Linshang Chemical
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1-Chloro-4-Iodo-2-Methoxybenzene
Linshang Chemical
|
HS Code |
516371 |
| Chemical Formula | C7H6ClIO |
| Molecular Weight | 270.48 |
| Appearance | Solid (Typical) |
| Boiling Point | Approximately 260 - 270 °C |
| Melting Point | Around 30 - 35 °C |
| Density | Estimated around 1.8 - 1.9 g/cm³ |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Calculated around 110 - 120 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Chloro-4-Iodo-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - chloro - 4 - iodo - 2 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 1 - Chloro - 4 - iodo - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent potential combustion or decomposition. It should be stored in a tightly - sealed container to avoid exposure to air and moisture, which could lead to chemical reactions. Keep it separated from oxidizing agents and incompatible substances. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - chloro - 4 - iodo - 2 - methoxybenzene is shipped in sealed, corrosion - resistant containers. They are carefully packaged to prevent breakage. Shipments follow strict chemical transportation regulations to ensure safety during transit. |
Competitive 1-Chloro-4-Iodo-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-4-Iodo-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-4-iodo-2-methoxybenzene?
1-Chloro-4-iodo-2-methoxybenzene, which is 1-chloro-4-iodo-2-methoxybenzene, is widely used.
In the field of organic synthesis, it often acts as a key intermediate. Due to the unique activity and localization effect of chlorine, iodine and methoxy groups in the molecule, it can be transformed by various chemical reactions. For example, in the nucleophilic substitution reaction of halogenated aromatics, chlorine atoms or iodine atoms can be replaced by various nucleophiles, thereby introducing different functional groups, expanding the diversity of molecular structures, and building the basic skeleton of complex organic compounds, which is of great significance in the fields of medicinal chemistry and materials science.
In the field of drug research and development, it provides the basis for the synthesis of new drug molecules. For example, by modifying the structure of this compound, or by obtaining molecules with specific biological activities, it is expected to be used in the treatment of diseases. Due to the existence of chlorine and iodine atoms, the electron cloud distribution and spatial configuration of molecules can be affected, and the interaction mode with biological targets can be changed. After rational design and modification, lead compounds with high efficiency and low toxicity can be found, paving the way for the creation of new drugs.
In the field of materials science, it can be used to prepare functional materials. For example, in the synthesis of organic optoelectronic materials, through structural modification and polymerization, polymer materials with special optoelectronic properties can be prepared. Methoxy groups can adjust the solubility and charge transport properties of materials, etc., and have great potential for R & D and application in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which can improve the performance and stability of devices.
Furthermore, it is also used in the preparation of fine chemical products. Such as the preparation of special fragrances, dyes, etc., with its unique molecular structure and reactivity, it endows the product with unique properties and functions, and enhances the quality and added value of fine chemical products. In short, 1-chloro-4-iodine-2-methoxylbenzene has important uses in many chemical-related fields, promoting development and innovation in various fields.
In the field of organic synthesis, it often acts as a key intermediate. Due to the unique activity and localization effect of chlorine, iodine and methoxy groups in the molecule, it can be transformed by various chemical reactions. For example, in the nucleophilic substitution reaction of halogenated aromatics, chlorine atoms or iodine atoms can be replaced by various nucleophiles, thereby introducing different functional groups, expanding the diversity of molecular structures, and building the basic skeleton of complex organic compounds, which is of great significance in the fields of medicinal chemistry and materials science.
In the field of drug research and development, it provides the basis for the synthesis of new drug molecules. For example, by modifying the structure of this compound, or by obtaining molecules with specific biological activities, it is expected to be used in the treatment of diseases. Due to the existence of chlorine and iodine atoms, the electron cloud distribution and spatial configuration of molecules can be affected, and the interaction mode with biological targets can be changed. After rational design and modification, lead compounds with high efficiency and low toxicity can be found, paving the way for the creation of new drugs.
In the field of materials science, it can be used to prepare functional materials. For example, in the synthesis of organic optoelectronic materials, through structural modification and polymerization, polymer materials with special optoelectronic properties can be prepared. Methoxy groups can adjust the solubility and charge transport properties of materials, etc., and have great potential for R & D and application in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which can improve the performance and stability of devices.
Furthermore, it is also used in the preparation of fine chemical products. Such as the preparation of special fragrances, dyes, etc., with its unique molecular structure and reactivity, it endows the product with unique properties and functions, and enhances the quality and added value of fine chemical products. In short, 1-chloro-4-iodine-2-methoxylbenzene has important uses in many chemical-related fields, promoting development and innovation in various fields.
What are the physical properties of 1-chloro-4-iodo-2-methoxybenzene?
1 - chloro - 4 - iodo - 2 - methoxybenzene is an organic compound with unique physical properties. It may be in a solid state at room temperature, and the molecules are arranged in an orderly manner due to the intermolecular force. Looking at its melting point, due to the influence of halogen atoms and methoxy groups, the intermolecular force is enhanced, and the melting point may be within a specific range.
When talking about the boiling point, because the molecule contains chlorine, iodine and methoxy groups, the relative molecular weight is large, and there is a dipole-dipole force between the molecules, which causes the boiling point to rise, and more energy is required to make the molecule break free from the liquid phase.
In terms of solubility, the compound contains methoxy groups and has a certain polarity, but the benzene ring and halogen atoms are hydrophobic. Therefore, in polar solvents such as alcohols, there may be a certain solubility, because methoxy groups can form hydrogen bonds with polar solvents; in non-polar solvents such as hydrocarbons, due to the hydrophobicity of benzene rings and halogen atoms, the solubility may be higher.
Appearance may be white to pale yellow crystalline powder. Due to the molecular structure and electronic transition characteristics, it has a specific way of light absorption and reflection. Its odor may have a special aroma, which originates from the benzene ring structure. However, halogen atoms are modified with methoxy groups, so that the odor is different from ordinary benzene series.
Density may be greater than that of water, and the weight per unit volume is increased due to the presence of chlorine and iodine heavy atoms. Under different temperature and pressure conditions, its physical properties may change, the temperature increases, the molecular thermal motion intensifies, and the melting point and boiling point may be affected; pressure changes also play a role in its phase transition.
When talking about the boiling point, because the molecule contains chlorine, iodine and methoxy groups, the relative molecular weight is large, and there is a dipole-dipole force between the molecules, which causes the boiling point to rise, and more energy is required to make the molecule break free from the liquid phase.
In terms of solubility, the compound contains methoxy groups and has a certain polarity, but the benzene ring and halogen atoms are hydrophobic. Therefore, in polar solvents such as alcohols, there may be a certain solubility, because methoxy groups can form hydrogen bonds with polar solvents; in non-polar solvents such as hydrocarbons, due to the hydrophobicity of benzene rings and halogen atoms, the solubility may be higher.
Appearance may be white to pale yellow crystalline powder. Due to the molecular structure and electronic transition characteristics, it has a specific way of light absorption and reflection. Its odor may have a special aroma, which originates from the benzene ring structure. However, halogen atoms are modified with methoxy groups, so that the odor is different from ordinary benzene series.
Density may be greater than that of water, and the weight per unit volume is increased due to the presence of chlorine and iodine heavy atoms. Under different temperature and pressure conditions, its physical properties may change, the temperature increases, the molecular thermal motion intensifies, and the melting point and boiling point may be affected; pressure changes also play a role in its phase transition.
What is the chemistry of 1-chloro-4-iodo-2-methoxybenzene?
1-Chloro-4-iodine-2-methoxybenzene is an organic compound with unique chemical properties. In its structure, the benzene ring is a stable hexamembered ring, and chlorine, iodine and methoxy groups are connected to it. This structure endows the compound with specific chemical activities and reaction tendencies.
Let's talk about the substitution reaction first. Because the benzene ring has an electron cloud, it is vulnerable to attack by electrophilic reagents. Although chlorine and iodine are electron-withdrawing groups, they will reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity. However, the methoxy group is the power supply daughter group, which can increase the electron cloud density of the ortho and para-position. Therefore, during the electrophilic substitution reaction, For example, when reacting with iron bromide and bromine under certain conditions, the methoxy ortho-position hydrogen atom on the bromine atom or the substituted benzene ring makes the ortho-position electron cloud density relatively high due to the methoxy power supply effect, which is conducive to the attack of electrophilic reagents.
Let's talk about the halogen atom reaction. Both the chlorine atom and the iodine atom are halogen atoms, which have the properties of halogenated hydrocarbons. In the nucleophilic substitution reaction, the activity of the iodine atom is higher than that of the chlorine atom, because of its large atomic radius, the C-I bond energy is relatively small, and the bond is more easily broken, which is replaced by the nucleophilic reagent. If the iodine atom reacts with sodium hydroxide
In addition, the methoxy part of the compound, the methoxy oxygen atom has a lone pair electron, which can participate in some coordination reactions or participate in the reaction as a nucleophilic check point. Under appropriate conditions, or with metal ions, the properties and reactivity of the compound can be changed.
The unique structure of 1-chloro-4-iodine-2-methoxybenzene is widely used in the field of organic synthesis. It can be used as an intermediate to construct complex organic molecular structures through a series of reactions and synthesize compounds with specific functions.
Let's talk about the substitution reaction first. Because the benzene ring has an electron cloud, it is vulnerable to attack by electrophilic reagents. Although chlorine and iodine are electron-withdrawing groups, they will reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity. However, the methoxy group is the power supply daughter group, which can increase the electron cloud density of the ortho and para-position. Therefore, during the electrophilic substitution reaction, For example, when reacting with iron bromide and bromine under certain conditions, the methoxy ortho-position hydrogen atom on the bromine atom or the substituted benzene ring makes the ortho-position electron cloud density relatively high due to the methoxy power supply effect, which is conducive to the attack of electrophilic reagents.
Let's talk about the halogen atom reaction. Both the chlorine atom and the iodine atom are halogen atoms, which have the properties of halogenated hydrocarbons. In the nucleophilic substitution reaction, the activity of the iodine atom is higher than that of the chlorine atom, because of its large atomic radius, the C-I bond energy is relatively small, and the bond is more easily broken, which is replaced by the nucleophilic reagent. If the iodine atom reacts with sodium hydroxide
In addition, the methoxy part of the compound, the methoxy oxygen atom has a lone pair electron, which can participate in some coordination reactions or participate in the reaction as a nucleophilic check point. Under appropriate conditions, or with metal ions, the properties and reactivity of the compound can be changed.
The unique structure of 1-chloro-4-iodine-2-methoxybenzene is widely used in the field of organic synthesis. It can be used as an intermediate to construct complex organic molecular structures through a series of reactions and synthesize compounds with specific functions.
What are 1-chloro-4-iodo-2-methoxybenzene synthesis methods?
Method for synthesizing 1-chloro-4-iodine-2-methoxybenzene, often involving numerical methods. One is to use methoxybenzene as the starting material and first undergo halogenation reaction. Methoxy is an ortho-para-position group. Under appropriate conditions, it can be obtained by interacting with chlorine sources such as chlorine gas or chlorination reagents. This step requires controlling the reaction conditions, such as temperature, catalyst, etc., to promote the selective substitution of chlorine atoms in ortho-positions or para-positions.
Then, the resulting chloro-methoxybenzene is iodinated. Suitable iodine substitution reagents can be selected, such as iodine elements combined with appropriate oxidizing agents, so that iodine atoms replace hydrogen atoms at specific positions in the benzene ring. In this process, it is necessary to pay attention to the selectivity of the reaction and avoid excessive halogenation.
The second method, or start from halogenated benzene. First introduce the methoxy group, and then use the nucleophilic substitution reaction to react the halogenated benzene with the methoxy reagent, such as sodium methoxide, under suitable solvents and conditions, to obtain the methoxy halogenated benzene. Then introduce another halogen atom in sequence, and realize the synthesis of 1-chloro-4-iodine-2-methoxy benzene through a suitable halogenation method.
Or there may be other synthesis paths, such as the use of palladium-catalyzed cross-coupling reaction. Aromatic derivatives containing different substituents can be prepared first, and then the cross-coupling reaction can be used to precisely construct the target molecular structure. However, each method has its own advantages and disadvantages, and it needs to be selected according to actual needs, such as the availability of raw materials, cost, reaction yield and selectivity.
Then, the resulting chloro-methoxybenzene is iodinated. Suitable iodine substitution reagents can be selected, such as iodine elements combined with appropriate oxidizing agents, so that iodine atoms replace hydrogen atoms at specific positions in the benzene ring. In this process, it is necessary to pay attention to the selectivity of the reaction and avoid excessive halogenation.
The second method, or start from halogenated benzene. First introduce the methoxy group, and then use the nucleophilic substitution reaction to react the halogenated benzene with the methoxy reagent, such as sodium methoxide, under suitable solvents and conditions, to obtain the methoxy halogenated benzene. Then introduce another halogen atom in sequence, and realize the synthesis of 1-chloro-4-iodine-2-methoxy benzene through a suitable halogenation method.
Or there may be other synthesis paths, such as the use of palladium-catalyzed cross-coupling reaction. Aromatic derivatives containing different substituents can be prepared first, and then the cross-coupling reaction can be used to precisely construct the target molecular structure. However, each method has its own advantages and disadvantages, and it needs to be selected according to actual needs, such as the availability of raw materials, cost, reaction yield and selectivity.
1-chloro-4-iodo-2-methoxybenzene What are the precautions during storage and transportation?
When storing and transporting 1-chloro-4-iodine-2-methoxybenzene, many things need to be taken into account.
This compound has certain chemical activity. When storing, the first choice is the environment. It should be stored in a cool, dry and well-ventilated place, away from direct sunlight. Cover sunlight or cause photochemical reactions, damage quality, or even cause danger. Temperature is also critical. If it is too high, it may promote decomposition, and if it is too low, it may affect its physical properties. Therefore, it is essential to maintain a suitable temperature range.
Furthermore, the choice of storage containers cannot be ignored. When using corrosion-resistant materials, such as glass or specific plastic containers, to prevent chemical reactions with the container. And the container must be tightly sealed to prevent its contact with air and moisture. Due to moisture or hydrolysis reactions, oxygen in the air or oxidation can adversely affect its stability.
During transportation, protective measures must be comprehensive. This compound may be toxic and irritating, and the person handling it should wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent it from contacting the skin and eyes. The packaging should also be firm and reliable to prevent damage to the container due to bumps and collisions, and material leakage. The internal environment of the transportation vehicle should also meet the storage requirements, maintain a suitable temperature and humidity, and keep away from fire, heat and other flammable and explosive materials.
In addition, relevant documentation is essential during transportation and storage. Information such as the name, quantity, source, and time of entry and exit of the compound should be recorded in detail for traceability, so as to ensure the safety of 1-chloro-4-iodine-2-methoxybenzene during storage and transportation.
This compound has certain chemical activity. When storing, the first choice is the environment. It should be stored in a cool, dry and well-ventilated place, away from direct sunlight. Cover sunlight or cause photochemical reactions, damage quality, or even cause danger. Temperature is also critical. If it is too high, it may promote decomposition, and if it is too low, it may affect its physical properties. Therefore, it is essential to maintain a suitable temperature range.
Furthermore, the choice of storage containers cannot be ignored. When using corrosion-resistant materials, such as glass or specific plastic containers, to prevent chemical reactions with the container. And the container must be tightly sealed to prevent its contact with air and moisture. Due to moisture or hydrolysis reactions, oxygen in the air or oxidation can adversely affect its stability.
During transportation, protective measures must be comprehensive. This compound may be toxic and irritating, and the person handling it should wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent it from contacting the skin and eyes. The packaging should also be firm and reliable to prevent damage to the container due to bumps and collisions, and material leakage. The internal environment of the transportation vehicle should also meet the storage requirements, maintain a suitable temperature and humidity, and keep away from fire, heat and other flammable and explosive materials.
In addition, relevant documentation is essential during transportation and storage. Information such as the name, quantity, source, and time of entry and exit of the compound should be recorded in detail for traceability, so as to ensure the safety of 1-chloro-4-iodine-2-methoxybenzene during storage and transportation.
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