Linshang Chemical
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1-Chloro-4-(Chloromethyl)-2-Fluorobenzene
Linshang Chemical
|
HS Code |
180033 |
| Chemical Formula | C7H5Cl2F |
| Molecular Weight | 181.02 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, but around 200 - 220 °C |
| Density | Approximately 1.3 - 1.4 g/cm³ |
| Solubility In Water | Poorly soluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Relatively high, estimated around 80 - 90 °C |
| Odor | May have a pungent, characteristic halogen - containing organic compound odor |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Chloro-4-(Chloromethyl)-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (chloromethyl)-2 - fluorobenzene: Packaged in 1 - kg bottles for safe storage. |
| Storage | 1 - Chloro - 4 - (chloromethyl)-2 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially lead to chemical reactions or decomposition. |
| Shipping | 1 - chloro - 4 - (chloromethyl)-2 - fluorobenzene is shipped in specialized, well - sealed containers. Transport follows strict chemical regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 1-Chloro-4-(Chloromethyl)-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 1-Chloro-4-(Chloromethyl)-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-4- (chloromethyl) -2-fluorobenzene?
1-Chloro-4- (chloromethyl) -2-fluorobenzene is one of the organic compounds. Its chemical properties are quite interesting and deserve further investigation.
The first part of its substitution reaction. Because there are chlorine methyl groups and chlorine atoms in the molecule, they are both active check points. The chlorine atom on the chlorine methyl group has considerable nucleophilic substitution activity. If it encounters nucleophilic reagents, such as sodium alcohol, amines, etc., the chlorine atom is easily replaced. For example, when it encounters sodium alcohol, the chlorine of the chlorine methyl group can be replaced by alkoxy groups to form corresponding ether compounds. In this reaction, the nucleophilic reagent attacks the carbon atom of chloromethyl, and the chlorine atom leaves in the form of chloride ions, following the typical nucleophilic substitution reaction mechanism.
Furthermore, the benzene ring of this compound also has special properties. Although the benzene ring has a certain stability, it will affect the electron cloud density of the benzene ring because of the chlorine and fluorine atoms connected to it. The fluorine atom has strong electron absorption, and the chlorine atom also has an electron absorption effect, resulting in a decrease in the electron cloud density of the benzene ring. In this way, in the electrophilic substitution reaction, its reactivity is lower than that of benzene. However, if the reaction conditions are suitable, the electrophilic substitution reaction can still occur, and the substitution position is Usually, chlorine and fluorine are ortho-para-localizers, and electrophilic reagents tend to attack the ortho or para-position of chlorine and fluorine atoms on the benzene ring.
And because of its halogen atoms such as chlorine and fluorine, under specific conditions, elimination reactions can occur. If a strong base is encountered and the corresponding stereochemical conditions are met, the chlorine atom or the chlorine atom of chloromethyl group can eliminate the hydrogen atom on the adjacent carbon atom to form an unsaturated compound containing carbon-carbon double bonds.
In addition, 1-chloro-4- (chloromethyl) -2-fluorobenzene can also participate in some redox reactions. For example, in some metal-catalyzed reaction systems, halogen atoms can be reduced and removed, or the oxidation state can be changed, which in turn affects the structure and properties of the entire molecule.
In short, 1-chloro-4- (chloromethyl) -2-fluorobenzene exhibits diverse chemical properties due to its unique molecular structure, and has important application potential in the field of organic synthesis. It can be converted into various valuable organic compounds through different reaction paths.
The first part of its substitution reaction. Because there are chlorine methyl groups and chlorine atoms in the molecule, they are both active check points. The chlorine atom on the chlorine methyl group has considerable nucleophilic substitution activity. If it encounters nucleophilic reagents, such as sodium alcohol, amines, etc., the chlorine atom is easily replaced. For example, when it encounters sodium alcohol, the chlorine of the chlorine methyl group can be replaced by alkoxy groups to form corresponding ether compounds. In this reaction, the nucleophilic reagent attacks the carbon atom of chloromethyl, and the chlorine atom leaves in the form of chloride ions, following the typical nucleophilic substitution reaction mechanism.
Furthermore, the benzene ring of this compound also has special properties. Although the benzene ring has a certain stability, it will affect the electron cloud density of the benzene ring because of the chlorine and fluorine atoms connected to it. The fluorine atom has strong electron absorption, and the chlorine atom also has an electron absorption effect, resulting in a decrease in the electron cloud density of the benzene ring. In this way, in the electrophilic substitution reaction, its reactivity is lower than that of benzene. However, if the reaction conditions are suitable, the electrophilic substitution reaction can still occur, and the substitution position is Usually, chlorine and fluorine are ortho-para-localizers, and electrophilic reagents tend to attack the ortho or para-position of chlorine and fluorine atoms on the benzene ring.
And because of its halogen atoms such as chlorine and fluorine, under specific conditions, elimination reactions can occur. If a strong base is encountered and the corresponding stereochemical conditions are met, the chlorine atom or the chlorine atom of chloromethyl group can eliminate the hydrogen atom on the adjacent carbon atom to form an unsaturated compound containing carbon-carbon double bonds.
In addition, 1-chloro-4- (chloromethyl) -2-fluorobenzene can also participate in some redox reactions. For example, in some metal-catalyzed reaction systems, halogen atoms can be reduced and removed, or the oxidation state can be changed, which in turn affects the structure and properties of the entire molecule.
In short, 1-chloro-4- (chloromethyl) -2-fluorobenzene exhibits diverse chemical properties due to its unique molecular structure, and has important application potential in the field of organic synthesis. It can be converted into various valuable organic compounds through different reaction paths.
What are the physical properties of 1-chloro-4- (chloromethyl) -2-fluorobenzene?
1-Chloro-4- (chloromethyl) -2-fluorobenzene is a kind of organic compound. Its physical properties are quite characteristic, let me tell you in detail.
First of all, its appearance, under normal circumstances, 1-chloro-4- (chloromethyl) -2-fluorobenzene is a colorless to light yellow liquid, clear and with a specific luster. It looks like flowing amber, flickering slightly under light.
When it comes to smell, this compound exudes a pungent and special smell, which is uncomfortable to smell, like a spicy and irritating mixture, which can keenly stimulate people's olfactory nerves.
Its boiling point is also one of the important physical properties. It has been determined by many researchers that at a certain temperature range, 1-chloro-4- (chloromethyl) -2-fluorobenzene will change from liquid to gaseous state, and the intermolecular forces will change significantly during this process.
Furthermore, the melting point cannot be ignored. In a specific low temperature environment, the compound will solidify from liquid to solid state. The temperature of this transition is the melting point, which reflects the arrangement and interaction of molecules at low temperatures.
As for the density, 1-chloro-4- (chloromethyl) -2-fluorobenzene has a certain density value compared to water, which makes it when mixed with liquids such as water, it will show a specific distribution state according to the density difference.
In terms of solubility, this compound exhibits good solubility in organic solvents, such as common ethanol, ether, etc., and can blend with these organic solvents to form a uniform mixed system. However, in water, its solubility is quite limited, and it mostly exists in a layered state, which is determined by the interaction characteristics of molecular structure and water molecules.
The physical properties of 1-chloro-4 - (chloromethyl) -2-fluorobenzene are the external manifestation of its chemical essence, and are of crucial significance in many fields such as chemical research and industrial production. Many chemical reactions and practical applications depend on the accurate grasp of their physical properties.
First of all, its appearance, under normal circumstances, 1-chloro-4- (chloromethyl) -2-fluorobenzene is a colorless to light yellow liquid, clear and with a specific luster. It looks like flowing amber, flickering slightly under light.
When it comes to smell, this compound exudes a pungent and special smell, which is uncomfortable to smell, like a spicy and irritating mixture, which can keenly stimulate people's olfactory nerves.
Its boiling point is also one of the important physical properties. It has been determined by many researchers that at a certain temperature range, 1-chloro-4- (chloromethyl) -2-fluorobenzene will change from liquid to gaseous state, and the intermolecular forces will change significantly during this process.
Furthermore, the melting point cannot be ignored. In a specific low temperature environment, the compound will solidify from liquid to solid state. The temperature of this transition is the melting point, which reflects the arrangement and interaction of molecules at low temperatures.
As for the density, 1-chloro-4- (chloromethyl) -2-fluorobenzene has a certain density value compared to water, which makes it when mixed with liquids such as water, it will show a specific distribution state according to the density difference.
In terms of solubility, this compound exhibits good solubility in organic solvents, such as common ethanol, ether, etc., and can blend with these organic solvents to form a uniform mixed system. However, in water, its solubility is quite limited, and it mostly exists in a layered state, which is determined by the interaction characteristics of molecular structure and water molecules.
The physical properties of 1-chloro-4 - (chloromethyl) -2-fluorobenzene are the external manifestation of its chemical essence, and are of crucial significance in many fields such as chemical research and industrial production. Many chemical reactions and practical applications depend on the accurate grasp of their physical properties.
What are the common uses of 1-chloro-4- (chloromethyl) -2-fluorobenzene?
1 - chloro - 4 - (chloromethyl) - 2 - fluorobenzene, Chinese name 1 - chloro - 4 - (chloromethyl) - 2 - fluorobenzene, this compound is commonly used as follows.
In the field of organic synthesis, it is an important intermediate. Its structure contains chlorine atoms and chloromethyl groups, both of which have high reactivity and can be converted into functional groups through various chemical reactions. For example, in nucleophilic substitution reactions, halogen atoms can be replaced by nucleophiles such as hydroxyl and amino groups, resulting in a series of compounds containing different functional groups. These products are essential in the preparation of fine chemical products such as pharmaceuticals and pesticides.
In the field of medicinal chemistry, using this as a starting material, molecular structures with specific biological activities can be constructed through multi-step reactions. Scientists can modify their chemical structures, change the physical and chemical properties and biological activities of compounds, and then develop new drugs.
In materials science, through a suitable reaction path, it can be introduced into the structure of polymers to give materials special properties. For example, improve the thermal stability, chemical stability or optical properties of materials, so that they can be applied in special fields, such as high-performance engineering plastics, optical materials, etc.
Furthermore, in the field of pesticides, pesticides developed on the basis of 1-chloro-4- (chloromethyl) -2-fluorobenzene, with their unique chemical structure, exhibit good control effects on specific pests or weeds, and because of their special structure, they may have low environmental toxicity and residues, which is in line with the direction of modern pesticide research and development.
In the field of organic synthesis, it is an important intermediate. Its structure contains chlorine atoms and chloromethyl groups, both of which have high reactivity and can be converted into functional groups through various chemical reactions. For example, in nucleophilic substitution reactions, halogen atoms can be replaced by nucleophiles such as hydroxyl and amino groups, resulting in a series of compounds containing different functional groups. These products are essential in the preparation of fine chemical products such as pharmaceuticals and pesticides.
In the field of medicinal chemistry, using this as a starting material, molecular structures with specific biological activities can be constructed through multi-step reactions. Scientists can modify their chemical structures, change the physical and chemical properties and biological activities of compounds, and then develop new drugs.
In materials science, through a suitable reaction path, it can be introduced into the structure of polymers to give materials special properties. For example, improve the thermal stability, chemical stability or optical properties of materials, so that they can be applied in special fields, such as high-performance engineering plastics, optical materials, etc.
Furthermore, in the field of pesticides, pesticides developed on the basis of 1-chloro-4- (chloromethyl) -2-fluorobenzene, with their unique chemical structure, exhibit good control effects on specific pests or weeds, and because of their special structure, they may have low environmental toxicity and residues, which is in line with the direction of modern pesticide research and development.
What are the synthesis methods of 1-chloro-4- (chloromethyl) -2-fluorobenzene?
The synthesis of 1-chloro-4- (chloromethyl) -2-fluorobenzene is an important topic in the field of organic synthesis. There are several common synthesis paths, which can be started from different starting materials and reaction processes.
First, 2-fluoro-4-methylchlorobenzene is used as the starting material. In this compound, the methyl group can be replaced by a specific halogenated reagent, such as N-chlorosuccinimide (NCS), and in the presence of an initiator such as benzoyl peroxide (BPO), under light or heating conditions, the radical substitution reaction occurs, so that the hydrogen atom on the methyl group is replaced by the chlorine atom, thereby generating the target product 1-chloro-4- (chloromethyl) -2-fluorobenzene. The reaction conditions are mild, the operation is relatively simple, and the yield is relatively promising.
Second, 2-fluoro-4-chlorobenzoic acid is used as the starting material. First, it is combined with a reducing agent, such as lithium aluminum hydride (LiAlH), to reduce the carboxyl group to hydroxymethyl to obtain 2-fluoro-4-chlorobenzyl alcohol. Subsequently, chlorination reagents, such as thionyl chloride (SOCl ²), are used to react with it, and the alcohol hydroxyl group is replaced by chlorine atoms to achieve the synthesis of 1-chloro-4- (chloromethyl) -2-fluorobenzene. Although this route has a little more steps, the reaction of each step is highly selective and the product purity is good.
Third, chloromethyl is introduced through Fu-gram alkylation reaction with suitable halogenated aromatics as raw materials. Chloromethylation reagents, such as chloromethyl methyl ether (MOMCl), are selected to undergo electrophilic substitution reaction with halogenated aromatics under the catalysis of Lewis acid catalysts, such as anhydrous zinc chloride (ZnCl ²), to generate 1-chloro-4- (chloromethyl) -2-fluorobenzene. This method needs to pay attention to the control of reaction conditions to avoid the formation of multiple substitution products.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, reaction conditions, product purity and yield, and carefully select a suitable synthesis path to efficiently prepare 1-chloro-4- (chloromethyl) -2-fluorobenzene.
First, 2-fluoro-4-methylchlorobenzene is used as the starting material. In this compound, the methyl group can be replaced by a specific halogenated reagent, such as N-chlorosuccinimide (NCS), and in the presence of an initiator such as benzoyl peroxide (BPO), under light or heating conditions, the radical substitution reaction occurs, so that the hydrogen atom on the methyl group is replaced by the chlorine atom, thereby generating the target product 1-chloro-4- (chloromethyl) -2-fluorobenzene. The reaction conditions are mild, the operation is relatively simple, and the yield is relatively promising.
Second, 2-fluoro-4-chlorobenzoic acid is used as the starting material. First, it is combined with a reducing agent, such as lithium aluminum hydride (LiAlH), to reduce the carboxyl group to hydroxymethyl to obtain 2-fluoro-4-chlorobenzyl alcohol. Subsequently, chlorination reagents, such as thionyl chloride (SOCl ²), are used to react with it, and the alcohol hydroxyl group is replaced by chlorine atoms to achieve the synthesis of 1-chloro-4- (chloromethyl) -2-fluorobenzene. Although this route has a little more steps, the reaction of each step is highly selective and the product purity is good.
Third, chloromethyl is introduced through Fu-gram alkylation reaction with suitable halogenated aromatics as raw materials. Chloromethylation reagents, such as chloromethyl methyl ether (MOMCl), are selected to undergo electrophilic substitution reaction with halogenated aromatics under the catalysis of Lewis acid catalysts, such as anhydrous zinc chloride (ZnCl ²), to generate 1-chloro-4- (chloromethyl) -2-fluorobenzene. This method needs to pay attention to the control of reaction conditions to avoid the formation of multiple substitution products.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, reaction conditions, product purity and yield, and carefully select a suitable synthesis path to efficiently prepare 1-chloro-4- (chloromethyl) -2-fluorobenzene.
What are the precautions for using 1-chloro-4- (chloromethyl) -2-fluorobenzene?
1-Chloro-4- (chloromethyl) -2-fluorobenzene, this is a common raw material for organic synthesis. There are many precautions to keep in mind during its use.
First, it is related to toxicity and health hazards. This compound is toxic to a certain extent, or causes damage to the human body. When operating, be sure to take protective measures. Wear protective clothing and gloves to avoid skin contact, because it may be absorbed through the skin, causing toxic reactions. At the same time, wear a suitable gas mask to prevent inhalation of its volatile gases and damage to the respiratory tract and nervous system. If you come into contact accidentally, rinse with plenty of water immediately and seek medical treatment in time.
Second, pay attention to its flammability. 1-Chloro-4- (chloromethyl) -2-fluorobenzene is exposed to open flames, hot topics or the danger of combustion and explosion. Fireworks are strictly prohibited in storage and use places, and should be kept away from fire and heat sources. When storing, it should be placed in a cool and ventilated warehouse to prevent danger caused by excessive temperature. At the same time, it needs to be stored separately from oxidants and acids. It must not be mixed in storage and transportation to avoid chemical reactions that can lead to fire or explosion accidents.
Third, pay attention to its chemical activity. The chemical properties of this substance are relatively active, and under specific conditions, it is easy to react with other substances. In the process of use, the reaction conditions, such as temperature, pressure, and the proportion of reactants, should be precisely controlled. Before the reaction, the reaction system needs to be fully evaluated and predicted to prevent accidents due to runaway reaction. At the same time, the products and waste after the reaction should also be properly disposed of, follow relevant environmental protection regulations, and do not discharge at will to avoid polluting the environment.
Fourth, about the operating specifications. When operating 1-chloro-4- (chloromethyl) -2-fluorobenzene, the operator should be professionally trained and familiar with its properties and operating procedures. The operation process should be rigorous and meticulous, and carried out in strict accordance with standard procedures to avoid safety accidents caused by improper operation. Experimental equipment should be regularly inspected and maintained to ensure that it is in good working condition to ensure the safety and accuracy of operation.
First, it is related to toxicity and health hazards. This compound is toxic to a certain extent, or causes damage to the human body. When operating, be sure to take protective measures. Wear protective clothing and gloves to avoid skin contact, because it may be absorbed through the skin, causing toxic reactions. At the same time, wear a suitable gas mask to prevent inhalation of its volatile gases and damage to the respiratory tract and nervous system. If you come into contact accidentally, rinse with plenty of water immediately and seek medical treatment in time.
Second, pay attention to its flammability. 1-Chloro-4- (chloromethyl) -2-fluorobenzene is exposed to open flames, hot topics or the danger of combustion and explosion. Fireworks are strictly prohibited in storage and use places, and should be kept away from fire and heat sources. When storing, it should be placed in a cool and ventilated warehouse to prevent danger caused by excessive temperature. At the same time, it needs to be stored separately from oxidants and acids. It must not be mixed in storage and transportation to avoid chemical reactions that can lead to fire or explosion accidents.
Third, pay attention to its chemical activity. The chemical properties of this substance are relatively active, and under specific conditions, it is easy to react with other substances. In the process of use, the reaction conditions, such as temperature, pressure, and the proportion of reactants, should be precisely controlled. Before the reaction, the reaction system needs to be fully evaluated and predicted to prevent accidents due to runaway reaction. At the same time, the products and waste after the reaction should also be properly disposed of, follow relevant environmental protection regulations, and do not discharge at will to avoid polluting the environment.
Fourth, about the operating specifications. When operating 1-chloro-4- (chloromethyl) -2-fluorobenzene, the operator should be professionally trained and familiar with its properties and operating procedures. The operation process should be rigorous and meticulous, and carried out in strict accordance with standard procedures to avoid safety accidents caused by improper operation. Experimental equipment should be regularly inspected and maintained to ensure that it is in good working condition to ensure the safety and accuracy of operation.
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