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1-Chloro-4-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
615435 |
| Chemical Formula | C7H4ClF3O |
| Molecular Weight | 196.55 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 158 - 160 °C |
| Density | 1.38 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents |
| Flash Point | 57 °C |
| Refractive Index | 1.446 - 1.448 |
As an accredited 1-Chloro-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 4 - (trifluoromethoxy) benzene: 500g in sealed, corrosion - resistant chemical - grade bottles. |
| Storage | 1 - Chloro - 4 - (trifluoromethoxy)benzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. It should be kept in a tightly sealed container, preferably made of materials resistant to chemical corrosion. Store it separately from oxidizing agents and reactive substances to prevent potential reactions. |
| Shipping | 1 - chloro - 4 - (trifluoromethoxy)benzene is shipped in specialized, tightly - sealed containers. It adheres to strict chemical transportation regulations due to its potentially hazardous nature, ensuring safe transit. |
Competitive 1-Chloro-4-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 1-chloro-4- (trifluoromethoxy) benzene?
1-chloro-4- (trifluoromethoxy) benzene, Chinese name 1-chloro-4- (trifluoromethoxy) benzene, its main uses are as follows.
This compound is widely used in the field of organic synthesis. First, it is often a key intermediate in the synthesis of medicine. In the process of many drug development, due to its unique chemical structure, it can participate in a variety of reactions and help build complex drug molecular structures. For example, in the preparation of some antihypertensive drugs, 1-chloro-4- (trifluoromethoxy) benzene can introduce key chemical groups through specific reaction steps, laying the foundation for the formation of the final pharmaceutical active ingredient.
Second, in the field of pesticide synthesis, it also plays an important role. With its fluorine and chlorine atom properties, pesticides can be endowed with unique biological activities. For example, in the creation of new pesticides, it is used to optimize the molecular structure, enhance the toxicity and targeting of pesticides to pests, and at the same time improve the environmental stability and shelf life of pesticides, thereby reducing the dosage and frequency of application, and playing an active role in agricultural production.
Third, in the field of materials science, it can be used as a starting material for the preparation of high-performance materials. After a series of polymerization or modification reactions, polymer materials with special properties can be prepared. For example, fluorinated aromatic polymers, which often have excellent thermal stability, chemical stability, and low dielectric constant, have potential applications in electronics, aerospace, and other fields, such as the manufacture of high-performance circuit board insulation materials and aerospace sealing materials.
This compound is widely used in the field of organic synthesis. First, it is often a key intermediate in the synthesis of medicine. In the process of many drug development, due to its unique chemical structure, it can participate in a variety of reactions and help build complex drug molecular structures. For example, in the preparation of some antihypertensive drugs, 1-chloro-4- (trifluoromethoxy) benzene can introduce key chemical groups through specific reaction steps, laying the foundation for the formation of the final pharmaceutical active ingredient.
Second, in the field of pesticide synthesis, it also plays an important role. With its fluorine and chlorine atom properties, pesticides can be endowed with unique biological activities. For example, in the creation of new pesticides, it is used to optimize the molecular structure, enhance the toxicity and targeting of pesticides to pests, and at the same time improve the environmental stability and shelf life of pesticides, thereby reducing the dosage and frequency of application, and playing an active role in agricultural production.
Third, in the field of materials science, it can be used as a starting material for the preparation of high-performance materials. After a series of polymerization or modification reactions, polymer materials with special properties can be prepared. For example, fluorinated aromatic polymers, which often have excellent thermal stability, chemical stability, and low dielectric constant, have potential applications in electronics, aerospace, and other fields, such as the manufacture of high-performance circuit board insulation materials and aerospace sealing materials.
What are the physical properties of 1-chloro-4- (trifluoromethoxy) benzene
1-Chloro-4- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties have many characteristics.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to slightly yellow transparent liquid, clear and free of impurities. Smell, there is a specific smell, but this smell is not a pungent and intolerable type, but it is also unique, making it recognizable.
When it comes to boiling point, it is about within a certain temperature range. Due to the presence of groups such as chlorine atoms and trifluoromethoxy in the molecular structure, the intermolecular forces are unique, so the boiling point is not extremely low or extremely high. The specific value is determined under specific conditions. This temperature is sufficient to convert it from liquid to gaseous.
Melting point also has corresponding values. At this temperature, a substance gradually melts from solid to liquid, reflecting the critical state of its solid and liquid states. This value is closely related to the arrangement and interaction of molecules.
In terms of density, it has a certain ratio to water. Due to the type and number of atoms in the molecule, its density may be greater than or less than that of water. This property is important for many practical applications, such as substance separation and mixing.
In terms of solubility, it has good solubility in some organic solvents, such as common ethanol, ether, etc. Due to the principle of "similarity and miscibility", its molecular structure is compatible with the molecular structure of organic solvents and can be miscible with each other. However, its solubility in water is poor. Due to the difference between the polarity of water and the polarity of the compound, it is difficult for the two to miscible.
In addition, the volatility of 1-chloro-4- (trifluoromethoxy) benzene is also one end of its physical properties. Under specific environmental conditions, there is a certain rate of volatilization, which can be gradually volatilized from the liquid surface to the gas phase. This property should be paid attention to during storage and use.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to slightly yellow transparent liquid, clear and free of impurities. Smell, there is a specific smell, but this smell is not a pungent and intolerable type, but it is also unique, making it recognizable.
When it comes to boiling point, it is about within a certain temperature range. Due to the presence of groups such as chlorine atoms and trifluoromethoxy in the molecular structure, the intermolecular forces are unique, so the boiling point is not extremely low or extremely high. The specific value is determined under specific conditions. This temperature is sufficient to convert it from liquid to gaseous.
Melting point also has corresponding values. At this temperature, a substance gradually melts from solid to liquid, reflecting the critical state of its solid and liquid states. This value is closely related to the arrangement and interaction of molecules.
In terms of density, it has a certain ratio to water. Due to the type and number of atoms in the molecule, its density may be greater than or less than that of water. This property is important for many practical applications, such as substance separation and mixing.
In terms of solubility, it has good solubility in some organic solvents, such as common ethanol, ether, etc. Due to the principle of "similarity and miscibility", its molecular structure is compatible with the molecular structure of organic solvents and can be miscible with each other. However, its solubility in water is poor. Due to the difference between the polarity of water and the polarity of the compound, it is difficult for the two to miscible.
In addition, the volatility of 1-chloro-4- (trifluoromethoxy) benzene is also one end of its physical properties. Under specific environmental conditions, there is a certain rate of volatilization, which can be gradually volatilized from the liquid surface to the gas phase. This property should be paid attention to during storage and use.
What are the chemical properties of 1-chloro-4- (trifluoromethoxy) benzene
1 - chloro - 4 - (trifluoromethoxy) benzene, an organic compound, has interesting chemical properties and is very important in the field of organic synthesis.
Looking at its structure, there are chlorine atoms and trifluoromethoxy groups attached to the benzene ring. Chlorine atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. And chlorine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds.
Trifluoromethoxy also has a strong electron-withdrawing effect because it contains many fluorine atoms and has high electronegativity. The existence of this group not only changes the electron cloud distribution of the benzene ring, but also has a profound impact on the physical and chemical properties For example, it can enhance the lipid solubility of molecules and affect their solubility in different solvents.
1-chloro-4 - (trifluoromethoxy) benzene exhibits certain stability for oxidation and reduction reactions. However, under certain conditions, the benzene ring can be oxidized, and in case of strong oxidants, oxygen-containing compounds may be formed. In reduction reactions, the benzene ring may be partially or completely reduced under suitable catalysts and conditions.
This compound can also participate in metal catalytic coupling reactions, such as Suzuki coupling, Heck coupling, etc. In these reactions, new carbon-carbon bonds can be formed by interacting with organometallic reagents, and then more complex organic molecules can be synthesized, which are widely used in medicinal chemistry, materials science and other fields.
In conclusion, 1-chloro-4- (trifluoromethoxy) benzene plays an important role in organic synthesis and related fields due to its unique structure and rich chemical properties, providing key starting materials and intermediates for the preparation of many organic compounds.
Looking at its structure, there are chlorine atoms and trifluoromethoxy groups attached to the benzene ring. Chlorine atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. And chlorine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds.
Trifluoromethoxy also has a strong electron-withdrawing effect because it contains many fluorine atoms and has high electronegativity. The existence of this group not only changes the electron cloud distribution of the benzene ring, but also has a profound impact on the physical and chemical properties For example, it can enhance the lipid solubility of molecules and affect their solubility in different solvents.
1-chloro-4 - (trifluoromethoxy) benzene exhibits certain stability for oxidation and reduction reactions. However, under certain conditions, the benzene ring can be oxidized, and in case of strong oxidants, oxygen-containing compounds may be formed. In reduction reactions, the benzene ring may be partially or completely reduced under suitable catalysts and conditions.
This compound can also participate in metal catalytic coupling reactions, such as Suzuki coupling, Heck coupling, etc. In these reactions, new carbon-carbon bonds can be formed by interacting with organometallic reagents, and then more complex organic molecules can be synthesized, which are widely used in medicinal chemistry, materials science and other fields.
In conclusion, 1-chloro-4- (trifluoromethoxy) benzene plays an important role in organic synthesis and related fields due to its unique structure and rich chemical properties, providing key starting materials and intermediates for the preparation of many organic compounds.
What are the preparation methods of 1-chloro-4- (trifluoromethoxy) benzene
There are several common methods for preparing 1-chloro-4- (trifluoromethoxy) benzene.
First, p-chlorophenol is used as the starting material. First, p-chlorophenol is mixed with a base, such as sodium hydroxide, in a suitable solvent (such as dimethyl sulfoxide, etc.) to form a phenate. Then a trifluoromethylating reagent, such as trifluoromethylsulfonic anhydride, is added. Under suitable temperature and reaction conditions, the oxygen atom of the phenate will undergo a nucleophilic substitution reaction with the trifluoromethylating reagent to generate 1-chloro-4- (trifluoromethoxy) benzene. The key to this reaction lies in the precise control of the reaction conditions. If the temperature is too low, the reaction will be slow, and if it is too high, it will be prone to side reactions.
Second, we can start from p-chloroaniline. First, p-chloroaniline is reacted with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form diazonium salts. Then, in the presence of specific reagents, such as copper salts, it reacts with trifluoromethanol or other reagents containing trifluoromethoxy groups. The diazonium group is replaced by trifluoromethoxy group to obtain the target product 1-chloro-4- (trifluoromethoxy) benzene. In this process, the diazotization reaction needs to be carried out at low temperature and strictly controlled conditions, otherwise the diazonium salt is easy
Third, p-chloroanisole is used as raw material. It is first halogenated. Under suitable halogenation reagents (such as chlorine gas) and reaction conditions, chlorine atoms are introduced into the benzene ring to obtain the corresponding halogenated products. After that, the methoxy group is converted to trifluoromethoxy group by specific reagents, such as using trifluoromethylation reagents and suitable catalysts, through a series of reaction steps, and finally 1-chloro-4- (trifluoromethoxy) benzene can be obtained. In this route, the selectivity of the halogenation reaction and the efficiency of the methoxy conversion step are both important factors affecting the yield.
Different preparation methods have their own advantages and disadvantages, and the appropriate preparation route should be weighed according to actual needs, such as raw material availability, cost, target product purity and other factors.
First, p-chlorophenol is used as the starting material. First, p-chlorophenol is mixed with a base, such as sodium hydroxide, in a suitable solvent (such as dimethyl sulfoxide, etc.) to form a phenate. Then a trifluoromethylating reagent, such as trifluoromethylsulfonic anhydride, is added. Under suitable temperature and reaction conditions, the oxygen atom of the phenate will undergo a nucleophilic substitution reaction with the trifluoromethylating reagent to generate 1-chloro-4- (trifluoromethoxy) benzene. The key to this reaction lies in the precise control of the reaction conditions. If the temperature is too low, the reaction will be slow, and if it is too high, it will be prone to side reactions.
Second, we can start from p-chloroaniline. First, p-chloroaniline is reacted with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form diazonium salts. Then, in the presence of specific reagents, such as copper salts, it reacts with trifluoromethanol or other reagents containing trifluoromethoxy groups. The diazonium group is replaced by trifluoromethoxy group to obtain the target product 1-chloro-4- (trifluoromethoxy) benzene. In this process, the diazotization reaction needs to be carried out at low temperature and strictly controlled conditions, otherwise the diazonium salt is easy
Third, p-chloroanisole is used as raw material. It is first halogenated. Under suitable halogenation reagents (such as chlorine gas) and reaction conditions, chlorine atoms are introduced into the benzene ring to obtain the corresponding halogenated products. After that, the methoxy group is converted to trifluoromethoxy group by specific reagents, such as using trifluoromethylation reagents and suitable catalysts, through a series of reaction steps, and finally 1-chloro-4- (trifluoromethoxy) benzene can be obtained. In this route, the selectivity of the halogenation reaction and the efficiency of the methoxy conversion step are both important factors affecting the yield.
Different preparation methods have their own advantages and disadvantages, and the appropriate preparation route should be weighed according to actual needs, such as raw material availability, cost, target product purity and other factors.
What are the precautions for storing and transporting 1-chloro-4- (trifluoromethoxy) benzene?
1 - chloro - 4 - (trifluoromethoxy) benzene, Chinese name 1 - chloro - 4 - (trifluoromethoxy) benzene, this substance in storage and transportation, many matters need to be paid attention to.
Its properties are organic halides, with certain toxicity and irritation. When storing, the first warehouse conditions. Choose a cool and ventilated warehouse, away from fire and heat sources. It is easy to cause danger due to heat, such as accelerated decomposition or ignition. The warehouse temperature should be controlled within a specific range to prevent material deterioration or reaction due to excessive temperature.
Furthermore, it should be stored separately from oxidants and bases, and should not be mixed. Due to its encounter with oxidizing agents, or violent chemical reactions, causing combustion and explosion; contact with alkalis may also react, damaging the properties and safety of materials.
For transportation, packaging must be solid and firm. Appropriate packaging materials must be selected in accordance with relevant regulations to ensure that there is no leakage during transportation. Transportation vehicles must also meet safety standards and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. During transportation, drivers and escorts must strictly abide by operating procedures to avoid bumps and shocks to prevent package damage.
If the transportation route passes through densely populated areas or environmentally sensitive areas, it is necessary to plan in advance and drive carefully to prevent accidental leakage from causing harm to people and the environment. In short, the storage and transportation of 1-chloro-4-trifluoromethoxy benzene requires safety, and all aspects must be strictly implemented in accordance with regulations to ensure the safety of personnel, the environment, and materials themselves.
Its properties are organic halides, with certain toxicity and irritation. When storing, the first warehouse conditions. Choose a cool and ventilated warehouse, away from fire and heat sources. It is easy to cause danger due to heat, such as accelerated decomposition or ignition. The warehouse temperature should be controlled within a specific range to prevent material deterioration or reaction due to excessive temperature.
Furthermore, it should be stored separately from oxidants and bases, and should not be mixed. Due to its encounter with oxidizing agents, or violent chemical reactions, causing combustion and explosion; contact with alkalis may also react, damaging the properties and safety of materials.
For transportation, packaging must be solid and firm. Appropriate packaging materials must be selected in accordance with relevant regulations to ensure that there is no leakage during transportation. Transportation vehicles must also meet safety standards and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. During transportation, drivers and escorts must strictly abide by operating procedures to avoid bumps and shocks to prevent package damage.
If the transportation route passes through densely populated areas or environmentally sensitive areas, it is necessary to plan in advance and drive carefully to prevent accidental leakage from causing harm to people and the environment. In short, the storage and transportation of 1-chloro-4-trifluoromethoxy benzene requires safety, and all aspects must be strictly implemented in accordance with regulations to ensure the safety of personnel, the environment, and materials themselves.
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