Linshang Chemical
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1-Chloro-4-Fluoro-2-Nitrobenzene
Linshang Chemical
|
HS Code |
156634 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Pale yellow to light brown solid |
| Melting Point | 45 - 47 °C |
| Boiling Point | 214 - 216 °C |
| Density | 1.487 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Vapor Pressure | Low vapor pressure |
| Flash Point | 92 °C |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Chloro-4-Fluoro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 4 - fluoro - 2 - nitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 1 - Chloro - 4 - fluoro - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Adhere to safety regulations to avoid potential hazards. |
| Shipping | 1 - Chloro - 4 - fluoro - 2 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous material regulations, ensuring proper handling to prevent spills and environmental or safety risks during transit. |
Competitive 1-Chloro-4-Fluoro-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-4-Fluoro-2-Nitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-Fluoro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-4-fluoro-2-nitrobenzene?
1-Chloro-4-fluoro-2-nitrobenzene is also an organic compound. It has a wide range of uses and has important applications in various fields of chemical industry.
The first one is the backbone raw material for organic synthesis. With its unique chemical structure, it can be derived from a variety of organic compounds through various chemical reactions. For example, it can be substituted with nucleophiles to prepare various derivatives containing chlorine, fluorine and nitro groups, which is of great significance in the field of medicinal chemistry. It can be converted into pharmaceutical intermediates with specific pharmacological activities through specific reaction pathways, providing a key foundation for the creation of new drugs.
Furthermore, it also has important functions in the field of materials science. It can be used as a starting material for the synthesis of special polymer materials. By means of polymerization reaction, its structural units are introduced into the polymer chain to endow the material with unique physical and chemical properties, such as enhancing the stability of the material, heat resistance or changing its optical properties. It has potential applications in electronic materials, high-performance coatings, etc.
In addition, it also has a place in the dye industry. Due to its structural characteristics, it can be properly modified and transformed to prepare dyes with brilliant colors and excellent performance. Using the functional groups such as chlorine, fluorine and nitro, the molecular structure and electron cloud distribution of the dye can be adjusted, so as to achieve precise regulation of key properties such as dye color, light resistance and dyeing fastness.
In conclusion, 1-chloro-4-fluoro-2-nitrobenzene, with its unique chemical structure, plays an indispensable role in many fields such as organic synthesis, materials science, and dye industry, and is of great significance to the development of related industries.
The first one is the backbone raw material for organic synthesis. With its unique chemical structure, it can be derived from a variety of organic compounds through various chemical reactions. For example, it can be substituted with nucleophiles to prepare various derivatives containing chlorine, fluorine and nitro groups, which is of great significance in the field of medicinal chemistry. It can be converted into pharmaceutical intermediates with specific pharmacological activities through specific reaction pathways, providing a key foundation for the creation of new drugs.
Furthermore, it also has important functions in the field of materials science. It can be used as a starting material for the synthesis of special polymer materials. By means of polymerization reaction, its structural units are introduced into the polymer chain to endow the material with unique physical and chemical properties, such as enhancing the stability of the material, heat resistance or changing its optical properties. It has potential applications in electronic materials, high-performance coatings, etc.
In addition, it also has a place in the dye industry. Due to its structural characteristics, it can be properly modified and transformed to prepare dyes with brilliant colors and excellent performance. Using the functional groups such as chlorine, fluorine and nitro, the molecular structure and electron cloud distribution of the dye can be adjusted, so as to achieve precise regulation of key properties such as dye color, light resistance and dyeing fastness.
In conclusion, 1-chloro-4-fluoro-2-nitrobenzene, with its unique chemical structure, plays an indispensable role in many fields such as organic synthesis, materials science, and dye industry, and is of great significance to the development of related industries.
What are the physical properties of 1-chloro-4-fluoro-2-nitrobenzene?
1-Chloro-4-fluoro-2-nitrobenzene is also an organic compound. Its physical properties are quite many, let me tell them one by one.
First of all, its appearance, at room temperature, 1-chloro-4-fluoro-2-nitrobenzene is a light yellow to brown liquid, which is quite colorful. The formation of this color is due to the arrangement of atoms in its molecular structure and the distribution of electron clouds, which cause it to absorb specific wavelengths of visible light, so that this color can be displayed.
Second, its boiling point is about 220 degrees Celsius. The level of boiling point depends on the strength of intermolecular forces. This compound contains van der Waals forces between molecules, and due to the presence of nitro groups, chlorine atoms and fluorine atoms, the molecular polarity is enhanced, resulting in dipole-dipole interaction, which increases the attractive force between molecules. To make it change from liquid to gaseous state, more energy needs to be supplied, so the boiling point is high.
Furthermore, its melting point is about -20 ° C. The melting point reflects the temperature at which the solid and liquid states of a substance are converted. The melting point is low. Although the molecular structure of the lid has a certain symmetry, it is still not enough to form a tightly ordered lattice structure. The lattice energy is limited, and the lattice is easily destroyed when heated slightly, thus melting.
The density of 1-chloro-4-fluoro-2-nitrobenzene is greater than that of water. When placed in water, it will sink to the bottom of the water. Due to the large number of atoms in the molecule, the relative molecular mass is large, and the molecular structure is relatively compact, the mass per unit volume is large, and the density is therefore greater than that of water.
In terms of solubility, it is difficult to dissolve in water. Because water is an extremely polar solvent, and 1-chloro-4-fluoro-2-nitrobenzene has a certain polarity, the proportion of hydrocarbons in the molecule is large, and the polarity is significantly different from that of water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., because the intermolecular force between the organic solvent and the compound is similar, and it can be mixed evenly with each other.
In addition, 1-chloro-4-fluoro-2-nitrobenzene is volatile to a certain extent and can evaporate slowly in the air. This is the result of the thermal movement of the molecule, and the molecule obtains enough energy to break free from the attractive force between molecules and escape into the gas phase. Its vapor has an irritating odor, which can be sensed by people, and may have a stimulating effect on the human respiratory tract and other parts. When used, it should be taken precautions.
First of all, its appearance, at room temperature, 1-chloro-4-fluoro-2-nitrobenzene is a light yellow to brown liquid, which is quite colorful. The formation of this color is due to the arrangement of atoms in its molecular structure and the distribution of electron clouds, which cause it to absorb specific wavelengths of visible light, so that this color can be displayed.
Second, its boiling point is about 220 degrees Celsius. The level of boiling point depends on the strength of intermolecular forces. This compound contains van der Waals forces between molecules, and due to the presence of nitro groups, chlorine atoms and fluorine atoms, the molecular polarity is enhanced, resulting in dipole-dipole interaction, which increases the attractive force between molecules. To make it change from liquid to gaseous state, more energy needs to be supplied, so the boiling point is high.
Furthermore, its melting point is about -20 ° C. The melting point reflects the temperature at which the solid and liquid states of a substance are converted. The melting point is low. Although the molecular structure of the lid has a certain symmetry, it is still not enough to form a tightly ordered lattice structure. The lattice energy is limited, and the lattice is easily destroyed when heated slightly, thus melting.
The density of 1-chloro-4-fluoro-2-nitrobenzene is greater than that of water. When placed in water, it will sink to the bottom of the water. Due to the large number of atoms in the molecule, the relative molecular mass is large, and the molecular structure is relatively compact, the mass per unit volume is large, and the density is therefore greater than that of water.
In terms of solubility, it is difficult to dissolve in water. Because water is an extremely polar solvent, and 1-chloro-4-fluoro-2-nitrobenzene has a certain polarity, the proportion of hydrocarbons in the molecule is large, and the polarity is significantly different from that of water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., because the intermolecular force between the organic solvent and the compound is similar, and it can be mixed evenly with each other.
In addition, 1-chloro-4-fluoro-2-nitrobenzene is volatile to a certain extent and can evaporate slowly in the air. This is the result of the thermal movement of the molecule, and the molecule obtains enough energy to break free from the attractive force between molecules and escape into the gas phase. Its vapor has an irritating odor, which can be sensed by people, and may have a stimulating effect on the human respiratory tract and other parts. When used, it should be taken precautions.
What is the chemistry of 1-chloro-4-fluoro-2-nitrobenzene?
1-Chloro-4-fluoro-2-nitrobenzene is also an organic compound. Its molecules contain chlorine, fluorine, nitro and other functional groups, which give their unique chemical properties.
Let's talk about halogen atoms first. Chlorine and fluorine are the genus of halogen elements. Halogen atoms are highly active and can involve many chemical reactions. Such as nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Because the electronegativity of fluorine is higher than that of chlorine, the electron cloud density of fluorine atoms is lower, and nucleophilic reagents are more likely to attack the position of fluorine atoms and replace them. However, this substitution is also affected by reaction conditions, such as nucleophilic reagent activity, solvent properties, temperature, etc. High temperature or strong nucleophilic reagents can promote the reaction to accelerate.
Let's talk about nitro again. Nitro is a strong electron-absorbing group and has an electron-pulling effect. It reduces the electron cloud density of the benzene ring and causes the activity of the electrophilic substitution of the benzene ring to decrease. If you want to make the benzene ring electrophilic substitution, more severe conditions are required than without nitro. However, nitro can enhance the polarity of molecules and affect their physical properties, such as boiling point and solubility. In addition, nitro can be reduced under specific conditions. For example, with iron, hydrochloric acid, etc. as reducing agents, nitro can be gradually converted into amino groups, which is very important for the preparation of amino-containing compounds in organic synthesis.
1-chloro-4-fluoro-2-nitrophenyl contains a variety of special functional groups, which are chemically active and can be used as intermediates in the field of organic synthesis such as drugs, pesticides, dyes, etc. When it participates in the reaction, the functional groups interact with each other, and the reaction is complex. The reaction conditions need to be carefully adjusted according to actual needs to achieve the desired product.
Let's talk about halogen atoms first. Chlorine and fluorine are the genus of halogen elements. Halogen atoms are highly active and can involve many chemical reactions. Such as nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Because the electronegativity of fluorine is higher than that of chlorine, the electron cloud density of fluorine atoms is lower, and nucleophilic reagents are more likely to attack the position of fluorine atoms and replace them. However, this substitution is also affected by reaction conditions, such as nucleophilic reagent activity, solvent properties, temperature, etc. High temperature or strong nucleophilic reagents can promote the reaction to accelerate.
Let's talk about nitro again. Nitro is a strong electron-absorbing group and has an electron-pulling effect. It reduces the electron cloud density of the benzene ring and causes the activity of the electrophilic substitution of the benzene ring to decrease. If you want to make the benzene ring electrophilic substitution, more severe conditions are required than without nitro. However, nitro can enhance the polarity of molecules and affect their physical properties, such as boiling point and solubility. In addition, nitro can be reduced under specific conditions. For example, with iron, hydrochloric acid, etc. as reducing agents, nitro can be gradually converted into amino groups, which is very important for the preparation of amino-containing compounds in organic synthesis.
1-chloro-4-fluoro-2-nitrophenyl contains a variety of special functional groups, which are chemically active and can be used as intermediates in the field of organic synthesis such as drugs, pesticides, dyes, etc. When it participates in the reaction, the functional groups interact with each other, and the reaction is complex. The reaction conditions need to be carefully adjusted according to actual needs to achieve the desired product.
What are 1-chloro-4-fluoro-2-nitrobenzene synthesis methods?
There are several methods for the synthesis of 1-chloro-4-fluoro-2-nitrobenzene.
First, 4-fluoro-2-nitroaniline is used as the starting material. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature. This process needs to be carefully controlled to prevent side reactions from breeding. After the diazotization is completed, the hydrochloric acid solution of cuprous chloride is added, and the Sandmeier reaction occurs, thereby replacing the diazo group with a chlorine atom to obtain the target product 1-chloro-4-fluoro-2-nitrobenzene. The conditions of this method are relatively mild and the yield is acceptable. However, the reagent sodium nitrite used has certain toxicity. Safety protection should be paid attention to during operation, and the diazotization reaction requires strict reaction conditions.
Second, 4-fluorochlorobenzene is used as the raw material. First carry out nitrification reaction, add an appropriate amount of mixed acid of nitric acid and sulfuric acid to the system, and react at an appropriate temperature. In the nitrification reaction, it is necessary to precisely control the temperature and the proportion of mixed acid, because different conditions will cause different nitro substitution positions in the product. By optimizing the conditions, the nitro is mainly substituted in the ortho-position of the chlorine atom to generate 1-chloro-4-fluoro-2-nitrobenzene. The raw materials in this way are relatively easy to obtain, but the nitrification reaction is highly dangerous, both sulfuric acid and nitric acid are highly corrosive, so care must be taken during operation, and the post-reaction treatment is complicated, and the waste acid needs to be properly disposed of.
Third, use 1,4-difluorobenzene as the starting material. First, let 1,4-difluorobenzene react with nitrogenation reagents to introduce nitro groups to generate 4-fluoro-1-nitrobenzene. After that, the chlorination reaction can be carried out, and suitable chlorination reagents such as chlorine gas and thionyl chloride can be selected. Under the action of the catalyst, the chlorine atom replaces the hydrogen at the ortho-position of the fluorine atom to obtain 1-chloro-4-fluoro-2-nitrobenzene. This method has a little more steps, but the selectivity of each step is relatively good, but some reagents such as chlorine should be paid attention to when using it, because it is toxic and strong oxidizing.
First, 4-fluoro-2-nitroaniline is used as the starting material. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature. This process needs to be carefully controlled to prevent side reactions from breeding. After the diazotization is completed, the hydrochloric acid solution of cuprous chloride is added, and the Sandmeier reaction occurs, thereby replacing the diazo group with a chlorine atom to obtain the target product 1-chloro-4-fluoro-2-nitrobenzene. The conditions of this method are relatively mild and the yield is acceptable. However, the reagent sodium nitrite used has certain toxicity. Safety protection should be paid attention to during operation, and the diazotization reaction requires strict reaction conditions.
Second, 4-fluorochlorobenzene is used as the raw material. First carry out nitrification reaction, add an appropriate amount of mixed acid of nitric acid and sulfuric acid to the system, and react at an appropriate temperature. In the nitrification reaction, it is necessary to precisely control the temperature and the proportion of mixed acid, because different conditions will cause different nitro substitution positions in the product. By optimizing the conditions, the nitro is mainly substituted in the ortho-position of the chlorine atom to generate 1-chloro-4-fluoro-2-nitrobenzene. The raw materials in this way are relatively easy to obtain, but the nitrification reaction is highly dangerous, both sulfuric acid and nitric acid are highly corrosive, so care must be taken during operation, and the post-reaction treatment is complicated, and the waste acid needs to be properly disposed of.
Third, use 1,4-difluorobenzene as the starting material. First, let 1,4-difluorobenzene react with nitrogenation reagents to introduce nitro groups to generate 4-fluoro-1-nitrobenzene. After that, the chlorination reaction can be carried out, and suitable chlorination reagents such as chlorine gas and thionyl chloride can be selected. Under the action of the catalyst, the chlorine atom replaces the hydrogen at the ortho-position of the fluorine atom to obtain 1-chloro-4-fluoro-2-nitrobenzene. This method has a little more steps, but the selectivity of each step is relatively good, but some reagents such as chlorine should be paid attention to when using it, because it is toxic and strong oxidizing.
What are the precautions in storage and transportation of 1-chloro-4-fluoro-2-nitrobenzene?
1-Chloro-4-fluoro-2-nitrobenzene is also an organic compound. During storage and transportation, many important things must not be ignored.
First word storage. This substance is dangerous and needs to be placed in a cool and well-ventilated place. Because of the cool environment, it can be prevented from changing due to excessive temperature. If it is heated, or its chemical properties change, and even dangerous reactions occur. Well ventilated, it can disperse harmful gases that may escape in time and keep the environment safe. And be sure to keep away from fire and heat sources, both of which are the causes of danger. Occasionally, fire or heat sources encounter this substance, which can easily trigger combustion and even explosion.
In addition, the storage place should be equipped with suitable materials to contain leaks. In case of leakage, it can be properly handled in time to prevent its spread and cause greater harm. It should also be separated from oxidants and food chemicals and should not be mixed. Due to the severe chemical reaction of oxidants or with 1-chloro-4-fluoro-2-nitrobenzene, and the food chemicals are mixed with it, once it leaks, it may cause food contamination and endanger life and health.
As for transportation, it is also necessary to be cautious. Vehicles must be in good condition and have reliable safety protection facilities. During transportation, always pay attention to changes in temperature and humidity, strictly control the speed and route of traffic, and avoid water sources and densely populated areas. If it passes through a populated place, in case of leakage, the harm will be infinite. And transportation personnel should be professionally trained and familiar with the characteristics and emergency treatment methods of 1-chloro-4-fluoro-2-nitrobenzene. In case of emergencies, they can properly respond and reduce the harm. In short, the storage and transportation of 1-chloro-4-fluoro-2-nitrobenzene must be paid attention to at all times and be careful at all times to ensure safety.
First word storage. This substance is dangerous and needs to be placed in a cool and well-ventilated place. Because of the cool environment, it can be prevented from changing due to excessive temperature. If it is heated, or its chemical properties change, and even dangerous reactions occur. Well ventilated, it can disperse harmful gases that may escape in time and keep the environment safe. And be sure to keep away from fire and heat sources, both of which are the causes of danger. Occasionally, fire or heat sources encounter this substance, which can easily trigger combustion and even explosion.
In addition, the storage place should be equipped with suitable materials to contain leaks. In case of leakage, it can be properly handled in time to prevent its spread and cause greater harm. It should also be separated from oxidants and food chemicals and should not be mixed. Due to the severe chemical reaction of oxidants or with 1-chloro-4-fluoro-2-nitrobenzene, and the food chemicals are mixed with it, once it leaks, it may cause food contamination and endanger life and health.
As for transportation, it is also necessary to be cautious. Vehicles must be in good condition and have reliable safety protection facilities. During transportation, always pay attention to changes in temperature and humidity, strictly control the speed and route of traffic, and avoid water sources and densely populated areas. If it passes through a populated place, in case of leakage, the harm will be infinite. And transportation personnel should be professionally trained and familiar with the characteristics and emergency treatment methods of 1-chloro-4-fluoro-2-nitrobenzene. In case of emergencies, they can properly respond and reduce the harm. In short, the storage and transportation of 1-chloro-4-fluoro-2-nitrobenzene must be paid attention to at all times and be careful at all times to ensure safety.
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