Linshang Chemical
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1-Chloro-4-(Methylsulfonyl)-Benzene
Linshang Chemical
|
HS Code |
331330 |
| Chemical Formula | C7H7ClO2S |
| Molar Mass | 190.65 g/mol |
| Appearance | Solid (usually white or off - white) |
| Odor | May have a characteristic, pungent odor |
| Melting Point | Typically in a certain temperature range (e.g., 70 - 75°C, approximate) |
| Boiling Point | At a relatively high temperature, details vary with conditions |
| Density | Specific value depending on conditions, but generally has a certain mass per unit volume |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some common organic solvents like dichloromethane |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 1-Chloro-4-(Methylsulfonyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (methylsulfonyl) - benzene: 500g in sealed, chemical - resistant bottle. |
| Storage | 1 - chloro - 4 - (methylsulfonyl) - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and ignition sources due to its potential flammability. Store in a tightly sealed container to prevent moisture absorption and vapor leakage. Separate from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 1 - chloro - 4 - (methylsulfonyl) - benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transit to prevent leakage and potential environmental or safety risks. |
Competitive 1-Chloro-4-(Methylsulfonyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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Where to Buy 1-Chloro-4-(Methylsulfonyl)-Benzene in China?
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As a leading 1-Chloro-4-(Methylsulfonyl)-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-4- (methylsulfonyl) benzene?
The chemical properties of 1 + -deuterium-4- (methyl tracer group) benzene are important in organic chemistry.
Deuterium, the isotope of hydrogen, has more neutrons than hydrogen. In the structure of benzene, if there is deuterium to replace hydrogen, because the mass of deuterium is larger than that of hydrogen, it can affect the physical and chemical properties of benzene. It can cause the vibration frequency of the molecule to change. In the reaction kinetics, the reaction rate of deuterated benzene may be different from that of ordinary benzene, which is the kinetic isotope effect. For example, in the electrophilic substitution reaction, when the C-H (or C-D) bond is broken, the reaction rate may be slightly slower because the energy of the C-D bond is slightly higher than that of the C-H bond.
As for the methyl tracer group connected to the benzene ring, methyl is the power supply sub-group, which can increase the electron cloud density of the benzene ring. This electronic effect makes the benzene ring more prone to electrophilic substitution, and the electron cloud density of the adjacent and para-position of methyl increases more significantly. Therefore, electrophilic reagents attack the o and para-position more. For example, the nitration of toluene is easier to carry out than benzene, and the main products are o-nitrotoluene and p-nitrotoluene. At the same time, methyl is affected by benzene ring, and its α-hydrogen also has certain activity, and can undergo oxidation and other reactions. For example, toluene can be oxidized to benzoic acid by acidic potassium permanganate solution.
In summary, 1 + -deuterium-4- (methyl tracer group) benzene has both deuteration and methyl substitution on the chemical properties of benzene, which is of great significance in the fields of organic synthesis and reaction mechanism research.
Deuterium, the isotope of hydrogen, has more neutrons than hydrogen. In the structure of benzene, if there is deuterium to replace hydrogen, because the mass of deuterium is larger than that of hydrogen, it can affect the physical and chemical properties of benzene. It can cause the vibration frequency of the molecule to change. In the reaction kinetics, the reaction rate of deuterated benzene may be different from that of ordinary benzene, which is the kinetic isotope effect. For example, in the electrophilic substitution reaction, when the C-H (or C-D) bond is broken, the reaction rate may be slightly slower because the energy of the C-D bond is slightly higher than that of the C-H bond.
As for the methyl tracer group connected to the benzene ring, methyl is the power supply sub-group, which can increase the electron cloud density of the benzene ring. This electronic effect makes the benzene ring more prone to electrophilic substitution, and the electron cloud density of the adjacent and para-position of methyl increases more significantly. Therefore, electrophilic reagents attack the o and para-position more. For example, the nitration of toluene is easier to carry out than benzene, and the main products are o-nitrotoluene and p-nitrotoluene. At the same time, methyl is affected by benzene ring, and its α-hydrogen also has certain activity, and can undergo oxidation and other reactions. For example, toluene can be oxidized to benzoic acid by acidic potassium permanganate solution.
In summary, 1 + -deuterium-4- (methyl tracer group) benzene has both deuteration and methyl substitution on the chemical properties of benzene, which is of great significance in the fields of organic synthesis and reaction mechanism research.
What are the main applications of 1-chloro-4- (methylsulfonyl) benzene?
1 + -Alkane-4- (methylimidazolyl) boron is mainly used in many fields. In the field of organic synthesis, it can act as a high-efficiency catalyst. With its unique electronic properties and spatial structure, it can effectively catalyze a variety of organic reactions, such as carbon-carbon bond formation reactions, functional group conversion reactions, etc., greatly improving the reaction efficiency and selectivity, and providing a convenient way for the synthesis of organic compounds. In the field of materials science, it can participate in the preparation of special functional materials. Due to its special chemical structure, it endows materials with unique properties such as excellent electrical conductivity, thermal stability, and mechanical properties, which is of great significance in fields such as electronic devices and aerospace that require strict material properties. In pharmaceutical chemistry, it can be used as a key intermediate for drug synthesis. With its structural properties, it can build structures similar to biologically active molecules, creating conditions for the development of new drugs, and helping to develop innovative drugs with better efficacy and fewer side effects. In the field of catalytic chemistry, as a new type of catalyst, it not only has high catalytic activity, but also can promote reactions under relatively mild conditions, reduce energy consumption and environmental pollution, and play an important role in sustainable chemical synthesis.
What is the preparation method of 1-chloro-4- (methylsulfonyl) benzene?
To prepare 1-bromo-4- (methoxycarbonyl) benzene, you can follow the following ancient method:
Take terephthalic acid first, place it in a kettle, infiltrate it with an appropriate amount of methanol, and then add a few drops of concentrated sulfuric acid as a catalytic agent. Seal the mouth of the kettle, heat it to a moderate temperature, and maintain it for several hours. This is an esterification reaction. Terephthalic acid interacts with methanol to obtain dimethyl terephthalate. The principle is that the acid and alcohol are catalyzed to dehydrate into esters.
After the reaction is completed, cool, and take out the resulting dimethyl terephthalate. Take another clean vessel, put it into this material, and dissolve it with an appropriate amount of anhydrous tetrahydrofuran. Under the protection of low temperature and nitrogen atmosphere, slowly add a solution containing brominating reagents, such as tetrahydrofuran solution of copper bromide, and stir at the same time. This step is a bromination reaction, in which bromine atoms replace hydrogen atoms on the benzene ring to obtain a crude product of 1-bromo-4- (methoxycarbonyl) benzene. The electron cloud density of the benzene ring is suitable, and the brominating reagent can undergo electrophilic substitution with it.
After the reaction is completed, quench the reaction with an appropriate amount of water, and then extract the product with an organic solvent such as dichloromethane. The organic phase is collected and dried with anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by vacuum distillation, and then purified by column chromatography to obtain pure 1-bromo-4- (methoxycarbonyl) benzene. Column chromatography, according to the difference in the distribution coefficient of different substances in the stationary phase and the mobile phase, to achieve separation and purification.
The whole process, pay attention to factors such as temperature, reagent dosage, reaction time, etc., a slight difference will affect the yield and purity of the product. When operating, it is also necessary to strictly follow the procedures to ensure safety.
Take terephthalic acid first, place it in a kettle, infiltrate it with an appropriate amount of methanol, and then add a few drops of concentrated sulfuric acid as a catalytic agent. Seal the mouth of the kettle, heat it to a moderate temperature, and maintain it for several hours. This is an esterification reaction. Terephthalic acid interacts with methanol to obtain dimethyl terephthalate. The principle is that the acid and alcohol are catalyzed to dehydrate into esters.
After the reaction is completed, cool, and take out the resulting dimethyl terephthalate. Take another clean vessel, put it into this material, and dissolve it with an appropriate amount of anhydrous tetrahydrofuran. Under the protection of low temperature and nitrogen atmosphere, slowly add a solution containing brominating reagents, such as tetrahydrofuran solution of copper bromide, and stir at the same time. This step is a bromination reaction, in which bromine atoms replace hydrogen atoms on the benzene ring to obtain a crude product of 1-bromo-4- (methoxycarbonyl) benzene. The electron cloud density of the benzene ring is suitable, and the brominating reagent can undergo electrophilic substitution with it.
After the reaction is completed, quench the reaction with an appropriate amount of water, and then extract the product with an organic solvent such as dichloromethane. The organic phase is collected and dried with anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by vacuum distillation, and then purified by column chromatography to obtain pure 1-bromo-4- (methoxycarbonyl) benzene. Column chromatography, according to the difference in the distribution coefficient of different substances in the stationary phase and the mobile phase, to achieve separation and purification.
The whole process, pay attention to factors such as temperature, reagent dosage, reaction time, etc., a slight difference will affect the yield and purity of the product. When operating, it is also necessary to strictly follow the procedures to ensure safety.
What are the precautions for storing and transporting 1-chloro-4- (methylsulfonyl) benzene?
In the process of storage and storage of 1 + -4- (methyl-based) benzene, the following things should be paid attention to:
First, because of its chemical activity, it should be dry, dry, and pass well. If the environment is damp, or it causes its water to react, it will change its self-chemical properties; if the degree is high, it will cause decomposition, polymerization and other reactions, which will endanger safety. And the oxidizing properties and other substances that are contrary to the original chemical properties should be stored separately to prevent the production of strong chemical reactions, such as explosion, fire and other damage.
Second, it is necessary to abide by the regulations of the phase-hazardous chemical products. The container should have good sealing to prevent leakage. In the same way, the container needs to be able to withstand the corrosion of materials. If the container is exposed to chemicals, it will not pollute the environment, or cause poisoning to the surrounding organisms. It is also equipped with emergency treatment, such as fire equipment, adsorption materials, etc. Once there is a sudden event such as leakage, it can quickly develop emergency treatment and reduce the harm.
Third, whether it exists or not, everyone is well-versed in the dangerous characteristics of materials, safe operation and emergency treatment methods. Operators must wear protective clothing, such as protective clothing, gloves, gas masks, etc., to avoid skin contact and inhalation and ensure their own safety.
First, because of its chemical activity, it should be dry, dry, and pass well. If the environment is damp, or it causes its water to react, it will change its self-chemical properties; if the degree is high, it will cause decomposition, polymerization and other reactions, which will endanger safety. And the oxidizing properties and other substances that are contrary to the original chemical properties should be stored separately to prevent the production of strong chemical reactions, such as explosion, fire and other damage.
Second, it is necessary to abide by the regulations of the phase-hazardous chemical products. The container should have good sealing to prevent leakage. In the same way, the container needs to be able to withstand the corrosion of materials. If the container is exposed to chemicals, it will not pollute the environment, or cause poisoning to the surrounding organisms. It is also equipped with emergency treatment, such as fire equipment, adsorption materials, etc. Once there is a sudden event such as leakage, it can quickly develop emergency treatment and reduce the harm.
Third, whether it exists or not, everyone is well-versed in the dangerous characteristics of materials, safe operation and emergency treatment methods. Operators must wear protective clothing, such as protective clothing, gloves, gas masks, etc., to avoid skin contact and inhalation and ensure their own safety.
What are the effects of 1-chloro-4- (methylsulfonyl) benzene on the environment and human health?
Radon is a radioactive substance. In the natural environment, it is often produced by radioactive substances in soil, rock, and water. And (methyl tert-butyl ether) this substance is also a substance that affects the environment and human health.
First of all, the shadow of radon. If radon is concentrated in the room, when people are exposed to it during the period, its radioactivity can cause damage to the lung cells. The decaying substance of radon emits a particle, which has high energy and can penetrate deep into the lungs, destroying the DNA of the lung cells, and greatly increasing the risk of lung cancer. Studies have shown that radon is the second leading cause of lung cancer, the second largest cause of lung cancer, and the second largest cause is inhalation. And in dense air, such as basements and rooms with poor ventilation, radon levels are easy to rise, which is especially harmful.
As for (methyl tert-butyl ether), its environmental impact cannot be ignored. If this substance enters the soil and groundwater, it will be degraded and retained for a long time. It can pollute groundwater sources and affect the survival of aquatic organisms. For humans, if (methyl tert-butyl ether) enters the human body with water or breathing, it may irritate the respiratory tract, eyes and skin. Some studies have also pointed out that it may be mutagenic, and human genes have not been completely affected, but it has been widely reported.
Therefore, radon (methyl tert-butyl ether) is a serious pollutant, such as adding measures to reduce indoor radon levels and control (methyl tert-butyl ether) emissions, in order to reduce its environmental and human health hazards.
First of all, the shadow of radon. If radon is concentrated in the room, when people are exposed to it during the period, its radioactivity can cause damage to the lung cells. The decaying substance of radon emits a particle, which has high energy and can penetrate deep into the lungs, destroying the DNA of the lung cells, and greatly increasing the risk of lung cancer. Studies have shown that radon is the second leading cause of lung cancer, the second largest cause of lung cancer, and the second largest cause is inhalation. And in dense air, such as basements and rooms with poor ventilation, radon levels are easy to rise, which is especially harmful.
As for (methyl tert-butyl ether), its environmental impact cannot be ignored. If this substance enters the soil and groundwater, it will be degraded and retained for a long time. It can pollute groundwater sources and affect the survival of aquatic organisms. For humans, if (methyl tert-butyl ether) enters the human body with water or breathing, it may irritate the respiratory tract, eyes and skin. Some studies have also pointed out that it may be mutagenic, and human genes have not been completely affected, but it has been widely reported.
Therefore, radon (methyl tert-butyl ether) is a serious pollutant, such as adding measures to reduce indoor radon levels and control (methyl tert-butyl ether) emissions, in order to reduce its environmental and human health hazards.
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