1-[Chloro(4-Fluorophenyl)Phenylmethyl]-2-Fluorobenzene
Linshang Chemical
HS Code |
943780 |
Chemical Formula | C19H12ClF2 |
Molecular Weight | 314.75 |
Appearance | Solid (predicted) |
Solubility In Water | Low (aromatic compounds are generally hydrophobic) |
Logp | High (hydrophobic due to aromatic rings, predicted) |
Vapor Pressure | Low (solid, predicted) |
Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-[Chloro(4-Fluorophenyl)Phenylmethyl]-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 1 - [chloro(4 - fluorophenyl)phenylmethyl]-2 - fluorobenzene in a sealed chemical - grade container. |
Storage | Store "1-[chloro(4 - fluorophenyl)phenylmethyl]-2 - fluorobenzene" in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. It should be separated from oxidizing agents, acids, and bases to avoid potential chemical reactions. |
Shipping | 1 - [Chloro(4 - fluorophenyl)phenylmethyl]-2 - fluorobenzene is shipped in specialized, sealed containers compliant with chemical transport regulations. Ensured proper labeling for hazard info during transit to maintain safety. |
Competitive 1-[Chloro(4-Fluorophenyl)Phenylmethyl]-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-[Chloro(4-Fluorophenyl)Phenylmethyl]-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
Looking at its structure, the benzene ring endows it with certain stability and aromaticity. The introduction of chlorine and fluorine atoms significantly affects its physical and chemical properties. Fluorine atoms have high electronegativity, which can enhance molecular polarity and affect intermolecular forces, resulting in changes in physical properties such as boiling point and melting point. At the same time, due to their strong electronegativity, it will reduce the density of adjacent and para-potential electron clouds. In the electrophilic substitution reaction, such positional activity may change, and the reaction check point and rate are affected by it.
Chlorine atoms also affect molecular properties. Although the electronegativity is weaker than that of fluorine atoms, they can participate in the substitution reaction as a leaving group in chemical reactions. Its existence also affects the spatial structure of molecules and affects the interaction between molecules and other substances.
In terms of chemical reactions, due to the fact that it contains multiple benzene rings, typical reactions of benzene rings can occur, such as electrophilic substitution reactions. Since there are substituents such as chlorine and fluorine connected to the benzene ring, the regional selectivity of the substitution reaction depends on the localization effect of the substituent. For example, fluorine atoms are ortho-and para-localizers, and chlorine atoms are also ortho-and para-localizers. Under the combined action of the two, the electrophilic reagent attacks the check point of the benzene ring, which will
In addition, the carbon-halogen bond connected to the benzene ring in this compound has certain activity, and under suitable conditions, reactions such as hydrolysis and alcoholysis can occur to generate corresponding alcohols or ether compounds. In short, 1-%5Bchloro%284-fluorophenyl%29phenylmethyl%5D-2-fluorobenzene shows various chemical properties due to its unique structure, and may have potential application value in organic synthesis and other fields.
When it comes to appearance, this compound is often colorless to light yellow liquid. Under the influence of light and air, it may change color slightly, but it generally does not leave this range. Its properties are stable. Under normal environmental conditions, it can maintain its own structure relatively stable, and it is not easy to spontaneously produce significant chemical changes.
Looking at its melting point, it is determined by precise experiments that it is about a certain temperature range. Below this temperature limit, the substance exists in solid form, with a stable lattice structure and an orderly arrangement of intermolecular forces. When the temperature rises above the melting point, the lattice disintegrates, and the molecular activity intensifies, thus transforming into a liquid state.
The boiling point is also an important physical property. In a standard atmospheric pressure environment, its boiling point falls at a specific value. When this temperature is reached, the molecule obtains enough energy to break free from the liquid phase and transform into a gaseous state to realize the phase transition.
In terms of solubility, this compound exhibits good solubility in organic solvents such as ethanol and ether. The molecules of the organic solvent interact with the molecules of the compound through specific forces, so that the two can be uniformly mixed. However, in water, due to the difference in molecular structure and water molecular characteristics, its solubility is poor, showing a state of separation from the water phase.
Density is also a key consideration. It has been scientifically measured to be slightly denser than water, and this property determines its location and behavior in certain processes involving liquid-liquid separation or mixing. In systems coexisting with water, due to its high density, it often sinks in the lower layer.
Furthermore, its volatility is relatively moderate. At room temperature, although some molecules escape from the liquid phase and enter the gas phase, the rate is not extremely fast. This property not only affects its diffusion in the environment, but also relates to the conditions of its storage and use. It needs to be properly controlled to prevent excessive volatilization from causing losses or causing safety problems.
In the field of medicinal chemistry, many compounds with such structures have been studied or have biological activities. The specific spatial configuration and electronic effect endowed by the benzene ring and the halogen atom can make the compound interact with specific targets in the body, such as binding with certain proteins and enzymes, and then exhibit pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor. Ancient physicians often searched for herbs to cure diseases, but today's pharmacists search for cures at the microscopic molecular level. This compound may be the key starting material for the development of new drugs. After modification, it may become a good medicine for the world.
In the field of materials science, compounds containing halogen atoms and benzene rings often have unique physical and chemical properties. For example, it can be used as a functional monomer to participate in the polymerization reaction to prepare polymer materials with special properties. Its halogen atoms can enhance the stability and flame retardancy of materials, while the benzene ring endows materials with rigidity and conjugate structure, or can improve the electrical and optical properties of materials. It is used in the manufacture of new electronic devices and optical materials, just like the ancient craftsmen used unique materials to build exquisite devices. Today's materials scientists use it to create advanced materials.
Furthermore, in the field of organic synthetic chemistry, this compound can act as an important intermediate. Because of its structure, there are multiple reaction check points, it can be derived through various organic reactions to build more complex organic molecular structures. Chemists, like ancient alchemists, skillfully manipulate reaction conditions to synthesize compounds with specific structures and functions, expanding the boundaries of organic chemistry and providing a rich material foundation for the development of various fields.
First, you can start with halogenation reaction. First, take a suitable aromatic hydrocarbon, and use a chlorinated reagent and a fluoroaromatic hydrocarbon with the assistance of a catalyst to carry out a halogenation reaction, so that the chlorine atom and the fluorine atom occupy the position respectively, to obtain the key intermediate. In this process, the choice of catalyst is very important, such as the commonly used Lewis acid catalyst, which can promote the efficient progress of the reaction. However, the selectivity of the halogenation reaction may be difficult to precisely control, or many by-products are produced, subsequent separation and purification will become a difficult task, and the reaction conditions need to be carefully designed to improve the yield of the main product.
Second, the Grignard reaction is also a common way. First prepare Grignard reagents containing halogenated aromatics, and then react with fluoroaryl halides or corresponding carbonyl compounds. Grignard reagents are very active and can effectively build carbon-carbon bonds. However, when preparing Grignard reagents, the reaction conditions are strict, and an anhydrous and oxygen-free environment is required. If there is a little carelessness, the reaction will fail. And the reagents used are mostly active, and caution is required for storage and operation.
Third, the transition metal catalytic coupling reaction is also a good strategy. For example, the coupling reaction catalyzed by palladium can couple different halogenated aromatics under the synergistic action of palladium catalyst, ligand and base. This method has good selectivity and can accurately construct the target molecular structure. However, palladium catalysts are expensive, and the selection of ligands needs to be carefully considered. The cost factor needs to be weighed in industrial production.
Or other novel synthesis paths can be tried, such as photocatalysis and electrochemical synthesis. Photocatalytic synthesis can initiate reactions under mild conditions with low energy consumption; electrochemical synthesis can avoid the use of some dangerous reagents. However, most of these methods are in the research stage, the technical maturity is still insufficient, and it may take time to study and improve to achieve industrial production.
Synthesis of 1- [chloro (4-fluorophenyl) phenylmethyl] -2 -fluorobenzene, all methods have their own advantages and disadvantages, and it is necessary to comprehensively weigh and weigh according to the availability of raw materials, cost budget, target product purity requirements and many other factors, and carefully choose to achieve the ideal synthesis effect.
First, safety protection is essential. This compound may have certain toxicity and irritation, and protective equipment should be strictly equipped during operation. If you wear protective gloves to prevent skin contact, it may be absorbed through the skin, causing physical discomfort; wear goggles to avoid the compound splashing into the eyes and causing damage to the eyes; wear experimental clothes to prevent it from being contaminated with clothes and indirectly touching the body.
Second, the operating environment should be carefully controlled. It should be operated in a well-ventilated place, preferably in a fume hood. This can remove volatile compounds in time, reduce their concentration in the air, and avoid inhalation into the body. Due to the inhalation of the compound's vapor, or causing respiratory irritation, causing symptoms such as cough and asthma, long-term inhalation or even damage to lungs and other organs.
Third, storage conditions cannot be ignored. It needs to be stored in a cool, dry and ventilated place, away from fire and heat sources. Because of its nature or instability, high temperature environment may cause chemical reactions, and even lead to danger. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., to prevent interactions and dangerous accidents.
Fourth, during use, precise operation is extremely critical. Strictly follow the experimental procedures and operating guidelines, and control the dosage and reaction conditions. If the dosage is improper, or the reaction is out of control, it will not only affect the experimental results, but also bring potential safety hazards. For the reaction temperature, time and other conditions, it is also necessary to strictly control to ensure the smooth progress of the reaction and avoid accidents.
Fifth, the waste treatment must be in compliance. After use, the remaining compounds and related waste cannot be discarded at will. It should be collected and treated in accordance with relevant regulations. This can avoid pollution to the environment and ensure the safety of the ecological environment.

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