Linshang Chemical
PRODUCTS
1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene
Linshang Chemical
|
HS Code |
340767 |
| Chemical Formula | C7H6ClNO4S |
| Molecular Weight | 235.64 |
| Appearance | Solid (usually a yellow - colored solid) |
| Melting Point | 108 - 110 °C |
| Boiling Point | Decomposes before boiling |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Approx. 1.59 g/cm³ |
| Odor | Typically has a faint, characteristic organic odor |
| Hazard Class | Irritant, may cause harm to eyes, skin and respiratory system |
As an accredited 1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (methylsulfonyl) - 2 - nitrobenzene, 500g packed in a sealed chemical - grade bottle. |
| Storage | 1 - Chloro - 4 - (methylsulfonyl) - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage. Store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential reactions. Follow proper safety regulations for handling and storing such chemicals. |
| Shipping | 1 - chloro - 4 - (methylsulfonyl) - 2 - nitrobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following hazardous chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leakage during transit. |
Competitive 1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene in China?
As a trusted 1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-(Methylsulfonyl)-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene?
1-Chloro-4- (methylsulfonyl) -2-nitrobenzene is also an organic compound. It has a wide range of uses and plays an important role in many fields.
In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the characteristics of chlorine atoms, methylsulfonyl groups and nitro groups in the structure, other specific functional groups can be introduced through various chemical reactions, and then complex drug molecular structures can be constructed. Taking the synthesis of a certain type of antibacterial drug as an example, this compound can be replaced by a specific nitrogen-containing heterocycle through nucleophilic substitution reaction, and then a series of reactions such as nitro reduction to obtain a drug precursor with antibacterial activity. After further modification, the finished drug can be obtained.
In the field of materials science, it also makes contributions. Because it contains strong electron-absorbing nitro groups and methyl sulfonyl groups with certain chemical stability, it can participate in the synthesis of polymer materials. For example, by condensation and polymerization with monomers containing hydroxyl groups or amino groups, polymers with special properties can be prepared. Such polymers may have good heat resistance and chemical corrosion resistance, and can be used as high-performance engineering plastics. They are used in aerospace, electronics and electrical appliances and other fields that require strict material properties.
Furthermore, in the field of pesticide synthesis, 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene is also a common raw material. After appropriate reaction modification, a variety of pesticide active ingredients can be synthesized. For example, by reacting with reagents containing sulfur, phosphorus and other elements, pesticides with insecticidal, bactericidal or herbicidal activities can be prepared, providing effective means for pest control and weed control in agricultural production.
In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the characteristics of chlorine atoms, methylsulfonyl groups and nitro groups in the structure, other specific functional groups can be introduced through various chemical reactions, and then complex drug molecular structures can be constructed. Taking the synthesis of a certain type of antibacterial drug as an example, this compound can be replaced by a specific nitrogen-containing heterocycle through nucleophilic substitution reaction, and then a series of reactions such as nitro reduction to obtain a drug precursor with antibacterial activity. After further modification, the finished drug can be obtained.
In the field of materials science, it also makes contributions. Because it contains strong electron-absorbing nitro groups and methyl sulfonyl groups with certain chemical stability, it can participate in the synthesis of polymer materials. For example, by condensation and polymerization with monomers containing hydroxyl groups or amino groups, polymers with special properties can be prepared. Such polymers may have good heat resistance and chemical corrosion resistance, and can be used as high-performance engineering plastics. They are used in aerospace, electronics and electrical appliances and other fields that require strict material properties.
Furthermore, in the field of pesticide synthesis, 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene is also a common raw material. After appropriate reaction modification, a variety of pesticide active ingredients can be synthesized. For example, by reacting with reagents containing sulfur, phosphorus and other elements, pesticides with insecticidal, bactericidal or herbicidal activities can be prepared, providing effective means for pest control and weed control in agricultural production.
What are the physical properties of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene
1 - chloro - 4 - (methylsulfonyl) -2 - nitrobenzene is an organic compound, and its physical properties are quite characteristic, as follows:
1. ** Appearance properties **: This substance is usually in solid form and exists stably at room temperature and pressure. As for its color, it can be white to light yellow powder or crystalline solid, depending on its purity and preparation method.
2. ** Melting boiling point **: Its melting point is in a specific temperature range, but the exact value varies depending on the measurement method and sample purity. In general, the melting point is relatively high, due to the strong interaction forces between molecules, such as van der Waals force and dipole-dipole interaction. As for the boiling point, it is also quite high, and in order to make it boil, a large amount of energy needs to be supplied to overcome the intermolecular forces.
3. ** Solubility **: The solubility in water is limited, because in its molecular structure, the hydrophobic aromatic ring coexists with the polar methyl sulfonyl group and nitro group, so that the overall polarity is not enough to form an effective interaction with water molecules. However, in organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., it exhibits good solubility. Due to the polarity and molecular structure of organic solvents, it can cooperate with 1-chloro-4- (methylsulfonyl) -2-nitrobenzene and cause it to dissolve through intermolecular forces.
4. ** Density **: The density is higher than that of water. When mixed with water, it will settle at the bottom. This property is due to the relative mass of its molecules and the way they are piled up, resulting in a higher mass per unit volume.
5. ** Volatility **: Low volatility. At room temperature, only a small amount of molecules have enough energy to leave the solid surface and enter the gas phase. This property is related to the strong interaction force between its molecules, which requires a large resistance to evaporate.
1. ** Appearance properties **: This substance is usually in solid form and exists stably at room temperature and pressure. As for its color, it can be white to light yellow powder or crystalline solid, depending on its purity and preparation method.
2. ** Melting boiling point **: Its melting point is in a specific temperature range, but the exact value varies depending on the measurement method and sample purity. In general, the melting point is relatively high, due to the strong interaction forces between molecules, such as van der Waals force and dipole-dipole interaction. As for the boiling point, it is also quite high, and in order to make it boil, a large amount of energy needs to be supplied to overcome the intermolecular forces.
3. ** Solubility **: The solubility in water is limited, because in its molecular structure, the hydrophobic aromatic ring coexists with the polar methyl sulfonyl group and nitro group, so that the overall polarity is not enough to form an effective interaction with water molecules. However, in organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., it exhibits good solubility. Due to the polarity and molecular structure of organic solvents, it can cooperate with 1-chloro-4- (methylsulfonyl) -2-nitrobenzene and cause it to dissolve through intermolecular forces.
4. ** Density **: The density is higher than that of water. When mixed with water, it will settle at the bottom. This property is due to the relative mass of its molecules and the way they are piled up, resulting in a higher mass per unit volume.
5. ** Volatility **: Low volatility. At room temperature, only a small amount of molecules have enough energy to leave the solid surface and enter the gas phase. This property is related to the strong interaction force between its molecules, which requires a large resistance to evaporate.
What is the chemical synthesis method of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene?
The synthesis method of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene can follow the following steps.
First take an appropriate amount of p-chlorotoluene, place it in a reactor, add an appropriate amount of fuming sulfuric acid, and make it sulfonate at a specific temperature. During this process, the methyl ortho-position of p-chlorotoluene will be replaced by sulfonyl groups to generate 4-chloro-2-methylbenzene sulfuric acid. The key to this step is to strictly control the reaction temperature and the amount of fuming sulfuric acid to ensure that the reaction proceeds in the expected direction and reduce the occurrence of side reactions.
Subsequently, the obtained 4-chloro-2-methylbenzenesulfonic acid is added with an appropriate amount of mixed acid (mixture of nitric acid and sulfuric acid) for nitrification. In this reaction, the ortho-position of the sulfonic acid group on the benzene ring will introduce the nitro group, and then generate 4-chloro-2-methyl-5-nitrobenzenesulfonic acid. This step requires close attention to the ratio of mixed acid and the change of reaction temperature to prevent undesirable conditions such as excessive nitrification.
Then 4-chloro-2-methyl-5-nitrobenzenesulfonic acid is mixed with an appropriate amount of sodium hypochlorite solution for chlorination. This reaction can convert methyl to chloromethyl to generate 1-chloro-4- (chloromethyl) -2-nitrobenzene. The concentration and reaction time of sodium hypochlorite solution need to be controlled to ensure the smooth progress of the reaction.
Finally, 1-chloro-4- (chloromethyl) -2-nitrobenzene is reacted with an appropriate amount of sodium methanethiol to generate 1-chloro-4- (methylthio) -2-nitrobenzene. After that, the methyl sulfide group is oxidized to methyl sulfonyl group with a suitable oxidizing agent, such as hydrogen peroxide, to finally obtain the target product 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene. In this oxidation step, the amount of oxidizing agent and reaction conditions must be precisely controlled to ensure the purity and yield of the product. Throughout the synthesis process, it is crucial to control the reaction conditions of each step, so that 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene can be prepared efficiently and with high purity.
First take an appropriate amount of p-chlorotoluene, place it in a reactor, add an appropriate amount of fuming sulfuric acid, and make it sulfonate at a specific temperature. During this process, the methyl ortho-position of p-chlorotoluene will be replaced by sulfonyl groups to generate 4-chloro-2-methylbenzene sulfuric acid. The key to this step is to strictly control the reaction temperature and the amount of fuming sulfuric acid to ensure that the reaction proceeds in the expected direction and reduce the occurrence of side reactions.
Subsequently, the obtained 4-chloro-2-methylbenzenesulfonic acid is added with an appropriate amount of mixed acid (mixture of nitric acid and sulfuric acid) for nitrification. In this reaction, the ortho-position of the sulfonic acid group on the benzene ring will introduce the nitro group, and then generate 4-chloro-2-methyl-5-nitrobenzenesulfonic acid. This step requires close attention to the ratio of mixed acid and the change of reaction temperature to prevent undesirable conditions such as excessive nitrification.
Then 4-chloro-2-methyl-5-nitrobenzenesulfonic acid is mixed with an appropriate amount of sodium hypochlorite solution for chlorination. This reaction can convert methyl to chloromethyl to generate 1-chloro-4- (chloromethyl) -2-nitrobenzene. The concentration and reaction time of sodium hypochlorite solution need to be controlled to ensure the smooth progress of the reaction.
Finally, 1-chloro-4- (chloromethyl) -2-nitrobenzene is reacted with an appropriate amount of sodium methanethiol to generate 1-chloro-4- (methylthio) -2-nitrobenzene. After that, the methyl sulfide group is oxidized to methyl sulfonyl group with a suitable oxidizing agent, such as hydrogen peroxide, to finally obtain the target product 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene. In this oxidation step, the amount of oxidizing agent and reaction conditions must be precisely controlled to ensure the purity and yield of the product. Throughout the synthesis process, it is crucial to control the reaction conditions of each step, so that 1-chloro-4- (methyl sulfonyl) -2-nitrobenzene can be prepared efficiently and with high purity.
What are the precautions for 1-chloro-4- (methylsulfonyl) -2-nitrobenzene during storage and transportation?
1-Chloro-4- (methylsulfonyl) -2-nitrobenzene, when storing and transporting, be sure to pay attention to many matters.
Its properties are chemical substances with specific chemical properties. When storing, the first choice is the environment. When placed in a cool, dry and well-ventilated place, it is moisture-proof and heat-insulated. If it is in a humid and warm place, it may cause its chemical properties to change, which will affect the quality.
Furthermore, the storage place should be away from fire, heat and oxidants. When this substance encounters an open flame, hot topic or oxidant, it may react violently, or even cause the risk of explosion, endangering the safety of the surrounding.
In terms of packaging, it should not be neglected. It must be packaged with suitable packaging materials to ensure good sealing and prevent leakage. If the packaging is damaged, the substance will escape, which will not only pollute the environment but also increase the risk of contact.
During transportation, it is necessary to drive with caution. Avoid bumps and collisions to prevent damage to the packaging. Transportation vehicles should also be equipped with fire equipment and emergency treatment equipment to prepare for emergencies.
Operators should strictly abide by the operating procedures and wear appropriate protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact with the substance and ensure their own safety.
In short, the storage and transportation of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene is related to safety and quality, and all links need to be handled with caution and in accordance with regulations.
Its properties are chemical substances with specific chemical properties. When storing, the first choice is the environment. When placed in a cool, dry and well-ventilated place, it is moisture-proof and heat-insulated. If it is in a humid and warm place, it may cause its chemical properties to change, which will affect the quality.
Furthermore, the storage place should be away from fire, heat and oxidants. When this substance encounters an open flame, hot topic or oxidant, it may react violently, or even cause the risk of explosion, endangering the safety of the surrounding.
In terms of packaging, it should not be neglected. It must be packaged with suitable packaging materials to ensure good sealing and prevent leakage. If the packaging is damaged, the substance will escape, which will not only pollute the environment but also increase the risk of contact.
During transportation, it is necessary to drive with caution. Avoid bumps and collisions to prevent damage to the packaging. Transportation vehicles should also be equipped with fire equipment and emergency treatment equipment to prepare for emergencies.
Operators should strictly abide by the operating procedures and wear appropriate protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact with the substance and ensure their own safety.
In short, the storage and transportation of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene is related to safety and quality, and all links need to be handled with caution and in accordance with regulations.
What are the effects of 1-chloro-4- (methylsulfonyl) -2-nitrobenzene on the environment and human health?
1-Chloro-4- (methylsulfonyl) -2-nitrobenzene is also an organic compound. The impact on the environment and human health cannot be ignored.
In the environment, this compound may be quite stable and not easy to degrade. If released in the soil, it may remain in it, accumulate gradually, cause soil properties to vary, affect the ecological balance of soil microbial communities, and then hinder the growth and nutrient uptake of plant roots. Inflow into water bodies can also endanger aquatic organisms. Because of its toxicity, it can damage the physiological functions of fish, plankton and other organisms, interfere with their important life activities such as respiration and reproduction, and destroy the structure and function of aquatic ecosystems.
As for human health, this compound may invade the human body through respiratory tract, skin contact or accidental ingestion. Its nitro and sulfonyl structures may make it potentially toxic and irritating. Long-term exposure, or irritating the skin and mucous membranes, can cause skin redness, itching, respiratory discomfort, cough, asthma and other diseases. Worse still, it may have a latent risk of carcinogenesis, teratogenesis and mutagenesis. After entering the body, or metabolically transformed, an active intermediate is formed, which damages the DNA of the cell. If the DNA repair mechanism fails, the cell may proliferate abnormally, induce cancer, or affect embryonic development, causing fetal deformities, and may also cause mutations in genetic material, harming future generations.
In summary, 1-chloro-4- (methylsulfonyl) -2-nitrobenzene poses a potential threat to the environment and human health, and should be treated with caution and its production, use and release should be strictly controlled.
In the environment, this compound may be quite stable and not easy to degrade. If released in the soil, it may remain in it, accumulate gradually, cause soil properties to vary, affect the ecological balance of soil microbial communities, and then hinder the growth and nutrient uptake of plant roots. Inflow into water bodies can also endanger aquatic organisms. Because of its toxicity, it can damage the physiological functions of fish, plankton and other organisms, interfere with their important life activities such as respiration and reproduction, and destroy the structure and function of aquatic ecosystems.
As for human health, this compound may invade the human body through respiratory tract, skin contact or accidental ingestion. Its nitro and sulfonyl structures may make it potentially toxic and irritating. Long-term exposure, or irritating the skin and mucous membranes, can cause skin redness, itching, respiratory discomfort, cough, asthma and other diseases. Worse still, it may have a latent risk of carcinogenesis, teratogenesis and mutagenesis. After entering the body, or metabolically transformed, an active intermediate is formed, which damages the DNA of the cell. If the DNA repair mechanism fails, the cell may proliferate abnormally, induce cancer, or affect embryonic development, causing fetal deformities, and may also cause mutations in genetic material, harming future generations.
In summary, 1-chloro-4- (methylsulfonyl) -2-nitrobenzene poses a potential threat to the environment and human health, and should be treated with caution and its production, use and release should be strictly controlled.
Scan to WhatsApp
