and dyeing industries.
It can be seen that although 1-chloro-3-methyl-2-nitrobenzene is a small organic molecule, it plays an indispensable role in many important fields such as medicine, materials, pesticides, dyes, etc. It is of great significance to promote the development of various fields.
In the field of medicinal chemistry, it is often a key intermediate. It can be converted into specific functional groups through a series of reactions, and then a molecular structure with specific biological activities can be constructed. For example, by nucleophilic substitution of chlorine atoms, groups containing heteroatoms such as nitrogen and oxygen can be introduced. After subsequent modification, it is expected to synthesize drug molecules that are effective on specific disease targets, providing an important starting material for the development of new drugs.
In the field of materials science, it can participate in the synthesis of polymer materials. The presence of methyl, nitro and chlorine atoms in its structure endows the compound with unique electron cloud distribution and steric hindrance. Introducing it into the polymer chain as a monomer can change the physical and chemical properties of the material, such as improving the thermal stability, mechanical properties or endowing it with special optical and electrical properties, thus preparing high-performance materials suitable for electronic devices, aerospace and other fields.
In the field of pesticide chemistry, 1-chloro-3-methyl-2-nitrobenzene also plays an important role. Based on its chemical structure, pesticide compounds with insecticidal, bactericidal or herbicidal activities can be synthesized by chemical modification. Its specific structure may interfere with the physiological process of some pests or pathogens, inhibit their growth and reproduction, and achieve the purpose of controlling pests and diseases and ensuring crop yield and quality.
In the dye industry, this compound can be used as an important raw material for synthesizing dyes. Using the chromophore and chromophore in its structure, through further chemical reactions, dye molecules with different colors and dyeing properties can be constructed to meet the needs of various dyes in textile, printing and dyeing industries.
It can be seen that although 1-chloro-3-methyl-2-nitrobenzene is a small organic molecule, it plays an indispensable role in many important fields such as medicine, materials, pesticides, dyes, etc. It is of great significance to promote the development of various fields.
What are 1-chloro-3-methyl-2-nitrobenzene synthesis methods?
To prepare 1-chloro-3-methyl-2-nitrobenzene, it can be prepared by nitration of m-methyl chlorobenzene. In m-methyl chlorobenzene, both methyl and chlorine atoms are ortho-para-sites, and the methyl group has stronger activating ability than chlorine atoms, so the nitro group mainly enters the methyl ortho-site during nitration.
First take an appropriate amount of m-methyl chlorobenzene and place it in a reaction vessel equipped with a stirrer, thermometer and drop funnel. Under low temperature stirring, slowly add mixed acid dropwise (concentrated nitric acid and concentrated sulfuric acid are mixed in a certain proportion). Because the nitrification reaction is an exothermic reaction, strict temperature control is required to prevent side reactions from occurring. After adding it dropwise, maintain a certain temperature and continue the reaction for a period of time to make
After the reaction is completed, the reaction solution is poured into ice water, and the nitro compounds are stratified due to their density greater than that of water. The organic phase is separated by liquid separation, and then washed with alkali solution and water in turn to remove residual acid and impurities. After that, the organic phase is dried with anhydrous magnesium sulfate, the desiccant is filtered off, and finally the specific boiling point fraction is collected by distillation to obtain pure 1-chloro-3-methyl-2-nitrobenzene.
Another way of thinking, m-toluidine can be prepared by diazotization and Sandmeyer reaction to obtain m-methyl chlorobenzene, and then nitrified. First, m-toluidine is dissolved in dilute hydrochloric acid, cooled to a low temperature, and sodium nitrite solution is slowly added for diazotization to obtain a diazonium salt solution. After that, the hydrochloric acid solution of cuprous chloride is added, and the Sandmeyer reaction occurs to generate m-methyl chlorobenzene. The subsequent nitration steps of m-methyl chlorobenzene are the same as the above method. This route step is slightly complicated, but it can effectively introduce chlorine atoms.
First take an appropriate amount of m-methyl chlorobenzene and place it in a reaction vessel equipped with a stirrer, thermometer and drop funnel. Under low temperature stirring, slowly add mixed acid dropwise (concentrated nitric acid and concentrated sulfuric acid are mixed in a certain proportion). Because the nitrification reaction is an exothermic reaction, strict temperature control is required to prevent side reactions from occurring. After adding it dropwise, maintain a certain temperature and continue the reaction for a period of time to make
After the reaction is completed, the reaction solution is poured into ice water, and the nitro compounds are stratified due to their density greater than that of water. The organic phase is separated by liquid separation, and then washed with alkali solution and water in turn to remove residual acid and impurities. After that, the organic phase is dried with anhydrous magnesium sulfate, the desiccant is filtered off, and finally the specific boiling point fraction is collected by distillation to obtain pure 1-chloro-3-methyl-2-nitrobenzene.
Another way of thinking, m-toluidine can be prepared by diazotization and Sandmeyer reaction to obtain m-methyl chlorobenzene, and then nitrified. First, m-toluidine is dissolved in dilute hydrochloric acid, cooled to a low temperature, and sodium nitrite solution is slowly added for diazotization to obtain a diazonium salt solution. After that, the hydrochloric acid solution of cuprous chloride is added, and the Sandmeyer reaction occurs to generate m-methyl chlorobenzene. The subsequent nitration steps of m-methyl chlorobenzene are the same as the above method. This route step is slightly complicated, but it can effectively introduce chlorine atoms.
What impact does 1-chloro-3-methyl-2-nitrobenzene have on the environment?
1-Chloro-3-methyl-2-nitrobenzene is an organic compound, and its influence on the environment cannot be ignored.
In this compound, the presence of chlorine atoms, methyl groups and nitro groups makes it have specific chemical properties. Chlorine atoms have certain electronegativity, which can affect the polarity of molecules, and under certain environmental conditions, substitution reactions may occur. Although methyl groups are alkyl groups, they are relatively stable, but they also affect the spatial structure and physical properties of molecules, and may play a role in their diffusion and distribution in the environment. The nitro group is a strong electron-absorbing group, which not only significantly changes the molecular polarity, but also enhances the chemical activity of the compound.
In the atmospheric environment, 1-chloro-3-methyl-2-nitrobenzene may migrate with the airflow. Because of its volatility, it can exist in the air. However, due to its relatively complex chemical structure, it may react with active substances such as free radicals in the atmosphere to form new pollutants and affect air quality.
If it enters the water body, it may be adsorbed on the surface of suspended particles and settle to the bottom of the water due to its hydrophobicity. In water, it may slowly hydrolyze, releasing chloride ions, etc., changing the chemical composition of the water body. And for aquatic organisms, the compound may have certain toxicity. Due to its special chemical structure, it may interfere with the physiological and biochemical processes of aquatic organisms, such as affecting their respiration, metabolism, etc., and even cause the death of organisms and destroy the balance of aquatic ecosystems.
In the soil environment, 1-chloro-3-methyl-2-nitrobenzene may be adsorbed by soil particles. Soil microorganisms may decompose it slowly, because its complex structure hinders microbial enzymatic hydrolysis. Long-term accumulation may change soil properties, affect nutrient cycling in soil and plant growth. After plant roots absorb this compound, it may accumulate in plants and pass through the food chain, posing a potential threat to high-trophic organisms.
In conclusion, 1-chloro-3-methyl-2-nitrobenzene has potential effects on various aspects of the environment, and it needs to be paid attention to and studied to ensure the safety of the ecological environment.
In this compound, the presence of chlorine atoms, methyl groups and nitro groups makes it have specific chemical properties. Chlorine atoms have certain electronegativity, which can affect the polarity of molecules, and under certain environmental conditions, substitution reactions may occur. Although methyl groups are alkyl groups, they are relatively stable, but they also affect the spatial structure and physical properties of molecules, and may play a role in their diffusion and distribution in the environment. The nitro group is a strong electron-absorbing group, which not only significantly changes the molecular polarity, but also enhances the chemical activity of the compound.
In the atmospheric environment, 1-chloro-3-methyl-2-nitrobenzene may migrate with the airflow. Because of its volatility, it can exist in the air. However, due to its relatively complex chemical structure, it may react with active substances such as free radicals in the atmosphere to form new pollutants and affect air quality.
If it enters the water body, it may be adsorbed on the surface of suspended particles and settle to the bottom of the water due to its hydrophobicity. In water, it may slowly hydrolyze, releasing chloride ions, etc., changing the chemical composition of the water body. And for aquatic organisms, the compound may have certain toxicity. Due to its special chemical structure, it may interfere with the physiological and biochemical processes of aquatic organisms, such as affecting their respiration, metabolism, etc., and even cause the death of organisms and destroy the balance of aquatic ecosystems.
In the soil environment, 1-chloro-3-methyl-2-nitrobenzene may be adsorbed by soil particles. Soil microorganisms may decompose it slowly, because its complex structure hinders microbial enzymatic hydrolysis. Long-term accumulation may change soil properties, affect nutrient cycling in soil and plant growth. After plant roots absorb this compound, it may accumulate in plants and pass through the food chain, posing a potential threat to high-trophic organisms.
In conclusion, 1-chloro-3-methyl-2-nitrobenzene has potential effects on various aspects of the environment, and it needs to be paid attention to and studied to ensure the safety of the ecological environment.
What is the market outlook for 1-chloro-3-methyl-2-nitrobenzene?
1 - chloro - 3 - methyl - 2 - nitrobenzene is one of the organic compounds. In the chemical industry, its market prospects are quite promising.
Looking back at the past, with the vigorous rise of industry, the demand for various fine chemicals has increased, and the position of this compound as an important intermediate in organic synthesis has become more and more prominent. In the process of dye manufacturing, through specific chemical reactions, dyes with bright color and good fastness can be prepared, which are widely sold in the market to meet the needs of textile and other industries.
Furthermore, the pharmaceutical field also has its uses. After a series of complex synthesis steps, it can be converted into substances with specific pharmacological activities, which can be used to develop new drugs to treat various diseases. In today's society, the demand for medicine continues to rise, and this compound is indispensable in the pharmaceutical synthesis chain, so the market demand is also rising.
However, its market prospects are not completely smooth. On the one hand, the process of preparing this compound involves many complex reactions and harsh conditions, and the control of production costs is crucial. If the cost remains high, it will affect its market competitiveness. On the other hand, environmental regulations are becoming more and more stringent, and the treatment of pollutants involved in the production process is also a major challenge. If it cannot be properly dealt with, it may be restricted by regulatory authorities, which will affect market supply.
But overall, with the continuous advancement of science and technology, new synthetic processes may reduce costs and pollution, and the rigidity of various industries' demand for them, the market prospect of 1-chloro-3-methyl-2-nitrobenzene still has broad space, and with time, it will be able to bloom more brilliantly in the fields of chemical industry, medicine and so on.
Looking back at the past, with the vigorous rise of industry, the demand for various fine chemicals has increased, and the position of this compound as an important intermediate in organic synthesis has become more and more prominent. In the process of dye manufacturing, through specific chemical reactions, dyes with bright color and good fastness can be prepared, which are widely sold in the market to meet the needs of textile and other industries.
Furthermore, the pharmaceutical field also has its uses. After a series of complex synthesis steps, it can be converted into substances with specific pharmacological activities, which can be used to develop new drugs to treat various diseases. In today's society, the demand for medicine continues to rise, and this compound is indispensable in the pharmaceutical synthesis chain, so the market demand is also rising.
However, its market prospects are not completely smooth. On the one hand, the process of preparing this compound involves many complex reactions and harsh conditions, and the control of production costs is crucial. If the cost remains high, it will affect its market competitiveness. On the other hand, environmental regulations are becoming more and more stringent, and the treatment of pollutants involved in the production process is also a major challenge. If it cannot be properly dealt with, it may be restricted by regulatory authorities, which will affect market supply.
But overall, with the continuous advancement of science and technology, new synthetic processes may reduce costs and pollution, and the rigidity of various industries' demand for them, the market prospect of 1-chloro-3-methyl-2-nitrobenzene still has broad space, and with time, it will be able to bloom more brilliantly in the fields of chemical industry, medicine and so on.
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