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1-Chloro-4-(Phenylsulfonyl)Benzene
Linshang Chemical
|
HS Code |
998101 |
| Chemical Formula | C12H9ClO2S |
| Molar Mass | 254.717 g/mol |
| Appearance | Solid (usually white to off - white) |
| Physical State At Room Temperature | Solid |
| Melting Point | Typically in the range of 115 - 119 °C |
| Solubility In Water | Low solubility, hydrophobic |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Odor | Typically odorless or has a very faint, non - characteristic smell |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 1-Chloro-4-(Phenylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (phenylsulfonyl)benzene, 100g packed in a sealed, chemical - resistant bottle. |
| Storage | 1 - Chloro - 4 - (phenylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. This helps prevent decomposition, potential chemical reactions, and evaporation, ensuring its stability and safety during storage. |
| Shipping | 1 - chloro - 4 - (phenylsulfonyl)benzene is shipped in well - sealed containers, compliant with chemical transportation regulations. Packing ensures protection from external factors during transit to prevent spills and maintain its integrity. |
Competitive 1-Chloro-4-(Phenylsulfonyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-4-(Phenylsulfonyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-chloro-4- (phenylsulfonyl) benzene?
1-chloro-4- (phenylsulfonyl) benzene, that is, 1-chloro-4- (benzenesulfonyl) benzene, is widely used. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, chlorine atoms and benzenesulfonyl groups are highly reactive, and many organic compounds can be derived through various chemical reactions, such as nucleophilic substitution and coupling reactions.
For example, in the field of medicinal chemistry, by means of nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents containing nitrogen, oxygen, and sulfur. This process is similar to ancient bartering, each taking what is needed, and then constructing molecular structures with specific pharmacological activities. The development of many new drugs often relies on this approach to obtain key intermediates, laying the foundation for the creation of drugs with better efficacy and fewer side effects, just like building a solid foundation first.
In the field of materials science, 1-chloro-4 - (benzenesulfonyl) benzene also has extraordinary performance. By polymerizing with other monomers, it is like gathering the forces of all parties, and high-performance polymer materials can be prepared. Such materials may have excellent thermal stability, mechanical properties, or unique electrical and optical properties, and have important applications in high-end fields such as aerospace, electronics and electrical appliances, as if they are plugging powerful wings into the development of these fields.
Furthermore, in the fine chemical industry, it can be used to synthesize various functional additives, such as surfactants and antioxidants. These additives are effective in optimizing the performance of coatings, plastics, rubber and other products, making the products more durable and high-quality, just like putting a layer of strong and practical "armor" on the products. Overall, 1-chloro-4- (benzenesulfonyl) benzene plays an indispensable role in many fields and contributes significantly to the development of related industries.
For example, in the field of medicinal chemistry, by means of nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents containing nitrogen, oxygen, and sulfur. This process is similar to ancient bartering, each taking what is needed, and then constructing molecular structures with specific pharmacological activities. The development of many new drugs often relies on this approach to obtain key intermediates, laying the foundation for the creation of drugs with better efficacy and fewer side effects, just like building a solid foundation first.
In the field of materials science, 1-chloro-4 - (benzenesulfonyl) benzene also has extraordinary performance. By polymerizing with other monomers, it is like gathering the forces of all parties, and high-performance polymer materials can be prepared. Such materials may have excellent thermal stability, mechanical properties, or unique electrical and optical properties, and have important applications in high-end fields such as aerospace, electronics and electrical appliances, as if they are plugging powerful wings into the development of these fields.
Furthermore, in the fine chemical industry, it can be used to synthesize various functional additives, such as surfactants and antioxidants. These additives are effective in optimizing the performance of coatings, plastics, rubber and other products, making the products more durable and high-quality, just like putting a layer of strong and practical "armor" on the products. Overall, 1-chloro-4- (benzenesulfonyl) benzene plays an indispensable role in many fields and contributes significantly to the development of related industries.
What are the physical properties of 1-chloro-4- (phenylsulfonyl) benzene
1 - chloro - 4 - (phenylsulfonyl) benzene is also a chemical substance. Its physical properties are not available.
The first word is that this substance is often solid and has a certain shape. The method of its degree of resistance, or the method of crystallization, the crystal shape is complete, and the light is also different, or it is transparent, or slightly different.
The melting of the second melting boiling has a specific value due to the molecular force, etc. In the molecule, the interaction of the chlorine atom and the benzenesulfonyl group makes the molecule have a fixed attractive force, causing it to melt at a certain degree. And the boiling temperature is higher, and the phase energy is required to make the molecule beam and melt.
Furthermore, the solubility is also important. In the solution, such as some common aromatic dissolution, because it is similar to 1-chloro-4 - (phenylsulfonyl) benzene, it can be dissolved according to the principle of similar compatibility. However, in water, because of the hydrophobicity of its molecules, it is difficult to dissolve. In terms of density, its density may be different from that of water. Depending on the way its molecules are formed, the weight of water can be reduced, or it can be reduced. This is also determined by its transformation.
In addition, the physical properties of this substance are low, because the molecular force is sufficient to maintain its condensation under normal conditions, and it is not easy to form, unless the environmental degree is increased to the degree of phase.
Therefore, the physical properties of 1-chloro-4 - (phenylsulfonyl) benzene are determined by their specific molecular properties, and the properties are mutually dependent. It is important for chemical research and application.
The first word is that this substance is often solid and has a certain shape. The method of its degree of resistance, or the method of crystallization, the crystal shape is complete, and the light is also different, or it is transparent, or slightly different.
The melting of the second melting boiling has a specific value due to the molecular force, etc. In the molecule, the interaction of the chlorine atom and the benzenesulfonyl group makes the molecule have a fixed attractive force, causing it to melt at a certain degree. And the boiling temperature is higher, and the phase energy is required to make the molecule beam and melt.
Furthermore, the solubility is also important. In the solution, such as some common aromatic dissolution, because it is similar to 1-chloro-4 - (phenylsulfonyl) benzene, it can be dissolved according to the principle of similar compatibility. However, in water, because of the hydrophobicity of its molecules, it is difficult to dissolve. In terms of density, its density may be different from that of water. Depending on the way its molecules are formed, the weight of water can be reduced, or it can be reduced. This is also determined by its transformation.
In addition, the physical properties of this substance are low, because the molecular force is sufficient to maintain its condensation under normal conditions, and it is not easy to form, unless the environmental degree is increased to the degree of phase.
Therefore, the physical properties of 1-chloro-4 - (phenylsulfonyl) benzene are determined by their specific molecular properties, and the properties are mutually dependent. It is important for chemical research and application.
What are the synthesis methods of 1-chloro-4- (phenylsulfonyl) benzene
1 - chloro - 4 - (phenylsulfonyl) benzene is an important compound in the field of organic synthesis. Its synthesis method often involves several classical organic reactions, which are described in detail below.
First, p-chlorothiophenol and bromobenzene can be used as starting materials. First, p-chlorothiophenol interacts with a base, such as sodium hydroxide, to form the corresponding phenol salt. This phenol salt has strong nucleophilicity, and then it undergoes a nucleophilic substitution reaction with bromobenzene under the catalysis of a suitable catalyst, such as a copper salt. The bromine atom of bromobenzene is suitably active and can be attacked by the sulfur atom of the phenol salt to form p-chlorophenyl phenyl sulfide. This step needs to be carried out in a suitable solvent, such as dimethyl sulfoxide (DMSO), to promote the smooth occurrence of the reaction. Subsequently, the generated p-chlorophenyl phenyl sulfide is oxidized, and m-chloroperoxybenzoic acid (m-CPBA) is used as the oxidant to oxidize the sulfide to sulfone to obtain 1-chloro-4- (phenylsulfonyl) benzene.
Second, p-chlorobenzene sulfonyl chloride and benzene are used as raw materials. Under the catalysis of Lewis acid such as anhydrous aluminum trichloride, p-chlorobenzene sulfonyl chloride and benzene undergo Fu-gram acylation reaction. The benzene ring is nucleophilic, and the acyl cation of p-chlorobenzenesulfonyl chloride is attacked by the benzene ring to form 1-chloro-4- (phenylsulfonyl) benzene. This reaction needs to be carried out under anhydrous conditions to avoid the hydrolysis of catalysts such as aluminum trichloride, and the reaction temperature needs to be strictly controlled, usually between low temperature and room temperature.
In addition, p-chlorobenzenesulfonyl boronic acid and 4-bromobenzenesulfonylbenzene can also be synthesized. Under the catalysis of palladium, the Suzuki coupling reaction occurs. In the presence of base and palladium catalyst, p-chlorophenylboronic acid and 4-bromobenzenesulfonyl benzene are coupled in a suitable solvent such as toluene-water mixed solvent under heating conditions to form a carbon-carbon bond, and then form the target product 1-chloro-4- (phenylsulfonyl) benzene. The key to this reaction lies in the activity of palladium catalyst and the type and amount of base. Appropriate selection can improve the reaction yield.
In summary, these three synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path needs to be reasonably selected according to the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product.
First, p-chlorothiophenol and bromobenzene can be used as starting materials. First, p-chlorothiophenol interacts with a base, such as sodium hydroxide, to form the corresponding phenol salt. This phenol salt has strong nucleophilicity, and then it undergoes a nucleophilic substitution reaction with bromobenzene under the catalysis of a suitable catalyst, such as a copper salt. The bromine atom of bromobenzene is suitably active and can be attacked by the sulfur atom of the phenol salt to form p-chlorophenyl phenyl sulfide. This step needs to be carried out in a suitable solvent, such as dimethyl sulfoxide (DMSO), to promote the smooth occurrence of the reaction. Subsequently, the generated p-chlorophenyl phenyl sulfide is oxidized, and m-chloroperoxybenzoic acid (m-CPBA) is used as the oxidant to oxidize the sulfide to sulfone to obtain 1-chloro-4- (phenylsulfonyl) benzene.
Second, p-chlorobenzene sulfonyl chloride and benzene are used as raw materials. Under the catalysis of Lewis acid such as anhydrous aluminum trichloride, p-chlorobenzene sulfonyl chloride and benzene undergo Fu-gram acylation reaction. The benzene ring is nucleophilic, and the acyl cation of p-chlorobenzenesulfonyl chloride is attacked by the benzene ring to form 1-chloro-4- (phenylsulfonyl) benzene. This reaction needs to be carried out under anhydrous conditions to avoid the hydrolysis of catalysts such as aluminum trichloride, and the reaction temperature needs to be strictly controlled, usually between low temperature and room temperature.
In addition, p-chlorobenzenesulfonyl boronic acid and 4-bromobenzenesulfonylbenzene can also be synthesized. Under the catalysis of palladium, the Suzuki coupling reaction occurs. In the presence of base and palladium catalyst, p-chlorophenylboronic acid and 4-bromobenzenesulfonyl benzene are coupled in a suitable solvent such as toluene-water mixed solvent under heating conditions to form a carbon-carbon bond, and then form the target product 1-chloro-4- (phenylsulfonyl) benzene. The key to this reaction lies in the activity of palladium catalyst and the type and amount of base. Appropriate selection can improve the reaction yield.
In summary, these three synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path needs to be reasonably selected according to the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product.
What should be paid attention to when storing and transporting 1-chloro-4- (phenylsulfonyl) benzene?
1-Chloro-4- (benzenesulfonyl) benzene is also an organic compound. When storing and transporting, many matters need to be paid careful attention.
Bear the brunt, the storage place must be dry and well ventilated. This compound is afraid of moisture. If it is placed in a humid place, or causes chemical reactions such as hydrolysis, it will damage its quality. And good ventilation can prevent the accumulation of harmful gases and ensure environmental safety.
Second, temperature control is essential. It should be stored in a cool place to avoid high temperature. Under high temperature, its chemical properties may become active, causing reactions such as decomposition and polymerization, or risk safety.
Furthermore, this compound has certain toxicity and irritation, and when storing and transporting, the packaging must be tight. To prevent leakage, if it leaks, or pollutes the environment, it endangers the health of humans and animals. Packaging materials also need to be resistant to chemical corrosion to ensure their stability.
When transporting, it is necessary to strictly follow relevant laws and regulations. Select suitable means of transportation, and ensure that transporters are professionally trained and familiar with the characteristics of this substance and emergency treatment methods.
In addition, fireworks should be prohibited in storage and transportation places. Because of its flammability, it may encounter open flames, hot topics, or cause combustion or even explosion.
In conclusion, 1-chloro-4- (benzenesulfonyl) benzene should be stored and transported with care in all aspects, from environmental conditions to packaging and regulatory compliance, in order to ensure safety and avoid accidents.
Bear the brunt, the storage place must be dry and well ventilated. This compound is afraid of moisture. If it is placed in a humid place, or causes chemical reactions such as hydrolysis, it will damage its quality. And good ventilation can prevent the accumulation of harmful gases and ensure environmental safety.
Second, temperature control is essential. It should be stored in a cool place to avoid high temperature. Under high temperature, its chemical properties may become active, causing reactions such as decomposition and polymerization, or risk safety.
Furthermore, this compound has certain toxicity and irritation, and when storing and transporting, the packaging must be tight. To prevent leakage, if it leaks, or pollutes the environment, it endangers the health of humans and animals. Packaging materials also need to be resistant to chemical corrosion to ensure their stability.
When transporting, it is necessary to strictly follow relevant laws and regulations. Select suitable means of transportation, and ensure that transporters are professionally trained and familiar with the characteristics of this substance and emergency treatment methods.
In addition, fireworks should be prohibited in storage and transportation places. Because of its flammability, it may encounter open flames, hot topics, or cause combustion or even explosion.
In conclusion, 1-chloro-4- (benzenesulfonyl) benzene should be stored and transported with care in all aspects, from environmental conditions to packaging and regulatory compliance, in order to ensure safety and avoid accidents.
What are the effects of 1-chloro-4- (phenylsulfonyl) benzene on the environment and the human body?
The effects of 1-chloro-4- (benzenesulfonyl) benzene on the environment and human body are of great concern to the world.
This compound has certain stability in the environment and is difficult to degrade, so it is easy to accumulate residues. If it enters water bodies or sewage sources, aquatic organisms are harmed by it. It may be enriched through the food chain, and gradually accumulate in large organisms from small organisms, causing ecological imbalance.
In the soil, it may inhibit the activity of soil microorganisms, hinder their normal metabolism and material circulation, and then affect plant growth. Or infiltrate into the ground and sewage groundwater, endangering the safety of surrounding water.
As for the human body, 1-chloro-4- (benzenesulfonyl) benzene may be potentially toxic. It enters the body through respiratory, dietary or skin contact, or interferes with the normal physiological functions of the human body. Or damage important organs such as the liver and kidneys, because of its metabolism in the body, or generate harmful substances, tired in the organs, resulting in abnormal function.
It may also affect the human endocrine system and disturb the balance of hormones. Hormones play a key role in human growth, development, reproduction and many other physiological processes, and their imbalances can cause developmental abnormalities, reproductive disorders and other problems.
Furthermore, long-term exposure to this substance may increase the risk of cancer. Although the exact mechanism is not fully understood, many studies have shown that its chemical structure is similar to that of some carcinogens, or causes cells to become cancerous, threatening human health.
From this perspective, 1-chloro-4 - (benzenesulfonyl) benzene poses a latent risk to the environment and the human body, and should be paid close attention to prevent its spread, protect the ecological environment and personal safety.
This compound has certain stability in the environment and is difficult to degrade, so it is easy to accumulate residues. If it enters water bodies or sewage sources, aquatic organisms are harmed by it. It may be enriched through the food chain, and gradually accumulate in large organisms from small organisms, causing ecological imbalance.
In the soil, it may inhibit the activity of soil microorganisms, hinder their normal metabolism and material circulation, and then affect plant growth. Or infiltrate into the ground and sewage groundwater, endangering the safety of surrounding water.
As for the human body, 1-chloro-4- (benzenesulfonyl) benzene may be potentially toxic. It enters the body through respiratory, dietary or skin contact, or interferes with the normal physiological functions of the human body. Or damage important organs such as the liver and kidneys, because of its metabolism in the body, or generate harmful substances, tired in the organs, resulting in abnormal function.
It may also affect the human endocrine system and disturb the balance of hormones. Hormones play a key role in human growth, development, reproduction and many other physiological processes, and their imbalances can cause developmental abnormalities, reproductive disorders and other problems.
Furthermore, long-term exposure to this substance may increase the risk of cancer. Although the exact mechanism is not fully understood, many studies have shown that its chemical structure is similar to that of some carcinogens, or causes cells to become cancerous, threatening human health.
From this perspective, 1-chloro-4 - (benzenesulfonyl) benzene poses a latent risk to the environment and the human body, and should be paid close attention to prevent its spread, protect the ecological environment and personal safety.
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