Linshang Chemical
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1-Chloro-4-(Ethylsulfonyl)-2-Nitrobenzene
Linshang Chemical
|
HS Code |
153904 |
| Chemical Formula | C8H8ClNO4S |
| Molecular Weight | 251.67 |
| Appearance | Solid (usually a yellow - colored solid) |
| Odor | May have a pungent odor |
| Melting Point | Specific value would need experimental determination |
| Boiling Point | Specific value would need experimental determination |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Specific value would need experimental determination |
| Flash Point | Specific value would need experimental determination |
| Stability | Stable under normal conditions but may react with strong oxidizing agents |
As an accredited 1-Chloro-4-(Ethylsulfonyl)-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 4 - (ethylsulfonyl) - 2 - nitrobenzene packaged in air - tight plastic bags. |
| Storage | 1 - Chloro - 4 - (ethylsulfonyl)-2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture and air exposure. Store it separately from incompatible substances like oxidizing agents and bases to avoid potential chemical reactions. |
| Shipping | 1 - chloro - 4 - (ethylsulfonyl) - 2 - nitrobenzene is a chemical. Shipments should be in well - sealed containers, compliant with hazardous material regulations, ensuring proper handling to prevent spills during transit. |
Competitive 1-Chloro-4-(Ethylsulfonyl)-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-4-(Ethylsulfonyl)-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene?
1 - chloro - 4 - (ethylsulfonyl) - 2 - nitrobenzene is 1 - chloro - 4 - (ethylsulfonyl) - 2 - nitrobenzene, which is widely used.
In the field of organic synthesis, it is a key intermediary. With the characteristics of chlorine atoms, ethylsulfonyl groups and nitro groups attached to the benzene ring, a series of unique organic compounds can be derived through various reactions. For example, chlorine atoms have good departure properties. In nucleophilic substitution reactions, they can be replaced by many nucleophilic reagents, such as hydroxyl groups and amino groups, etc., to construct benzene derivatives modified with different functional groups, which is of great significance in medicinal chemistry and materials science.
In the field of drug development, 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene can be used as a starting material to prepare compounds with specific pharmacological activities through multi-step reactions. Nitro can be converted into amino groups by reduction. Amino groups are key activity checking points in many drug molecules and participate in interactions with biological targets, such as binding to receptor proteins, to exert therapeutic effects. At the same time, the presence of ethanesulfonyl groups can affect the physical and chemical properties of molecules such as polarity and water solubility, and play a role in the absorption, distribution, metabolism and excretion of drugs in vivo.
In materials science, compounds derived from them can be applied to the synthesis of polymer materials. By connecting them to the polymer skeleton through appropriate reactions, materials can be endowed with special properties. For example, the introduction of monomers containing this structure to participate in the polymerization reaction may make polymer materials have unique electrical, optical or thermal properties, providing an opportunity for the creation of new functional materials.
In addition, in the dye industry, dyes synthesized from this raw material may exhibit excellent dyeing performance and color fastness due to the synergy effect of different functional groups on the benzene ring, meeting the needs of high-quality dyes in textile, printing and dyeing industries.
In the field of organic synthesis, it is a key intermediary. With the characteristics of chlorine atoms, ethylsulfonyl groups and nitro groups attached to the benzene ring, a series of unique organic compounds can be derived through various reactions. For example, chlorine atoms have good departure properties. In nucleophilic substitution reactions, they can be replaced by many nucleophilic reagents, such as hydroxyl groups and amino groups, etc., to construct benzene derivatives modified with different functional groups, which is of great significance in medicinal chemistry and materials science.
In the field of drug development, 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene can be used as a starting material to prepare compounds with specific pharmacological activities through multi-step reactions. Nitro can be converted into amino groups by reduction. Amino groups are key activity checking points in many drug molecules and participate in interactions with biological targets, such as binding to receptor proteins, to exert therapeutic effects. At the same time, the presence of ethanesulfonyl groups can affect the physical and chemical properties of molecules such as polarity and water solubility, and play a role in the absorption, distribution, metabolism and excretion of drugs in vivo.
In materials science, compounds derived from them can be applied to the synthesis of polymer materials. By connecting them to the polymer skeleton through appropriate reactions, materials can be endowed with special properties. For example, the introduction of monomers containing this structure to participate in the polymerization reaction may make polymer materials have unique electrical, optical or thermal properties, providing an opportunity for the creation of new functional materials.
In addition, in the dye industry, dyes synthesized from this raw material may exhibit excellent dyeing performance and color fastness due to the synergy effect of different functional groups on the benzene ring, meeting the needs of high-quality dyes in textile, printing and dyeing industries.
What are the physical properties of 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene
1-Chloro-4- (ethylsulfonyl) -2-nitrobenzene, this substance has specific properties and several physical properties.
Its appearance is often solid, but it also varies according to the surrounding conditions. The color is mostly light, or nearly colorless, slightly shiny, and the appearance is quite pure.
The melting point is one of the key physical properties to consider this substance. Its melting point is within a specific range. When heated, it begins to melt from solid to liquid at a certain temperature. This temperature is an important indicator to define its characteristics, and it is of great significance in many chemical processes, such as purification and separation. The boiling point of
is also a key physical property. When heated, this substance will change from liquid to gaseous at a certain high temperature. The value of this boiling point helps chemical workers control its vaporization state. It is very important in the method of distillation and fractionation to distinguish this substance from others.
In terms of solubility, this substance exhibits different degrees of solubility in various organic solvents. In polar organic solvents, such as alcohols and ketones, it may have a certain solubility and can be miscible with it; in non-polar solvents, such as alkanes, its solubility may be very small. This difference in solubility can be used as a basis for operation in chemical synthesis, product extraction and other steps.
Density is also a property that cannot be ignored. Its density is higher or lower than that of water. This property can determine its position in the mixed liquid during the liquid-liquid separation process, and greatly assist the separation operation.
In addition, the stability of this substance also belongs to the category of physical properties. Under normal environmental conditions, it is relatively stable. However, in case of extreme conditions such as high temperature, strong oxidizing agent, strong alkali, or chemical changes, its stability will change accordingly. When chemical workers operate this substance, they must carefully observe such properties to ensure the safety and efficiency of the process.
Its appearance is often solid, but it also varies according to the surrounding conditions. The color is mostly light, or nearly colorless, slightly shiny, and the appearance is quite pure.
The melting point is one of the key physical properties to consider this substance. Its melting point is within a specific range. When heated, it begins to melt from solid to liquid at a certain temperature. This temperature is an important indicator to define its characteristics, and it is of great significance in many chemical processes, such as purification and separation. The boiling point of
is also a key physical property. When heated, this substance will change from liquid to gaseous at a certain high temperature. The value of this boiling point helps chemical workers control its vaporization state. It is very important in the method of distillation and fractionation to distinguish this substance from others.
In terms of solubility, this substance exhibits different degrees of solubility in various organic solvents. In polar organic solvents, such as alcohols and ketones, it may have a certain solubility and can be miscible with it; in non-polar solvents, such as alkanes, its solubility may be very small. This difference in solubility can be used as a basis for operation in chemical synthesis, product extraction and other steps.
Density is also a property that cannot be ignored. Its density is higher or lower than that of water. This property can determine its position in the mixed liquid during the liquid-liquid separation process, and greatly assist the separation operation.
In addition, the stability of this substance also belongs to the category of physical properties. Under normal environmental conditions, it is relatively stable. However, in case of extreme conditions such as high temperature, strong oxidizing agent, strong alkali, or chemical changes, its stability will change accordingly. When chemical workers operate this substance, they must carefully observe such properties to ensure the safety and efficiency of the process.
What are the chemical properties of 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene?
The chemical properties of 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene are very important and are related to many chemical processes and reactions. This compound has functional groups such as chlorine atom, ethanesulfonyl group and nitro group, and each functional group endows it with unique chemical properties.
Chlorine atom has a certain nucleophilic substitution activity. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced to form new compounds. For example, when reacting with nucleophiles containing hydroxyl groups and amino groups, chlorine atoms may be replaced by hydroxyl groups and amino groups to form corresponding alcohols or amine derivatives. This nucleophilic substitution reaction may be carried out in an alkaline environment to enhance the activity of nucleophilic reagents.
ethanesulfonyl group also has characteristics. It is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, make the benzene ring more stable, and affect the reactivity of other substituents on the benzene ring. In the electrophilic substitution reaction, the presence of ethanesulfonyl group will make the reaction check point more inclined to the meta-position. And because of its sulfur-oxygen double bond, it may participate in some reactions involving the change of the oxidation state of sulfur atoms. For example, under the action of specific oxidants, sulfur atoms may be further oxidized.
Nitro is also a strong electron-absorbing group. The presence of nitro groups greatly reduces the electron cloud density of the benzene ring, which greatly reduces the electrophilic substitution reaction activity of the benzene However, the nitro group can be reduced under the action of an appropriate reducing agent to form an amino group. This reaction is often used in organic synthesis to prepare compounds containing amino groups. The reduction reaction of nitro groups may use a combination of metals and acids, such as iron and hydrochloric acid, or catalytic hydrogenation.
In addition, the functional groups in the 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene molecule may interact with each other. The strong electron-absorbing effect of ethanesulfonyl groups and nitro groups may affect the nucleophilic substitution activity of chlorine atoms, making their activity different from that of simple chlorobenzene. At the same time, the positional relationship of the substituents on the benzene ring also affects the overall chemical properties and reactivity of the molecule. The chemical properties of this compound are complex and diverse, and it has important research and application value in the fields of organic synthesis and medicinal chemistry.
Chlorine atom has a certain nucleophilic substitution activity. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced to form new compounds. For example, when reacting with nucleophiles containing hydroxyl groups and amino groups, chlorine atoms may be replaced by hydroxyl groups and amino groups to form corresponding alcohols or amine derivatives. This nucleophilic substitution reaction may be carried out in an alkaline environment to enhance the activity of nucleophilic reagents.
ethanesulfonyl group also has characteristics. It is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, make the benzene ring more stable, and affect the reactivity of other substituents on the benzene ring. In the electrophilic substitution reaction, the presence of ethanesulfonyl group will make the reaction check point more inclined to the meta-position. And because of its sulfur-oxygen double bond, it may participate in some reactions involving the change of the oxidation state of sulfur atoms. For example, under the action of specific oxidants, sulfur atoms may be further oxidized.
Nitro is also a strong electron-absorbing group. The presence of nitro groups greatly reduces the electron cloud density of the benzene ring, which greatly reduces the electrophilic substitution reaction activity of the benzene However, the nitro group can be reduced under the action of an appropriate reducing agent to form an amino group. This reaction is often used in organic synthesis to prepare compounds containing amino groups. The reduction reaction of nitro groups may use a combination of metals and acids, such as iron and hydrochloric acid, or catalytic hydrogenation.
In addition, the functional groups in the 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene molecule may interact with each other. The strong electron-absorbing effect of ethanesulfonyl groups and nitro groups may affect the nucleophilic substitution activity of chlorine atoms, making their activity different from that of simple chlorobenzene. At the same time, the positional relationship of the substituents on the benzene ring also affects the overall chemical properties and reactivity of the molecule. The chemical properties of this compound are complex and diverse, and it has important research and application value in the fields of organic synthesis and medicinal chemistry.
What are the synthesis methods of 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene?
There are many ways to synthesize 1-chloro-4- (ethanesulfonyl) -2-nitrobenzene. In the past, many sages have studied this wonderful method, and now they choose the one that is important for you.
One method is to take benzene as the base first and replace it with chlorine, so that the chlorine atom is attached to the benzene ring to obtain chlorobenzene. Chlorobenzene is the foundation of the reaction. Then, the chlorobenzene is interacted with ethanesulfonyl chloride, and a suitable catalyst is required to help it bond. The key to this step is the choice of catalyst and the control of the reaction conditions. Temperature and pressure cannot be ignored. After ingenious combination of the two, ethylsulfonyl is connected to the benzene ring to obtain 1-chloro-4-ethylsulfonylbenzene. After obtaining this substance, nitro is introduced by the technique of nitrification. Nitrifying agent, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is commonly used. The two are combined, and the nitro group enters a specific position in the benzene ring, and finally becomes 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene.
There is another way. Or start with benzene and carry out the method of nitrification, so that the nitro is added to the benzene ring to form nitrobenzene. Then chlorination, chlorine atoms are attached to the benzene ring according to the rules, to obtain 1-chloro-2-nitrobenzene Then 1-chloro-2-nitrobenzene meets the ethanesulfonylation reagent, and under the right conditions, the ethanesulfonyl group is ingeniously connected to obtain the target product. In this process, each step of the reaction needs to be carefully operated, and the reaction parameters need to be carefully adjusted, such as temperature, reaction time, reagent ratio, slightly poor pool, or the product is impure, or the yield is not high.
In addition, there are also those who use other compounds as starting materials and convert them through multiple steps to reach them. However, no matter what method, it depends on the deep understanding of the organic reaction mechanism and the mastery of experimental skills to obtain this 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene, which is a shining pearl in the treasure house of organic synthesis.
One method is to take benzene as the base first and replace it with chlorine, so that the chlorine atom is attached to the benzene ring to obtain chlorobenzene. Chlorobenzene is the foundation of the reaction. Then, the chlorobenzene is interacted with ethanesulfonyl chloride, and a suitable catalyst is required to help it bond. The key to this step is the choice of catalyst and the control of the reaction conditions. Temperature and pressure cannot be ignored. After ingenious combination of the two, ethylsulfonyl is connected to the benzene ring to obtain 1-chloro-4-ethylsulfonylbenzene. After obtaining this substance, nitro is introduced by the technique of nitrification. Nitrifying agent, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is commonly used. The two are combined, and the nitro group enters a specific position in the benzene ring, and finally becomes 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene.
There is another way. Or start with benzene and carry out the method of nitrification, so that the nitro is added to the benzene ring to form nitrobenzene. Then chlorination, chlorine atoms are attached to the benzene ring according to the rules, to obtain 1-chloro-2-nitrobenzene Then 1-chloro-2-nitrobenzene meets the ethanesulfonylation reagent, and under the right conditions, the ethanesulfonyl group is ingeniously connected to obtain the target product. In this process, each step of the reaction needs to be carefully operated, and the reaction parameters need to be carefully adjusted, such as temperature, reaction time, reagent ratio, slightly poor pool, or the product is impure, or the yield is not high.
In addition, there are also those who use other compounds as starting materials and convert them through multiple steps to reach them. However, no matter what method, it depends on the deep understanding of the organic reaction mechanism and the mastery of experimental skills to obtain this 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene, which is a shining pearl in the treasure house of organic synthesis.
What should be paid attention to when storing and transporting 1-chloro-4- (ethylsulfonyl) -2-nitrobenzene?
1 - chloro - 4 - (ethylsulfonyl) - 2 - nitrobenzene is an organic compound. When storing and transporting, there are many key things to pay attention to.
First, it is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is sensitive to heat and high temperature can easily cause decomposition and cause danger, it is necessary to keep away from heat and fire sources. Warehouse temperatures should be controlled within a specific range to prevent excessive temperatures. In addition, it is necessary to maintain a dry environment, as it may react with water, which will affect quality and stability. Therefore, moisture protection measures should be taken, such as storing in sealed containers and placing desiccant in the warehouse. In addition, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., to avoid mixed storage. Because of its active chemical properties, contact with these substances can easily cause chemical reactions, resulting in serious consequences such as fire and explosion.
Second, about transportation. Be sure to ensure that the packaging is complete and well sealed before transportation. Packaging materials should have good corrosion resistance and pressure resistance, which can resist bumps and collisions during transportation, and prevent chemical leakage caused by package damage. During transportation, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, emergency treatment can be carried out in time. Moreover, during transportation, drive according to the specified route and do not stop in densely populated areas and residential areas to prevent accidents from causing harm to many people. Transportation personnel also need to undergo professional training to be familiar with the nature of the chemical and emergency treatment methods to ensure the safety of the transportation process.
First, it is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is sensitive to heat and high temperature can easily cause decomposition and cause danger, it is necessary to keep away from heat and fire sources. Warehouse temperatures should be controlled within a specific range to prevent excessive temperatures. In addition, it is necessary to maintain a dry environment, as it may react with water, which will affect quality and stability. Therefore, moisture protection measures should be taken, such as storing in sealed containers and placing desiccant in the warehouse. In addition, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., to avoid mixed storage. Because of its active chemical properties, contact with these substances can easily cause chemical reactions, resulting in serious consequences such as fire and explosion.
Second, about transportation. Be sure to ensure that the packaging is complete and well sealed before transportation. Packaging materials should have good corrosion resistance and pressure resistance, which can resist bumps and collisions during transportation, and prevent chemical leakage caused by package damage. During transportation, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, emergency treatment can be carried out in time. Moreover, during transportation, drive according to the specified route and do not stop in densely populated areas and residential areas to prevent accidents from causing harm to many people. Transportation personnel also need to undergo professional training to be familiar with the nature of the chemical and emergency treatment methods to ensure the safety of the transportation process.
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