Linshang Chemical
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1-Chloro-4-(Chloromethylthio)Benzene
Linshang Chemical
|
HS Code |
927318 |
| Chemical Formula | C7H6Cl2S |
| Molecular Weight | 193.09 |
| Appearance | Typically a solid or liquid (appearance can vary based on purity and conditions) |
| Odor | May have a characteristic, pungent odor |
| Solubility In Water | Expected to be insoluble or sparingly soluble in water due to non - polar nature |
| Solubility In Organic Solvents | Likely soluble in common organic solvents like chloroform, dichloromethane |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 1-Chloro-4-(Chloromethylthio)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 4 - (chloromethylthio)benzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 1 - Chloro - 4 - (chloromethylthio)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Label the storage container clearly with relevant hazard information. |
| Shipping | 1 - chloro - 4 - (chloromethylthio)benzene is a chemical that requires careful shipping. It must be packaged in appropriate, leak - proof containers. Shipments should follow all relevant hazardous material regulations to ensure safe transport. |
Competitive 1-Chloro-4-(Chloromethylthio)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 1-chloro-4- (chloromethylthio) benzene?
1-Chloro-4- (chloromethyl) benzene is also an organic compound. Its chemical properties are unique and valuable to explore.
In this compound, the presence of chlorine atoms and sulfur-containing groups endows it with specific reactivity. Chlorine atoms are electrophilic and easily participate in nucleophilic substitution reactions. Under appropriate reaction conditions, nucleophilic reagents can attack the carbon atoms attached to chlorine, causing chlorine to leave, and then form new organic compounds.
In the (chloromethylthio) part, the electronic properties of sulfur atoms also affect the properties of compounds. Sulfur atoms have a certain electron-giving ability, which can affect the electron cloud density distribution of benzene rings. It can make the electron cloud density of the ortho and para-position of the benzene ring relatively increase. In the electrophilic substitution reaction, it has an effect on the positioning effect of the reaction, making the electrophilic reagent more inclined to attack the ortho and para-position.
In addition, the chemical stability of the compound also needs to be considered. Due to the presence of elements such as chlorine and sulfur, under different environmental conditions, decomposition and oxidation reactions may occur. For example, under the action of strong oxidants, sulfur atoms may be oxidized, resulting in changes in the structure and properties of the compound. In addition, under specific conditions such as high temperature and light, reactions such as dissociation of chlorine atoms may also be initiated, which affects the stability of the compound.
In addition, its solubility is also an important property. Usually in organic solvents, such as ethanol, ether, etc., there may be a certain solubility, but the solubility in water may be low, which is related to the polarity of its molecular structure. Although there are polar groups in the molecule, the overall structure is still highly hydrophobic, so it is difficult to dissolve in water. This solubility characteristic is of key guiding significance in its separation, purification and selection of media involved in the reaction.
In this compound, the presence of chlorine atoms and sulfur-containing groups endows it with specific reactivity. Chlorine atoms are electrophilic and easily participate in nucleophilic substitution reactions. Under appropriate reaction conditions, nucleophilic reagents can attack the carbon atoms attached to chlorine, causing chlorine to leave, and then form new organic compounds.
In the (chloromethylthio) part, the electronic properties of sulfur atoms also affect the properties of compounds. Sulfur atoms have a certain electron-giving ability, which can affect the electron cloud density distribution of benzene rings. It can make the electron cloud density of the ortho and para-position of the benzene ring relatively increase. In the electrophilic substitution reaction, it has an effect on the positioning effect of the reaction, making the electrophilic reagent more inclined to attack the ortho and para-position.
In addition, the chemical stability of the compound also needs to be considered. Due to the presence of elements such as chlorine and sulfur, under different environmental conditions, decomposition and oxidation reactions may occur. For example, under the action of strong oxidants, sulfur atoms may be oxidized, resulting in changes in the structure and properties of the compound. In addition, under specific conditions such as high temperature and light, reactions such as dissociation of chlorine atoms may also be initiated, which affects the stability of the compound.
In addition, its solubility is also an important property. Usually in organic solvents, such as ethanol, ether, etc., there may be a certain solubility, but the solubility in water may be low, which is related to the polarity of its molecular structure. Although there are polar groups in the molecule, the overall structure is still highly hydrophobic, so it is difficult to dissolve in water. This solubility characteristic is of key guiding significance in its separation, purification and selection of media involved in the reaction.
What are the main uses of 1-chloro-4- (chloromethylthio) benzene?
1 - chloro - 4 - (chloromethylthio) benzene, the Chinese name is often Chlorobenzyl thiochlorine, the use of this substance is.
First, in the field of synthesis, its role is very important. Due to the special properties of compounds, it can be used as a synthetic compound. For example, in the research of some antibacterial compounds, it can be used to form molecules with antibacterial activity by interacting with a series of antibacterial compounds and other functionalities. The chlorine atoms and chloromethylthio groups in it can be replaced by nuclear substitution and other reactions, and the molecules of the compound can be introduced into specific functionalities to increase the inhibition or suppression ability of specific pathogens.
Second, it can also be used in manufacturing. It can be used for the synthesis of new kinds of raw materials. Part of the synthesis is based on its starting materials. Through chemical modification, using its active groups, it can be derived from compounds with high efficiency in removing or reducing crop hazards. Because of its versatile transformation, it can be used to create different hazards and control various products, which can effectively ensure the growth of crops and improve the production capacity.
Third, in the field of materials science, 1-chloro-4- (chloromethylthio) benzene can also be used. It can be used for the synthesis of polymer materials. The polymerization reaction, which is introduced into the polymer, gives the material special properties. For example, it can improve the corrosion resistance and resistance of the material. Its special functions can generate reactions with other materials, forming interactions or specific interactions, thus enhancing the physical properties of materials and expanding the application of materials in many special environments.
First, in the field of synthesis, its role is very important. Due to the special properties of compounds, it can be used as a synthetic compound. For example, in the research of some antibacterial compounds, it can be used to form molecules with antibacterial activity by interacting with a series of antibacterial compounds and other functionalities. The chlorine atoms and chloromethylthio groups in it can be replaced by nuclear substitution and other reactions, and the molecules of the compound can be introduced into specific functionalities to increase the inhibition or suppression ability of specific pathogens.
Second, it can also be used in manufacturing. It can be used for the synthesis of new kinds of raw materials. Part of the synthesis is based on its starting materials. Through chemical modification, using its active groups, it can be derived from compounds with high efficiency in removing or reducing crop hazards. Because of its versatile transformation, it can be used to create different hazards and control various products, which can effectively ensure the growth of crops and improve the production capacity.
Third, in the field of materials science, 1-chloro-4- (chloromethylthio) benzene can also be used. It can be used for the synthesis of polymer materials. The polymerization reaction, which is introduced into the polymer, gives the material special properties. For example, it can improve the corrosion resistance and resistance of the material. Its special functions can generate reactions with other materials, forming interactions or specific interactions, thus enhancing the physical properties of materials and expanding the application of materials in many special environments.
What are the synthesis methods of 1-chloro-4- (chloromethylthio) benzene
There are many ways to synthesize 1-chloro-4- (chloromethyl thio) benzene, and several are listed below.
One method can be prepared by p-chlorothiophenol and chloromethyl chloride under appropriate reaction conditions. P-chlorothiophenol has an active thiohydrogen group. When encountering chloromethyl chloride, the sulfur atom of the thiohydrogen group nucleophilically attacks the carbon atom of the chloromethyl chloride, and the chlorine atom leaves to form 1-chloro-4- (chloromethyl thio) benzene. This reaction often needs to be carried out in the presence of a base, which can neutralize the hydrogen chloride generated by the reaction and prompt the reaction to proceed to the right. The alkali used, such as potassium carbonate, sodium carbonate, etc., the reaction solvent can be selected from organic solvents such as acetonitrile, N, N-dimethylformamide, which have good solubility to the reactants and are conducive to the reaction.
The second method uses p-chlorobenzyl chloride and sodium hydrosulfide as raw materials. First, p-chlorobenzyl chloride reacts with sodium hydrosulfide to generate p-chlorobenzyl mercaptan. In this step, the ratio of temperature to reactants needs to be controlled to obtain a higher yield. Then, p-chlorobenzyl mercaptan reacts with chlorinated reagents, such as dichlorosulfoxide, etc., and the hydrogen atom of the mercaptan group is replaced by the chlorine atom, resulting in 1-chloro-4- (chloromethyl thio) benzene. In this process, the first step of the reaction needs to pay attention to the dosage of sodium hydrosulfide and the pH value of the reaction system, and the second step of the chlorination reaction needs to pay attention to the reaction temperature and time to avoid the occurrence of side reactions such as excessive chlorination.
Some people use thiophenol as the starting material. First, chloromethyl is introduced into the benzene ring of thiophenol through chloromethylation reaction to generate 4- (chloromethylthio) benzene. Then chlorination is carried out on the benzene ring, and chlorine atoms are introduced at the 4-position to obtain the target product 1-chloro-4- (chloromethylthio) benzene. The commonly used reagents for chloromethylation reactions are polyformaldehyde and hydrogen chloride, which are carried out in the presence of appropriate catalysts such as zinc salts. For subsequent chlorination reactions, chlorine gas, ferric chloride and other chlorinated reagents can be selected to control the reaction conditions to ensure the selective introduction of chlorine atoms into the 4-position.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and difficulty in controlling reaction conditions, and choose the good one and use it.
One method can be prepared by p-chlorothiophenol and chloromethyl chloride under appropriate reaction conditions. P-chlorothiophenol has an active thiohydrogen group. When encountering chloromethyl chloride, the sulfur atom of the thiohydrogen group nucleophilically attacks the carbon atom of the chloromethyl chloride, and the chlorine atom leaves to form 1-chloro-4- (chloromethyl thio) benzene. This reaction often needs to be carried out in the presence of a base, which can neutralize the hydrogen chloride generated by the reaction and prompt the reaction to proceed to the right. The alkali used, such as potassium carbonate, sodium carbonate, etc., the reaction solvent can be selected from organic solvents such as acetonitrile, N, N-dimethylformamide, which have good solubility to the reactants and are conducive to the reaction.
The second method uses p-chlorobenzyl chloride and sodium hydrosulfide as raw materials. First, p-chlorobenzyl chloride reacts with sodium hydrosulfide to generate p-chlorobenzyl mercaptan. In this step, the ratio of temperature to reactants needs to be controlled to obtain a higher yield. Then, p-chlorobenzyl mercaptan reacts with chlorinated reagents, such as dichlorosulfoxide, etc., and the hydrogen atom of the mercaptan group is replaced by the chlorine atom, resulting in 1-chloro-4- (chloromethyl thio) benzene. In this process, the first step of the reaction needs to pay attention to the dosage of sodium hydrosulfide and the pH value of the reaction system, and the second step of the chlorination reaction needs to pay attention to the reaction temperature and time to avoid the occurrence of side reactions such as excessive chlorination.
Some people use thiophenol as the starting material. First, chloromethyl is introduced into the benzene ring of thiophenol through chloromethylation reaction to generate 4- (chloromethylthio) benzene. Then chlorination is carried out on the benzene ring, and chlorine atoms are introduced at the 4-position to obtain the target product 1-chloro-4- (chloromethylthio) benzene. The commonly used reagents for chloromethylation reactions are polyformaldehyde and hydrogen chloride, which are carried out in the presence of appropriate catalysts such as zinc salts. For subsequent chlorination reactions, chlorine gas, ferric chloride and other chlorinated reagents can be selected to control the reaction conditions to ensure the selective introduction of chlorine atoms into the 4-position.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and difficulty in controlling reaction conditions, and choose the good one and use it.
What are the precautions for 1-chloro-4- (chloromethylthio) benzene during storage and transportation?
1-Chloro-4- (chloromethyl thio) benzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First talk about storage. This compound should be placed in a cool and ventilated warehouse. Because the temperature is too high, the ventilation is not smooth, or it may cause chemical reactions, and even cause danger. The temperature of the warehouse should be strictly controlled, not too high, to prevent its volatilization from intensifying, and to maintain good ventilation to disperse harmful gases that may accumulate. In addition, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to the active nature of this compound, contact with the above-mentioned substances can easily cause violent reactions, or cause fires, explosions and other disasters. At the same time, the storage area should be equipped with suitable materials to contain the leakage, so that in the event of leakage, it can be properly handled in time to prevent its spread and cause greater harm.
As for transportation, the transportation vehicle must ensure that the vehicle is in good condition and has corresponding safety facilities. During transportation, it is necessary to protect against exposure to the sun and rain, and avoid high temperature and humid environment. In case of exposure to the sun, the temperature rises sharply, the compound may evaporate and decompose, resulting in danger; rain may damage the packaging and cause leakage. In addition, when transporting, you should follow the specified route and do not stay in densely populated areas and places with open flames. This is because the compound has certain toxicity and danger, and once an accident occurs in the above area, the consequences are unimaginable. When loading and unloading, the operator should also pack and unload lightly. It is strictly forbidden to drop and heavy pressure to prevent damage to the packaging container and cause compound leakage.
In short, during the storage and transportation of 1-chloro-4- (chloromethyl thio) benzene, care must be taken, and relevant specifications and requirements must be strictly followed to ensure that personnel safety and the environment are not endangered.
First talk about storage. This compound should be placed in a cool and ventilated warehouse. Because the temperature is too high, the ventilation is not smooth, or it may cause chemical reactions, and even cause danger. The temperature of the warehouse should be strictly controlled, not too high, to prevent its volatilization from intensifying, and to maintain good ventilation to disperse harmful gases that may accumulate. In addition, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to the active nature of this compound, contact with the above-mentioned substances can easily cause violent reactions, or cause fires, explosions and other disasters. At the same time, the storage area should be equipped with suitable materials to contain the leakage, so that in the event of leakage, it can be properly handled in time to prevent its spread and cause greater harm.
As for transportation, the transportation vehicle must ensure that the vehicle is in good condition and has corresponding safety facilities. During transportation, it is necessary to protect against exposure to the sun and rain, and avoid high temperature and humid environment. In case of exposure to the sun, the temperature rises sharply, the compound may evaporate and decompose, resulting in danger; rain may damage the packaging and cause leakage. In addition, when transporting, you should follow the specified route and do not stay in densely populated areas and places with open flames. This is because the compound has certain toxicity and danger, and once an accident occurs in the above area, the consequences are unimaginable. When loading and unloading, the operator should also pack and unload lightly. It is strictly forbidden to drop and heavy pressure to prevent damage to the packaging container and cause compound leakage.
In short, during the storage and transportation of 1-chloro-4- (chloromethyl thio) benzene, care must be taken, and relevant specifications and requirements must be strictly followed to ensure that personnel safety and the environment are not endangered.
What are the effects of 1-chloro-4- (chloromethylthio) benzene on the environment and human health?
1-Chloro-4- (chloromethylthio) benzene is also an organic compound. Its impact on the environment and human health cannot be underestimated.
First of all, its impact on the environment. If this substance is released in nature, in the atmosphere, or can participate in photochemical reactions, resulting in increased pollutants in the atmosphere, and because it is volatile to a certain extent, or causes air quality to decline, causing respiratory discomfort. Entering water bodies, because it is insoluble in water and toxic, or can accumulate in aquatic organisms, disturbing the balance of aquatic ecosystems. For example, if aquatic organisms such as fish and shrimp are exposed to this substance for a long time, their physiological functions may be damaged, their reproductive ability will decrease, and even the population number will decrease sharply. And this substance can also remain in the soil, affecting the activity of soil microorganisms and community structure, causing soil fertility to decline and hindering plant growth.
As for the impact on human health, it is also harmful. Inhaled through the respiratory tract, this substance may irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. If exposed to the skin, it can cause skin allergies, redness, swelling, itching, and in severe cases, blisters and ulceration. If eaten by mistake, it can also cause digestive system disorders, including nausea, vomiting, abdominal pain, diarrhea, etc. Long-term exposure to this substance environment may accumulate in the human body, damaging important organs such as the liver and kidneys. The liver is the hub of detoxification in the human body. If damaged, the detoxification function will be reduced; the kidney mainly excretes, and if invaded, metabolic waste will be difficult to leave the body. What's more, this substance may be carcinogenic, and long-term exposure or increased risk of cancer.
In summary, 1-chloro-4- (chloromethylthio) benzene has potential serious harm to the environment and human health. During its production, use and disposal, care should be taken to reduce its harm to the environment and human body.
First of all, its impact on the environment. If this substance is released in nature, in the atmosphere, or can participate in photochemical reactions, resulting in increased pollutants in the atmosphere, and because it is volatile to a certain extent, or causes air quality to decline, causing respiratory discomfort. Entering water bodies, because it is insoluble in water and toxic, or can accumulate in aquatic organisms, disturbing the balance of aquatic ecosystems. For example, if aquatic organisms such as fish and shrimp are exposed to this substance for a long time, their physiological functions may be damaged, their reproductive ability will decrease, and even the population number will decrease sharply. And this substance can also remain in the soil, affecting the activity of soil microorganisms and community structure, causing soil fertility to decline and hindering plant growth.
As for the impact on human health, it is also harmful. Inhaled through the respiratory tract, this substance may irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. If exposed to the skin, it can cause skin allergies, redness, swelling, itching, and in severe cases, blisters and ulceration. If eaten by mistake, it can also cause digestive system disorders, including nausea, vomiting, abdominal pain, diarrhea, etc. Long-term exposure to this substance environment may accumulate in the human body, damaging important organs such as the liver and kidneys. The liver is the hub of detoxification in the human body. If damaged, the detoxification function will be reduced; the kidney mainly excretes, and if invaded, metabolic waste will be difficult to leave the body. What's more, this substance may be carcinogenic, and long-term exposure or increased risk of cancer.
In summary, 1-chloro-4- (chloromethylthio) benzene has potential serious harm to the environment and human health. During its production, use and disposal, care should be taken to reduce its harm to the environment and human body.
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