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1-Chloro-4-Methylsulfonyl-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
395417 |
| Chemical Formula | C8H6ClF3O2S |
As an accredited 1-Chloro-4-Methylsulfonyl-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl)benzene in sealed chemical - grade containers. |
| Storage | 1 - Chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially cause chemical reactions. |
| Shipping | 1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl)benzene is shipped in specialized, leak - proof containers. It adheres to strict chemical transportation regulations to ensure safe transit due to its potentially hazardous nature. |
Competitive 1-Chloro-4-Methylsulfonyl-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Chloro-4-Methylsulfonyl-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene?
1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene, Chinese name 1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene, this substance has a wide range of uses and is a key raw material and intermediate in the field of organic synthesis.
In the field of medicinal chemistry, it can be used to prepare many special drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions. After ingenious design and transformation, it is introduced into the molecular structure of drugs, thereby endowing drugs with specific physiological activities and pharmacological properties. For example, in the development of new antimicrobial drugs, it may be possible to build a core structure with antimicrobial activity through a series of reactions, providing novel drug options for fighting bacteria.
In the field of materials science, it also has important uses. With its own characteristics, it can be used to synthesize special polymer materials. For example, by polymerizing with specific monomers, polymers with special properties, such as excellent chemical resistance and hot topic stability, can be prepared. Such materials are very useful in high-end fields such as aerospace and electronics, and can provide high-performance material solutions for aircraft parts, electronic equipment shells, etc.
In addition, in the field of pesticide chemistry, it can also emerge. As a key intermediate in the synthesis of new pesticides, it helps to create high-efficiency, low-toxicity and environmentally friendly pesticide varieties. Through chemical modification and reaction, pesticides with high selectivity and strong killing power against specific pests are created, providing strong support for the prevention and control of agricultural pests and ensuring crop harvest.
In summary, 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene, with its unique structure and reactivity, plays an indispensable role in the fields of medicine, materials, pesticides, etc., promoting technological innovation and industrial development in various fields.
In the field of medicinal chemistry, it can be used to prepare many special drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions. After ingenious design and transformation, it is introduced into the molecular structure of drugs, thereby endowing drugs with specific physiological activities and pharmacological properties. For example, in the development of new antimicrobial drugs, it may be possible to build a core structure with antimicrobial activity through a series of reactions, providing novel drug options for fighting bacteria.
In the field of materials science, it also has important uses. With its own characteristics, it can be used to synthesize special polymer materials. For example, by polymerizing with specific monomers, polymers with special properties, such as excellent chemical resistance and hot topic stability, can be prepared. Such materials are very useful in high-end fields such as aerospace and electronics, and can provide high-performance material solutions for aircraft parts, electronic equipment shells, etc.
In addition, in the field of pesticide chemistry, it can also emerge. As a key intermediate in the synthesis of new pesticides, it helps to create high-efficiency, low-toxicity and environmentally friendly pesticide varieties. Through chemical modification and reaction, pesticides with high selectivity and strong killing power against specific pests are created, providing strong support for the prevention and control of agricultural pests and ensuring crop harvest.
In summary, 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene, with its unique structure and reactivity, plays an indispensable role in the fields of medicine, materials, pesticides, etc., promoting technological innovation and industrial development in various fields.
What are the physical properties of 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene
1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene is an organic compound with specific physical properties, which is very important for chemical research and industrial applications. Its physical properties are described in detail below.
Its properties are usually solid. Due to the intermolecular force, it contains chlorine, methyl sulfonyl and trifluoromethyl, which makes the molecules arranged in an orderly manner and stable at room temperature and pressure.
Melting point is one of the important physical properties of substances. The melting point of 1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene is within a certain range, but the exact value is affected by factors such as purity. This melting point characteristic causes it to change from solid to liquid at a specific temperature, which is of great significance for its storage and use.
The boiling point is also a key physical property. Under a specific pressure, the compound will boil at a certain temperature, that is, it will change from liquid to gaseous. The boiling point reflects its volatility. The boiling point of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene indicates that its volatility is weak and it is not volatile at room temperature and pressure. This property makes it relatively stable during storage and transportation.
In terms of solubility, its solubility varies in organic solvents. Usually, it is soluble in some organic solvents, such as toluene and xylene of aromatics, dichloromethane of halogenated hydrocarbons, chloroform, etc. This is due to the principle of similar phase dissolution. The molecular structure of the compound contains hydrophobic groups, which interact with organic solvents to promote its dissolution. However, its solubility in water is poor. Due to the large difference between molecular polarity and water, the force between water molecules and compound molecules is weak, making it difficult to disperse in water.
Density is also one of the physical properties. The density of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene is greater than that of water, which is of great significance when it comes to operations such as liquid-liquid separation. It will be in the lower layer in the mixed system.
In addition, the compound may have a certain odor. Although the odor description is highly subjective, the specific odor can be used as a preliminary identification basis. And it has certain characteristics of light and thermal stability. Light and thermal conditions may affect its chemical structure and physical properties. Environmental factors should be paid attention to when storing and using.
Its properties are usually solid. Due to the intermolecular force, it contains chlorine, methyl sulfonyl and trifluoromethyl, which makes the molecules arranged in an orderly manner and stable at room temperature and pressure.
Melting point is one of the important physical properties of substances. The melting point of 1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene is within a certain range, but the exact value is affected by factors such as purity. This melting point characteristic causes it to change from solid to liquid at a specific temperature, which is of great significance for its storage and use.
The boiling point is also a key physical property. Under a specific pressure, the compound will boil at a certain temperature, that is, it will change from liquid to gaseous. The boiling point reflects its volatility. The boiling point of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene indicates that its volatility is weak and it is not volatile at room temperature and pressure. This property makes it relatively stable during storage and transportation.
In terms of solubility, its solubility varies in organic solvents. Usually, it is soluble in some organic solvents, such as toluene and xylene of aromatics, dichloromethane of halogenated hydrocarbons, chloroform, etc. This is due to the principle of similar phase dissolution. The molecular structure of the compound contains hydrophobic groups, which interact with organic solvents to promote its dissolution. However, its solubility in water is poor. Due to the large difference between molecular polarity and water, the force between water molecules and compound molecules is weak, making it difficult to disperse in water.
Density is also one of the physical properties. The density of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene is greater than that of water, which is of great significance when it comes to operations such as liquid-liquid separation. It will be in the lower layer in the mixed system.
In addition, the compound may have a certain odor. Although the odor description is highly subjective, the specific odor can be used as a preliminary identification basis. And it has certain characteristics of light and thermal stability. Light and thermal conditions may affect its chemical structure and physical properties. Environmental factors should be paid attention to when storing and using.
1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene
1 - chloro - 4 - methylsulfonyl - 2 - (trifluoromethyl) benzene, an organic compound, has unique physical and chemical properties and plays a significant role in the field of organic synthesis.
Looking at its physical properties, it may be in a solid state at room temperature, because many aromatic compounds containing chlorine, fluorine and sulfonyl groups have high melting points. The exact value of its melting point is affected by intermolecular forces, such as van der Waals force, dipole-dipole interaction, etc. This compound contains polar methylsulfonyl groups and trifluoromethyl groups, which enhance the intermolecular forces and then increase the melting point.
When it comes to solubility, because it has both polar groups and non-polar benzene rings, it may exhibit specific solubility in organic solvents. Polar organic solvents such as dichloromethane and acetone may be better soluble. Due to the principle of "similar miscibility", polar solvents interact with the polar part of the compound to help it disperse in the solvent. However, the solubility in water is poor. Although there are polar groups, non-polar benzene rings account for a large proportion and have strong overall hydrophobicity.
In terms of chemical properties, chlorine atoms are its active check point. Due to the difference in electronegativity, the density of electron clouds connected to the benzene ring is uneven, and nucleophilic substitution reactions are prone to occur. Nucleophiles can attack the carbon atoms attached to chlorine, and the chloride ions leave to form new organic compounds. For example, react with sodium alcohol, or form corresponding ether compounds.
methyl sulfonyl group also affects the reactivity of the compound. This group has an electron-absorbing effect, which can reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring more difficult. However, it can stabilize the reaction intermediate and has a unique effect on specific reactions.
Trifluoromethyl also has a great influence on the properties of compounds. Trifluoromethyl is extremely electronegative and has a strong electron-absorbing effect. It not only affects the electron cloud distribution of the benzene ring, changes the reactivity of the benzene ring, but also enhances the stability and lipid solubility of the compound. In the field of medicinal chemistry, the introduction of trifluoromethyl can often improve the metabolic stability and bioavailability of drugs.
The physical and chemical properties of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene make it widely used in organic synthesis, drug development and other fields. It can participate in many organic reactions as a key intermediate and construct organic compounds with diverse structures.
Looking at its physical properties, it may be in a solid state at room temperature, because many aromatic compounds containing chlorine, fluorine and sulfonyl groups have high melting points. The exact value of its melting point is affected by intermolecular forces, such as van der Waals force, dipole-dipole interaction, etc. This compound contains polar methylsulfonyl groups and trifluoromethyl groups, which enhance the intermolecular forces and then increase the melting point.
When it comes to solubility, because it has both polar groups and non-polar benzene rings, it may exhibit specific solubility in organic solvents. Polar organic solvents such as dichloromethane and acetone may be better soluble. Due to the principle of "similar miscibility", polar solvents interact with the polar part of the compound to help it disperse in the solvent. However, the solubility in water is poor. Although there are polar groups, non-polar benzene rings account for a large proportion and have strong overall hydrophobicity.
In terms of chemical properties, chlorine atoms are its active check point. Due to the difference in electronegativity, the density of electron clouds connected to the benzene ring is uneven, and nucleophilic substitution reactions are prone to occur. Nucleophiles can attack the carbon atoms attached to chlorine, and the chloride ions leave to form new organic compounds. For example, react with sodium alcohol, or form corresponding ether compounds.
methyl sulfonyl group also affects the reactivity of the compound. This group has an electron-absorbing effect, which can reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring more difficult. However, it can stabilize the reaction intermediate and has a unique effect on specific reactions.
Trifluoromethyl also has a great influence on the properties of compounds. Trifluoromethyl is extremely electronegative and has a strong electron-absorbing effect. It not only affects the electron cloud distribution of the benzene ring, changes the reactivity of the benzene ring, but also enhances the stability and lipid solubility of the compound. In the field of medicinal chemistry, the introduction of trifluoromethyl can often improve the metabolic stability and bioavailability of drugs.
The physical and chemical properties of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene make it widely used in organic synthesis, drug development and other fields. It can participate in many organic reactions as a key intermediate and construct organic compounds with diverse structures.
What are the synthesis methods of 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene
The synthesis method of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene is often studied in the field of organic synthesis. To synthesize this substance, there are different ways, and there are several common ones.
First, it can be started by a benzene derivative containing the corresponding substituent. For example, 4-methylsulfonyl-2 - (trifluoromethyl) aniline is used as a raw material, through diazotization reaction, and then interacts with cuprous chloride to introduce chlorine atoms. The steps are as follows: First dissolve 4-methylsulfonyl-2- (trifluoromethyl) aniline in an appropriate amount of inorganic acid, and add sodium nitrite solution dropwise at low temperature to form a diazonium salt. Subsequently, the diazonium salt solution is slowly added to the solution containing cuprous chloride, and the reaction temperature and time are controlled to obtain 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene. This method requires attention to the conditions of the diazotization reaction, and the temperature should be low to prevent the decomposition of diazonium salts.
Second, halogenated benzene can also be used. For example, select a suitable halogenated benzene with one of methyl sulfonyl or trifluoromethyl groups on it, and introduce the remaining substituents through a metal-catalyzed coupling reaction. If 1-chloro-2- (trifluoromethyl) benzene is used as the starting material, a palladium-catalyzed reaction can be used to react with a methyl sulfonylation reagent to achieve the synthesis of the target product. This process requires careful selection of palladium catalysts and their ligands to regulate the pH and reaction time of the reaction to improve the reaction yield and selectivity.
Furthermore, benzene is used as the starting material and the desired substituent is constructed through a multi-step reaction. Benzene is first sulfonated, methanesulfonyl is introduced, then chlorine atoms are introduced through halogenation reaction, and finally trifluoromethyl is introduced by suitable methods. However, this approach has many steps, and the reaction conditions of each step need to be carefully controlled, and the yield of each step affects the yield of the final product.
There are many methods for synthesizing 1-chloro-4-methanesulfonyl-2 - (trifluoromethyl) benzene, each with its own advantages and disadvantages. In practical application, the choice needs to be weighed according to factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the cost.
First, it can be started by a benzene derivative containing the corresponding substituent. For example, 4-methylsulfonyl-2 - (trifluoromethyl) aniline is used as a raw material, through diazotization reaction, and then interacts with cuprous chloride to introduce chlorine atoms. The steps are as follows: First dissolve 4-methylsulfonyl-2- (trifluoromethyl) aniline in an appropriate amount of inorganic acid, and add sodium nitrite solution dropwise at low temperature to form a diazonium salt. Subsequently, the diazonium salt solution is slowly added to the solution containing cuprous chloride, and the reaction temperature and time are controlled to obtain 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene. This method requires attention to the conditions of the diazotization reaction, and the temperature should be low to prevent the decomposition of diazonium salts.
Second, halogenated benzene can also be used. For example, select a suitable halogenated benzene with one of methyl sulfonyl or trifluoromethyl groups on it, and introduce the remaining substituents through a metal-catalyzed coupling reaction. If 1-chloro-2- (trifluoromethyl) benzene is used as the starting material, a palladium-catalyzed reaction can be used to react with a methyl sulfonylation reagent to achieve the synthesis of the target product. This process requires careful selection of palladium catalysts and their ligands to regulate the pH and reaction time of the reaction to improve the reaction yield and selectivity.
Furthermore, benzene is used as the starting material and the desired substituent is constructed through a multi-step reaction. Benzene is first sulfonated, methanesulfonyl is introduced, then chlorine atoms are introduced through halogenation reaction, and finally trifluoromethyl is introduced by suitable methods. However, this approach has many steps, and the reaction conditions of each step need to be carefully controlled, and the yield of each step affects the yield of the final product.
There are many methods for synthesizing 1-chloro-4-methanesulfonyl-2 - (trifluoromethyl) benzene, each with its own advantages and disadvantages. In practical application, the choice needs to be weighed according to factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the cost.
What is the price range of 1-chloro-4-methylsulfonyl-2- (trifluoromethyl) benzene in the market?
What is the price of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene in the market? To clarify this price, you need to check the quotations of various merchants. However, the market conditions are ever-changing, and the price is also changeable. This compound is mostly used in various fields of chemical industry, and its price varies with quality and quantity, and it is also related to the state of supply and demand.
If the market conditions are low from the past, the quantity is small and the quality is high, and the price may be high. To cover the complexity of its production, all kinds of fine methods are required, and a lot of materials and working hours are consumed. If the purchase quantity is large, the merchant may reduce the price to promote. And its price often changes due to the supply and demand of the city. If it needs to be prosperous and the supply is small, the price will rise; if it is supplied and needs to decline, the price will be depressed.
In the past, the price of similar fine chemical products was between thousands of yuan per kilogram and tens of thousands per kilogram. However, the confirmed price of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene must be consulted with the merchants of chemical raw materials, or the trading platforms of chemical products, in order to obtain the accurate price in the near future. And the price may vary from place to place due to differences in logistics and taxes. Therefore, if you want to know the confirmed price on the market, you should search for information widely and compare it with the reports of various companies to get a more suitable price.
If the market conditions are low from the past, the quantity is small and the quality is high, and the price may be high. To cover the complexity of its production, all kinds of fine methods are required, and a lot of materials and working hours are consumed. If the purchase quantity is large, the merchant may reduce the price to promote. And its price often changes due to the supply and demand of the city. If it needs to be prosperous and the supply is small, the price will rise; if it is supplied and needs to decline, the price will be depressed.
In the past, the price of similar fine chemical products was between thousands of yuan per kilogram and tens of thousands per kilogram. However, the confirmed price of 1-chloro-4-methylsulfonyl-2 - (trifluoromethyl) benzene must be consulted with the merchants of chemical raw materials, or the trading platforms of chemical products, in order to obtain the accurate price in the near future. And the price may vary from place to place due to differences in logistics and taxes. Therefore, if you want to know the confirmed price on the market, you should search for information widely and compare it with the reports of various companies to get a more suitable price.
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