Linshang Chemical
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1-Chloro-3-Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
518068 |
| Chemical Formula | C7H4ClF3O |
| Molar Mass | 196.55 g/mol |
| Appearance | colorless to light yellow liquid |
| Boiling Point | 150 - 152 °C |
| Density | 1.375 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 49 °C |
As an accredited 1-Chloro-3-Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottles filled with 1 - chloro - 3 - (trifluoromethoxy)benzene, well - sealed. |
| Storage | 1 - (Chloro - 3 - trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. This helps prevent leakage and degradation, ensuring its stability during storage. |
| Shipping | 1 - (Chloro - 3 - trifluoromethoxy)benzene is a chemical. Shipping requires compliance with hazardous material regulations. It must be properly packaged, labeled, and transported by carriers licensed to handle such chemicals safely. |
Competitive 1-Chloro-3-Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the main uses of 1-chloro-3-trifluoromethoxybenzene?
1-Bromo-3-trifluoromethoxylbenzene is widely used in the field of chemical medicine. It is often a key intermediate in the synthesis of medicine. Due to its special structure, it contains bromine atoms and trifluoromethoxy groups, giving this compound unique chemical activity and physical properties.
When creating new drugs, chemists rely on 1-bromo-3-trifluoromethoxylbenzene to build the skeleton of drug molecules. Due to the high activity of bromine atoms, it is easy to react with other reagents. With the carefully designed reaction path, various functional groups can be introduced into the molecule, thereby shaping the structure with specific pharmacological activities.
And the presence of trifluoromethoxy significantly affects the electron cloud distribution and lipophilicity of molecules. This property is of great significance in drug development, which can regulate the binding force between drugs and targets, improve the absorption, distribution, metabolism and excretion characteristics of drugs, and improve the drug-forming properties. For example, in the development of drugs for the treatment of neurological diseases, compounds derived from 1-bromo-3-trifluoromethoxylbenzene may be able to penetrate the blood-brain barrier more efficiently through its special structure, reach the target of action, and exert therapeutic effects.
In the field of materials science, 1-bromo-3-trifluoromethoxylbenzene also has its uses. Due to its unique chemical structure, it can be used to synthesize special polymer materials. After polymerization with other monomers, the material is endowed with excellent properties such as chemical corrosion resistance and high temperature resistance. These materials may be applied to high-precision fields such as aerospace and electronics industries to meet their strict requirements for special properties of materials.
And because of the characteristics of halogen atoms and fluorine-containing groups in its structure, 1-bromo-3-trifluoromethoxy benzene is often used as a model substrate in the methodological research of organic synthetic chemistry. Researchers use the study of various reactions in which it participates to explore novel reaction mechanisms and synthesis strategies, and promote the development of organic chemistry.
When creating new drugs, chemists rely on 1-bromo-3-trifluoromethoxylbenzene to build the skeleton of drug molecules. Due to the high activity of bromine atoms, it is easy to react with other reagents. With the carefully designed reaction path, various functional groups can be introduced into the molecule, thereby shaping the structure with specific pharmacological activities.
And the presence of trifluoromethoxy significantly affects the electron cloud distribution and lipophilicity of molecules. This property is of great significance in drug development, which can regulate the binding force between drugs and targets, improve the absorption, distribution, metabolism and excretion characteristics of drugs, and improve the drug-forming properties. For example, in the development of drugs for the treatment of neurological diseases, compounds derived from 1-bromo-3-trifluoromethoxylbenzene may be able to penetrate the blood-brain barrier more efficiently through its special structure, reach the target of action, and exert therapeutic effects.
In the field of materials science, 1-bromo-3-trifluoromethoxylbenzene also has its uses. Due to its unique chemical structure, it can be used to synthesize special polymer materials. After polymerization with other monomers, the material is endowed with excellent properties such as chemical corrosion resistance and high temperature resistance. These materials may be applied to high-precision fields such as aerospace and electronics industries to meet their strict requirements for special properties of materials.
And because of the characteristics of halogen atoms and fluorine-containing groups in its structure, 1-bromo-3-trifluoromethoxy benzene is often used as a model substrate in the methodological research of organic synthetic chemistry. Researchers use the study of various reactions in which it participates to explore novel reaction mechanisms and synthesis strategies, and promote the development of organic chemistry.
What are the physical properties of 1-chloro-3-trifluoromethoxybenzene?
1-Bromo-3-trifluoromethoxylbenzene is an organic compound, and its physical properties are as follows:
Under normal conditions, 1-bromo-3-trifluoromethoxylbenzene is mostly a colorless to light yellow transparent liquid, with a pure and fluid appearance and no visible impurities or suspended solids. This form is convenient for use as a reactant or solvent in many organic synthesis reactions, because its liquid form is conducive to fully mixing and contacting with other substances to accelerate the reaction process.
Smell, the compound has a special odor, but this odor is not a pungent and intolerable odor, but the smell of a unique organic chemical. Although it is difficult to describe accurately, in a chemical experimental environment, trained personnel can use this odor to initially identify its existence.
Measure its boiling point, which is between 145 and 147 ° C. The boiling point is one of the important physical properties of a substance. Under this boiling point condition, 1-bromo-3-trifluoromethoxylbenzene changes from a liquid state to a gaseous state. Knowing the boiling point is of great significance for the separation and purification of the compound. In experimental operations such as distillation, the appropriate temperature can be set according to this boiling point to effectively separate it from the mixture.
Measure its density, which is about 1.64 g/mL. Density reflects the mass per unit volume of a substance. 1-bromo-3-trifluoromethoxylbenzene has a higher density than water, so if mixed with water, it will sink to the bottom. This property is critical when it comes to liquid-liquid separation operations or studying its distribution in different media.
Looking at its solubility, 1-bromo-3-trifluoromethoxylbenzene is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. Organic solvents have good solubility, making them widely used in the field of organic synthesis. They can be used as a reaction medium to promote various organic reactions. At the same time, they also play an important role in compound extraction, recrystallization and other operations, assisting in the separation and purification of target products. However, it has little solubility in water, similar to most organic halides, due to the hydrophobic halogen atom and trifluoromethoxy group in its molecular structure.
Under normal conditions, 1-bromo-3-trifluoromethoxylbenzene is mostly a colorless to light yellow transparent liquid, with a pure and fluid appearance and no visible impurities or suspended solids. This form is convenient for use as a reactant or solvent in many organic synthesis reactions, because its liquid form is conducive to fully mixing and contacting with other substances to accelerate the reaction process.
Smell, the compound has a special odor, but this odor is not a pungent and intolerable odor, but the smell of a unique organic chemical. Although it is difficult to describe accurately, in a chemical experimental environment, trained personnel can use this odor to initially identify its existence.
Measure its boiling point, which is between 145 and 147 ° C. The boiling point is one of the important physical properties of a substance. Under this boiling point condition, 1-bromo-3-trifluoromethoxylbenzene changes from a liquid state to a gaseous state. Knowing the boiling point is of great significance for the separation and purification of the compound. In experimental operations such as distillation, the appropriate temperature can be set according to this boiling point to effectively separate it from the mixture.
Measure its density, which is about 1.64 g/mL. Density reflects the mass per unit volume of a substance. 1-bromo-3-trifluoromethoxylbenzene has a higher density than water, so if mixed with water, it will sink to the bottom. This property is critical when it comes to liquid-liquid separation operations or studying its distribution in different media.
Looking at its solubility, 1-bromo-3-trifluoromethoxylbenzene is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. Organic solvents have good solubility, making them widely used in the field of organic synthesis. They can be used as a reaction medium to promote various organic reactions. At the same time, they also play an important role in compound extraction, recrystallization and other operations, assisting in the separation and purification of target products. However, it has little solubility in water, similar to most organic halides, due to the hydrophobic halogen atom and trifluoromethoxy group in its molecular structure.
What are the chemical properties of 1-chloro-3-trifluoromethoxybenzene?
1-% -3-trifluoromethoxylbenzene is an organic compound. Its chemical properties are unique and have attracted much attention in the field of organic synthesis.
In terms of its physical properties, 1-% -3-trifluoromethoxylbenzene is often colorless to light yellow liquid and has a special odor. Its physical constants such as boiling point and melting point depend on the intermolecular force and structure. Due to the introduction of trifluoromethoxy, the molecular polarity changes, which affects its boiling point and solubility.
In terms of chemical properties, the benzene ring in this compound is aromatic and can undergo many typical reactions of aromatic hydrocarbons. First, electrophilic substitution reaction is an important reaction type. Because the trifluoromethoxy group is an electron-withdrawing group, the electron cloud density of the benzene ring can be reduced, so that the electrophilic substitution reaction activity is slightly lower than that of benzene, but it can still react with electrophilic reagents such as halogen and nitro, and the reaction check point is mostly in the meta position. For example, under the action of bromine in the catalyst, m-bromo-1-% 3-trifluoromethoxylbenzene can be formed.
Second, 1-% 3-trifluoromethoxylbenzene can also participate in the coupling reaction of metal catalysis. Under the action of metal catalysts such as palladium and nickel, it can be coupled with halogenated hydrocarbons, borate esters, etc., to form carbon-carbon bonds or carbon-hetero bonds. This reaction is extremely critical in the organic synthesis of complex molecules. It can introduce diverse functional groups and expand the complexity of molecular structures.
Third, the solitary pair electrons of oxygen atoms in trifluoromethoxy can make the compound exhibit a certain alkalinity. Although the alkalinity is weak, it can react with proton donors such as strong acids to generate corresponding salts.
In addition, 1-% -3-trifluoromethoxy benzene also has unique performance in redox reactions. Under certain conditions, the benzene ring or trifluoromethoxy moiety can be oxidized or reduced, and the specific reaction path and product depend on the oxidizing agent, reducing agent and reaction conditions used.
In short, 1-% -3-trifluoromethoxy benzene has rich chemical properties due to its unique chemical structure, and has broad application prospects in organic synthesis, pharmaceutical chemistry and other fields.
In terms of its physical properties, 1-% -3-trifluoromethoxylbenzene is often colorless to light yellow liquid and has a special odor. Its physical constants such as boiling point and melting point depend on the intermolecular force and structure. Due to the introduction of trifluoromethoxy, the molecular polarity changes, which affects its boiling point and solubility.
In terms of chemical properties, the benzene ring in this compound is aromatic and can undergo many typical reactions of aromatic hydrocarbons. First, electrophilic substitution reaction is an important reaction type. Because the trifluoromethoxy group is an electron-withdrawing group, the electron cloud density of the benzene ring can be reduced, so that the electrophilic substitution reaction activity is slightly lower than that of benzene, but it can still react with electrophilic reagents such as halogen and nitro, and the reaction check point is mostly in the meta position. For example, under the action of bromine in the catalyst, m-bromo-1-% 3-trifluoromethoxylbenzene can be formed.
Second, 1-% 3-trifluoromethoxylbenzene can also participate in the coupling reaction of metal catalysis. Under the action of metal catalysts such as palladium and nickel, it can be coupled with halogenated hydrocarbons, borate esters, etc., to form carbon-carbon bonds or carbon-hetero bonds. This reaction is extremely critical in the organic synthesis of complex molecules. It can introduce diverse functional groups and expand the complexity of molecular structures.
Third, the solitary pair electrons of oxygen atoms in trifluoromethoxy can make the compound exhibit a certain alkalinity. Although the alkalinity is weak, it can react with proton donors such as strong acids to generate corresponding salts.
In addition, 1-% -3-trifluoromethoxy benzene also has unique performance in redox reactions. Under certain conditions, the benzene ring or trifluoromethoxy moiety can be oxidized or reduced, and the specific reaction path and product depend on the oxidizing agent, reducing agent and reaction conditions used.
In short, 1-% -3-trifluoromethoxy benzene has rich chemical properties due to its unique chemical structure, and has broad application prospects in organic synthesis, pharmaceutical chemistry and other fields.
What is the preparation method of 1-chloro-3-trifluoromethoxybenzene?
1-% -3-trifluoromethoxylbenzene of the method is as follows:
first take the amount of 3-bromotrifluoromethoxylbenzene, which is placed in the reactor, adding a certain amount of crumbs to tetrafuran solution, at the appropriate temperature and mixing parts, lead to Grignard's reaction. This step requires control of the reaction rate and reaction rate, in order to prevent the generation of side reactions. After the reaction is fully processed, 3-trifluoromethoxylphenyl bromide of Grignard's reaction rate is generated.
, another container is taken, and the borate compound is added to the above-mentioned reactor containing Grignard's reaction rate, and the two are fully mixed. This reaction is intended to introduce boron groups and generate borate esters in the phase. After the reaction is completed, the reaction mixture is hydrolyzed, and the dilute acid solution is slowly added to hydrolyze the borate ester of 3-trifluoromethoxyphenylboronic acid.
Next, take 3-trifluoromethoxyphenylboronic acid and add it to the reaction system containing the source. This reaction source can be used for the appropriate reaction. In the same way, the catalyst of the reaction is added, such as some gold catalysts and their formulations. Under specific reaction conditions, the catalyst can promote the source of 3-trifluoromethoxyphenylboronic acid in the boron-oxygen source, and gradually reduce it to 1-% 3-trifluoromethoxybenzene.
After the reaction is completed, it is necessary to separate the reaction material. First, it is extracted with a solution, so that the target material can be moved to the active phase. Then, through the column precipitation method, the fixed phase of the compound is used to separate the flow phase, and the 1-% 3-trifluoromethoxy benzene is used to obtain a high-grade compound. The whole process requires a grid to control the reaction of each step to obtain this compound.
first take the amount of 3-bromotrifluoromethoxylbenzene, which is placed in the reactor, adding a certain amount of crumbs to tetrafuran solution, at the appropriate temperature and mixing parts, lead to Grignard's reaction. This step requires control of the reaction rate and reaction rate, in order to prevent the generation of side reactions. After the reaction is fully processed, 3-trifluoromethoxylphenyl bromide of Grignard's reaction rate is generated.
, another container is taken, and the borate compound is added to the above-mentioned reactor containing Grignard's reaction rate, and the two are fully mixed. This reaction is intended to introduce boron groups and generate borate esters in the phase. After the reaction is completed, the reaction mixture is hydrolyzed, and the dilute acid solution is slowly added to hydrolyze the borate ester of 3-trifluoromethoxyphenylboronic acid.
Next, take 3-trifluoromethoxyphenylboronic acid and add it to the reaction system containing the source. This reaction source can be used for the appropriate reaction. In the same way, the catalyst of the reaction is added, such as some gold catalysts and their formulations. Under specific reaction conditions, the catalyst can promote the source of 3-trifluoromethoxyphenylboronic acid in the boron-oxygen source, and gradually reduce it to 1-% 3-trifluoromethoxybenzene.
After the reaction is completed, it is necessary to separate the reaction material. First, it is extracted with a solution, so that the target material can be moved to the active phase. Then, through the column precipitation method, the fixed phase of the compound is used to separate the flow phase, and the 1-% 3-trifluoromethoxy benzene is used to obtain a high-grade compound. The whole process requires a grid to control the reaction of each step to obtain this compound.
What are the precautions for storing and transporting 1-chloro-3-trifluoromethoxybenzene?
1-Chloro-3-trifluoromethoxybenzene is an important raw material commonly used in organic synthesis. During storage and transportation, there are many key precautions that must not be neglected.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Because of its certain chemical activity, it may be dangerous to be heated or exposed to open flames. The temperature should be kept stable to prevent large fluctuations in temperature from affecting its chemical properties. And it must be stored separately from oxidants, acids, bases and other substances, and must not be mixed. Due to its chemical properties, contact with the above substances can easily cause chemical reactions, or cause serious accidents such as fire and explosion.
Furthermore, the choice of storage container is also extremely important. A well-sealed container must be used to prevent it from evaporating and escaping. Commonly used container materials should have good corrosion resistance, because 1-chloro-3-trifluoromethoxy benzene may have corrosive effects on some materials. And the container must be marked with the name of the substance, characteristics, hazards and other relevant information for identification and management.
As for transportation, the transportation vehicle must meet the requirements for the transportation of hazardous chemicals. Equipped with corresponding fire fighting equipment and leakage emergency treatment equipment for emergencies. During transportation, ensure that the vehicle runs smoothly to avoid violent vibration and collision to prevent material leakage caused by container damage. Drivers and escorts must have professional training and be familiar with the characteristics of 1-chloro-3-trifluoromethoxybenzene and emergency treatment methods.
In addition, the planning of transportation routes should not be ignored. Sensitive areas such as densely populated areas and water source reserves should be avoided to reduce the possible harm caused by accidents. And the transportation time should also be reasonably arranged to avoid transportation during peak traffic periods or bad weather conditions. All of this is to ensure the safety of 1-chloro-3-trifluoromethoxybenzene during storage and transportation, and must not be taken lightly.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Because of its certain chemical activity, it may be dangerous to be heated or exposed to open flames. The temperature should be kept stable to prevent large fluctuations in temperature from affecting its chemical properties. And it must be stored separately from oxidants, acids, bases and other substances, and must not be mixed. Due to its chemical properties, contact with the above substances can easily cause chemical reactions, or cause serious accidents such as fire and explosion.
Furthermore, the choice of storage container is also extremely important. A well-sealed container must be used to prevent it from evaporating and escaping. Commonly used container materials should have good corrosion resistance, because 1-chloro-3-trifluoromethoxy benzene may have corrosive effects on some materials. And the container must be marked with the name of the substance, characteristics, hazards and other relevant information for identification and management.
As for transportation, the transportation vehicle must meet the requirements for the transportation of hazardous chemicals. Equipped with corresponding fire fighting equipment and leakage emergency treatment equipment for emergencies. During transportation, ensure that the vehicle runs smoothly to avoid violent vibration and collision to prevent material leakage caused by container damage. Drivers and escorts must have professional training and be familiar with the characteristics of 1-chloro-3-trifluoromethoxybenzene and emergency treatment methods.
In addition, the planning of transportation routes should not be ignored. Sensitive areas such as densely populated areas and water source reserves should be avoided to reduce the possible harm caused by accidents. And the transportation time should also be reasonably arranged to avoid transportation during peak traffic periods or bad weather conditions. All of this is to ensure the safety of 1-chloro-3-trifluoromethoxybenzene during storage and transportation, and must not be taken lightly.
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