Linshang Chemical
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1-Chloro-4-Iodobenzene
Linshang Chemical
|
HS Code |
139323 |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Density | 1.94 g/cm³ |
| Boiling Point | 211 - 212 °C |
| Melting Point | 19 - 21 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 93.9 °C |
| Refractive Index | 1.647 |
As an accredited 1-Chloro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1-chloro - 4-iodobenzene packaged in 100 - gram bottles for chemical use. |
| Storage | 1 - Chloro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions. |
| Shipping | 1 - Chloro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. These are carefully packed to prevent breakage. Shipments follow strict hazardous material regulations due to its chemical nature. |
Competitive 1-Chloro-4-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What is the chemistry of 1-chloro-4-iodobenzene?
1-chloro-4-iodobenzene is an organic compound with chlorine atoms and iodine atoms attached to the counterposition of the benzene ring in its molecular structure. The chemical properties of this substance are quite unique.
First of all, the reactivity of the halogen atom is significant. Although both chlorine and iodine are halogen elements, the reactivity of the two is different due to the difference in atomic radius and electronegativity. The iodine atom has a large radius and the C-I bond energy is relatively small, so in many reactions, the iodine atom is more likely to leave, showing higher reactivity. For example, in nucleophilic substitution reactions, the iodine atom can be replaced by a variety of nucleophilic reagents to generate corresponding substitution products. Common nucleophilic reagents such as sodium alcohol and amines can undergo nucleophilic substitution with 1-chloro-4-iodobenzene, iodine atoms are replaced, and chlorine atoms can also participate in the reaction under specific conditions, but compared with iodine atoms, the reaction conditions are often more harsh.
Furthermore, the electron cloud distribution of the benzene ring is affected by halogen atoms. Chlorine and iodine are both electron-sucking groups, which will reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution reaction activity of the benzene ring. However, the two have different degrees of influence on the benzene ring electron cloud. The chlorine atom has a strong electron-sucking induction effect, while the iodine atom affects the benzene ring electron cloud with the conjugation effect of This difference results in different electron cloud densities at different positions on the benzene ring, which in turn affects the localization law of the electrophilic substitution reaction. During the electrophilic substitution reaction, the newly introduced group mainly enters the adjacent and para-position of the halogen atom in the benzene ring. However, due to the electron-absorbing action of the halogen atom, the reaction rate is slower than that of benzene itself.
In addition, 1-chloro-4-iodobenzene also has unique performance in some reduction reactions. Halogen atoms can be reduced and removed to form benzene derivatives by appropriate reducing agents. Different reducing agents and reaction conditions will affect the reduction products and reaction selectivity.
In summary, 1-chloro-4-iodobenzene exhibits unique chemical properties in various reactions such as nucleophilic substitution, electrophilic substitution and reduction due to its special molecular structure. It has important application value in the field of organic synthesis and can provide key intermediates for the preparation of various organic compounds.
First of all, the reactivity of the halogen atom is significant. Although both chlorine and iodine are halogen elements, the reactivity of the two is different due to the difference in atomic radius and electronegativity. The iodine atom has a large radius and the C-I bond energy is relatively small, so in many reactions, the iodine atom is more likely to leave, showing higher reactivity. For example, in nucleophilic substitution reactions, the iodine atom can be replaced by a variety of nucleophilic reagents to generate corresponding substitution products. Common nucleophilic reagents such as sodium alcohol and amines can undergo nucleophilic substitution with 1-chloro-4-iodobenzene, iodine atoms are replaced, and chlorine atoms can also participate in the reaction under specific conditions, but compared with iodine atoms, the reaction conditions are often more harsh.
Furthermore, the electron cloud distribution of the benzene ring is affected by halogen atoms. Chlorine and iodine are both electron-sucking groups, which will reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution reaction activity of the benzene ring. However, the two have different degrees of influence on the benzene ring electron cloud. The chlorine atom has a strong electron-sucking induction effect, while the iodine atom affects the benzene ring electron cloud with the conjugation effect of This difference results in different electron cloud densities at different positions on the benzene ring, which in turn affects the localization law of the electrophilic substitution reaction. During the electrophilic substitution reaction, the newly introduced group mainly enters the adjacent and para-position of the halogen atom in the benzene ring. However, due to the electron-absorbing action of the halogen atom, the reaction rate is slower than that of benzene itself.
In addition, 1-chloro-4-iodobenzene also has unique performance in some reduction reactions. Halogen atoms can be reduced and removed to form benzene derivatives by appropriate reducing agents. Different reducing agents and reaction conditions will affect the reduction products and reaction selectivity.
In summary, 1-chloro-4-iodobenzene exhibits unique chemical properties in various reactions such as nucleophilic substitution, electrophilic substitution and reduction due to its special molecular structure. It has important application value in the field of organic synthesis and can provide key intermediates for the preparation of various organic compounds.
What are the main uses of 1-chloro-4-iodobenzene?
1-Chloro-4-iodobenzene, Chinese name 1-chloro-4-iodobenzene, is an organic compound with unique chemical properties and has important uses in many fields such as chemical industry, medicine, and materials.
In the field of chemical synthesis, it is often used as a key intermediate. Due to the different reactivity of chlorine atoms and iodine atoms on the benzene ring, multiple functional groups can be introduced by means of nucleophilic substitution, coupling and other reactions to synthesize complex organic compounds. For example, in the construction of polycyclic aromatic hydrocarbon systems, 1-chloro-4-iodobenzene can be coupled by palladium catalysis to react with compounds containing alkenyl or alkynyl groups to achieve carbon-carbon bond formation, which lays the foundation for the synthesis of organic materials with special structures and properties.
In the field of medicine, it also plays an important role. Its structure can be modified to meet the needs of specific biological targets. By adjusting the substituents on the benzene ring, the lipid solubility, water solubility and interaction ability with biological macromolecules of the compound can be optimized. Therefore, it is often used to synthesize lead compounds with potential biological activities. After further pharmacological research and optimization, it is expected to be developed into new drugs.
In terms of materials science, 1-chloro-4-iodobenzene can participate in the preparation of functional polymer materials. By polymerizing with other monomers, its structure is introduced into the main chain or side chain of the polymer, giving the material special optoelectronic properties. For example, when preparing organic semiconductor materials, its structural units can adjust the electron transport and energy level structure of the material, and improve the performance of the material in devices such as organic Light Emitting Diodes and field effect transistors.
In summary, 1-chloro-4-iodobenzene plays an important role in many fields due to its unique structure, providing a key foundation and broad space for organic synthesis, pharmaceutical research and development, and material innovation.
In the field of chemical synthesis, it is often used as a key intermediate. Due to the different reactivity of chlorine atoms and iodine atoms on the benzene ring, multiple functional groups can be introduced by means of nucleophilic substitution, coupling and other reactions to synthesize complex organic compounds. For example, in the construction of polycyclic aromatic hydrocarbon systems, 1-chloro-4-iodobenzene can be coupled by palladium catalysis to react with compounds containing alkenyl or alkynyl groups to achieve carbon-carbon bond formation, which lays the foundation for the synthesis of organic materials with special structures and properties.
In the field of medicine, it also plays an important role. Its structure can be modified to meet the needs of specific biological targets. By adjusting the substituents on the benzene ring, the lipid solubility, water solubility and interaction ability with biological macromolecules of the compound can be optimized. Therefore, it is often used to synthesize lead compounds with potential biological activities. After further pharmacological research and optimization, it is expected to be developed into new drugs.
In terms of materials science, 1-chloro-4-iodobenzene can participate in the preparation of functional polymer materials. By polymerizing with other monomers, its structure is introduced into the main chain or side chain of the polymer, giving the material special optoelectronic properties. For example, when preparing organic semiconductor materials, its structural units can adjust the electron transport and energy level structure of the material, and improve the performance of the material in devices such as organic Light Emitting Diodes and field effect transistors.
In summary, 1-chloro-4-iodobenzene plays an important role in many fields due to its unique structure, providing a key foundation and broad space for organic synthesis, pharmaceutical research and development, and material innovation.
What are 1-chloro-4-iodobenzene synthesis methods?
1-Chloro-4-iodobenzene is also a compound commonly used in organic synthesis. There are several common methods for its synthesis.
First, benzene can be started. First, the benzene is chlorinated, and a suitable chlorinating agent, such as chlorine gas, can be obtained under the catalysis of a suitable catalyst, such as ferric chloride. Then, the chlorobenzene and iodine undergo an iodization reaction. This iodization reaction requires the selection of a suitable iodizing reagent, such as a mixture of iodine elemental substance and potassium iodide, and a catalyst, such as copper powder, is often required to introduce the counterposition of chlorobenzene into the iodine atom, and finally 1-chloro-4-iodobenzene can be obtained.
Second, p-chloroaniline is used as raw material. First, p-chloroaniline is reacted by diazotization, with sodium nitrite and hydrochloric acid as reagents, and a diazonium salt is prepared at low temperature. Then the diazonium salt is reacted with potassium iodide, and the diazonium group is replaced by an iodine atom to generate 1-chloro-4-iodobenzene. This approach needs to pay attention to the control of the conditions of the diazotization reaction. The reaction needs to be rapid at low temperature to prevent the decomposition of diazonium salts.
Third, p-dihalobenzene is used as raw material. If there is p-chlorobrobenz Iodine ions have strong nucleophilicity. In an alcoholic solution of potassium iodide, under suitable conditions such as heating, iodine ions can replace bromine atoms in p-chlorobromobenzene to obtain 1-chloro-4-iodobenzene. This method requires attention to the utilization of the difference in the activity of halogen atoms and the choice of reaction conditions to ensure the smooth progress of the reaction and the purity of the product.
All these methods have their own advantages and disadvantages. In the actual synthesis, it is necessary to weigh and choose according to the availability of raw materials, the difficulty of reaction conditions, cost and product purity.
First, benzene can be started. First, the benzene is chlorinated, and a suitable chlorinating agent, such as chlorine gas, can be obtained under the catalysis of a suitable catalyst, such as ferric chloride. Then, the chlorobenzene and iodine undergo an iodization reaction. This iodization reaction requires the selection of a suitable iodizing reagent, such as a mixture of iodine elemental substance and potassium iodide, and a catalyst, such as copper powder, is often required to introduce the counterposition of chlorobenzene into the iodine atom, and finally 1-chloro-4-iodobenzene can be obtained.
Second, p-chloroaniline is used as raw material. First, p-chloroaniline is reacted by diazotization, with sodium nitrite and hydrochloric acid as reagents, and a diazonium salt is prepared at low temperature. Then the diazonium salt is reacted with potassium iodide, and the diazonium group is replaced by an iodine atom to generate 1-chloro-4-iodobenzene. This approach needs to pay attention to the control of the conditions of the diazotization reaction. The reaction needs to be rapid at low temperature to prevent the decomposition of diazonium salts.
Third, p-dihalobenzene is used as raw material. If there is p-chlorobrobenz Iodine ions have strong nucleophilicity. In an alcoholic solution of potassium iodide, under suitable conditions such as heating, iodine ions can replace bromine atoms in p-chlorobromobenzene to obtain 1-chloro-4-iodobenzene. This method requires attention to the utilization of the difference in the activity of halogen atoms and the choice of reaction conditions to ensure the smooth progress of the reaction and the purity of the product.
All these methods have their own advantages and disadvantages. In the actual synthesis, it is necessary to weigh and choose according to the availability of raw materials, the difficulty of reaction conditions, cost and product purity.
What are the precautions in storage and transportation of 1-chloro-4-iodobenzene?
1-Chloro-4-iodobenzene is an organic compound. During storage and transportation, many things need to be paid attention to to ensure safety.
First, when storing, choose a cool and ventilated warehouse. This compound is easy to decompose when heated, and the high temperature environment may cause dangerous chemical reactions. Therefore, a cool place can ensure its stability. And good ventilation can disperse the gas that may leak in time and reduce safety hazards.
Second, it should be stored separately from oxidants and active metal powders, and must not be mixed. Because of its certain chemical activity, contact with oxidants, or cause severe oxidation reactions, active metal powders may also chemically react with them, forming unstable products, which can lead to safety accidents.
Third, the storage area must be equipped with suitable materials to contain leaks. Once a leak occurs, it can be collected in time to prevent its spread, avoid pollution to the environment, and reduce the difficulty of subsequent treatment.
Fourth, during transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. If its packaging is damaged, it is easy to cause material leakage, which brings risks. Transportation vehicles should also be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment to deal with emergencies.
Fifth, summer transportation should be carried out in the morning and evening. In summer, the temperature is high, especially at noon. The risk of this compound increases under high temperature, and the temperature in the morning and evening is relatively low, which can reduce the possibility of danger.
Sixth, during transportation, it should be protected from exposure to the sun, rain, and high temperature. Exposure to the sun and rain will affect the stability of the compound, and high temperature may also cause it to decompose or cause other dangerous reactions.
In short, the storage and transportation of 1-chloro-4-iodobenzene must strictly follow relevant safety regulations, pay attention to details, and operate carefully, so as to ensure the safety of personnel and the environment.
First, when storing, choose a cool and ventilated warehouse. This compound is easy to decompose when heated, and the high temperature environment may cause dangerous chemical reactions. Therefore, a cool place can ensure its stability. And good ventilation can disperse the gas that may leak in time and reduce safety hazards.
Second, it should be stored separately from oxidants and active metal powders, and must not be mixed. Because of its certain chemical activity, contact with oxidants, or cause severe oxidation reactions, active metal powders may also chemically react with them, forming unstable products, which can lead to safety accidents.
Third, the storage area must be equipped with suitable materials to contain leaks. Once a leak occurs, it can be collected in time to prevent its spread, avoid pollution to the environment, and reduce the difficulty of subsequent treatment.
Fourth, during transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. If its packaging is damaged, it is easy to cause material leakage, which brings risks. Transportation vehicles should also be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment to deal with emergencies.
Fifth, summer transportation should be carried out in the morning and evening. In summer, the temperature is high, especially at noon. The risk of this compound increases under high temperature, and the temperature in the morning and evening is relatively low, which can reduce the possibility of danger.
Sixth, during transportation, it should be protected from exposure to the sun, rain, and high temperature. Exposure to the sun and rain will affect the stability of the compound, and high temperature may also cause it to decompose or cause other dangerous reactions.
In short, the storage and transportation of 1-chloro-4-iodobenzene must strictly follow relevant safety regulations, pay attention to details, and operate carefully, so as to ensure the safety of personnel and the environment.
1-chloro-4-iodobenzene impact on the environment and human health
1-Chloro-4-iodobenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
In the environment, 1-chloro-4-iodobenzene has a certain stability and is not easy to degrade. If released in nature, it may survive for a long time. It can be transported and diffused by air, water and soil. In the aquatic environment, it may endanger aquatic organisms. Because it may be enriched through the food chain, after the small fish and shrimp ingest it, the big fish eat it again, accumulating layer by layer, eventually resulting in a very high concentration in high organisms, destroying the aquatic ecological balance. In the soil, it may affect the activity of soil microorganisms and soil fertility, and also have adverse effects on plant growth, hindering its normal development.
As for human health, 1-chloro-4-iodobenzene may be potentially harmful. It enters the human body through respiratory tract, skin contact or accidental ingestion. This compound may have certain toxicity, or affect the human nervous system, causing symptoms such as headache, vertigo, fatigue, etc. Long-term exposure may damage the function of important organs such as liver and kidneys, and interfere with the normal metabolism of the human body. And it may have a carcinogenic risk. Although the relevant research is not conclusive, it should not be taken lightly. Therefore, in daily production and life, it is necessary to treat 1-chloro-4-iodobenzene with caution, and do a good job of protection and treatment to reduce its threat to the environment and human health.
In the environment, 1-chloro-4-iodobenzene has a certain stability and is not easy to degrade. If released in nature, it may survive for a long time. It can be transported and diffused by air, water and soil. In the aquatic environment, it may endanger aquatic organisms. Because it may be enriched through the food chain, after the small fish and shrimp ingest it, the big fish eat it again, accumulating layer by layer, eventually resulting in a very high concentration in high organisms, destroying the aquatic ecological balance. In the soil, it may affect the activity of soil microorganisms and soil fertility, and also have adverse effects on plant growth, hindering its normal development.
As for human health, 1-chloro-4-iodobenzene may be potentially harmful. It enters the human body through respiratory tract, skin contact or accidental ingestion. This compound may have certain toxicity, or affect the human nervous system, causing symptoms such as headache, vertigo, fatigue, etc. Long-term exposure may damage the function of important organs such as liver and kidneys, and interfere with the normal metabolism of the human body. And it may have a carcinogenic risk. Although the relevant research is not conclusive, it should not be taken lightly. Therefore, in daily production and life, it is necessary to treat 1-chloro-4-iodobenzene with caution, and do a good job of protection and treatment to reduce its threat to the environment and human health.
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