Linshang Chemical
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1-Chloro-3-Methyl-5-Nitro-Benzene
Linshang Chemical
|
HS Code |
776478 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Solid |
| Color | Yellowish |
| Odor | Characteristic |
| Melting Point | 46 - 48 °C |
| Boiling Point | 256 - 258 °C |
| Density | 1.39 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
As an accredited 1-Chloro-3-Methyl-5-Nitro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - methyl - 5 - nitro - benzene: Packed in 500g bottles for chemical storage. |
| Storage | 1 - Chloro - 3 - methyl - 5 - nitro - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions. |
| Shipping | 1 - Chloro - 3 - methyl - 5 - nitro - benzene is a hazardous chemical. It must be shipped in properly labeled, sturdy containers compliant with safety regulations, ensuring secure handling to prevent spills and protect transportation workers and the environment. |
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What is the chemistry of 1-chloro-3-methyl-5-nitro-benzene?
1-Chloro-3-methyl-5-nitrobenzene is also an organic compound. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
In this compound, the chlorine atom, methyl group and nitro group each show their own characteristics and interact with each other, resulting in specific reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult, but making the nucleophilic substitution reaction easier.
From the perspective of halogenation reaction, due to the localization effect of nitro and chlorine atoms, the subsequent halogenation reaction has a specific trend of checking points. Nitro and chlorine atoms are both meta-localizers, and methyl is an ortho-para-locator. Under the combined action, the subsequent halogenation reactions mostly occur at specific positions.
Re-discussion on its redox properties. Nitro can be reduced to amino groups, which is an important transition in organic synthesis and can be achieved by various reducing agents, such as iron and hydrochloric acid systems, catalytic hydrogenation, etc. Chlorine atoms can be replaced by nucleophiles under specific conditions, such as reacting with sodium alcohol, phenols, etc., to form corresponding ethers or phenolic ethers.
Although methyl is relatively stable, it can be oxidized to carboxyl groups under the action of strong oxidants. This compound contains a variety of functional groups, and the interaction between the functional groups makes its chemical properties rich and variable. It has potential application value in many fields such as drug synthesis and materials science.
In this compound, the chlorine atom, methyl group and nitro group each show their own characteristics and interact with each other, resulting in specific reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult, but making the nucleophilic substitution reaction easier.
From the perspective of halogenation reaction, due to the localization effect of nitro and chlorine atoms, the subsequent halogenation reaction has a specific trend of checking points. Nitro and chlorine atoms are both meta-localizers, and methyl is an ortho-para-locator. Under the combined action, the subsequent halogenation reactions mostly occur at specific positions.
Re-discussion on its redox properties. Nitro can be reduced to amino groups, which is an important transition in organic synthesis and can be achieved by various reducing agents, such as iron and hydrochloric acid systems, catalytic hydrogenation, etc. Chlorine atoms can be replaced by nucleophiles under specific conditions, such as reacting with sodium alcohol, phenols, etc., to form corresponding ethers or phenolic ethers.
Although methyl is relatively stable, it can be oxidized to carboxyl groups under the action of strong oxidants. This compound contains a variety of functional groups, and the interaction between the functional groups makes its chemical properties rich and variable. It has potential application value in many fields such as drug synthesis and materials science.
What are the physical properties of 1-chloro-3-methyl-5-nitro-benzene?
1-Chloro-3-methyl-5-nitrobenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its appearance, under room temperature and pressure, is mostly solid, or crystalline powder, color or nearly white, or slightly yellow, depending on its purity. The melting point and boiling point of this compound are also key physical properties. The melting point is about [X] ° C, and the boiling point is around [X] ° C. This specific temperature range depends on its use in various chemical operations and experimental applications.
Furthermore, the solubility is discussed. The solubility of 1-chloro-3-methyl-5-nitrobenzene in water is very small. Because of its molecular structure, hydrophobic groups dominate, making it difficult to dissolve in polar water. However, in organic solvents, such as ether, chloroform, dichloromethane, etc., it shows good solubility. This property makes it well used in the extraction and separation steps of organic synthesis.
Its density is higher than that of water, and it will sink to the bottom when placed in water. And because of its specific molecular structure, it has a certain volatility and will slowly evaporate into the air in an open environment.
In addition, 1-chloro-3-methyl-5-nitrobenzene contains nitro and chlorine atoms, which have certain chemical activity and stability. Nitro is a strong electron-absorbing group, and chlorine atoms also affect the distribution of electron clouds in molecules. These two make it unique in chemical reactions. It can participate in a variety of organic reactions, such as nucleophilic substitution, reduction, etc. However, under general conditions, it has relative stability. It is not easy to react violently on its own unless it encounters special reagents and conditions.
First of all, its appearance, under room temperature and pressure, is mostly solid, or crystalline powder, color or nearly white, or slightly yellow, depending on its purity. The melting point and boiling point of this compound are also key physical properties. The melting point is about [X] ° C, and the boiling point is around [X] ° C. This specific temperature range depends on its use in various chemical operations and experimental applications.
Furthermore, the solubility is discussed. The solubility of 1-chloro-3-methyl-5-nitrobenzene in water is very small. Because of its molecular structure, hydrophobic groups dominate, making it difficult to dissolve in polar water. However, in organic solvents, such as ether, chloroform, dichloromethane, etc., it shows good solubility. This property makes it well used in the extraction and separation steps of organic synthesis.
Its density is higher than that of water, and it will sink to the bottom when placed in water. And because of its specific molecular structure, it has a certain volatility and will slowly evaporate into the air in an open environment.
In addition, 1-chloro-3-methyl-5-nitrobenzene contains nitro and chlorine atoms, which have certain chemical activity and stability. Nitro is a strong electron-absorbing group, and chlorine atoms also affect the distribution of electron clouds in molecules. These two make it unique in chemical reactions. It can participate in a variety of organic reactions, such as nucleophilic substitution, reduction, etc. However, under general conditions, it has relative stability. It is not easy to react violently on its own unless it encounters special reagents and conditions.
What is 1-chloro-3-methyl-5-nitro-benzene synthesis method?
To prepare 1-chloro-3-methyl-5-nitro-benzene, the following method can be used.
First take m-xylene as the starting material, because the methyl group on the benzene ring is an ortho-para-localization group, and the two methyl groups work together to make its meta-localization activity relatively enhanced. Put m-xylene in an appropriate reaction vessel, and use a mixed acid of concentrated nitric acid and concentrated sulfuric acid in a certain proportion as the nitrifying agent, and carry out the nitrification reaction at a suitable temperature. During this reaction, due to the localization effect of methyl groups, the nitro group mainly enters the two meta-sites, thereby preparing 3-methyl-5-nitro-xylene. In the reaction, close attention should be paid to the temperature control. If the temperature is too high, it is easy to cause side reactions such as polynitro substitution, which affects the purity of the product.
Subsequently, the obtained 3-methyl-5-nitro-xylene is chlorinated. With chlorine gas as the chlorination reagent, the o-para hydrogen atom of the methyl group can be replaced by the chlorine atom under the condition of light or the presence of a catalyst (such as Lewis acid such as ferric chloride). Because the nitro group is an meta-localization group, it will affect the distribution of the electron cloud of the benzene ring and change the activity of the methyl group. Under suitable reaction conditions, the ortho-chlorination of one of the methyl groups can be realized to obtain 1-chloro-3-methyl-5-nitro-xylene. This step also requires good control of the reaction conditions, including reaction temperature, chlorine gas entry rate, catalyst dosage, etc., to prevent excessive chlorination or other side reactions.
Finally, oxidize 1-chloro-3-methyl-5-nitro-xylene for demethylation. With a suitable oxidizing agent, such as acidic potassium permanganate solution, methyl can be oxidized to carboxyl groups, and then decarboxylated to remove the final product 1-chloro-3-methyl-5-nitro-benzene. In this oxidation step, attention should be paid to controlling the amount of oxidant and reaction time to prevent excessive oxidation from affecting chlorine atoms and nitro groups, and to ensure the formation and purity of the product.
First take m-xylene as the starting material, because the methyl group on the benzene ring is an ortho-para-localization group, and the two methyl groups work together to make its meta-localization activity relatively enhanced. Put m-xylene in an appropriate reaction vessel, and use a mixed acid of concentrated nitric acid and concentrated sulfuric acid in a certain proportion as the nitrifying agent, and carry out the nitrification reaction at a suitable temperature. During this reaction, due to the localization effect of methyl groups, the nitro group mainly enters the two meta-sites, thereby preparing 3-methyl-5-nitro-xylene. In the reaction, close attention should be paid to the temperature control. If the temperature is too high, it is easy to cause side reactions such as polynitro substitution, which affects the purity of the product.
Subsequently, the obtained 3-methyl-5-nitro-xylene is chlorinated. With chlorine gas as the chlorination reagent, the o-para hydrogen atom of the methyl group can be replaced by the chlorine atom under the condition of light or the presence of a catalyst (such as Lewis acid such as ferric chloride). Because the nitro group is an meta-localization group, it will affect the distribution of the electron cloud of the benzene ring and change the activity of the methyl group. Under suitable reaction conditions, the ortho-chlorination of one of the methyl groups can be realized to obtain 1-chloro-3-methyl-5-nitro-xylene. This step also requires good control of the reaction conditions, including reaction temperature, chlorine gas entry rate, catalyst dosage, etc., to prevent excessive chlorination or other side reactions.
Finally, oxidize 1-chloro-3-methyl-5-nitro-xylene for demethylation. With a suitable oxidizing agent, such as acidic potassium permanganate solution, methyl can be oxidized to carboxyl groups, and then decarboxylated to remove the final product 1-chloro-3-methyl-5-nitro-benzene. In this oxidation step, attention should be paid to controlling the amount of oxidant and reaction time to prevent excessive oxidation from affecting chlorine atoms and nitro groups, and to ensure the formation and purity of the product.
1-chloro-3-methyl-5-nitro-benzene in what areas?
1-Chloro-3-methyl-5-nitrobenzene, which is used in many fields.
In the field of medicine, it can be a key intermediate for the synthesis of specific drugs. The presence of chlorine, methyl and nitro groups in the molecular structure endows the molecule with unique chemical properties, which can participate in various chemical reactions and help to construct complex molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 1-chloro-3-methyl-5-nitrobenzene can introduce key functional groups through a series of reactions to shape the structure of the drug and the target to achieve antibacterial effect.
In the field of pesticides, it also plays an important role. It can be used as a raw material to prepare a variety of high-efficiency pesticides. Due to its structural characteristics, synthetic pesticides may have highly selective toxic effects on specific pests, or can interfere with the physiological and metabolic processes of pests. For example, after the chemical transformation of 1-chloro-3-methyl-5-nitrobenzene, the product can block the nervous system conduction of pests, paralyze and die, and protect crops from insect attacks.
In the dye industry, 1-chloro-3-methyl-5-nitrobenzene also plays an important role. The dyes it participates in the synthesis may have unique color and good dyeing properties. Due to the specific interaction between the molecular structure and the fiber molecules during the dyeing process, the dye firmly adheres to the fiber, showing the effect of bright color and long-lasting non-fading. It is widely used in textile printing and dyeing and other industries to add rich and colorful colors to fabrics.
In the field of chemical research, it is an important organic synthesis reagent. Researchers often use its structural characteristics to carry out research on various organic reaction mechanisms and explore the synthesis of new compounds. Through nucleophilic substitution, reduction and other reactions, it expands the boundaries of organic chemistry knowledge and develops novel compounds, providing a foundation for innovation in materials science, drug research and development and other fields.
In the field of medicine, it can be a key intermediate for the synthesis of specific drugs. The presence of chlorine, methyl and nitro groups in the molecular structure endows the molecule with unique chemical properties, which can participate in various chemical reactions and help to construct complex molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 1-chloro-3-methyl-5-nitrobenzene can introduce key functional groups through a series of reactions to shape the structure of the drug and the target to achieve antibacterial effect.
In the field of pesticides, it also plays an important role. It can be used as a raw material to prepare a variety of high-efficiency pesticides. Due to its structural characteristics, synthetic pesticides may have highly selective toxic effects on specific pests, or can interfere with the physiological and metabolic processes of pests. For example, after the chemical transformation of 1-chloro-3-methyl-5-nitrobenzene, the product can block the nervous system conduction of pests, paralyze and die, and protect crops from insect attacks.
In the dye industry, 1-chloro-3-methyl-5-nitrobenzene also plays an important role. The dyes it participates in the synthesis may have unique color and good dyeing properties. Due to the specific interaction between the molecular structure and the fiber molecules during the dyeing process, the dye firmly adheres to the fiber, showing the effect of bright color and long-lasting non-fading. It is widely used in textile printing and dyeing and other industries to add rich and colorful colors to fabrics.
In the field of chemical research, it is an important organic synthesis reagent. Researchers often use its structural characteristics to carry out research on various organic reaction mechanisms and explore the synthesis of new compounds. Through nucleophilic substitution, reduction and other reactions, it expands the boundaries of organic chemistry knowledge and develops novel compounds, providing a foundation for innovation in materials science, drug research and development and other fields.
What are 1-chloro-3-methyl-5-nitro-benzene storage conditions?
1-Chloro-3-methyl-5-nitrobenzene is an organic compound with certain chemical activity and potential danger, and its storage conditions are quite important.
The cover should be stored in a cool and ventilated warehouse because of its flammability, and the risk of combustion and explosion when heated, exposed to open flames or in contact with oxidants. The temperature of the warehouse should not be too high to prevent the compound from increasing its reactivity and causing danger due to the increase in temperature. And it must be kept away from fire and heat sources. Open flames and high temperatures are major hidden dangers that cause accidents and must be eliminated.
Furthermore, this compound should be stored separately from oxidants and edible chemicals, and must not be mixed. The edge oxidant can react violently with 1-chloro-3-methyl-5-nitrobenzene, or cause serious consequences such as combustion and explosion; and mixed with edible chemicals, if there is an accident such as leakage, it is easy to cause edible chemical pollution and endanger human health.
The storage area should be equipped with suitable materials to contain leaks. In the event of a leak, it can be adsorbed with inert materials such as sand and vermiculite to avoid the spread of leaks, pollute the environment, and facilitate subsequent cleaning and disposal. And it should be equipped with corresponding varieties and quantities of fire-fighting equipment. For fires that may be caused by them, appropriate fire-extinguishing agents, such as carbon dioxide, dry powder, etc. should be selected according to their chemical characteristics to effectively extinguish fires and ensure the safety of personnel and property.
During storage, it is also necessary to check regularly to see if the packaging is in good condition and there are no signs of leakage. If any problems are found, timely measures should be taken to prevent the danger from expanding. In this way, 1-chloro-3-methyl-5-nitrobenzene can be stored safely and accidents can be avoided.
The cover should be stored in a cool and ventilated warehouse because of its flammability, and the risk of combustion and explosion when heated, exposed to open flames or in contact with oxidants. The temperature of the warehouse should not be too high to prevent the compound from increasing its reactivity and causing danger due to the increase in temperature. And it must be kept away from fire and heat sources. Open flames and high temperatures are major hidden dangers that cause accidents and must be eliminated.
Furthermore, this compound should be stored separately from oxidants and edible chemicals, and must not be mixed. The edge oxidant can react violently with 1-chloro-3-methyl-5-nitrobenzene, or cause serious consequences such as combustion and explosion; and mixed with edible chemicals, if there is an accident such as leakage, it is easy to cause edible chemical pollution and endanger human health.
The storage area should be equipped with suitable materials to contain leaks. In the event of a leak, it can be adsorbed with inert materials such as sand and vermiculite to avoid the spread of leaks, pollute the environment, and facilitate subsequent cleaning and disposal. And it should be equipped with corresponding varieties and quantities of fire-fighting equipment. For fires that may be caused by them, appropriate fire-extinguishing agents, such as carbon dioxide, dry powder, etc. should be selected according to their chemical characteristics to effectively extinguish fires and ensure the safety of personnel and property.
During storage, it is also necessary to check regularly to see if the packaging is in good condition and there are no signs of leakage. If any problems are found, timely measures should be taken to prevent the danger from expanding. In this way, 1-chloro-3-methyl-5-nitrobenzene can be stored safely and accidents can be avoided.
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