Linshang Chemical
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1-Chloro-3-Nitro-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
450123 |
| Chemical Formula | C7H3ClF3NO2 |
| Molecular Weight | 225.55 |
| Appearance | Typically a colorless to light - yellow liquid or solid |
| Boiling Point | Around 208 - 210 °C |
| Melting Point | Approximately 35 - 38 °C |
| Density | Around 1.56 g/cm³ |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Around 86 °C |
| Vapor Pressure | Low at room temperature |
| Odor | May have a pungent or characteristic odor |
| Stability | Stable under normal conditions, but can react with strong reducing agents, bases |
As an accredited 1-Chloro-3-Nitro-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 3 - nitro - 5 - (trifluoromethyl)benzene in 100 - gram bottles for packaging. |
| Storage | 1 - Chloro - 3 - nitro - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames due to its flammability risks. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions. |
| Shipping | 1 - chloro - 3 - nitro - 5 - (trifluoromethyl)benzene is a chemical. It should be shipped in properly labeled, corrosion - resistant containers. Ensure compliance with hazardous material shipping regulations, with appropriate handling to prevent leakage. |
Competitive 1-Chloro-3-Nitro-5-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-3-Nitro-5-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-3-nitro-5- (trifluoromethyl) benzene?
1 - chloro - 3 - nitro - 5 - (trifluoromethyl) benzene, Chinese name 1 - chloro - 3 - nitro - 5 - (trifluoromethyl) benzene, this substance is widely used in various fields of chemical industry.
First, it is often used as a key intermediate in the synthesis of medicine. Taking the preparation of specific antibacterial drugs as an example, the chlorine atom, nitro group and trifluoromethyl in its structure can add unique activities and properties to the subsequent reaction, helping the drug molecule to achieve the required pharmacological function. Through a series of organic reactions, other functional groups can be precisely introduced to construct complex molecular structures with specific biological activities, thereby facilitating the development of new antibacterial drugs.
Second, it also plays an important role in the field of pesticide creation. Due to its unique chemical structure, the derived pesticide products may have excellent insecticidal, bactericidal or herbicidal effects. For example, some insecticides containing this structure have high-efficiency poisoning ability against specific pests, and can interact with biological macromolecules in pests through their special functional groups, interfering with the normal physiological metabolism of pests, and achieving the purpose of pest control.
Third, it is also useful in the field of materials science. It can be used as raw materials to participate in the synthesis of special polymer materials. Due to the strong electron absorption of trifluoromethyl and the chemical activity of chlorine atoms and nitro groups, the synthesized polymer materials have unique properties, such as excellent chemical stability, corrosion resistance and thermal stability. Such materials may be used to manufacture high-end chemical equipment linings, special components in the aerospace field, to meet the strict requirements of material properties in special environments.
In summary, 1-chloro-3-nitro-5 - (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, pesticides and materials science, and has made great contributions to promoting the technological progress and innovation of related industries.
First, it is often used as a key intermediate in the synthesis of medicine. Taking the preparation of specific antibacterial drugs as an example, the chlorine atom, nitro group and trifluoromethyl in its structure can add unique activities and properties to the subsequent reaction, helping the drug molecule to achieve the required pharmacological function. Through a series of organic reactions, other functional groups can be precisely introduced to construct complex molecular structures with specific biological activities, thereby facilitating the development of new antibacterial drugs.
Second, it also plays an important role in the field of pesticide creation. Due to its unique chemical structure, the derived pesticide products may have excellent insecticidal, bactericidal or herbicidal effects. For example, some insecticides containing this structure have high-efficiency poisoning ability against specific pests, and can interact with biological macromolecules in pests through their special functional groups, interfering with the normal physiological metabolism of pests, and achieving the purpose of pest control.
Third, it is also useful in the field of materials science. It can be used as raw materials to participate in the synthesis of special polymer materials. Due to the strong electron absorption of trifluoromethyl and the chemical activity of chlorine atoms and nitro groups, the synthesized polymer materials have unique properties, such as excellent chemical stability, corrosion resistance and thermal stability. Such materials may be used to manufacture high-end chemical equipment linings, special components in the aerospace field, to meet the strict requirements of material properties in special environments.
In summary, 1-chloro-3-nitro-5 - (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, pesticides and materials science, and has made great contributions to promoting the technological progress and innovation of related industries.
What are the physical properties of 1-chloro-3-nitro-5- (trifluoromethyl) benzene
1-Chloro-3-nitro-5- (trifluoromethyl) benzene is an organic compound. Its physical properties are quite important and have a profound impact on its application in chemical and related fields.
First of all, the appearance of this compound is often light yellow to yellow liquid, with a clear texture. It can be seen that its fluidity is good, and it exists stably at room temperature and pressure. However, when exposed to air or light, it may gradually change color due to photochemical reactions, resulting in changes in appearance.
In terms of boiling point, it is about 230-232 ° C. This boiling point indicates that considerable heat is required to convert it from liquid to gas. At high temperatures, the kinetic energy of molecules increases, which is sufficient to overcome the gasification of intermolecular forces. Due to its high boiling point, it is not easy to volatilize at room temperature and is relatively stable, which is conducive to storage and transportation. However, when operating in high temperature environments, it is necessary to pay attention to its gasification risks.
The melting point is around -14 ° C. At this low temperature, the molecular movement slows down, and the interaction forces between molecules arrange in an orderly manner, and the substance solidifies from liquid to solid. The low melting point means that the compound is not easy to solidify in cold environments. Under outdoor conditions in winter in most areas, it may still be able to maintain a liquid state. In practical applications, it can reduce problems such as pipeline blockage due to low temperature solidification.
The density is about 1.63 g/cm ³, which is larger than that of water. When mixed with water, it will sink to the bottom of the water. This property is of great significance in the separation, purification and construction of related chemical reaction systems. It can be separated from low-density substances such as water by means of density difference and liquid separation.
In terms of solubility, it is slightly soluble in water. Because its molecular structure contains groups such as chlorine, nitro and trifluoromethyl, the polarity of these groups is very different from that of water molecules. According to the principle of "similar miscibility", it is difficult to form effective intermolecular forces with water, so it is difficult to dissolve in water. However, it is soluble in most organic solvents, such as dichloromethane, chloroform, toluene, etc. The interaction between organic solvent molecules and the compound molecules is suitable and miscible. This property provides convenience for its use in organic synthesis reactions. It can choose suitable organic solvents to build a homogeneous reaction system and promote the reaction.
In addition, the compound has a certain odor, but there are few relevant odor descriptions, or because of its volatility, the odor emission is not significant. However, in a closed space or high concentration environment, the odor may be more obvious, which is irritating to human senses. Pay attention to ventilation protection during operation.
First of all, the appearance of this compound is often light yellow to yellow liquid, with a clear texture. It can be seen that its fluidity is good, and it exists stably at room temperature and pressure. However, when exposed to air or light, it may gradually change color due to photochemical reactions, resulting in changes in appearance.
In terms of boiling point, it is about 230-232 ° C. This boiling point indicates that considerable heat is required to convert it from liquid to gas. At high temperatures, the kinetic energy of molecules increases, which is sufficient to overcome the gasification of intermolecular forces. Due to its high boiling point, it is not easy to volatilize at room temperature and is relatively stable, which is conducive to storage and transportation. However, when operating in high temperature environments, it is necessary to pay attention to its gasification risks.
The melting point is around -14 ° C. At this low temperature, the molecular movement slows down, and the interaction forces between molecules arrange in an orderly manner, and the substance solidifies from liquid to solid. The low melting point means that the compound is not easy to solidify in cold environments. Under outdoor conditions in winter in most areas, it may still be able to maintain a liquid state. In practical applications, it can reduce problems such as pipeline blockage due to low temperature solidification.
The density is about 1.63 g/cm ³, which is larger than that of water. When mixed with water, it will sink to the bottom of the water. This property is of great significance in the separation, purification and construction of related chemical reaction systems. It can be separated from low-density substances such as water by means of density difference and liquid separation.
In terms of solubility, it is slightly soluble in water. Because its molecular structure contains groups such as chlorine, nitro and trifluoromethyl, the polarity of these groups is very different from that of water molecules. According to the principle of "similar miscibility", it is difficult to form effective intermolecular forces with water, so it is difficult to dissolve in water. However, it is soluble in most organic solvents, such as dichloromethane, chloroform, toluene, etc. The interaction between organic solvent molecules and the compound molecules is suitable and miscible. This property provides convenience for its use in organic synthesis reactions. It can choose suitable organic solvents to build a homogeneous reaction system and promote the reaction.
In addition, the compound has a certain odor, but there are few relevant odor descriptions, or because of its volatility, the odor emission is not significant. However, in a closed space or high concentration environment, the odor may be more obvious, which is irritating to human senses. Pay attention to ventilation protection during operation.
What is the chemical synthesis method of 1-chloro-3-nitro-5- (trifluoromethyl) benzene?
The synthesis of 1-chloro-3-nitro-5- (trifluoromethyl) benzene requires clever chemical steps.
First, it is often started with an appropriate starting material. If m-trifluoromethylaniline is used as the starting material, it is first reacted by diazotization. In a low temperature and acidic environment, m-trifluoromethylaniline interacts with sodium nitrite and acid to form a diazosalt. This diazosalt is active and prone to various transformations.
Then, the diazosalt reacts with the hydrochloric acid solution of cuprous chloride, which is a Sandmeier reaction. The diazoyl group is replaced by a chlorine atom, and then m-chlorotrifluoromethylbenzene is obtained.
After that, the nitration reaction of m-chlorotrifluoromethylbenzene is carried out. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying agent, and the nitro group is selectively introduced into the specific position of the benzene ring at a suitable temperature. After fine control of the reaction conditions, such as temperature and the proportion of reactants, the nitro group is mainly substituted in the chlorine atom and trifluoromethyl interposition in m-chlorotrifluoromethylbenzene, and finally 1-chloro-3-nitro-5- (trifluoromethyl) benzene.
There may also be other methods, such as m-trifluoromethylbenzoic acid as the starting material, first by halogenation reaction, the chlorine atom is introduced into the benz However, regardless of the method, it is necessary to carefully control the reaction conditions in order to achieve the goal of high yield and high purity.
First, it is often started with an appropriate starting material. If m-trifluoromethylaniline is used as the starting material, it is first reacted by diazotization. In a low temperature and acidic environment, m-trifluoromethylaniline interacts with sodium nitrite and acid to form a diazosalt. This diazosalt is active and prone to various transformations.
Then, the diazosalt reacts with the hydrochloric acid solution of cuprous chloride, which is a Sandmeier reaction. The diazoyl group is replaced by a chlorine atom, and then m-chlorotrifluoromethylbenzene is obtained.
After that, the nitration reaction of m-chlorotrifluoromethylbenzene is carried out. The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying agent, and the nitro group is selectively introduced into the specific position of the benzene ring at a suitable temperature. After fine control of the reaction conditions, such as temperature and the proportion of reactants, the nitro group is mainly substituted in the chlorine atom and trifluoromethyl interposition in m-chlorotrifluoromethylbenzene, and finally 1-chloro-3-nitro-5- (trifluoromethyl) benzene.
There may also be other methods, such as m-trifluoromethylbenzoic acid as the starting material, first by halogenation reaction, the chlorine atom is introduced into the benz However, regardless of the method, it is necessary to carefully control the reaction conditions in order to achieve the goal of high yield and high purity.
What to pay attention to when storing and transporting 1-chloro-3-nitro-5- (trifluoromethyl) benzene
1-Chloro-3-nitro-5- (trifluoromethyl) benzene is also an organic compound. During its storage and transportation, many matters must not be ignored.
First words storage, this material is more active, and it should be placed in a cool, dry and well-ventilated place. Cover a cool environment to reduce the risk of reaction due to excessive temperature; dry place, it can avoid the risk of moisture hydrolysis; well-ventilated place, it can avoid the accumulation of harmful gases. And it must be kept away from fires and heat sources to prevent fires. Because of its flammability and certain toxicity, a little carelessness can cause disaster. And it should be stored separately from oxidants, alkalis, etc., and must not be mixed with storage. When this compound encounters an oxidizing agent, it may cause a violent oxidation reaction; when it coexists with alkalis, a chemical reaction may also occur, causing its properties to change or dangerous products to be produced.
As for transportation, there are also many details. Appropriate transportation tools need to be selected to ensure that the container is well sealed to prevent leakage. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. Escort personnel must be familiar with its properties and emergency treatment methods, and can respond quickly in case of emergencies. And transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment for emergencies. When loading and unloading, operators must be light and light, and it is strictly forbidden to drop and heavy pressure, so as not to damage the packaging and cause material leakage, endangering the environment and personal safety.
All of these are for the storage and transportation of 1-chloro-3-nitro-5 - (trifluoromethyl) benzene should pay attention, a little negligence, it may lead to safety accidents, must be careful.
First words storage, this material is more active, and it should be placed in a cool, dry and well-ventilated place. Cover a cool environment to reduce the risk of reaction due to excessive temperature; dry place, it can avoid the risk of moisture hydrolysis; well-ventilated place, it can avoid the accumulation of harmful gases. And it must be kept away from fires and heat sources to prevent fires. Because of its flammability and certain toxicity, a little carelessness can cause disaster. And it should be stored separately from oxidants, alkalis, etc., and must not be mixed with storage. When this compound encounters an oxidizing agent, it may cause a violent oxidation reaction; when it coexists with alkalis, a chemical reaction may also occur, causing its properties to change or dangerous products to be produced.
As for transportation, there are also many details. Appropriate transportation tools need to be selected to ensure that the container is well sealed to prevent leakage. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. Escort personnel must be familiar with its properties and emergency treatment methods, and can respond quickly in case of emergencies. And transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment for emergencies. When loading and unloading, operators must be light and light, and it is strictly forbidden to drop and heavy pressure, so as not to damage the packaging and cause material leakage, endangering the environment and personal safety.
All of these are for the storage and transportation of 1-chloro-3-nitro-5 - (trifluoromethyl) benzene should pay attention, a little negligence, it may lead to safety accidents, must be careful.
What are the effects of 1-chloro-3-nitro-5- (trifluoromethyl) benzene on the environment and human health?
1-Chloro-3-nitro-5- (trifluoromethyl) benzene has an immeasurable impact on the environment and human health. If this substance escapes between nature, it can cause various disasters in the ecological environment or.
In water bodies, it may cause water quality deterioration, and aquatic organisms bear the brunt. Fish, shellfish, etc., may be damaged due to their physiological functions, growth and reproduction are blocked, and even population numbers are sharply reduced. Cover because of its toxicity, or can interfere with the nervous, immune and reproductive systems of aquatic organisms.
In soil, its residues can accumulate, affecting the activity and structure of soil microorganisms. Soil microorganisms have a significant impact on soil fertility and material circulation. If it is disturbed, the ecological balance of the soil will be disrupted, which in turn affects the growth of plants. Plants may be stunted and yield reduced.
As for human health, if people are exposed to this substance through breathing, diet or skin, there are many hidden dangers. The respiratory system may be damaged, causing cough, asthma and other diseases, living in its environment for a long time, or causing lung diseases, such as pneumonia, emphysema, etc.
And it may be carcinogenic. Long-term exposure to it, the genes of human cells or damage mutations, and the risk of cancer increases greatly. The nervous system is also not immune, or headaches, dizziness, insomnia, etc. In severe cases, cognitive and memory functions are also affected. In the reproductive system, it may interfere with endocrine, affect the secretion of reproductive hormones, and pose a threat to fertility.
In short, 1-chloro-3-nitro-5- (trifluoromethyl) benzene has potential harm to the environment and human health, and should not be taken lightly. It should be handled with caution to prevent the spread of its harm.
In water bodies, it may cause water quality deterioration, and aquatic organisms bear the brunt. Fish, shellfish, etc., may be damaged due to their physiological functions, growth and reproduction are blocked, and even population numbers are sharply reduced. Cover because of its toxicity, or can interfere with the nervous, immune and reproductive systems of aquatic organisms.
In soil, its residues can accumulate, affecting the activity and structure of soil microorganisms. Soil microorganisms have a significant impact on soil fertility and material circulation. If it is disturbed, the ecological balance of the soil will be disrupted, which in turn affects the growth of plants. Plants may be stunted and yield reduced.
As for human health, if people are exposed to this substance through breathing, diet or skin, there are many hidden dangers. The respiratory system may be damaged, causing cough, asthma and other diseases, living in its environment for a long time, or causing lung diseases, such as pneumonia, emphysema, etc.
And it may be carcinogenic. Long-term exposure to it, the genes of human cells or damage mutations, and the risk of cancer increases greatly. The nervous system is also not immune, or headaches, dizziness, insomnia, etc. In severe cases, cognitive and memory functions are also affected. In the reproductive system, it may interfere with endocrine, affect the secretion of reproductive hormones, and pose a threat to fertility.
In short, 1-chloro-3-nitro-5- (trifluoromethyl) benzene has potential harm to the environment and human health, and should not be taken lightly. It should be handled with caution to prevent the spread of its harm.
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