Linshang Chemical
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1-Chloro-4-Nitro-2-(Trifluoromethyl)-Benzene
Linshang Chemical
|
HS Code |
972855 |
| Chemical Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Color | Off - white to yellowish |
| Odor | Pungent (likely) |
| Melting Point | 39 - 41 °C |
| Boiling Point | 213 - 214 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
As an accredited 1-Chloro-4-Nitro-2-(Trifluoromethyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - nitro - 2 - (trifluoromethyl) - benzene, 500g packed in a sealed chemical - grade bottle. |
| Storage | 1 - Chloro - 4 - nitro - 2 - (trifluoromethyl) - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It must be separated from oxidizing agents, reducing agents, and reactive compounds. Keep it in a tightly - sealed container made of suitable materials like glass or corrosion - resistant plastics to prevent leakage and exposure to air or moisture. |
| Shipping | 1 - chloro - 4 - nitro - 2 - (trifluoromethyl) - benzene is a chemical. Shipping requires compliance with hazardous material regulations. It must be properly packaged, labeled, and transported by approved carriers to ensure safety during transit. |
Competitive 1-Chloro-4-Nitro-2-(Trifluoromethyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 1-chloro-4-nitro-2- (trifluoromethyl) benzene?
1 - chloro - 4 - nitro - 2 - (trifluoromethyl) benzene, the Chinese name for 1 - chloro - 4 - nitro - 2 - (trifluoromethyl) benzene, the main use of this substance, mostly in the field of synthesis.
First, it can be used in synthesis. In today's research and development, it is very important to have the best synthesis. 1-Chloro-4-nitro-2 - (trifluoromethyl) benzene can be synthesized by multiplication and reaction, such as nuclear substitution and reaction, etc., to introduce specific functional and biologically active molecules, laying the foundation for the research of new compounds.
Second, it is also valuable in the field of synthesis. The research of this compound is designed to effectively prevent and control diseases and ensure production. This compound can be synthesized with high efficiency and low toxicity. Due to its fluorine-containing atoms, it can increase the lipid solubility of compounds, improve the qualitative properties of their biological activities, make it easier to penetrate biofilms, increase the effect of target organisms, and reduce the retention in the environment. It is in line with the development of modern color.
Third, it is also useful in materials science. It can be used as a starting material for synthesizing special polymer materials. By introducing it into polymers, it can give polymer materials many special properties, such as resistance and high resistance. Due to the high absorptivity of fluorine atoms and the high performance of carbon-fluorine atoms, it can effectively improve the qualitative inertness of materials, so that they can still maintain good performance in special environments. It may have extraordinary performance in high-end fields such as aerospace and electronics.
First, it can be used in synthesis. In today's research and development, it is very important to have the best synthesis. 1-Chloro-4-nitro-2 - (trifluoromethyl) benzene can be synthesized by multiplication and reaction, such as nuclear substitution and reaction, etc., to introduce specific functional and biologically active molecules, laying the foundation for the research of new compounds.
Second, it is also valuable in the field of synthesis. The research of this compound is designed to effectively prevent and control diseases and ensure production. This compound can be synthesized with high efficiency and low toxicity. Due to its fluorine-containing atoms, it can increase the lipid solubility of compounds, improve the qualitative properties of their biological activities, make it easier to penetrate biofilms, increase the effect of target organisms, and reduce the retention in the environment. It is in line with the development of modern color.
Third, it is also useful in materials science. It can be used as a starting material for synthesizing special polymer materials. By introducing it into polymers, it can give polymer materials many special properties, such as resistance and high resistance. Due to the high absorptivity of fluorine atoms and the high performance of carbon-fluorine atoms, it can effectively improve the qualitative inertness of materials, so that they can still maintain good performance in special environments. It may have extraordinary performance in high-end fields such as aerospace and electronics.
What are the physical properties of 1-chloro-4-nitro-2- (trifluoromethyl) benzene
1 - chloro - 4 - nitro - 2 - (trifluoromethyl) benzene is an organic compound with unique physical properties and is very important in the field of chemistry. The appearance of this compound is often colorless to light yellow liquid with a special odor. Due to the presence of fluorine atoms, the relative density is greater than that of water, about 1.6g/cm ³, which has high stability. Its boiling point is 220-225 ° C. At this temperature, the molecules gain enough energy to overcome the intermolecular forces and change from liquid to gaseous state. The melting point is about -3 ° C. Below this temperature, the molecular movement slows down, the arrangement is orderly, and the compound solidifies.
1 - chloro - 4 - nitro - 2 - (trifluoromethyl) benzene is slightly soluble in water. Because water is a polar molecule, the compound contains nitro, trifluoromethyl, etc., and the structure is asymmetric. Although it has a certain polarity, it is less polar than water. According to the principle of similar miscibility, it is difficult to dissolve in water. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. The polarity of organic solvents is similar to that of this compound, and weak interactions can be formed between molecules to promote dissolution.
The vapor pressure of this compound is low, indicating that it evaporates slowly at room temperature. The vapor pressure is related to the intermolecular force, and there are van der Waals forces and nitro, trifluoromethyl and other groups interacting between the molecules, resulting in a small tendency for the molecules to escape from the liquid surface to form steam. In addition, 1-chloro-4-nitro-2 - (trifluoromethyl) benzene has certain stability to light and heat. Because it contains stable carbon-fluorine bonds and has high carbon-fluorine bond energy, it needs high energy to break down. Therefore, it is not easy to decompose under general light and heat conditions, and its chemical properties are relatively stable. It is widely used in organic synthesis and other fields.
1 - chloro - 4 - nitro - 2 - (trifluoromethyl) benzene is slightly soluble in water. Because water is a polar molecule, the compound contains nitro, trifluoromethyl, etc., and the structure is asymmetric. Although it has a certain polarity, it is less polar than water. According to the principle of similar miscibility, it is difficult to dissolve in water. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. The polarity of organic solvents is similar to that of this compound, and weak interactions can be formed between molecules to promote dissolution.
The vapor pressure of this compound is low, indicating that it evaporates slowly at room temperature. The vapor pressure is related to the intermolecular force, and there are van der Waals forces and nitro, trifluoromethyl and other groups interacting between the molecules, resulting in a small tendency for the molecules to escape from the liquid surface to form steam. In addition, 1-chloro-4-nitro-2 - (trifluoromethyl) benzene has certain stability to light and heat. Because it contains stable carbon-fluorine bonds and has high carbon-fluorine bond energy, it needs high energy to break down. Therefore, it is not easy to decompose under general light and heat conditions, and its chemical properties are relatively stable. It is widely used in organic synthesis and other fields.
What are the chemical properties of 1-chloro-4-nitro-2- (trifluoromethyl) benzene
1-Chloro-4-nitro-2- (trifluoromethyl) benzene has unique chemical properties and is of great value for investigation. This compound has the properties of halogenated aromatic hydrocarbons, and the chlorine atom is attached to the benzene ring, resulting in its activity of nucleophilic substitution reaction. The large electronegativity of the capped chlorine atom changes the electron cloud density distribution of the benzene ring. Under appropriate conditions, the chlorine atom can be replaced by nucleophilic reagents, such as reacting with nucleophilic reagents such as sodium alcohol and amines to generate corresponding substitution products.
And because it contains nitro, the nitro group is a strong electron-absorbing group, which not only greatly reduces the electron cloud density of the benzene ring, but also decreases the activity of the electrophilic substitution reaction of the benz Therefore, when electrophilic reagents attack, they mainly generate meso-substituted products. At the same time, nitro can be reduced, and can be converted into amino groups under suitable reducing agents such as iron and hydrochloric acid, catalytic hydrogenation, etc. This is an important way to synthesize amino-containing aromatic compounds.
Furthermore, trifluoromethyl in the molecule also affects its properties. Trifluoromethyl has a strong electron-absorbing induction effect, which can further reduce the electron cloud density of the benzene ring and strengthen the related properties of nitro and chlorine atoms. And the existence of trifluoromethyl makes the compound have a certain fat solubility, which affects its solubility and partition coefficient in different solvents. In the field of organic synthesis and medicinal chemistry, this property is related to the efficacy and metabolic pathways of the compound. In conclusion, the interaction of various functional groups of 1-chloro-4-nitro-2 - (trifluoromethyl) benzene results in its rich chemical properties, which have important applications in many fields such as organic synthesis, materials science, and drug development.
And because it contains nitro, the nitro group is a strong electron-absorbing group, which not only greatly reduces the electron cloud density of the benzene ring, but also decreases the activity of the electrophilic substitution reaction of the benz Therefore, when electrophilic reagents attack, they mainly generate meso-substituted products. At the same time, nitro can be reduced, and can be converted into amino groups under suitable reducing agents such as iron and hydrochloric acid, catalytic hydrogenation, etc. This is an important way to synthesize amino-containing aromatic compounds.
Furthermore, trifluoromethyl in the molecule also affects its properties. Trifluoromethyl has a strong electron-absorbing induction effect, which can further reduce the electron cloud density of the benzene ring and strengthen the related properties of nitro and chlorine atoms. And the existence of trifluoromethyl makes the compound have a certain fat solubility, which affects its solubility and partition coefficient in different solvents. In the field of organic synthesis and medicinal chemistry, this property is related to the efficacy and metabolic pathways of the compound. In conclusion, the interaction of various functional groups of 1-chloro-4-nitro-2 - (trifluoromethyl) benzene results in its rich chemical properties, which have important applications in many fields such as organic synthesis, materials science, and drug development.
What are the synthesis methods of 1-chloro-4-nitro-2- (trifluoromethyl) benzene
The synthesis method of 1-chloro-4-nitro-2- (trifluoromethyl) benzene is now your way.
First, trifluoromethylbenzene is used as the starting material. First, a mixed acid (a mixture of nitric acid and sulfuric acid) is used for nitrification. At an appropriate temperature (such as 50-60 ° C), a nitro group is introduced into the benzene ring of trifluoromethylbenzene to obtain 4-nitro-trifluoromethylbenzene. After chlorine gas is used as a halogenating agent, under the condition of light or the presence of a catalyst (such as ferric chloride), 4-nitro-trifluoromethylbenzene is chlorinated, and chlorine atoms are introduced into the ortho-position of the benzene ring to obtain 1-chloro-4-nitro-2- (trifluoromethyl) benzene.
Second, it can be started with 2-chloro-5-nitrotoluene. First, under specific conditions (such as high temperature and high pressure), methyl is converted to trifluoromethyl to obtain 1-chloro-4-nitro-2 - (trifluoromethyl) benzene with appropriate fluorination reagents (such as a mixed system of hydrogen fluoride and potassium fluoride). This process requires attention to the precise control of reaction conditions to prevent side reactions from occurring.
Third, 1-chloro-2 - (trifluoromethyl) benzene is used as the raw material. After mixed acid nitration, nitro is introduced into the para-position of benzene ring. During the reaction, factors such as temperature and acid concentration should be controlled to ensure that the reaction proceeds in the direction of the target product, and then 1-chloro-4-nitro-2- (trifluoromethyl) benzene is synthesized.
All synthesis methods have advantages and disadvantages. The choice of starting materials and the control of reaction conditions are all related to the yield and purity of the product. In practice, it is necessary to weigh according to the specific situation and choose the best method.
First, trifluoromethylbenzene is used as the starting material. First, a mixed acid (a mixture of nitric acid and sulfuric acid) is used for nitrification. At an appropriate temperature (such as 50-60 ° C), a nitro group is introduced into the benzene ring of trifluoromethylbenzene to obtain 4-nitro-trifluoromethylbenzene. After chlorine gas is used as a halogenating agent, under the condition of light or the presence of a catalyst (such as ferric chloride), 4-nitro-trifluoromethylbenzene is chlorinated, and chlorine atoms are introduced into the ortho-position of the benzene ring to obtain 1-chloro-4-nitro-2- (trifluoromethyl) benzene.
Second, it can be started with 2-chloro-5-nitrotoluene. First, under specific conditions (such as high temperature and high pressure), methyl is converted to trifluoromethyl to obtain 1-chloro-4-nitro-2 - (trifluoromethyl) benzene with appropriate fluorination reagents (such as a mixed system of hydrogen fluoride and potassium fluoride). This process requires attention to the precise control of reaction conditions to prevent side reactions from occurring.
Third, 1-chloro-2 - (trifluoromethyl) benzene is used as the raw material. After mixed acid nitration, nitro is introduced into the para-position of benzene ring. During the reaction, factors such as temperature and acid concentration should be controlled to ensure that the reaction proceeds in the direction of the target product, and then 1-chloro-4-nitro-2- (trifluoromethyl) benzene is synthesized.
All synthesis methods have advantages and disadvantages. The choice of starting materials and the control of reaction conditions are all related to the yield and purity of the product. In practice, it is necessary to weigh according to the specific situation and choose the best method.
What are the precautions for using 1-chloro-4-nitro-2- (trifluoromethyl) benzene?
1-Chloro-4-nitro-2- (trifluoromethyl) benzene, many things should be paid attention to when using it.
First of all, this product is toxic and irritating, and can cause damage to the human body if it touches the skin, eyes or inhales its vapors. Therefore, when using it, be sure to wear suitable protective equipment, such as protective gloves, goggles and gas masks, to ensure your own safety. The operating environment should also be well ventilated so that harmful vapors can dissipate in time and do not accumulate.
Second, 1-chloro-4-nitro-2- (trifluoromethyl) benzene is chemically active and easily reacts with many substances. When storing, it should be kept away from oxidizing agents, strong alkalis, etc., to prevent violent reactions and even the risk of explosion. During the use process, the operating procedures should also be strictly followed to avoid mixing with incompatible substances.
Furthermore, this substance may be harmful to the environment, and the waste after use must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations, or handed over to professional institutions for disposal to prevent pollution of environmental factors such as soil and water sources.
In addition, when using 1-chloro-4-nitro-2- (trifluoromethyl) benzene, the accuracy and cleanliness of the equipment are extremely critical. Only accurate instruments can ensure accurate experimental data, and clean equipment can avoid impurities interfering with the reaction process. After each use, the equipment should be cleaned up in time for subsequent use.
In short, when using 1-chloro-4-nitro-2- (trifluoromethyl) benzene, be vigilant at all times, take comprehensive protection, and operate in a standardized manner, so as to achieve the purpose of use and ensure the safety of personnel and the environment.
First of all, this product is toxic and irritating, and can cause damage to the human body if it touches the skin, eyes or inhales its vapors. Therefore, when using it, be sure to wear suitable protective equipment, such as protective gloves, goggles and gas masks, to ensure your own safety. The operating environment should also be well ventilated so that harmful vapors can dissipate in time and do not accumulate.
Second, 1-chloro-4-nitro-2- (trifluoromethyl) benzene is chemically active and easily reacts with many substances. When storing, it should be kept away from oxidizing agents, strong alkalis, etc., to prevent violent reactions and even the risk of explosion. During the use process, the operating procedures should also be strictly followed to avoid mixing with incompatible substances.
Furthermore, this substance may be harmful to the environment, and the waste after use must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations, or handed over to professional institutions for disposal to prevent pollution of environmental factors such as soil and water sources.
In addition, when using 1-chloro-4-nitro-2- (trifluoromethyl) benzene, the accuracy and cleanliness of the equipment are extremely critical. Only accurate instruments can ensure accurate experimental data, and clean equipment can avoid impurities interfering with the reaction process. After each use, the equipment should be cleaned up in time for subsequent use.
In short, when using 1-chloro-4-nitro-2- (trifluoromethyl) benzene, be vigilant at all times, take comprehensive protection, and operate in a standardized manner, so as to achieve the purpose of use and ensure the safety of personnel and the environment.
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