Linshang Chemical
PRODUCTS
1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
806235 |
| Chemical Formula | C8H3ClF3NS |
| Molecular Weight | 239.63 |
| Appearance | Typically a liquid, color may vary (possibly colorless to pale yellow) |
| Boiling Point | Specific data needed (estimated around 200 - 250°C under normal pressure) |
| Melting Point | Specific data needed |
| Density | Specific data needed |
| Solubility | Soluble in organic solvents like dichloromethane, toluene |
| Vapor Pressure | Specific data needed |
| Flash Point | Specific data needed |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents, amines |
As an accredited 1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 4 - isothiocyanato - 2 - (trifluoromethyl)benzene in sealed chemical - grade vial. |
| Storage | 1 - Chloro - 4 - isothiocyanato - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like oxidizing agents, bases, and moisture - sensitive materials to prevent reactions. |
| Shipping | 1 - chloro - 4 - isothiocyanato - 2 - (trifluoromethyl)benzene is a chemical. Shipping should be in accordance with hazardous chemical regulations, using appropriate containers, and ensuring proper labeling for safe transportation. |
Competitive 1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene in China?
As a trusted 1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-4-isothiocyanato-2- (trifluoromethyl) benzene?
1-Chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene, this is an organic compound. Its chemical properties are unique and interesting.
First talk about its reactivity. Isothiocyanate (-NCS) is highly active and easily reacts with nucleophiles. Nucleophilic addition reactions can occur in compounds containing active hydrogen, such as alcohols and amines. Taking alcohols as an example, hydrogen in the hydroxyl group (-OH) of alcohols is active and can combine with the nitrogen atom of isothiocyanate to form carbamate derivatives. This reaction is very important in the field of organic synthesis and can be used to create compounds with diverse structures.
Re-discussion on the chlorine atom (-Cl). Chlorine atoms above the benzene ring also have certain reactivity. Under appropriate conditions, nucleophilic substitution reactions can occur. For example, treated with strong nucleophilic reagents, chlorine atoms can be replaced by other groups, such as alkoxy groups, amino groups, etc., so that molecular structures can be modified to synthesize compounds with different functions.
In addition, trifluoromethyl (-CF 🥰) on the benzene ring has a significant impact on the chemical properties of the compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring, thereby affecting the reactivity of other substituents on the benzene ring. Due to its electron-absorbing effect, the benzene ring is more prone to electrophilic substitution reactions, and the reaction check points are mostly concentrated away from the trifluoromethyl group.
This compound is rich in chemical properties due to its different functional groups. These properties provide organic synthetic chemists with many opportunities. Through ingenious design of reactions, a series of organic compounds with novel structures and unique functions can be prepared, which have potential applications in many fields such as medicinal chemistry and materials science.
First talk about its reactivity. Isothiocyanate (-NCS) is highly active and easily reacts with nucleophiles. Nucleophilic addition reactions can occur in compounds containing active hydrogen, such as alcohols and amines. Taking alcohols as an example, hydrogen in the hydroxyl group (-OH) of alcohols is active and can combine with the nitrogen atom of isothiocyanate to form carbamate derivatives. This reaction is very important in the field of organic synthesis and can be used to create compounds with diverse structures.
Re-discussion on the chlorine atom (-Cl). Chlorine atoms above the benzene ring also have certain reactivity. Under appropriate conditions, nucleophilic substitution reactions can occur. For example, treated with strong nucleophilic reagents, chlorine atoms can be replaced by other groups, such as alkoxy groups, amino groups, etc., so that molecular structures can be modified to synthesize compounds with different functions.
In addition, trifluoromethyl (-CF 🥰) on the benzene ring has a significant impact on the chemical properties of the compound. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring, thereby affecting the reactivity of other substituents on the benzene ring. Due to its electron-absorbing effect, the benzene ring is more prone to electrophilic substitution reactions, and the reaction check points are mostly concentrated away from the trifluoromethyl group.
This compound is rich in chemical properties due to its different functional groups. These properties provide organic synthetic chemists with many opportunities. Through ingenious design of reactions, a series of organic compounds with novel structures and unique functions can be prepared, which have potential applications in many fields such as medicinal chemistry and materials science.
What are the main uses of 1-chloro-4-isothiocyanato-2- (trifluoromethyl) benzene?
1-Chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene is an important raw material for organic synthesis and is widely used in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate. It can be cleverly combined with other organic molecules through a specific reaction path to construct compounds with unique structures and biological activities. Such as the development of new antibacterial drugs, which can precisely interact with specific bacterial targets by virtue of their structural characteristics, interfere with the normal physiological activities of bacteria, and achieve antibacterial effect; or in the exploration of anti-cancer drugs, build complex molecular structures based on this, hoping to achieve effective inhibition of cancer cell growth and proliferation.
Second, in the field of materials science, its use is also quite critical. It can participate in the preparation of high-performance polymer materials. After appropriate polymerization, it is introduced into the main chain or side chain of the polymer. With the strong electronegativity and unique electronic effect of trifluoromethyl, the polymer is endowed with characteristics such as excellent weather resistance, chemical stability and low surface energy. These characteristics enable the material to exhibit excellent performance in outdoor facilities, chemical equipment coatings, etc., prolonging the service life of the material and reducing maintenance costs.
Third, in the field of pesticide research and development, 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene also plays an important role. It can be used as a lead compound for structural modification and optimization to create new pesticides. Due to its specific chemical structure, it has a unique mechanism of action on some pests or pathogens, or interferes with their nervous system, or destroys their respiratory and metabolic processes, thus effectively controlling crop diseases and pests and ensuring a bumper harvest in agricultural production.
First, in the field of medicinal chemistry, it is often a key intermediate. It can be cleverly combined with other organic molecules through a specific reaction path to construct compounds with unique structures and biological activities. Such as the development of new antibacterial drugs, which can precisely interact with specific bacterial targets by virtue of their structural characteristics, interfere with the normal physiological activities of bacteria, and achieve antibacterial effect; or in the exploration of anti-cancer drugs, build complex molecular structures based on this, hoping to achieve effective inhibition of cancer cell growth and proliferation.
Second, in the field of materials science, its use is also quite critical. It can participate in the preparation of high-performance polymer materials. After appropriate polymerization, it is introduced into the main chain or side chain of the polymer. With the strong electronegativity and unique electronic effect of trifluoromethyl, the polymer is endowed with characteristics such as excellent weather resistance, chemical stability and low surface energy. These characteristics enable the material to exhibit excellent performance in outdoor facilities, chemical equipment coatings, etc., prolonging the service life of the material and reducing maintenance costs.
Third, in the field of pesticide research and development, 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene also plays an important role. It can be used as a lead compound for structural modification and optimization to create new pesticides. Due to its specific chemical structure, it has a unique mechanism of action on some pests or pathogens, or interferes with their nervous system, or destroys their respiratory and metabolic processes, thus effectively controlling crop diseases and pests and ensuring a bumper harvest in agricultural production.
What is the synthesis method of 1-chloro-4-isothiocyanato-2- (trifluoromethyl) benzene?
The synthesis method of 1-chloro-4-isothiocyanate-2- (trifluoromethyl) benzene is detailed as follows.
First take 2- (trifluoromethyl) -1,4-dichlorobenzene as the starting material, this compound is quite critical. In a suitable reaction vessel, add an appropriate amount of organic solvent, such as N, N-dimethylformamide (DMF), which can provide a good environment for the reaction. The reaction system is cooled to a certain range, about 0 ° C to 5 ° C. This low temperature environment is conducive to the precise progress of subsequent reactions.
Slowly add thiocyanate, such as potassium thiocyanate (KSCN), and pay close attention to the reaction situation. Thiocyanate ions will undergo nucleophilic substitution with one of the chlorine atoms in 2- (trifluoromethyl) -1,4-dichlorobenzene. During this reaction process, it is necessary to continuously stir to make the reactants fully contact to promote the smooth progress of the reaction.
After waiting for the reaction for a period of time, the progress of the reaction is monitored by thin-layer chromatography (TLC). When it is confirmed that the reaction is basically completed, that is, the raw material point disappears or reaches the expected degree of reaction, the reaction system is raised to room temperature. Then, an appropriate amount of water is added to the system to stop the reaction and promote the precipitation of the product.
Then, use conventional separation methods, such as extraction, liquid separation, etc. Extract with a suitable organic solvent, such as dichloromethane, and after multiple extractions, combine the organic phases. Then dry the organic phase with anhydrous sodium sulfate to remove the moisture. After
, the organic solvent is removed by vacuum distillation to obtain a crude product. In order to obtain high-purity 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene, further purification of the crude product is required, such as column chromatography. Select a suitable silica gel column, mix n-hexane and ethyl acetate in a certain proportion as an eluent, and then elute and collect the corresponding fractions to obtain the final target product.
The above is a common synthesis method of 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene.
First take 2- (trifluoromethyl) -1,4-dichlorobenzene as the starting material, this compound is quite critical. In a suitable reaction vessel, add an appropriate amount of organic solvent, such as N, N-dimethylformamide (DMF), which can provide a good environment for the reaction. The reaction system is cooled to a certain range, about 0 ° C to 5 ° C. This low temperature environment is conducive to the precise progress of subsequent reactions.
Slowly add thiocyanate, such as potassium thiocyanate (KSCN), and pay close attention to the reaction situation. Thiocyanate ions will undergo nucleophilic substitution with one of the chlorine atoms in 2- (trifluoromethyl) -1,4-dichlorobenzene. During this reaction process, it is necessary to continuously stir to make the reactants fully contact to promote the smooth progress of the reaction.
After waiting for the reaction for a period of time, the progress of the reaction is monitored by thin-layer chromatography (TLC). When it is confirmed that the reaction is basically completed, that is, the raw material point disappears or reaches the expected degree of reaction, the reaction system is raised to room temperature. Then, an appropriate amount of water is added to the system to stop the reaction and promote the precipitation of the product.
Then, use conventional separation methods, such as extraction, liquid separation, etc. Extract with a suitable organic solvent, such as dichloromethane, and after multiple extractions, combine the organic phases. Then dry the organic phase with anhydrous sodium sulfate to remove the moisture. After
, the organic solvent is removed by vacuum distillation to obtain a crude product. In order to obtain high-purity 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene, further purification of the crude product is required, such as column chromatography. Select a suitable silica gel column, mix n-hexane and ethyl acetate in a certain proportion as an eluent, and then elute and collect the corresponding fractions to obtain the final target product.
The above is a common synthesis method of 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene.
What are the precautions for 1-chloro-4-isothiocyanato-2- (trifluoromethyl) benzene during storage and transportation?
For 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene, many things need to be taken into account during storage and transportation.
The first thing to focus on is its chemical properties. This substance contains chlorine, isothiocyanate and trifluoromethyl, and is active in nature. When storing, it must be in a cool, dry and well-ventilated place, away from fires and heat sources. Because it is heated or exposed to open flames, it may cause severe reactions and cause danger.
Furthermore, it has strict requirements on packaging. Packaging must be strong and well sealed to prevent leakage. The packaging materials used must be resistant to corrosion, such as specific plastic or metal containers, and their dangerous characteristics and warning labels should be clearly marked on the outside of the packaging.
During transportation, it should not be slack. It should be shipped separately from oxidants, acids, alkalis, etc., to avoid chemical reactions caused by mixed packaging. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prevent accidents. Escort personnel must be familiar with their characteristics and emergency response methods, and always pay attention to the transportation situation.
In addition, due to its irritation and toxicity, contact may endanger the human body. Storage and transportation sites should be equipped with appropriate personal protective equipment, such as gas masks, protective gloves and protective clothing, to protect the safety of workers. And the place should be equipped with eyewash and shower equipment to deal with accidents in a timely manner.
In short, the storage and transportation of 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene are all related to safety and must be operated in strict accordance with regulations without any negligence.
The first thing to focus on is its chemical properties. This substance contains chlorine, isothiocyanate and trifluoromethyl, and is active in nature. When storing, it must be in a cool, dry and well-ventilated place, away from fires and heat sources. Because it is heated or exposed to open flames, it may cause severe reactions and cause danger.
Furthermore, it has strict requirements on packaging. Packaging must be strong and well sealed to prevent leakage. The packaging materials used must be resistant to corrosion, such as specific plastic or metal containers, and their dangerous characteristics and warning labels should be clearly marked on the outside of the packaging.
During transportation, it should not be slack. It should be shipped separately from oxidants, acids, alkalis, etc., to avoid chemical reactions caused by mixed packaging. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prevent accidents. Escort personnel must be familiar with their characteristics and emergency response methods, and always pay attention to the transportation situation.
In addition, due to its irritation and toxicity, contact may endanger the human body. Storage and transportation sites should be equipped with appropriate personal protective equipment, such as gas masks, protective gloves and protective clothing, to protect the safety of workers. And the place should be equipped with eyewash and shower equipment to deal with accidents in a timely manner.
In short, the storage and transportation of 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene are all related to safety and must be operated in strict accordance with regulations without any negligence.
What are the effects of 1-chloro-4-isothiocyanato-2- (trifluoromethyl) benzene on the environment and human health?
The impact of 1-chloro-4-isothiocyanate-2 - (trifluoromethyl) benzene on the environment and human health is an urgent matter to be investigated.
Looking at this chemical, it may have long-lasting and refractory properties in the environment. Once released into nature, it can move between soil and water bodies. In soil, it may interfere with the structure of soil and nutrient circulation, cause soil fertility to decline, endanger the uptake of nutrients by plant roots, and then affect the growth and breeding of vegetation. In water bodies, it may pose a threat to aquatic organisms and destroy the balance of aquatic ecosystems. Due to its chlorine, fluorine and other elements, or cause damage to the physiological functions of algae, fish and other organisms, or cause their development deformities, or even death, the diversity of aquatic organisms will also decrease sharply in the long run.
As for human health, if you accidentally come into contact with this chemical, the harm is quite serious. Through skin contact, or cause skin allergies, redness, swelling and itching, eroding the protective barrier of the skin. If inhaled through the respiratory tract, it may irritate the mucous membranes of the respiratory tract, causing coughing, asthma, or even more serious respiratory diseases. Long-term exposure to it will also greatly increase the risk of lung diseases. If ingested by mistake, it will cause damage to the digestive system, causing vomiting, diarrhea and other symptoms. In severe cases, it may be life-threatening. In addition, due to its special chemical structure, or its potential carcinogenicity, teratogenicity and mutagenicity, it poses a potential threat to human genetic material and affects the health of future generations.
Therefore, it is necessary to strengthen the supervision and prevention of such chemical substances. During production and use, strict protective measures need to be taken to prevent them from escaping into the environment and endangering the ecological environment and human health.
Looking at this chemical, it may have long-lasting and refractory properties in the environment. Once released into nature, it can move between soil and water bodies. In soil, it may interfere with the structure of soil and nutrient circulation, cause soil fertility to decline, endanger the uptake of nutrients by plant roots, and then affect the growth and breeding of vegetation. In water bodies, it may pose a threat to aquatic organisms and destroy the balance of aquatic ecosystems. Due to its chlorine, fluorine and other elements, or cause damage to the physiological functions of algae, fish and other organisms, or cause their development deformities, or even death, the diversity of aquatic organisms will also decrease sharply in the long run.
As for human health, if you accidentally come into contact with this chemical, the harm is quite serious. Through skin contact, or cause skin allergies, redness, swelling and itching, eroding the protective barrier of the skin. If inhaled through the respiratory tract, it may irritate the mucous membranes of the respiratory tract, causing coughing, asthma, or even more serious respiratory diseases. Long-term exposure to it will also greatly increase the risk of lung diseases. If ingested by mistake, it will cause damage to the digestive system, causing vomiting, diarrhea and other symptoms. In severe cases, it may be life-threatening. In addition, due to its special chemical structure, or its potential carcinogenicity, teratogenicity and mutagenicity, it poses a potential threat to human genetic material and affects the health of future generations.
Therefore, it is necessary to strengthen the supervision and prevention of such chemical substances. During production and use, strict protective measures need to be taken to prevent them from escaping into the environment and endangering the ecological environment and human health.
Scan to WhatsApp
