Linshang Chemical
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1-Chloro-4-Fluoro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
574221 |
| Chemical Formula | C6H3ClFNO2 |
| Molecular Weight | 177.54 |
| Appearance | Yellow to orange solid |
| Boiling Point | 236 - 238 °C |
| Melting Point | 38 - 42 °C |
| Density | 1.52 g/cm³ |
| Flash Point | 100 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Chloro-4-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - fluoro - 3 - nitrobenzene in 1 - kg sealed containers for chemical packaging. |
| Storage | 1 - Chloro - 4 - fluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture. It should be separated from incompatible substances, and the storage area should be clearly labeled for easy identification and safety. |
| Shipping | 1 - Chloro - 4 - fluoro - 3 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported via approved chemical - handling carriers, following strict safety regulations to prevent spills and ensure safe transit. |
Competitive 1-Chloro-4-Fluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-4-Fluoro-3-Nitrobenzene in China?
As a trusted 1-Chloro-4-Fluoro-3-Nitrobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-4-fluoro-3-nitrobenzene?
1-Chloro-4-fluoro-3-nitrobenzene is an organic compound with the Chinese name 1-chloro-4-fluoro-3-nitrobenzene. Its main uses are many, and are described as follows:
First in the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique reactivity of functional groups such as chlorine, fluorine and nitro in the molecule, chemists can modify and transform its structure through various chemical reactions, and then synthesize organic compounds with more complex structures and more specific functions. For example, through nucleophilic substitution reactions, chlorine atoms or fluorine atoms can be replaced by other nucleophilic reagents to derive a series of new organic molecules, which is of great significance in the field of medicinal chemistry and materials science.
Furthermore, in the process of drug development, 1-chloro-4-fluoro-3-nitrobenzene also plays a pivotal role. Due to its special chemical structure, it can be used as the starting material for lead compounds. After structural optimization and modification, it is expected to create drug molecules with specific biological activities. Studies have shown that compounds containing such structures show certain affinity and inhibitory activity to certain disease targets, opening up broad prospects for the development of new drugs.
In the field of materials science, this compound is also useful. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials, giving the materials unique electrical, optical or thermal properties. For example, when synthesizing optoelectronic materials, the introduction of this structure may improve the charge transport properties and luminous efficiency of the materials, and then be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs).
In addition, 1-chloro-4-fluoro-3-nitrobenzene is also used in the dye industry. Using its structural properties, dyes with special colors and stability can be synthesized to meet the needs of high-quality dyes in textile, printing and other industries.
In summary, 1-chloro-4-fluoro-3-nitrobenzene, with its unique structure and reactivity, plays a key role in many fields such as organic synthesis, drug research and development, materials science, and dye industry, and has made significant contributions to the development of related industries.
First in the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique reactivity of functional groups such as chlorine, fluorine and nitro in the molecule, chemists can modify and transform its structure through various chemical reactions, and then synthesize organic compounds with more complex structures and more specific functions. For example, through nucleophilic substitution reactions, chlorine atoms or fluorine atoms can be replaced by other nucleophilic reagents to derive a series of new organic molecules, which is of great significance in the field of medicinal chemistry and materials science.
Furthermore, in the process of drug development, 1-chloro-4-fluoro-3-nitrobenzene also plays a pivotal role. Due to its special chemical structure, it can be used as the starting material for lead compounds. After structural optimization and modification, it is expected to create drug molecules with specific biological activities. Studies have shown that compounds containing such structures show certain affinity and inhibitory activity to certain disease targets, opening up broad prospects for the development of new drugs.
In the field of materials science, this compound is also useful. Through appropriate chemical reactions, it can be introduced into the structure of polymer materials, giving the materials unique electrical, optical or thermal properties. For example, when synthesizing optoelectronic materials, the introduction of this structure may improve the charge transport properties and luminous efficiency of the materials, and then be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs).
In addition, 1-chloro-4-fluoro-3-nitrobenzene is also used in the dye industry. Using its structural properties, dyes with special colors and stability can be synthesized to meet the needs of high-quality dyes in textile, printing and other industries.
In summary, 1-chloro-4-fluoro-3-nitrobenzene, with its unique structure and reactivity, plays a key role in many fields such as organic synthesis, drug research and development, materials science, and dye industry, and has made significant contributions to the development of related industries.
What are the physical properties of 1-chloro-4-fluoro-3-nitrobenzene?
1-Chloro-4-fluoro-3-nitrobenzene is also an organic compound. Its physical properties are particularly important and are listed below.
First of all, its appearance, under room temperature and pressure, 1-chloro-4-fluoro-3-nitrobenzene is colorless to light yellow liquid, clear and has a special odor. Looking at its color and shape, this is a preliminary sign of identification.
When it comes to the melting point, it is about -10 ° C. At this temperature, the substance changes from solid to liquid. The determination of the melting point is crucial for the identification and purity judgment of the substance. The boiling point is about 235 ° C. When the temperature reaches this point, the compound converts from a liquid state to a gaseous state, and the boiling phenomenon characterizes the critical temperature of its gas-liquid phase transition.
In terms of density, it is about 1.5g/cm ³. This value is related to its distribution when mixed with other substances, the size of the density, and its behavior in different media.
Solubility is one of the important properties. 1-Chloro-4-fluoro-3-nitrobenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it suitable for the selection of solvents in the field of organic synthesis.
In addition, the compound has a certain volatility and can evaporate slowly in the air. This property should be paid attention to when storing and using, because its volatilization may affect the environment and human health. And because its molecular structure contains functional groups such as chlorine, fluorine, and nitro, it has a certain polarity, which affects its physical and chemical properties, such as its interaction with other molecules. All these physical properties lay the foundation for the study and application of 1-chloro-4-fluoro-3-nitrobenzene. In many fields such as chemical industry and medicine, its properties need to be understood in detail before they can be used effectively.
First of all, its appearance, under room temperature and pressure, 1-chloro-4-fluoro-3-nitrobenzene is colorless to light yellow liquid, clear and has a special odor. Looking at its color and shape, this is a preliminary sign of identification.
When it comes to the melting point, it is about -10 ° C. At this temperature, the substance changes from solid to liquid. The determination of the melting point is crucial for the identification and purity judgment of the substance. The boiling point is about 235 ° C. When the temperature reaches this point, the compound converts from a liquid state to a gaseous state, and the boiling phenomenon characterizes the critical temperature of its gas-liquid phase transition.
In terms of density, it is about 1.5g/cm ³. This value is related to its distribution when mixed with other substances, the size of the density, and its behavior in different media.
Solubility is one of the important properties. 1-Chloro-4-fluoro-3-nitrobenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic makes it suitable for the selection of solvents in the field of organic synthesis.
In addition, the compound has a certain volatility and can evaporate slowly in the air. This property should be paid attention to when storing and using, because its volatilization may affect the environment and human health. And because its molecular structure contains functional groups such as chlorine, fluorine, and nitro, it has a certain polarity, which affects its physical and chemical properties, such as its interaction with other molecules. All these physical properties lay the foundation for the study and application of 1-chloro-4-fluoro-3-nitrobenzene. In many fields such as chemical industry and medicine, its properties need to be understood in detail before they can be used effectively.
What are the chemical properties of 1-chloro-4-fluoro-3-nitrobenzene?
1-Chloro-4-fluoro-3-nitrobenzene is also an organic compound. Its molecular structure contains chlorine atoms, fluorine atoms and nitro groups, which give it unique chemical properties.
As far as its nucleophilic substitution reactivity is concerned, the nitro group has strong electron absorption, which can reduce the electron cloud density of the benzene ring, making the carbon atoms on the benzene ring more vulnerable to attack by nucleophilic reagents. Among them, the positions of chlorine atoms and fluorine atoms are affected by nitro groups, so they can all participate in the nucleophilic substitution reaction. However, due to the high C-F bond energy of fluorine atoms, chlorine atoms are usually more easily replaced by nucleophilic reagents.
Furthermore, its reducing properties are also worthy of attention. Nitro groups can be reduced under suitable conditions. Common reducing agents such as iron and hydrochloric acid, hydrogen and catalysts can gradually reduce nitro groups to amino groups to obtain corresponding chlorofluoroanilines.
In addition, 1-chloro-4-fluoro-3-nitrobenzene can also participate in aromatic electrophilic substitution reactions. Although nitro groups are meta-sites, the electrophilic substitution reaction mainly occurs in the position between nitro groups, but due to the presence of chlorine atoms and fluorine atoms, the reactivity and localization effects will also change. The selectivity of the reaction check point needs to comprehensively consider the electronic and spatial effects of each atomic group.
This compound is widely used in the field of organic synthesis and can be used as an intermediate to prepare a variety of organic compounds such as drugs, pesticides and materials. With its diverse chemical properties, it plays an important role in organic synthesis chemistry.
As far as its nucleophilic substitution reactivity is concerned, the nitro group has strong electron absorption, which can reduce the electron cloud density of the benzene ring, making the carbon atoms on the benzene ring more vulnerable to attack by nucleophilic reagents. Among them, the positions of chlorine atoms and fluorine atoms are affected by nitro groups, so they can all participate in the nucleophilic substitution reaction. However, due to the high C-F bond energy of fluorine atoms, chlorine atoms are usually more easily replaced by nucleophilic reagents.
Furthermore, its reducing properties are also worthy of attention. Nitro groups can be reduced under suitable conditions. Common reducing agents such as iron and hydrochloric acid, hydrogen and catalysts can gradually reduce nitro groups to amino groups to obtain corresponding chlorofluoroanilines.
In addition, 1-chloro-4-fluoro-3-nitrobenzene can also participate in aromatic electrophilic substitution reactions. Although nitro groups are meta-sites, the electrophilic substitution reaction mainly occurs in the position between nitro groups, but due to the presence of chlorine atoms and fluorine atoms, the reactivity and localization effects will also change. The selectivity of the reaction check point needs to comprehensively consider the electronic and spatial effects of each atomic group.
This compound is widely used in the field of organic synthesis and can be used as an intermediate to prepare a variety of organic compounds such as drugs, pesticides and materials. With its diverse chemical properties, it plays an important role in organic synthesis chemistry.
What are 1-chloro-4-fluoro-3-nitrobenzene synthesis methods?
There are several ways to synthesize 1-chloro-4-fluoro-3-nitrobenzene.
First, 4-fluoro-3-nitroaniline is used as the starting material. First, 4-fluoro-3-nitroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature. This reaction requires strict temperature control to prevent the decomposition of diazonium salts. After the diazotization is completed, it reacts with the hydrochloric acid solution of cuprous chloride to undergo a Sandmeier reaction to obtain 1-chloro-4-fluoro-3-nitrobenzene. The advantage of this method is that the reaction selectivity is quite high and the product purity is good.
Second, start from 4-fluoroaniline. First, 4-fluoroaniline is nitrified, and the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrification reagent. The nitro group is introduced to generate 4-fluoro-3-nitroaniline. Then, as mentioned above, the synthesis of 1-chloro-4-fluoro-3-nitrobenzene is achieved by diazotization and Sandmeier reaction. This path is relatively direct and the raw materials are relatively easy to obtain.
Third, 1-chloro-4-fluorobenzene is used as the starting material. In the presence of suitable catalysts, such as aluminum trichloride, nitrification is carried out with fuming nitric acid, and nitro groups are directly introduced into the benzene ring to obtain 1-chloro-4-fluoro-3-nitrobenzene. This method is a short step, but the reaction conditions need to be carefully adjusted to ensure the positional selectivity of nitro introduction.
The above synthesis methods have their own advantages and disadvantages. In actual operation, the most suitable synthesis path should be selected according to the comprehensive consideration of various factors such as raw material availability, cost, reaction conditions and product purity requirements.
First, 4-fluoro-3-nitroaniline is used as the starting material. First, 4-fluoro-3-nitroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature. This reaction requires strict temperature control to prevent the decomposition of diazonium salts. After the diazotization is completed, it reacts with the hydrochloric acid solution of cuprous chloride to undergo a Sandmeier reaction to obtain 1-chloro-4-fluoro-3-nitrobenzene. The advantage of this method is that the reaction selectivity is quite high and the product purity is good.
Second, start from 4-fluoroaniline. First, 4-fluoroaniline is nitrified, and the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrification reagent. The nitro group is introduced to generate 4-fluoro-3-nitroaniline. Then, as mentioned above, the synthesis of 1-chloro-4-fluoro-3-nitrobenzene is achieved by diazotization and Sandmeier reaction. This path is relatively direct and the raw materials are relatively easy to obtain.
Third, 1-chloro-4-fluorobenzene is used as the starting material. In the presence of suitable catalysts, such as aluminum trichloride, nitrification is carried out with fuming nitric acid, and nitro groups are directly introduced into the benzene ring to obtain 1-chloro-4-fluoro-3-nitrobenzene. This method is a short step, but the reaction conditions need to be carefully adjusted to ensure the positional selectivity of nitro introduction.
The above synthesis methods have their own advantages and disadvantages. In actual operation, the most suitable synthesis path should be selected according to the comprehensive consideration of various factors such as raw material availability, cost, reaction conditions and product purity requirements.
1-chloro-4-fluoro-3-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-4-fluoro-3-nitrobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage, this compound is dangerous and should be stored in a cool and ventilated warehouse. Due to the danger caused by heat, the temperature of the warehouse should not be too high, preferably below 30 ° C. And it is sensitive to air, moisture or can be stored in a sealed manner to prevent the risk of deterioration in contact with air and moisture. At the same time, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed to avoid chemical reactions and accidents.
As for transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals. Transportation vehicles must have corresponding qualifications and protective facilities to ensure safety. During the handling process, the operator should be light and light, do not drop, heavy pressure, so as not to damage the packaging and cause material leakage. In addition, during transportation, it is necessary to prevent exposure to the sun, rain, and avoid high temperature and humid environment. The means of transportation should be kept clean, and no substances that can react with it should be left. The packaging must also be strong and tight, and hazard signs should be posted as required for identification and prevention. In this way, it is necessary to ensure the safety of 1-chloro-4-fluoro-3-nitrobenzene during storage and transportation.
First words storage, this compound is dangerous and should be stored in a cool and ventilated warehouse. Due to the danger caused by heat, the temperature of the warehouse should not be too high, preferably below 30 ° C. And it is sensitive to air, moisture or can be stored in a sealed manner to prevent the risk of deterioration in contact with air and moisture. At the same time, it should be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed to avoid chemical reactions and accidents.
As for transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals. Transportation vehicles must have corresponding qualifications and protective facilities to ensure safety. During the handling process, the operator should be light and light, do not drop, heavy pressure, so as not to damage the packaging and cause material leakage. In addition, during transportation, it is necessary to prevent exposure to the sun, rain, and avoid high temperature and humid environment. The means of transportation should be kept clean, and no substances that can react with it should be left. The packaging must also be strong and tight, and hazard signs should be posted as required for identification and prevention. In this way, it is necessary to ensure the safety of 1-chloro-4-fluoro-3-nitrobenzene during storage and transportation.
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