Linshang Chemical
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1-Chloro-4-Isocyanatobenzene
Linshang Chemical
|
HS Code |
834022 |
| Chemical Formula | C7H4ClNO |
| Molar Mass | 153.565 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 230 - 232 °C |
| Melting Point | 13 - 14 °C |
| Density | 1.266 g/cm³ |
| Vapor Pressure | Low at room temperature |
| Solubility | Insoluble in water, soluble in organic solvents like benzene, toluene |
| Flash Point | 104 °C |
| Stability | Stable under normal conditions, but reactive with water, alcohols, amines |
As an accredited 1-Chloro-4-Isocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - isocyanatobenzene in 100 - gram bottles, well - sealed for safe storage. |
| Storage | 1 - Chloro - 4 - isocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and moisture. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like acids, bases, and amines to prevent reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - Chloro - 4 - isocyanatobenzene is a hazardous chemical. Shipping requires compliance with strict regulations. It must be packaged in appropriate, leak - proof containers, clearly labeled, and transported by carriers authorized for such chemicals. |
Competitive 1-Chloro-4-Isocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloro-4-Isocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 1-chloro-4-isocyanatobenzene?
1-Chloro-4-isocyanate benzene is one of the organic compounds. It is active and has unique chemical characteristics.
In this substance, both chlorine atoms and isocyanate are active functional groups. Chlorine atoms can often participate in nucleophilic substitution reactions. Because of their high electronegativity, they can reduce the density of electron clouds on the benzene ring and make nucleophiles easy to attack. And chlorine atoms are easily replaced by other nucleophilic groups, such as hydroxyl groups, amino groups, etc., to form new compounds.
And isocyanate (-NCO) is particularly active. In isocyanate, the electronegativity difference between nitrogen and oxygen atoms makes the carbon-nitrogen double bond and carbon-oxygen double bond highly reactive. It is easy to react with compounds containing active hydrogen, such as water, alcohol, amine, etc. When it reacts with water, it hydrolyzes to form amines and carbon dioxide; when it reacts with alcohol, it forms carbamate; when it reacts with amines, urea compounds can be obtained.
1-chloro-4-isocyanate phenyl has this diactive functional group and is widely used in the field of organic synthesis. It can be used to prepare intermediates for a variety of medicines, pesticides, and polymer materials. By gradually transforming their functional groups, complex organic molecular structures can be constructed. However, due to its liveliness, it is necessary to be careful when storing and using it to prevent it from reacting with water vapor and other active substances in the air, causing deterioration or causing safety accidents.
In this substance, both chlorine atoms and isocyanate are active functional groups. Chlorine atoms can often participate in nucleophilic substitution reactions. Because of their high electronegativity, they can reduce the density of electron clouds on the benzene ring and make nucleophiles easy to attack. And chlorine atoms are easily replaced by other nucleophilic groups, such as hydroxyl groups, amino groups, etc., to form new compounds.
And isocyanate (-NCO) is particularly active. In isocyanate, the electronegativity difference between nitrogen and oxygen atoms makes the carbon-nitrogen double bond and carbon-oxygen double bond highly reactive. It is easy to react with compounds containing active hydrogen, such as water, alcohol, amine, etc. When it reacts with water, it hydrolyzes to form amines and carbon dioxide; when it reacts with alcohol, it forms carbamate; when it reacts with amines, urea compounds can be obtained.
1-chloro-4-isocyanate phenyl has this diactive functional group and is widely used in the field of organic synthesis. It can be used to prepare intermediates for a variety of medicines, pesticides, and polymer materials. By gradually transforming their functional groups, complex organic molecular structures can be constructed. However, due to its liveliness, it is necessary to be careful when storing and using it to prevent it from reacting with water vapor and other active substances in the air, causing deterioration or causing safety accidents.
What are the main uses of 1-chloro-4-isocyanatobenzene?
1-Chloro-4-isocyanate benzene, an important compound in organic chemistry, has a wide range of uses and is of key significance in many fields.
First, in the field of materials science, it is often used as a raw material for the synthesis of special polymers. By reacting with compounds containing active hydrogen, such as polyols, polyurethane polymers can be formed. Polyurethane materials are widely used, such as in foam manufacturing, can produce materials with excellent heat insulation and sound insulation properties, often used in building insulation, furniture filling, etc. In the paint industry, polyurethane coatings have good wear resistance, corrosion resistance and decorative properties, and are widely used in surface coating of automobiles, ships, etc.
Second, in the field of medicinal chemistry, 1-chloro-4-isocyanate benzene also plays an important role. It can be used as a key raw material for the synthesis of specific drug intermediates. Through a series of organic reactions, its structure is modified and modified, and then drug molecules with specific pharmacological activities are synthesized, providing an important structural basis for drug development.
Third, in organic synthetic chemistry, it is an important synthetic building block and participates in the construction of many complex organic compounds. Due to the high reactivity of isocyanate and chlorine atoms, it can react with various nucleophiles through different reaction paths to achieve the construction of chemical bonds such as carbon-nitrogen and carbon-oxygen, and help synthesize organic molecules with diverse structures, providing a powerful tool for the development of organic synthetic chemistry.
Furthermore, in the dye industry, it can be used as a precursor for the synthesis of some functional dyes. Through further chemical modification, the dyes are endowed with special properties, such as improving the light resistance and washable properties of the dyes, to meet the needs of different fabrics and dyeing processes.
In conclusion, 1-chloro-4-isocyanate benzene has shown important uses in many fields such as materials, medicine, organic synthesis, and dyes due to its unique chemical structure and reactivity, promoting technological development and product innovation in various fields.
First, in the field of materials science, it is often used as a raw material for the synthesis of special polymers. By reacting with compounds containing active hydrogen, such as polyols, polyurethane polymers can be formed. Polyurethane materials are widely used, such as in foam manufacturing, can produce materials with excellent heat insulation and sound insulation properties, often used in building insulation, furniture filling, etc. In the paint industry, polyurethane coatings have good wear resistance, corrosion resistance and decorative properties, and are widely used in surface coating of automobiles, ships, etc.
Second, in the field of medicinal chemistry, 1-chloro-4-isocyanate benzene also plays an important role. It can be used as a key raw material for the synthesis of specific drug intermediates. Through a series of organic reactions, its structure is modified and modified, and then drug molecules with specific pharmacological activities are synthesized, providing an important structural basis for drug development.
Third, in organic synthetic chemistry, it is an important synthetic building block and participates in the construction of many complex organic compounds. Due to the high reactivity of isocyanate and chlorine atoms, it can react with various nucleophiles through different reaction paths to achieve the construction of chemical bonds such as carbon-nitrogen and carbon-oxygen, and help synthesize organic molecules with diverse structures, providing a powerful tool for the development of organic synthetic chemistry.
Furthermore, in the dye industry, it can be used as a precursor for the synthesis of some functional dyes. Through further chemical modification, the dyes are endowed with special properties, such as improving the light resistance and washable properties of the dyes, to meet the needs of different fabrics and dyeing processes.
In conclusion, 1-chloro-4-isocyanate benzene has shown important uses in many fields such as materials, medicine, organic synthesis, and dyes due to its unique chemical structure and reactivity, promoting technological development and product innovation in various fields.
What are 1-chloro-4-isocyanatobenzene synthesis methods?
The synthesis of 1-chloro-4-isocyanate benzene has attracted much attention in the field of organic synthesis. This compound has important applications in many fields such as materials science and medicinal chemistry.
One of the methods is to use p-chloroaniline as the starting material. First, p-chloroaniline is reacted with phosgene, and this reaction needs to be carried out under suitable temperature and pressure conditions. Phosgene acts as an acylating agent and reacts with the amino group of p-chloroaniline to form the corresponding isocyanate intermediate. During this process, the reaction conditions must be strictly controlled to ensure the selectivity and yield of the reaction. Phosgene is highly toxic and should be handled with extreme caution. It should be carried out in a well-ventilated environment and proper protective measures should be taken.
Another method can start from p-chlorobenzoic acid. First, p-chlorobenzoic acid is converted into its acyl chloride derivative. The commonly used chlorination reagents are thionyl chloride. After the formation of p-chlorobenzoyl chloride, it is reacted with urea or other compounds containing amino groups. After a series of rearrangements, 1-chloro-4-isocyanate benzene can be obtained. In this route, the optimization of the reaction conditions at each step is crucial, such as the reaction temperature, reaction time, and the molar ratio of the reactants, all of which have a significant impact on the reaction results.
There are also p-chloronitrobenzene as the starting material. First, p-chloronitrobenzene is reduced to p-chloroaniline, and the reduction method can be catalytic hydrogenation or a system using metals and acids. After obtaining p-chloroaniline, the method of reacting with phosgene as described above is followed to obtain the target product. This path needs to pay attention to the degree of reduction reaction control to avoid excessive reduction or incomplete reduction.
All these synthesis methods have their own advantages and disadvantages. It is necessary to carefully choose the appropriate way according to the actual needs and conditions to achieve the synthesis goal of high efficiency, economy and environmental protection.
One of the methods is to use p-chloroaniline as the starting material. First, p-chloroaniline is reacted with phosgene, and this reaction needs to be carried out under suitable temperature and pressure conditions. Phosgene acts as an acylating agent and reacts with the amino group of p-chloroaniline to form the corresponding isocyanate intermediate. During this process, the reaction conditions must be strictly controlled to ensure the selectivity and yield of the reaction. Phosgene is highly toxic and should be handled with extreme caution. It should be carried out in a well-ventilated environment and proper protective measures should be taken.
Another method can start from p-chlorobenzoic acid. First, p-chlorobenzoic acid is converted into its acyl chloride derivative. The commonly used chlorination reagents are thionyl chloride. After the formation of p-chlorobenzoyl chloride, it is reacted with urea or other compounds containing amino groups. After a series of rearrangements, 1-chloro-4-isocyanate benzene can be obtained. In this route, the optimization of the reaction conditions at each step is crucial, such as the reaction temperature, reaction time, and the molar ratio of the reactants, all of which have a significant impact on the reaction results.
There are also p-chloronitrobenzene as the starting material. First, p-chloronitrobenzene is reduced to p-chloroaniline, and the reduction method can be catalytic hydrogenation or a system using metals and acids. After obtaining p-chloroaniline, the method of reacting with phosgene as described above is followed to obtain the target product. This path needs to pay attention to the degree of reduction reaction control to avoid excessive reduction or incomplete reduction.
All these synthesis methods have their own advantages and disadvantages. It is necessary to carefully choose the appropriate way according to the actual needs and conditions to achieve the synthesis goal of high efficiency, economy and environmental protection.
1-chloro-4-isocyanatobenzene need to pay attention to when storing and transporting
1-Chloro-4-isocyanate benzene is one of the organic compounds. When storing and transporting this substance, care must be taken, and many matters should be paid attention to.
The first word for storage, first, it is necessary to choose a cool, dry and well-ventilated place. This is because of its active nature, hot or wet, prone to adverse reactions, so it is essential to avoid heat and moisture. Second, be sure to keep it separate from oxidants, acids, bases and food chemicals. Cover 1-chloro-4-isocyanate benzene and the above substances, which are prone to chemical reactions and cause danger. Third, the storage place should be equipped with suitable equipment to contain leaks. In case of leakage, it can be contained in time to avoid greater harm.
As for transportation, there are also many points. First, transport vehicles must ensure that they are in good condition and have corresponding safety facilities. Such as fire prevention, explosion-proof devices, etc., to prevent accidents during transportation. Second, transport personnel should be professionally trained to be familiar with the characteristics of 1-chloro-4-isocyanate benzene and emergency treatment methods. Third, when transporting, the packaging must be tight to prevent leakage. Fourth, strictly follow the specified route to avoid densely populated areas and traffic arteries. And during transportation, pay close attention to the condition of the goods, and if there is any abnormality, dispose of it quickly.
In short, 1-chloro-4-isocyanate benzene cannot be ignored in all aspects of storage and transportation, and must be operated according to specifications to ensure safety.
The first word for storage, first, it is necessary to choose a cool, dry and well-ventilated place. This is because of its active nature, hot or wet, prone to adverse reactions, so it is essential to avoid heat and moisture. Second, be sure to keep it separate from oxidants, acids, bases and food chemicals. Cover 1-chloro-4-isocyanate benzene and the above substances, which are prone to chemical reactions and cause danger. Third, the storage place should be equipped with suitable equipment to contain leaks. In case of leakage, it can be contained in time to avoid greater harm.
As for transportation, there are also many points. First, transport vehicles must ensure that they are in good condition and have corresponding safety facilities. Such as fire prevention, explosion-proof devices, etc., to prevent accidents during transportation. Second, transport personnel should be professionally trained to be familiar with the characteristics of 1-chloro-4-isocyanate benzene and emergency treatment methods. Third, when transporting, the packaging must be tight to prevent leakage. Fourth, strictly follow the specified route to avoid densely populated areas and traffic arteries. And during transportation, pay close attention to the condition of the goods, and if there is any abnormality, dispose of it quickly.
In short, 1-chloro-4-isocyanate benzene cannot be ignored in all aspects of storage and transportation, and must be operated according to specifications to ensure safety.
1-chloro-4-isocyanatobenzene impact on the environment and human health
1-Chloro-4-isocyanate benzene has a great impact on the environment and human health.
This substance is quite toxic to the environment. If it accidentally enters the water body, aquatic organisms will bear the brunt. Due to its chemical properties, or causing physiological disorders in aquatic organisms, such as destroying the respiratory and nervous systems of fish, causing abnormal behavior, stunted reproduction, and even a large number of deaths, resulting in aquatic ecosystem imbalance. And in the water body, this substance is not easy to degrade, and will remain for a long time, accumulating and amplifying through the food chain. For example, small fish swallow microorganisms containing this substance, large fish eat small fish, and eventually humans eat contaminated fish, and harmful substances will enter the human body.
As for human health, 1-chloro-4-isocyanate synbenzene is also very harmful. Its volatile gaseous substances, if inhaled by humans, will strongly irritate the respiratory tract. Mild cases can cause cough, asthma, sore throat, and severe cases can cause severe respiratory diseases such as bronchitis and pulmonary edema, causing permanent damage to lung function. If the skin is exposed to this substance, it will cause contact dermatitis, redness, swelling, itching, blisters and other symptoms. Long-term or repeated exposure may increase the risk of skin cancer. If taken inadvertently, it will damage the digestive system, corrode the oral, esophageal and gastric mucosa, cause severe pain and ulcers, and in severe cases endanger life.
In summary, 1-chloro-4-isocyanate benzene is a major threat to the environment and human health, and must be handled and prevented with caution.
This substance is quite toxic to the environment. If it accidentally enters the water body, aquatic organisms will bear the brunt. Due to its chemical properties, or causing physiological disorders in aquatic organisms, such as destroying the respiratory and nervous systems of fish, causing abnormal behavior, stunted reproduction, and even a large number of deaths, resulting in aquatic ecosystem imbalance. And in the water body, this substance is not easy to degrade, and will remain for a long time, accumulating and amplifying through the food chain. For example, small fish swallow microorganisms containing this substance, large fish eat small fish, and eventually humans eat contaminated fish, and harmful substances will enter the human body.
As for human health, 1-chloro-4-isocyanate synbenzene is also very harmful. Its volatile gaseous substances, if inhaled by humans, will strongly irritate the respiratory tract. Mild cases can cause cough, asthma, sore throat, and severe cases can cause severe respiratory diseases such as bronchitis and pulmonary edema, causing permanent damage to lung function. If the skin is exposed to this substance, it will cause contact dermatitis, redness, swelling, itching, blisters and other symptoms. Long-term or repeated exposure may increase the risk of skin cancer. If taken inadvertently, it will damage the digestive system, corrode the oral, esophageal and gastric mucosa, cause severe pain and ulcers, and in severe cases endanger life.
In summary, 1-chloro-4-isocyanate benzene is a major threat to the environment and human health, and must be handled and prevented with caution.
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