Linshang Chemical
PRODUCTS
1-Chloro-4-(1,1-Dimethylethyl)Benzene
Linshang Chemical
|
HS Code |
865209 |
| Chemical Formula | C10H13Cl |
| Molar Mass | 168.667 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Aromatic odor |
| Density | 0.989 g/cm³ (at 20 °C) |
| Boiling Point | 204 - 206 °C |
| Melting Point | −43 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 75 °C |
| Vapor Pressure | 0.13 kPa at 25 °C |
As an accredited 1-Chloro-4-(1,1-Dimethylethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (1,1 - dimethylethyl)benzene: 500 mL in a tightly - sealed, chemical - resistant bottle. |
| Storage | 1 - chloro - 4 - (1,1 - dimethylethyl)benzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, acids, and bases to prevent potential chemical reactions. Ensure the storage location is compliant with safety regulations. |
| Shipping | 1 - Chloro - 4 - (1,1 - dimethylethyl)benzene is shipped in specialized, tightly - sealed containers. These are designed to prevent leakage, following strict regulations due to its chemical nature, ensuring safe transport. |
Competitive 1-Chloro-4-(1,1-Dimethylethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-4-(1,1-Dimethylethyl)Benzene in China?
As a trusted 1-Chloro-4-(1,1-Dimethylethyl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-(1,1-Dimethylethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-4- (1,1-dimethylethyl) benzene
1 - chloro - 4 - (1,1 - dimethylethyl) benzene, that is, p-chloro-tert-butylbenzene, is an organic compound. It has the following chemical properties:
1. ** Electrophilic Substitution Reaction **:
- ** Halogenation Reaction **: Under the catalysis of iron or iron trihalide, the hydrogen atom on the benzene ring can be replaced by a halogen atom. Because the tert-butyl group is an ortho-and para-site group, and the chlorine atom is also an ortho-and para-site group, the positioning effect of the two is the same, so the halogenation reaction mainly occurs in the ortho-position of the tert-bu For example, under the catalysis of iron bromide, it reacts with bromine to generate 2-bromo-1-chloro-4- (1,1-dimethylethyl) benzene-based products. During the reaction, the bromine molecule is polarized under the action of the catalyst, and the positively charged bromine atom attacks the benzene ring to form a carbon-positive ion intermediate, and then the intermediate loses protons to form the product.
- ** Nitrification Reaction **: Co-heating with the mixed acid of concentrated nitric acid and concentrated sulfuric acid can occur. Also due to the localization effect, the nitro group mainly enters the ortho position of the tert-butyl group and the chlorine atom. In the mixed acid, concentrated sulfuric acid acts as a catalyst and dehydration, promoting the protonation of nitric acid and generating nitroyl positive ions (NO 2 ^), which attack the benzene ring as an electrophilic reagent, and obtain nitrification products through an intermediate process similar to halogenation reaction.
- ** Sulfonation Reaction **: Under the action of concentrated sulfuric acid, the benzene ring can undergo a sulfonation reaction, and the sulfonic acid group (-SO ^ H) is mainly introduced into the ortho-position of the tert-butyl group and the chlorine atom. Concentrated sulfuric acid provides the electrophilic reagent sulfur trioxide (SO ^), which reacts with the benzene ring to form an intermediate and is then transferred by protons to obtain a sulfonated product.
2. ** Substituent Reaction **:
- ** Reaction of Chlorine Atoms **: Although the chlorine atom on the benzene ring is less active than the halogen atom in aliphatic halogenated hydrocarbons due to conjugation with the benzene ring, nucleophilic substitution reaction can occur under high temperature, high pressure and the presence of strong bases or some nucleophilic reagents. If co-heated with an alcohol solution of sodium hydroxide, the chlorine atom can be replaced by a hydroxyl group to form p-tert-butyl phenol. In this process, the hydroxide ion attacks the carbon atom connected to the chlorine atom as a nucleophilic reagent, and the chlorine atom leaves with a pair of electrons.
- ** Reaction of tert-butyl **: Tert- Under light or high temperature conditions, free radical substitution reactions can occur with halogen elements, and α-hydrogen atoms are replaced by halogen atoms. For example, when reacting with chlorine under light, the α-hydrogen atom of tert-butyl can be gradually replaced by chlorine atoms. The reaction begins when chlorine is homogenized into chlorine radicals under light, and the chlorine radicals capture the α-hydrogen atom of tert-butyl to form carbon radicals. The carbon radicals then react with chlorine to form halogenated products and new chlorine radicals, and so on.
3. ** Oxidation Reaction **:
- If treated with a strong oxidizing agent such as acidic potassium permanganate solution, the tert-butyl group of the side chain of tert-butyl phenyl ring is usually difficult to oxidize. Due to the absence of α-hydrogen atoms in tert-butyl, the oxidation of the side chain of the benzene ring generally requires α-hydrogen atoms to occur. However, under special conditions or stronger oxidation systems, the benzene ring may be oxidized and destroyed, resulting in complex oxidation products.
4. ** Reduction Reaction **:
- The benzene ring of p-chloro-tert-butylbenzene can be reduced under specific conditions. For example, under the action of metal sodium and liquid ammonia, a Birch reduction reaction occurs, and the benzene ring is reduced to a 1,4-cyclohexadiene structure. During the reaction, sodium provides electrons and liquid ammonia provides protons. A series of electron transfer and proton transfer steps are performed to achieve partial reduction of the benzene ring.
1. ** Electrophilic Substitution Reaction **:
- ** Halogenation Reaction **: Under the catalysis of iron or iron trihalide, the hydrogen atom on the benzene ring can be replaced by a halogen atom. Because the tert-butyl group is an ortho-and para-site group, and the chlorine atom is also an ortho-and para-site group, the positioning effect of the two is the same, so the halogenation reaction mainly occurs in the ortho-position of the tert-bu For example, under the catalysis of iron bromide, it reacts with bromine to generate 2-bromo-1-chloro-4- (1,1-dimethylethyl) benzene-based products. During the reaction, the bromine molecule is polarized under the action of the catalyst, and the positively charged bromine atom attacks the benzene ring to form a carbon-positive ion intermediate, and then the intermediate loses protons to form the product.
- ** Nitrification Reaction **: Co-heating with the mixed acid of concentrated nitric acid and concentrated sulfuric acid can occur. Also due to the localization effect, the nitro group mainly enters the ortho position of the tert-butyl group and the chlorine atom. In the mixed acid, concentrated sulfuric acid acts as a catalyst and dehydration, promoting the protonation of nitric acid and generating nitroyl positive ions (NO 2 ^), which attack the benzene ring as an electrophilic reagent, and obtain nitrification products through an intermediate process similar to halogenation reaction.
- ** Sulfonation Reaction **: Under the action of concentrated sulfuric acid, the benzene ring can undergo a sulfonation reaction, and the sulfonic acid group (-SO ^ H) is mainly introduced into the ortho-position of the tert-butyl group and the chlorine atom. Concentrated sulfuric acid provides the electrophilic reagent sulfur trioxide (SO ^), which reacts with the benzene ring to form an intermediate and is then transferred by protons to obtain a sulfonated product.
2. ** Substituent Reaction **:
- ** Reaction of Chlorine Atoms **: Although the chlorine atom on the benzene ring is less active than the halogen atom in aliphatic halogenated hydrocarbons due to conjugation with the benzene ring, nucleophilic substitution reaction can occur under high temperature, high pressure and the presence of strong bases or some nucleophilic reagents. If co-heated with an alcohol solution of sodium hydroxide, the chlorine atom can be replaced by a hydroxyl group to form p-tert-butyl phenol. In this process, the hydroxide ion attacks the carbon atom connected to the chlorine atom as a nucleophilic reagent, and the chlorine atom leaves with a pair of electrons.
- ** Reaction of tert-butyl **: Tert- Under light or high temperature conditions, free radical substitution reactions can occur with halogen elements, and α-hydrogen atoms are replaced by halogen atoms. For example, when reacting with chlorine under light, the α-hydrogen atom of tert-butyl can be gradually replaced by chlorine atoms. The reaction begins when chlorine is homogenized into chlorine radicals under light, and the chlorine radicals capture the α-hydrogen atom of tert-butyl to form carbon radicals. The carbon radicals then react with chlorine to form halogenated products and new chlorine radicals, and so on.
3. ** Oxidation Reaction **:
- If treated with a strong oxidizing agent such as acidic potassium permanganate solution, the tert-butyl group of the side chain of tert-butyl phenyl ring is usually difficult to oxidize. Due to the absence of α-hydrogen atoms in tert-butyl, the oxidation of the side chain of the benzene ring generally requires α-hydrogen atoms to occur. However, under special conditions or stronger oxidation systems, the benzene ring may be oxidized and destroyed, resulting in complex oxidation products.
4. ** Reduction Reaction **:
- The benzene ring of p-chloro-tert-butylbenzene can be reduced under specific conditions. For example, under the action of metal sodium and liquid ammonia, a Birch reduction reaction occurs, and the benzene ring is reduced to a 1,4-cyclohexadiene structure. During the reaction, sodium provides electrons and liquid ammonia provides protons. A series of electron transfer and proton transfer steps are performed to achieve partial reduction of the benzene ring.
What are the physical properties of 1-chloro-4- (1,1-dimethylethyl) benzene
1 - chloro - 4 - (1,1 - dimethylethyl) benzene, that is, p-chlorotert-butylbenzene, its physical properties are as follows:
This substance is a colorless to light yellow liquid at room temperature, with a special aromatic odor. Looking at it, it is clear and transparent, with no visible impurities. Its boiling point is about 199 - 200 ° C. At this temperature, the liquid will transform into a gaseous state. The melting point is about -6.1 ° C. Below this temperature, it will condense from a liquid state to a solid state.
The relative density (water = 1) is about 1.01, which is slightly heavier than water. If mixed with water, it will sink underwater. Its vapor pressure has a specific value at a certain temperature, which indicates its volatility. The higher the vapor pressure, the stronger the volatility. This substance is insoluble in water and will appear stratified when mixed with water because it is incompatible with water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Due to the principle of similarity and miscibility, organic solvents and p-chlorotert-butylbenzene have similar structures and can dissolve each other.
The refractive index of p-chlorotert-butylbenzene is a specific constant, reflecting its optical properties. When light passes through the substance, it will be refracted. The refractive index value can be used to identify the purity and concentration of the substance. In addition, its flash point is about 77 ° C, in case of open flame, hot topic, there is a risk of combustion and explosion, storage and use should be cautious.
This substance is a colorless to light yellow liquid at room temperature, with a special aromatic odor. Looking at it, it is clear and transparent, with no visible impurities. Its boiling point is about 199 - 200 ° C. At this temperature, the liquid will transform into a gaseous state. The melting point is about -6.1 ° C. Below this temperature, it will condense from a liquid state to a solid state.
The relative density (water = 1) is about 1.01, which is slightly heavier than water. If mixed with water, it will sink underwater. Its vapor pressure has a specific value at a certain temperature, which indicates its volatility. The higher the vapor pressure, the stronger the volatility. This substance is insoluble in water and will appear stratified when mixed with water because it is incompatible with water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Due to the principle of similarity and miscibility, organic solvents and p-chlorotert-butylbenzene have similar structures and can dissolve each other.
The refractive index of p-chlorotert-butylbenzene is a specific constant, reflecting its optical properties. When light passes through the substance, it will be refracted. The refractive index value can be used to identify the purity and concentration of the substance. In addition, its flash point is about 77 ° C, in case of open flame, hot topic, there is a risk of combustion and explosion, storage and use should be cautious.
What are the main uses of 1-chloro-4- (1,1-dimethylethyl) benzene?
1 - chloro - 4 - (1,1 - dimethylethyl) benzene is p-chloro-tert-butylbenzene, and its main uses are as follows:
In the field of organic synthesis, p-chloro-tert-butylbenzene is an important raw material. Due to the unique structure of chlorine atoms and tert-butyl groups on the benzene ring, it can participate in various chemical reactions. For example, in nucleophilic substitution reactions, chlorine atoms are highly active and can be replaced by many nucleophiles. With this property, chemists can use it to form carbon-heteroatom bonds to synthesize heteroatom organic compounds such as nitrogen, oxygen, sulfur, etc. Such compounds are widely used in medicine, pesticides and other industries.
In the field of fine chemistry, p-chlorotert-butylbenzene also plays a key role. It can be used as a basic raw material for the synthesis of special fragrances and dye intermediates. Starting from it, through a series of chemical reactions, fragrances and dyes with unique structures and excellent properties can be prepared to meet the special needs of different fields for color and odor.
In the field of materials science, the polymer materials synthesized by p-chlorotert-butylbenzene exhibit special physical and chemical properties due to the steric resistance effect of tert-butyl and the electronic effect of chlorine atoms. For example, some polymers synthesized from this raw material have good thermal stability, chemical corrosion resistance, etc., and can be used to make high-performance engineering plastics, coatings and other materials, which are used in high-end fields such as aerospace and automobile manufacturing.
In addition, in pharmaceutical chemistry research, p-chloro tert-butylbenzene derivatives may have unique biological activities. Scientists are expected to develop new drugs by modifying and modifying their structures, contributing to human health.
In the field of organic synthesis, p-chloro-tert-butylbenzene is an important raw material. Due to the unique structure of chlorine atoms and tert-butyl groups on the benzene ring, it can participate in various chemical reactions. For example, in nucleophilic substitution reactions, chlorine atoms are highly active and can be replaced by many nucleophiles. With this property, chemists can use it to form carbon-heteroatom bonds to synthesize heteroatom organic compounds such as nitrogen, oxygen, sulfur, etc. Such compounds are widely used in medicine, pesticides and other industries.
In the field of fine chemistry, p-chlorotert-butylbenzene also plays a key role. It can be used as a basic raw material for the synthesis of special fragrances and dye intermediates. Starting from it, through a series of chemical reactions, fragrances and dyes with unique structures and excellent properties can be prepared to meet the special needs of different fields for color and odor.
In the field of materials science, the polymer materials synthesized by p-chlorotert-butylbenzene exhibit special physical and chemical properties due to the steric resistance effect of tert-butyl and the electronic effect of chlorine atoms. For example, some polymers synthesized from this raw material have good thermal stability, chemical corrosion resistance, etc., and can be used to make high-performance engineering plastics, coatings and other materials, which are used in high-end fields such as aerospace and automobile manufacturing.
In addition, in pharmaceutical chemistry research, p-chloro tert-butylbenzene derivatives may have unique biological activities. Scientists are expected to develop new drugs by modifying and modifying their structures, contributing to human health.
What are the synthesis methods of 1-chloro-4- (1,1-dimethylethyl) benzene
1-Chloro-4- (1,1-dimethylethyl) benzene is p-chloro-tert-butylbenzene. The common synthesis methods include the following:
First, tert-butylbenzene is used as raw material and prepared by chlorination reaction. Tert-butylbenzene is placed in a reaction vessel, an appropriate amount of catalyst is added, such as anhydrous aluminum trichloride, etc., and chlorine gas is introduced at a certain temperature. At this time, chlorine gas undergoes an electrophilic substitution reaction with tert-butylbenzene, and chlorine atoms replace hydrogen atoms on the benzene ring that are in the para-position with tert-butylbenzene, thereby generating p-chloro tert-butylbenzene. This reaction condition is relatively mild, so it is necessary to
Second, using p-chloroacetophenone as raw material, it is prepared by Huangminglong reduction reaction and halogenation reaction. First, p-chloroacetophenone, hydrazine hydrate, potassium hydroxide, etc. are co-placed in a high boiling point solvent, heated and refluxed, so that the carbonyl group is reduced to methylene to form p-chloroethylbenzene. Next, under the condition of light or the presence of an initiator, p-chloroethylbenzene reacts with chlorine gas, and the hydrogen atom on the side chain is replaced by the chlorine atom, and then the p-chlorotert-butylbenzene can be obtained through the elimination reaction. This method is a little more complicated, but the raw material is relatively easy to obtain.
Third, take p-chlorobenzoic acid as the starting material, first reduce it to p-chlorobenzyl alcohol, and then form p-chlorobenzyl chloride through halogenation reaction, and then react with tert-butyl Grignard reagent to obtain the target product p-chloro tert-butyl benzene. This method requires the use of Grignard reagent, which requires harsh reaction conditions and an anhydrous and anaerobic environment, but can effectively construct the target molecular structure.
Synthesis of p-chloro tert-butyl benzene has its own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, reaction conditions, cost and many other factors to choose an appropriate method.
First, tert-butylbenzene is used as raw material and prepared by chlorination reaction. Tert-butylbenzene is placed in a reaction vessel, an appropriate amount of catalyst is added, such as anhydrous aluminum trichloride, etc., and chlorine gas is introduced at a certain temperature. At this time, chlorine gas undergoes an electrophilic substitution reaction with tert-butylbenzene, and chlorine atoms replace hydrogen atoms on the benzene ring that are in the para-position with tert-butylbenzene, thereby generating p-chloro tert-butylbenzene. This reaction condition is relatively mild, so it is necessary to
Second, using p-chloroacetophenone as raw material, it is prepared by Huangminglong reduction reaction and halogenation reaction. First, p-chloroacetophenone, hydrazine hydrate, potassium hydroxide, etc. are co-placed in a high boiling point solvent, heated and refluxed, so that the carbonyl group is reduced to methylene to form p-chloroethylbenzene. Next, under the condition of light or the presence of an initiator, p-chloroethylbenzene reacts with chlorine gas, and the hydrogen atom on the side chain is replaced by the chlorine atom, and then the p-chlorotert-butylbenzene can be obtained through the elimination reaction. This method is a little more complicated, but the raw material is relatively easy to obtain.
Third, take p-chlorobenzoic acid as the starting material, first reduce it to p-chlorobenzyl alcohol, and then form p-chlorobenzyl chloride through halogenation reaction, and then react with tert-butyl Grignard reagent to obtain the target product p-chloro tert-butyl benzene. This method requires the use of Grignard reagent, which requires harsh reaction conditions and an anhydrous and anaerobic environment, but can effectively construct the target molecular structure.
Synthesis of p-chloro tert-butyl benzene has its own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, reaction conditions, cost and many other factors to choose an appropriate method.
What are the precautions for 1-chloro-4- (1,1-dimethylethyl) benzene during storage and transportation?
1-Chloro-4- (1,1-dimethylethyl) benzene, also known as p-chloro-tert-butylbenzene, must pay attention to many key matters during storage and transportation.
First, this is a chemical substance, which may be more active in nature. When storing, place it in a cool and ventilated warehouse, away from fire and heat sources to prevent danger caused by excessive temperature. The temperature of the warehouse should be controlled within a suitable range, and the humidity should also be properly adjusted to avoid affecting its stability due to excessive humidity.
Second, this substance has high packaging requirements. Suitable packaging materials must be used to ensure that the packaging is well sealed and prevent leakage. If the packaging is damaged, the material escapes, or comes into contact with air, moisture, etc., or causes a chemical reaction, it will not only affect the quality of the product, but also may bring potential safety hazards.
Third, during transportation, ensure that the vehicle is in good condition and has complete shock-proof, anti-collision and anti-leakage facilities. Avoid mixed transportation with oxidants, acids, alkalis, etc., because it may react violently with these substances. Transportation personnel also need to have professional knowledge and be familiar with emergency treatment methods. In the event of an emergency, they can respond quickly and properly.
Fourth, the storage area should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. In the event of a leak, measures can be taken in a timely manner to prevent the spread of pollution and reduce hazards. And the storage place must have obvious warning signs to remind personnel to pay attention to safety.
In short, 1-chloro-4 - (1,1-dimethyl ethyl) benzene needs to be treated with caution in terms of environmental control, packaging requirements, transportation specifications, and emergency preparedness during storage and transportation, and must not be negligent to ensure personnel safety and material stability.
First, this is a chemical substance, which may be more active in nature. When storing, place it in a cool and ventilated warehouse, away from fire and heat sources to prevent danger caused by excessive temperature. The temperature of the warehouse should be controlled within a suitable range, and the humidity should also be properly adjusted to avoid affecting its stability due to excessive humidity.
Second, this substance has high packaging requirements. Suitable packaging materials must be used to ensure that the packaging is well sealed and prevent leakage. If the packaging is damaged, the material escapes, or comes into contact with air, moisture, etc., or causes a chemical reaction, it will not only affect the quality of the product, but also may bring potential safety hazards.
Third, during transportation, ensure that the vehicle is in good condition and has complete shock-proof, anti-collision and anti-leakage facilities. Avoid mixed transportation with oxidants, acids, alkalis, etc., because it may react violently with these substances. Transportation personnel also need to have professional knowledge and be familiar with emergency treatment methods. In the event of an emergency, they can respond quickly and properly.
Fourth, the storage area should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. In the event of a leak, measures can be taken in a timely manner to prevent the spread of pollution and reduce hazards. And the storage place must have obvious warning signs to remind personnel to pay attention to safety.
In short, 1-chloro-4 - (1,1-dimethyl ethyl) benzene needs to be treated with caution in terms of environmental control, packaging requirements, transportation specifications, and emergency preparedness during storage and transportation, and must not be negligent to ensure personnel safety and material stability.
Scan to WhatsApp
