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1-Chloro-4-(Phenylsulfanyl)Benzene
Linshang Chemical
|
HS Code |
627687 |
| Chemical Formula | C12H9ClS |
| Molecular Weight | 220.72 |
| Appearance | Solid (Typical appearance, can vary) |
| Odor | May have a characteristic sulfur - containing odor |
| Melting Point | Data may vary, check literature |
| Boiling Point | Data may vary, check literature |
| Solubility In Water | Low solubility (Aromatic and sulfur - containing organic compounds generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, etc. (Based on its organic nature) |
| Density | Data may vary, check literature |
| Flash Point | Data may vary, check literature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
| Vapor Pressure | Low (Typical for non - volatile organic solids) |
As an accredited 1-Chloro-4-(Phenylsulfanyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (phenylsulfanyl)benzene, 500g, packaged in a sealed glass bottle. |
| Storage | 1 - chloro - 4 - (phenylsulfanyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and contact with moisture. Avoid storing near incompatible substances. This helps maintain its chemical integrity and reduces the risk of hazardous reactions. |
| Shipping | 1 - chloro - 4 - (phenylsulfanyl)benzene is shipped in well - sealed, corrosion - resistant containers. It's transported under strict regulations, ensuring proper handling to prevent spills as it's a chemical with potential hazards. |
Competitive 1-Chloro-4-(Phenylsulfanyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 1-chloro-4- (phenylsulfanyl) benzene?
1-Chloro-4- (phenylsulfanyl) benzene, the Chinese name for 1-chloro-4- (phenylsulfanyl) benzene, is composed of three parts.
Benzene is the backbone of this compound, which is a six-membered carbon. Each carbon atom is interconnected with each other in a common way to form a fixed plane. The carbon atoms on the benzene have a sp ² mixed domain, so that the benzene is highly co-located, which gives it special chemical properties.
At the 1-carbon position of benzene, there is a chlorine atom. The chlorine atom is a prime atom, and the carbon of the benzene atom is a common phase. The chlorine atom is more reliable than carbon, so in this system, the chlorine atom is biased towards the chlorine atom, so that this part is certain. This property affects the physical chemistry of the compound. For example, in the nuclear substitution inverse, the chlorine atom can be used as a deradicalization.
In the 4-carbon position of benzene, a phenylsulfanyl is followed. The phenylsulfanyl is formed from a benzene-sulfur atom, and the sulfur atom is a 4-carbon phase of benzene. The sulfur atom forms a co-carbon, which also has a certain sub-effect. The benzene part of the benzene-thio group forms a co-effect of the main benzene, which can affect the molecular and anti-activity of the whole molecule.
Therefore, the chemical reaction of 1-chloro-4- (phenylthio) benzene, due to the combination of benzene, chlorine atom and phenylthio group, makes it have special physical and chemical properties. It plays an important role in the research of chemical synthesis and chemical reaction.
Benzene is the backbone of this compound, which is a six-membered carbon. Each carbon atom is interconnected with each other in a common way to form a fixed plane. The carbon atoms on the benzene have a sp ² mixed domain, so that the benzene is highly co-located, which gives it special chemical properties.
At the 1-carbon position of benzene, there is a chlorine atom. The chlorine atom is a prime atom, and the carbon of the benzene atom is a common phase. The chlorine atom is more reliable than carbon, so in this system, the chlorine atom is biased towards the chlorine atom, so that this part is certain. This property affects the physical chemistry of the compound. For example, in the nuclear substitution inverse, the chlorine atom can be used as a deradicalization.
In the 4-carbon position of benzene, a phenylsulfanyl is followed. The phenylsulfanyl is formed from a benzene-sulfur atom, and the sulfur atom is a 4-carbon phase of benzene. The sulfur atom forms a co-carbon, which also has a certain sub-effect. The benzene part of the benzene-thio group forms a co-effect of the main benzene, which can affect the molecular and anti-activity of the whole molecule.
Therefore, the chemical reaction of 1-chloro-4- (phenylthio) benzene, due to the combination of benzene, chlorine atom and phenylthio group, makes it have special physical and chemical properties. It plays an important role in the research of chemical synthesis and chemical reaction.
What are the physical properties of 1-chloro-4- (phenylsulfanyl) benzene?
1 - chloro - 4 - (phenylsulfanyl) benzene, the Chinese name is often 4 - chlorophenyl phenyl sulfide. The physical properties of this substance are as follows:
Its external properties are often solid. In terms of melting, there may be differences between different texts, probably within a certain range. This melting property is due to the molecular force phase, such as van der Force, π-π stack action, etc., so that it can be fixed and liquid at a specific temperature.
is also affected by the molecular force, and the boiling phase is high due to the common system of benzene in the molecule. The boiling process is the process by which the molecule obtains sufficient energy to overcome the molecular force and escape from the liquid phase. The boiling process of this compound reflects the degree of its molecular force.
In terms of solubility, it is soluble in many kinds of soluble compounds, such as ether and dichloromethane. Due to the fact that the benzene and sulfur atomic parts in its molecules have a certain hydrophobicity, there is a non-soluble partial interaction, which conforms to the principle of similarity solubility. However, its solubility in water is poor, and the hydrophobic part of the compound can form an effective interaction due to the hydrophobicity of the water molecule.
In terms of density, there is a certain value relative to water, and this value depends on the molecular weight and the molecular stacking method. Its density characteristics affect its distribution in the mixed system. For example, in operations such as liquid-liquid extraction, it can be divided according to different densities.
Therefore, the physical properties of 1-chloro-4- (phenylsulfanyl) benzene are determined by its molecules, and are of great importance in the operation of chemical synthesis, materials production, and other fields.
Its external properties are often solid. In terms of melting, there may be differences between different texts, probably within a certain range. This melting property is due to the molecular force phase, such as van der Force, π-π stack action, etc., so that it can be fixed and liquid at a specific temperature.
is also affected by the molecular force, and the boiling phase is high due to the common system of benzene in the molecule. The boiling process is the process by which the molecule obtains sufficient energy to overcome the molecular force and escape from the liquid phase. The boiling process of this compound reflects the degree of its molecular force.
In terms of solubility, it is soluble in many kinds of soluble compounds, such as ether and dichloromethane. Due to the fact that the benzene and sulfur atomic parts in its molecules have a certain hydrophobicity, there is a non-soluble partial interaction, which conforms to the principle of similarity solubility. However, its solubility in water is poor, and the hydrophobic part of the compound can form an effective interaction due to the hydrophobicity of the water molecule.
In terms of density, there is a certain value relative to water, and this value depends on the molecular weight and the molecular stacking method. Its density characteristics affect its distribution in the mixed system. For example, in operations such as liquid-liquid extraction, it can be divided according to different densities.
Therefore, the physical properties of 1-chloro-4- (phenylsulfanyl) benzene are determined by its molecules, and are of great importance in the operation of chemical synthesis, materials production, and other fields.
What are the common synthesis methods of 1-chloro-4- (phenylsulfanyl) benzene?
The common synthesis methods of 1-chloro-4- (phenylsulfanyl) benzene are as follows:
One is the nucleophilic substitution method. Using p-chloroiodobenzene and thiophenol salt as raw materials, react in an appropriate solvent. Among them, the iodine atom in p-chloroiodobenzene is highly active, and the sulfur negative ion in thiophenol salt is nucleophilic. When the two meet, the sulfur negative ion attacks the carbon atom connected to iodine in p-chloroiodobenzene, and the iodine ion leaves, then the target product is obtained. During the reaction, a suitable solvent, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), should be selected to facilitate the dissolution and ionic activity of the reactants. At the same time, an appropriate amount of alkali, such as potassium carbonate, can be added to promote the conversion of phenylthiophenol to phenylthiophenol salts and improve the reaction efficiency.
The second is palladium catalytic coupling method. Using p-chlorophenylboronic acid and phenylthiohalide as raw materials, the reaction is reacted in the presence of palladium catalyst, ligand and base. The palladium catalyst can activate the carbon-halogen bond and carbon-boron bond in the reactant, and the ligand coordinates with palladium to stabilize the catalyst and regulate its electronic properties and spatial structure. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands such as triphenylphosphine, etc. The reaction solvent can be selected from toluene, dioxane and other organic solvents. Under heating conditions, the two go through a series of complex intermediate steps to realize carbon-sulfur bond coupling to generate 1-chloro-4- (phenylthio) benzene.
Third, 4-chlorothiophenol can also be reacted with halogenated benzene under basic conditions. 4-chlorothiophenol forms thiophenate negative ions under the action of alkali. The halogen atom in the halogenated benzene is attacked by nucleophiles, and the halogen ions leave to form the target product. The reaction requires the selection of halobenzene, and the activity of the halogen atom needs to be moderate to ensure that the reaction can occur without being too violent. The type and dosage of bases have a great impact on the reaction rate and yield, and need to be carefully regulated.
All synthesis methods have their own advantages and disadvantages. The nucleophilic substitution method has common raw materials and is relatively simple to operate, but it requires high activity of the reactants. The palladium catalytic coupling method has good selectivity and wide application range, but the catalyst is expensive and the reaction conditions are harsh. For the method using 4-chlorothiophenol as the raw material, the source of raw materials may be limited, but the steps may be relatively simple. In actual synthesis, the appropriate method is carefully selected according to factors such as raw material availability, cost, and product purity requirements.
One is the nucleophilic substitution method. Using p-chloroiodobenzene and thiophenol salt as raw materials, react in an appropriate solvent. Among them, the iodine atom in p-chloroiodobenzene is highly active, and the sulfur negative ion in thiophenol salt is nucleophilic. When the two meet, the sulfur negative ion attacks the carbon atom connected to iodine in p-chloroiodobenzene, and the iodine ion leaves, then the target product is obtained. During the reaction, a suitable solvent, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), should be selected to facilitate the dissolution and ionic activity of the reactants. At the same time, an appropriate amount of alkali, such as potassium carbonate, can be added to promote the conversion of phenylthiophenol to phenylthiophenol salts and improve the reaction efficiency.
The second is palladium catalytic coupling method. Using p-chlorophenylboronic acid and phenylthiohalide as raw materials, the reaction is reacted in the presence of palladium catalyst, ligand and base. The palladium catalyst can activate the carbon-halogen bond and carbon-boron bond in the reactant, and the ligand coordinates with palladium to stabilize the catalyst and regulate its electronic properties and spatial structure. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands such as triphenylphosphine, etc. The reaction solvent can be selected from toluene, dioxane and other organic solvents. Under heating conditions, the two go through a series of complex intermediate steps to realize carbon-sulfur bond coupling to generate 1-chloro-4- (phenylthio) benzene.
Third, 4-chlorothiophenol can also be reacted with halogenated benzene under basic conditions. 4-chlorothiophenol forms thiophenate negative ions under the action of alkali. The halogen atom in the halogenated benzene is attacked by nucleophiles, and the halogen ions leave to form the target product. The reaction requires the selection of halobenzene, and the activity of the halogen atom needs to be moderate to ensure that the reaction can occur without being too violent. The type and dosage of bases have a great impact on the reaction rate and yield, and need to be carefully regulated.
All synthesis methods have their own advantages and disadvantages. The nucleophilic substitution method has common raw materials and is relatively simple to operate, but it requires high activity of the reactants. The palladium catalytic coupling method has good selectivity and wide application range, but the catalyst is expensive and the reaction conditions are harsh. For the method using 4-chlorothiophenol as the raw material, the source of raw materials may be limited, but the steps may be relatively simple. In actual synthesis, the appropriate method is carefully selected according to factors such as raw material availability, cost, and product purity requirements.
Where is 1-chloro-4- (phenylsulfanyl) benzene used?
1-chloro-4- (phenylsulfanyl) benzene, Chinese name or 1-chloro-4- (phenylsulfanyl) benzene, this substance is used in many fields.
In the field of organic synthesis, it has a wide range of uses. It can be used as a key intermediate to prepare other sulfur-containing organic compounds. Using it as a starting material, through the nucleophilic substitution reaction of sulfur atoms, it can interact with a variety of halogenated hydrocarbons to generate thioethers with more complex structures. For example, under basic conditions with halogenated alkanes, new compounds with both alkyl and phenylthio groups can be formed. Such compounds may exhibit unique properties in the fields of drug development and materials science.
In the field of medicinal chemistry, it also has potential significance. Sulfur-containing organic compounds often play an important role in the design of drug molecules because they can change the physicochemical properties and biological activities of compounds. The structure of 1-chloro-4- (phenylthio) benzene can be used as the basic skeleton of drug molecules. After modification and modification, lead compounds with specific pharmacological activities can be obtained. For example, the introduction of specific functional groups may enhance their interaction with biological targets, and then develop new drugs.
In the field of materials science, this compound also has application opportunities. It can be used as a raw material for the synthesis of functional materials. Such as polymerization with specific monomers, or polymer materials with special electrical and optical properties can be formed. The synthesized polymers exhibit unique electron conductivity or light absorption properties due to the presence of phenylthio groups, and may be useful in organic electronic devices and optical materials.
In addition, in the field of fine chemicals, 1-chloro-4- (phenylthio) benzene can be used to prepare high-end dyes, fragrances and other fine chemicals. By chemical modification, chromophores or aroma groups can be introduced to give the product unique color or odor characteristics.
In the field of organic synthesis, it has a wide range of uses. It can be used as a key intermediate to prepare other sulfur-containing organic compounds. Using it as a starting material, through the nucleophilic substitution reaction of sulfur atoms, it can interact with a variety of halogenated hydrocarbons to generate thioethers with more complex structures. For example, under basic conditions with halogenated alkanes, new compounds with both alkyl and phenylthio groups can be formed. Such compounds may exhibit unique properties in the fields of drug development and materials science.
In the field of medicinal chemistry, it also has potential significance. Sulfur-containing organic compounds often play an important role in the design of drug molecules because they can change the physicochemical properties and biological activities of compounds. The structure of 1-chloro-4- (phenylthio) benzene can be used as the basic skeleton of drug molecules. After modification and modification, lead compounds with specific pharmacological activities can be obtained. For example, the introduction of specific functional groups may enhance their interaction with biological targets, and then develop new drugs.
In the field of materials science, this compound also has application opportunities. It can be used as a raw material for the synthesis of functional materials. Such as polymerization with specific monomers, or polymer materials with special electrical and optical properties can be formed. The synthesized polymers exhibit unique electron conductivity or light absorption properties due to the presence of phenylthio groups, and may be useful in organic electronic devices and optical materials.
In addition, in the field of fine chemicals, 1-chloro-4- (phenylthio) benzene can be used to prepare high-end dyes, fragrances and other fine chemicals. By chemical modification, chromophores or aroma groups can be introduced to give the product unique color or odor characteristics.
How safe is 1-chloro-4- (phenylsulfanyl) benzene?
1 - chloro - 4 - (phenylsulfanyl) benzene, the Chinese name is often 4 - chlorophenyl phenyl sulfide. The safety of this compound is important and needs to be increased.
In terms of its chemical properties, the chlorine atom contains a phenylsulfanyl group, and the activity of the chlorine atom can cause its substitution reaction. In case of chlorine, the chlorine atom may be replaced by a group such as a group; in case of a nucleus, the sulfur atom of the phenylsulfanyl group can be used as a nucleus center. If the amount of this reaction or emission is not controlled, it may cause the reaction to go out of control and endanger safety.
And toxicity, due to the presence of benzene, or have certain toxicity. Respiratory inhalation, skin contact or food can endanger people. Inhalation can cause respiratory irritation, such as coughing, respiratory distress; skin contact or sensitization, inflammation; food damage to the digestive system, or cause heart, vomiting, abdominal pain and other diseases. And exposure may be carcinogenic during the period, because of benzodiazepine, benzodiazepine, or accumulation.
Considering its physical properties, the compound is solid or liquid, depending on the product. If it is liquid, it can be steamed or affected in the air. High steaming means more steaming and release, increasing inhalation exposure. And its solubility affects the environment, if it dissolves in water, or pollutes water, endangering aquatic organisms; if it dissolves in water, it has solubility or its interaction, increasing fire and explosion risk.
The storage angle, the storage angle, the storage angle, the ignition source, and the oxidation. Because of its anti-oxidation activity, the oxidation mixture or the strong reaction. The storage container should be well sealed to prevent leakage. It is also necessary to follow the relevant rules and properly pack it to prevent collision and leakage.
Therefore, 1-chloro-4- (phenylsulfanyl) benzene needs to be controlled in a grid to ensure the safety of people and the environment is not endangered.
In terms of its chemical properties, the chlorine atom contains a phenylsulfanyl group, and the activity of the chlorine atom can cause its substitution reaction. In case of chlorine, the chlorine atom may be replaced by a group such as a group; in case of a nucleus, the sulfur atom of the phenylsulfanyl group can be used as a nucleus center. If the amount of this reaction or emission is not controlled, it may cause the reaction to go out of control and endanger safety.
And toxicity, due to the presence of benzene, or have certain toxicity. Respiratory inhalation, skin contact or food can endanger people. Inhalation can cause respiratory irritation, such as coughing, respiratory distress; skin contact or sensitization, inflammation; food damage to the digestive system, or cause heart, vomiting, abdominal pain and other diseases. And exposure may be carcinogenic during the period, because of benzodiazepine, benzodiazepine, or accumulation.
Considering its physical properties, the compound is solid or liquid, depending on the product. If it is liquid, it can be steamed or affected in the air. High steaming means more steaming and release, increasing inhalation exposure. And its solubility affects the environment, if it dissolves in water, or pollutes water, endangering aquatic organisms; if it dissolves in water, it has solubility or its interaction, increasing fire and explosion risk.
The storage angle, the storage angle, the storage angle, the ignition source, and the oxidation. Because of its anti-oxidation activity, the oxidation mixture or the strong reaction. The storage container should be well sealed to prevent leakage. It is also necessary to follow the relevant rules and properly pack it to prevent collision and leakage.
Therefore, 1-chloro-4- (phenylsulfanyl) benzene needs to be controlled in a grid to ensure the safety of people and the environment is not endangered.
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