Linshang Chemical
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1-Chloro-4-Fluoro-2-Methylbenzene
Linshang Chemical
|
HS Code |
873683 |
| Chemical Formula | C7H6ClF |
| Molecular Weight | 144.57 |
| Appearance | Liquid (usually) |
| Odor | Typical aromatic odor |
| Boiling Point | Approx. 165 - 167 °C |
| Density | Approx. 1.18 - 1.20 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approx. 52 - 54 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions |
As an accredited 1-Chloro-4-Fluoro-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - fluoro - 2 - methylbenzene packaged in 5 - liter containers. |
| Storage | 1 - Chloro - 4 - fluoro - 2 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. |
| Shipping | 1 - chloro - 4 - fluoro - 2 - methylbenzene should be shipped in tightly sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, with proper labeling indicating its nature to ensure safe transportation. |
Competitive 1-Chloro-4-Fluoro-2-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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Where to Buy 1-Chloro-4-Fluoro-2-Methylbenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-Fluoro-2-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-4-fluoro-2-methylbenzene?
1-Chloro-4-fluoro-2-methylbenzene, also known as p-fluoro-o-chlorotoluene, is a crucial raw material and intermediate in the field of organic compounds, and is widely used in many fields.
First, in the field of pharmaceutical synthesis, it plays an indispensable role. For example, in the process of creating some antibacterial drugs, 1-chloro-4-fluoro-2-methylbenzene can be used as a key starting material. Because its molecular structure contains specific functional groups, it can precisely build the molecular framework required for drug activity through a series of organic reactions, such as substitution reactions, addition reactions, etc. After careful design and reaction regulation, compounds with specific pharmacological activities can be obtained, opening up an effective path for the development of antimicrobial drugs and contributing to human health.
Second, in the field of pesticides, 1-chloro-4-fluoro-2-methylbenzene also plays an important role. It can be used as an important intermediate for the synthesis of new pesticides. With its unique chemical properties, it can react with other compounds to generate pesticide products with high insecticidal, bactericidal or herbicidal properties. These pesticides play a key role in modern agricultural production, which can effectively prevent and control crop diseases and pests, improve crop yield and quality, and ensure food security.
Furthermore, in the field of materials science, 1-chloro-4-fluoro-2-methylbenzene also has outstanding performance. For example, in the synthesis of special polymer materials, it can be introduced into the polymer chain as a functional monomer to give the material unique properties, such as improving the heat resistance and chemical corrosion resistance of the material. These high-performance materials are widely used in high-end fields such as aerospace and electronics, promoting technological progress and development in related industries.
In summary, although 1-chloro-4-fluoro-2-methylbenzene is one of the organic compounds, it has shown great application value in many fields such as medicine, pesticides, and materials science by virtue of its unique chemical structure and properties, and plays a pivotal role in promoting the development of various fields.
First, in the field of pharmaceutical synthesis, it plays an indispensable role. For example, in the process of creating some antibacterial drugs, 1-chloro-4-fluoro-2-methylbenzene can be used as a key starting material. Because its molecular structure contains specific functional groups, it can precisely build the molecular framework required for drug activity through a series of organic reactions, such as substitution reactions, addition reactions, etc. After careful design and reaction regulation, compounds with specific pharmacological activities can be obtained, opening up an effective path for the development of antimicrobial drugs and contributing to human health.
Second, in the field of pesticides, 1-chloro-4-fluoro-2-methylbenzene also plays an important role. It can be used as an important intermediate for the synthesis of new pesticides. With its unique chemical properties, it can react with other compounds to generate pesticide products with high insecticidal, bactericidal or herbicidal properties. These pesticides play a key role in modern agricultural production, which can effectively prevent and control crop diseases and pests, improve crop yield and quality, and ensure food security.
Furthermore, in the field of materials science, 1-chloro-4-fluoro-2-methylbenzene also has outstanding performance. For example, in the synthesis of special polymer materials, it can be introduced into the polymer chain as a functional monomer to give the material unique properties, such as improving the heat resistance and chemical corrosion resistance of the material. These high-performance materials are widely used in high-end fields such as aerospace and electronics, promoting technological progress and development in related industries.
In summary, although 1-chloro-4-fluoro-2-methylbenzene is one of the organic compounds, it has shown great application value in many fields such as medicine, pesticides, and materials science by virtue of its unique chemical structure and properties, and plays a pivotal role in promoting the development of various fields.
What are the physical properties of 1-chloro-4-fluoro-2-methylbenzene?
1-chloro-4-fluoro-2-methylbenzene is an organic compound with unique physical properties. Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid, which is caused by the combination and interaction of various atoms in its molecular structure.
When it comes to odor, it often has a special aromatic odor, which is a typical characteristic given by the structure of the benzene ring. The conjugate system of the benzene ring makes the molecule volatile to a certain extent, and some molecules escape into the air, which is perceived by the sense of smell.
Its boiling point is also an important physical property. It is roughly in a certain temperature range, which is determined by the intermolecular forces. There are van der Waals forces between molecules, including dispersion forces, induction forces and orientation forces. In addition, the presence of methyl groups, chlorine atoms and fluorine atoms affects the size of the intermolecular forces, resulting in a boiling point in a specific range. Specifically, the introduction of halogen atoms and methyl groups increases molecular polarity and enhances intermolecular forces, so the boiling point is slightly higher than that of benzene.
In terms of melting point, it is also affected by molecular structure. The regularity of molecular arrangement and intermolecular forces together determine the melting point. The molecular structure of this compound gives the molecular arrangement certain characteristics, and then has the corresponding melting point value.
In terms of solubility, 1-chloro-4-fluoro-2-methylbenzene is insoluble in water. This is because water is a polar molecule, and although the halogen atoms in the compound are slightly polar, the non-polar characteristics of the benzene ring are dominant. According to the principle of "similar miscibility", it is difficult to dissolve in polar water. However, in organic solvents, such as ethanol, ether, etc., the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are compatible with the intermolecular forces of the compound and are easy to mix with each other.
Density is also a key physical property. Compared with the density of water, there is a specific numerical relationship. Generally speaking, because the relative mass of halogen atoms in the molecule is larger, the overall density is greater than that of water. This property is important in practical application scenarios such as delamination.
When it comes to odor, it often has a special aromatic odor, which is a typical characteristic given by the structure of the benzene ring. The conjugate system of the benzene ring makes the molecule volatile to a certain extent, and some molecules escape into the air, which is perceived by the sense of smell.
Its boiling point is also an important physical property. It is roughly in a certain temperature range, which is determined by the intermolecular forces. There are van der Waals forces between molecules, including dispersion forces, induction forces and orientation forces. In addition, the presence of methyl groups, chlorine atoms and fluorine atoms affects the size of the intermolecular forces, resulting in a boiling point in a specific range. Specifically, the introduction of halogen atoms and methyl groups increases molecular polarity and enhances intermolecular forces, so the boiling point is slightly higher than that of benzene.
In terms of melting point, it is also affected by molecular structure. The regularity of molecular arrangement and intermolecular forces together determine the melting point. The molecular structure of this compound gives the molecular arrangement certain characteristics, and then has the corresponding melting point value.
In terms of solubility, 1-chloro-4-fluoro-2-methylbenzene is insoluble in water. This is because water is a polar molecule, and although the halogen atoms in the compound are slightly polar, the non-polar characteristics of the benzene ring are dominant. According to the principle of "similar miscibility", it is difficult to dissolve in polar water. However, in organic solvents, such as ethanol, ether, etc., the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are compatible with the intermolecular forces of the compound and are easy to mix with each other.
Density is also a key physical property. Compared with the density of water, there is a specific numerical relationship. Generally speaking, because the relative mass of halogen atoms in the molecule is larger, the overall density is greater than that of water. This property is important in practical application scenarios such as delamination.
Is 1-chloro-4-fluoro-2-methylbenzene chemically stable?
The chemical properties of 1-chloro-4-fluoro-2-methylbenzene are quite stable under normal conditions. The structure of the benzene ring has a unique conjugated system, which endows the benzene ring with special stability, making 1-chloro-4-fluoro-2-methylbenzene more stable than many polyopen-chain compounds.
In terms of its substituents, although the chlorine atom and the fluorine atom have a certain electron-withdrawing effect, in the conjugated system of the benzene ring, the influence of this electron-withdrawing effect is not enough to significantly damage the stability of the benzene ring. Methyl is the power supply group, which can increase the electron cloud density of the benzene ring, and also help to enhance the stability of the molecule to a certain extent.
In the general chemical environment, if there are no special reaction conditions, such as high temperature, high pressure, strong catalyst, etc., 1-chloro-4-fluoro-2-methylbenzene is difficult to chemically react. When encountering strong oxidizing agents or specific electrophilic reagents, substitution and other reactions can also occur due to the density distribution of electron clouds on the benzene ring. However, the occurrence of these reactions requires suitable conditions to overcome the energy barrier of the reaction.
It is important to note that 1-chloro-4-fluoro-2-methylbenzene has relatively stable chemical properties under common chemical environments and conditions, and is not prone to spontaneous significant chemical changes.
In terms of its substituents, although the chlorine atom and the fluorine atom have a certain electron-withdrawing effect, in the conjugated system of the benzene ring, the influence of this electron-withdrawing effect is not enough to significantly damage the stability of the benzene ring. Methyl is the power supply group, which can increase the electron cloud density of the benzene ring, and also help to enhance the stability of the molecule to a certain extent.
In the general chemical environment, if there are no special reaction conditions, such as high temperature, high pressure, strong catalyst, etc., 1-chloro-4-fluoro-2-methylbenzene is difficult to chemically react. When encountering strong oxidizing agents or specific electrophilic reagents, substitution and other reactions can also occur due to the density distribution of electron clouds on the benzene ring. However, the occurrence of these reactions requires suitable conditions to overcome the energy barrier of the reaction.
It is important to note that 1-chloro-4-fluoro-2-methylbenzene has relatively stable chemical properties under common chemical environments and conditions, and is not prone to spontaneous significant chemical changes.
What are 1-chloro-4-fluoro-2-methylbenzene synthesis methods?
There are several common methods for synthesizing 1-chloro-4-fluoro-2-methylbenzene.
First, it can be started from 2-methyl-4-fluoroaniline. First, it reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Subsequently, the diazonium salt is heated with a hydrochloric acid solution of cuprous chloride, and the diazonium group is replaced by a chlorine atom through a Sandmeier reaction to obtain 1-chloro-4-fluoro-2-methylbenzene. In this process, the diazotization reaction needs to be strictly controlled at temperature to prevent the decomposition of diazonium salts and affect the yield. And the preparation and use of cuprous chloride also need to follow a specific process to ensure the smooth progress of the reaction.
Second, 2-methyl-4-fluorobenzoic acid is used as raw material. First, it is converted into an acyl chloride, which can be co-heated with dichlorosulfoxide. Next, the acyl chloride interacts with a reducing agent such as lithium aluminum hydride to reduce it to an alcohol. Then the alcohol is chlorinated, and chlorination reagents such as phosphorus trichloride or sulfoxide chloride can be used to obtain the corresponding chlorine. Finally, the carboxyl group is removed through decarboxylation reaction to obtain the target product. There are a few more steps in this route, and each step of the reaction needs to be controlled by the reaction conditions, such as temperature, ratio of reactants, etc., in order to improve the yield of each step, and then ensure the yield of the final product.
Third, the nucleophilic substitution reaction of halogenated aromatics is used. Take 1-chloro-2-methylbenzene as the starting material, and react with fluorinating reagents such as potassium fluoride in the presence of appropriate solvents and catalysts. This reaction requires the selection of suitable solvents, such as dimethyl sulfoxide, etc., to enhance the solubility of potassium fluoride and promote the reaction. At the same time, the choice and dosage of catalysts also have an important impact on the reaction rate and yield. After nucleophilic substitution, the chlorine atom is replaced by the fluorine atom to generate 1-chloro-4-fluoro-2-methylbenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling reaction conditions and production costs, and choose the appropriate method.
First, it can be started from 2-methyl-4-fluoroaniline. First, it reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Subsequently, the diazonium salt is heated with a hydrochloric acid solution of cuprous chloride, and the diazonium group is replaced by a chlorine atom through a Sandmeier reaction to obtain 1-chloro-4-fluoro-2-methylbenzene. In this process, the diazotization reaction needs to be strictly controlled at temperature to prevent the decomposition of diazonium salts and affect the yield. And the preparation and use of cuprous chloride also need to follow a specific process to ensure the smooth progress of the reaction.
Second, 2-methyl-4-fluorobenzoic acid is used as raw material. First, it is converted into an acyl chloride, which can be co-heated with dichlorosulfoxide. Next, the acyl chloride interacts with a reducing agent such as lithium aluminum hydride to reduce it to an alcohol. Then the alcohol is chlorinated, and chlorination reagents such as phosphorus trichloride or sulfoxide chloride can be used to obtain the corresponding chlorine. Finally, the carboxyl group is removed through decarboxylation reaction to obtain the target product. There are a few more steps in this route, and each step of the reaction needs to be controlled by the reaction conditions, such as temperature, ratio of reactants, etc., in order to improve the yield of each step, and then ensure the yield of the final product.
Third, the nucleophilic substitution reaction of halogenated aromatics is used. Take 1-chloro-2-methylbenzene as the starting material, and react with fluorinating reagents such as potassium fluoride in the presence of appropriate solvents and catalysts. This reaction requires the selection of suitable solvents, such as dimethyl sulfoxide, etc., to enhance the solubility of potassium fluoride and promote the reaction. At the same time, the choice and dosage of catalysts also have an important impact on the reaction rate and yield. After nucleophilic substitution, the chlorine atom is replaced by the fluorine atom to generate 1-chloro-4-fluoro-2-methylbenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling reaction conditions and production costs, and choose the appropriate method.
1-chloro-4-fluoro-2-methylbenzene What are the precautions in storage and transportation?
1-Chloro-4-fluoro-2-methylbenzene is also one of the organic compounds. During storage and transportation, many matters must be paid attention to.
First words storage. This compound should be placed in a cool and ventilated place. Because of its volatility, high temperature or vapor pressure rise, there is a risk of leakage. The warehouse temperature should be controlled in a suitable range to prevent danger caused by excessive temperature. And it must be kept away from fire and heat sources. The cover can be burned in case of open flame or hot topic because it is flammable. At the same time, it should be stored separately from oxidizing agents, acids, alkalis, etc. These substances come into contact with it or react violently, resulting in accidents. The storage area should also be equipped with suitable materials to contain leaks, so as to prevent timely disposal in case of leakage.
Times and transportation. Before transportation, the packaging must ensure that it is tight. Appropriate packaging materials should be selected in accordance with relevant regulations to ensure that there is no leakage or damage during transportation. During transportation, the vehicles used shall be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from sun exposure, rain and high temperature. During transportation, it should be driven according to the prescribed route, and do not stop in residential areas and densely populated areas. When loading and unloading, care must also be taken to prevent damage to packaging and containers.
All of these are to be taken into account when storing and transporting 1-chloro-4-fluoro-2-methylbenzene, so as to ensure safety and avoid disasters.
First words storage. This compound should be placed in a cool and ventilated place. Because of its volatility, high temperature or vapor pressure rise, there is a risk of leakage. The warehouse temperature should be controlled in a suitable range to prevent danger caused by excessive temperature. And it must be kept away from fire and heat sources. The cover can be burned in case of open flame or hot topic because it is flammable. At the same time, it should be stored separately from oxidizing agents, acids, alkalis, etc. These substances come into contact with it or react violently, resulting in accidents. The storage area should also be equipped with suitable materials to contain leaks, so as to prevent timely disposal in case of leakage.
Times and transportation. Before transportation, the packaging must ensure that it is tight. Appropriate packaging materials should be selected in accordance with relevant regulations to ensure that there is no leakage or damage during transportation. During transportation, the vehicles used shall be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it should be protected from sun exposure, rain and high temperature. During transportation, it should be driven according to the prescribed route, and do not stop in residential areas and densely populated areas. When loading and unloading, care must also be taken to prevent damage to packaging and containers.
All of these are to be taken into account when storing and transporting 1-chloro-4-fluoro-2-methylbenzene, so as to ensure safety and avoid disasters.
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