1-Chloro-4-Nitrosobenzene
Linshang Chemical
HS Code |
964053 |
Chemical Formula | C6H4ClNO |
Molecular Weight | 143.55 g/mol |
Appearance | Yellow - orange solid |
Odor | Pungent odor |
Melting Point | 44 - 46 °C |
Boiling Point | 230 - 232 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
Density | 1.322 g/cm³ |
Vapor Pressure | Low vapor pressure |
Stability | Unstable, decomposes on exposure to light and heat |
Hazardous Nature | Toxic, harmful if swallowed, inhaled or in contact with skin |
As an accredited 1-Chloro-4-Nitrosobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 1 - chloro - 4 - nitrosobenzene packaged in 100 - gram vials, sealed for safety. |
Storage | 1 - Chloro - 4 - nitrosobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points due to its potential flammability. It must be kept in a tightly sealed container to prevent release of vapors. Store it separately from oxidizing agents and reducing substances to avoid hazardous reactions. Keep it out of reach of unauthorized personnel. |
Shipping | 1 - Chloro - 4 - nitrosobenzene is a hazardous chemical. Shipping must comply with strict regulations. It should be properly packaged in approved containers, labeled clearly, and transported by carriers licensed for such hazardous substances. |
Competitive 1-Chloro-4-Nitrosobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 1-Chloro-4-Nitrosobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
First, in the synthesis of complex organic compounds, 1-chloro-4-nitrosobenzene can be used as a starting material. Because of the activity of chlorine atoms and nitroso groups, it can participate in a variety of chemical reactions, such as substitution and addition, to prepare organic molecules with different structures. For example, nucleophilic substitution reactions can be used to replace chlorine atoms with other functional groups, thereby forming new carbon-heteroatomic bonds, which lays the foundation for the synthesis of organic materials with special properties.
Second, in the field of medicinal chemistry, it also plays an important role. In the synthesis path of some drugs, 1-chloro-4-nitrosobenzene can be used as a key intermediate. By chemically modifying and transforming it, bioactive compounds can be obtained, and then new drugs can be developed to deal with various diseases.
Furthermore, in the field of materials science, organic compounds synthesized from this raw material can be used to prepare optoelectronic materials. Due to the characteristics of molecular structure, after rational design and synthesis, the prepared materials may have special optical and electrical properties, and have potential applications in electronic devices, optical displays, etc.
1-chloro-4-nitrosobenzene is an indispensable substance in many fields such as chemical industry, medicine, materials, etc., and plays an important role in promoting the development of related fields.
In terms of color state, it is often a yellow to brown crystalline solid, which exists stably at room temperature and pressure. This color state is easy to recognize by the naked eye and is an important appearance characterization of it.
Melting point is between about 44-46 degrees Celsius. When the ambient temperature rises near the melting point, this substance gradually melts from a solid state to a liquid state. This melting point characteristic is very critical when identifying and separating substances.
In terms of boiling point, it is about 251.8 degrees Celsius. At this temperature, 1-chloro-4-nitrosobenzene is converted from a liquid state to a gas state, and can be separated by distillation or other methods.
In terms of solubility, slightly soluble in water, but soluble in organic solvents such as ethanol and ether. This difference in solubility can be used to extract and separate the substance from the mixture, and the solubility of different solvents can be used to achieve the purpose of separation.
In addition, 1-chloro-4-nitrosobenzene is volatile to a certain extent and can evaporate slowly in air, but the volatilization rate varies according to ambient temperature, humidity and ventilation conditions. Its density is also a specific value. This physical property is related to measurement and mixing in chemical production and laboratory operations.
This substance has the property of nucleophilic substitution. Because its chlorine atom is quite active, chlorine is easily replaced by nucleophilic groups when encountering nucleophilic reagents. For example, when encountering hydroxyl negative ions (OH), chlorine can be replaced by hydroxyl groups to produce 4-nitrosophenol derivatives. This reaction is easier to carry out in alkaline media.
1-chloro-4-nitrosobenzene also exhibits reducing properties. Nitroso (-NO) can be reduced. In case of suitable reducing agent, nitroso can be gradually changed to amino (-NH2O) to obtain 1-chloro-4-aminobenzene. This process is commonly used in the organic synthesis of aromatic amines.
And because of the conjugated system in the molecule, 1-chloro-4-nitrosobenzene has certain electronic delocalization characteristics, which affects its chemical activity and spectral properties. In the ultraviolet-visible spectrum, it can show a specific absorption peak, which is helpful for its qualitative and quantitative analysis.
In addition, the nitroso group of 1-chloro-4-nitrosobenzene has a weak coordination ability and can form complexes with metal ions. This property may be potentially useful in the field of coordination chemistry. However, its toxicity should also be paid attention to. When operating, follow safety procedures to prevent harm to people and the environment.
Furthermore, it can also be started from p-chloronitrobenzene. With an appropriate reducing agent, under specific conditions, the nitro group is partially reduced to nitroso. However, the choice of reducing agent and the control of reaction conditions are crucial. Select the appropriate metal or metal salt, with a specific solvent and pH, so that the reaction can be smooth and the product with higher yield can be obtained.
Another way is to use benzene as the starting material, first through the chlorination reaction to obtain chlorobenzene, and then re-nitrate to obtain p-chloronitrobenzene, and finally as the above reduction steps, to form 1-chloro-4-nitrosobenzene. This whole process requires sequential control of each step of the reaction, so that the purity and yield of the product are ideal. All synthesis methods have advantages and disadvantages, and they need to be selected according to actual needs and weighed.
First, the storage place must be cool, dry and well ventilated. This chemical is very sensitive to heat and humidity. If placed in a high temperature or humid place, it may decompose or deteriorate, which may cause danger.
Second, it must be strictly isolated from oxidants, acids, alkalis, etc. 1-chloro-4-nitrosobenzene and the above substances are prone to violent reactions, or serious accidents such as fires and explosions.
Third, the storage container should be made of corrosion-resistant materials, such as glass, ceramics or specific plastics. Because of its corrosive nature, ordinary metal containers are susceptible to corrosion, resulting in leakage.
Fourth, when transporting, make sure that the container is tightly sealed to prevent leakage. Transportation vehicles also need to be equipped with corresponding emergency treatment equipment and protective equipment to deal with emergencies.
Fifth, during the handling process, the operator must handle it with care, and must not drop it or put heavy pressure on it. After the chemical is vibrated or hit, its stability is easily lost, or it may cause danger.
Sixth, whether it is storage or transportation, the place should be equipped with obvious warning signs to remind everyone to pay attention to safety. At the same time, relevant personnel must be professionally trained and familiar with its characteristics and emergency treatment methods.
First, in the field of organic synthesis, it is often used as a key intermediate. It can be converted into many other types of organic compounds through a series of chemical reactions. For example, by virtue of specific reaction conditions, it can react with many nucleophiles, thereby introducing various functional groups to build more complex organic molecules, laying the foundation for the synthesis of new drugs and functional materials.
Second, it also plays an important role in the dye industry. It can be used as a starting material for the synthesis of specific dyes. With the help of chemical modification and reaction, the dyes are endowed with unique colors and properties, so that the dyes show good adhesion, light resistance and other characteristics during the dyeing process, and improve the quality and application range of dyes.
Third, in the field of materials science, some organic materials involved in the synthesis of 1-chloro-4-nitrosobenzene have special electrical, optical or mechanical properties. These materials may be applied to electronic devices, optical sensors, etc., to promote the development of related fields.
In summary, although 1-chloro-4-nitrosobenzene is a small organic molecule, its use in the fields of organic synthesis, dye industry, and materials science is crucial, and it plays an indispensable role in promoting progress and development in various fields.
In terms of its smell, it is quite irritating. If you smell it, you can feel the breath pungent, like being in a place surrounded by spicy gas, which makes people feel slightly uncomfortable.
As for the melting point, the melting point is about [specific value] ° C, just like the winter ice is gradually warming and melting; the boiling point is around [specific value] ° C, if water is heated and evaporates.
Its density is heavier than that of water, and it is placed in water, just like a stone sinking to the bottom of the water, slowly sinking. And its solubility in water is not good, and it is difficult to dissolve with water, just like oil floating in water, and it is distinct.
However, in organic solvents, such as ethanol, ether, etc., it has good solubility and can be miscible with it, just like water emulsion blends and fuses into one.
Furthermore, it is volatile. In the air, if light smoke curls up, it slowly emits, but its degree of volatilization is not rapid, but a relatively gentle state. This kind of physical property is a key consideration in the fields of chemical industry and scientific research, and it is related to its experimental operation and application directions.
First of all, the presence of chlorine atoms (-Cl) and nitrosobenzene (-NO) in this compound gives it a specific reactivity. Chlorine atoms have a certain nucleophilic substitution activity. Because of their relatively high electronegativity, the carbon-chlorine bond electron cloud is biased towards the chlorine atom, making the carbon atom have a certain degree of positive electricity. Therefore, when encountering a nucleophilic reagent, the nucleophilic reagent can attack the carbon atom, and a nucleophilic substitution reaction occurs, and the chlorine atom is replaced by a nucleophilic group.
Furthermore, the presence of nitroso groups is also crucial. Nitroso double bonds have high activity and are prone to addition reactions. In case of some unsaturated compounds, the Nitroso double bonds can be added with them to form new compounds. This reaction is quite important in organic synthesis and can be used to construct new carbon-nitrogen or carbon-oxygen bonds.
In addition, 1-chloro-4-nitrosobenzene may also participate in redox reactions. The nitroso moiety can be oxidized to nitro (-NO 2) or reduced to amino (-NH 2) under appropriate conditions. This redox transformation can greatly change the properties and reactivity of compounds, and is a key step in the design of organic synthesis routes.
And due to the presence of benzene ring conjugation system, 1-chloro-4-nitrosobenzene can undergo aromatic electrophilic substitution. Although both chlorine atoms and nitrosos are blunt groups, the blunt effect of nitrosos is stronger. When encountering electrophilic reagents, electrophilic reagents tend to attack positions with relatively high electron cloud density on the benzene ring, such as meta-sites (due to the combined effect of chlorine atoms and nitroso groups), and then generate various electrophilic substitution products.
In summary, the chemical properties of 1-chloro-4-nitrosobenzene are rich and diverse. Nucleophilic substitution, addition, redox and aromatic electrophilic substitution are all important chemical behaviors and have important application value in the field of organic synthetic chemistry.
One can start with benzene. First, benzene is nitrified to obtain nitrobenzene. After iron and hydrochloric acid as a medium, nitrobenzene is reduced to aniline. Then acetylation of aniline with an acetylating agent, such as acetic anhydride, gives acetylaniline. Then acetylaniline is treated with mixed acid (sulfuric acid and nitric acid), and nitro is introduced in the para-position. Finally, by hydrolysis, the acetyl group is deacetylated to obtain p-nitroaniline. P-nitroaniline is reacted by diazotization, and then heated with cuprous chloride and hydrochloric acid to obtain 1-chloro-4-nitrobenzene.
Second, use p-chloroaniline as raw material. First make it diazotically, and use reagents such as sodium nitrite and hydrochloric acid. After the diazonium salt is formed, add sodium sulfite to obtain 1-chloro-4-nitrosobenzene.
Third, or it can be prepared from p-chloronitrobenzene. With an appropriate reducing agent, such as sodium sulfide, under specific conditions, p-chloronitrobenzene is partially reduced, and 1-chloro-4-nitrosobenzene can also be obtained. However, all methods have their own advantages and disadvantages. When experimenting, it is necessary to weigh and use them.
When storing it, first choose a cool, dry and well-ventilated place. This substance is extremely sensitive to temperature and humidity. High temperature and humid conditions can easily cause its properties to change, or even cause dangerous reactions. Therefore, the warehouse temperature should be controlled within a specific range, and the humidity should not be too high.
Furthermore, it must be strictly separated from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with the above-mentioned substances is likely to trigger violent chemical reactions, such as combustion, explosion and other serious accidents.
The choice of storage container is crucial. Be sure to use corrosion-resistant materials, such as special glass bottles or metal cans, and ensure that they are tightly sealed to prevent leakage. And on the container, there should be clear and prominent warning signs indicating its toxicity and hazard characteristics.
As for the transportation process, it should not be taken lightly. Transport vehicles must be equipped with professional protective and emergency equipment, and escorts must also be professionally trained to be familiar with the dangerous characteristics of the substance and emergency response methods. During transportation, vibration, impact and high temperature should be avoided, and the driving route should also avoid densely populated areas and important facilities.
When loading and unloading, the operation must be gentle, and brutal operation is strictly prohibited to prevent packaging damage. In the unfortunate event of leakage, emergency plans should be activated immediately, surrounding personnel should be evacuated, and effective leak plugging and cleaning measures should be taken to prevent the spread of pollution. Only in this way can the safety of 1-chloro-4-nitrosobenzene be guaranteed during storage and transportation.

Scan to WhatsApp