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1-Chloro-4-Trifluoromethxybenzene
Linshang Chemical
|
HS Code |
749511 |
| Chemical Formula | C7H4ClF3O |
| Molecular Weight | 196.55 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 175 - 177 °C |
| Density | Approx. 1.38 g/cm³ |
| Vapor Pressure | Low at room temperature |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Flash Point | Approx. 62 °C |
| Odor | Typical aromatic - halogenated odor |
As an accredited 1-Chloro-4-Trifluoromethxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 1 - chloro - 4 - trifluoromethylbenzene chemical. |
| Storage | 1 - Chloro - 4 - trifluoromethylbenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials, to prevent leakage. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 1 - Chloro - 4 - trifluoromethoxybenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations, ensuring safe handling during transit to prevent spills and environmental hazards. |
Competitive 1-Chloro-4-Trifluoromethxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the main uses of 1-chloro-4-trifluoromethxybenzene?
1-Chloro-4-trifluoromethoxy benzene is widely used. In the field of organic synthesis, it is often used as a key intermediate. For example, when creating various fluorine-containing fine chemicals, 1-chloro-4-trifluoromethoxy benzene can participate in a series of chemical reactions with its unique structure, and then build a complex molecular structure.
In the field of medicinal chemistry, it also has important functions. In the development of many new drugs, 1-chloro-4-trifluoromethoxy benzene will be used as the starting material and modified by multi-step reactions to introduce specific functional groups, endowing the drug with unique physiological activities and providing the possibility for the treatment of various diseases.
In the field of pesticides, it also plays an important role. Fluorinated pesticides synthesized on this basis often have the advantages of high efficiency, low toxicity and environmental friendliness. It can effectively kill pests and weeds, ensure the healthy growth of crops, and improve crop yield and quality.
In addition, in the field of materials science, 1-chloro-4-trifluoromethoxy benzene can be used to prepare polymer materials with special properties. By introducing it into the polymer chain, it endows the material with excellent characteristics such as chemical corrosion resistance and high temperature resistance, expanding the application range of the material, and has potential application value in high-end fields such as aerospace and electronics.
In the field of medicinal chemistry, it also has important functions. In the development of many new drugs, 1-chloro-4-trifluoromethoxy benzene will be used as the starting material and modified by multi-step reactions to introduce specific functional groups, endowing the drug with unique physiological activities and providing the possibility for the treatment of various diseases.
In the field of pesticides, it also plays an important role. Fluorinated pesticides synthesized on this basis often have the advantages of high efficiency, low toxicity and environmental friendliness. It can effectively kill pests and weeds, ensure the healthy growth of crops, and improve crop yield and quality.
In addition, in the field of materials science, 1-chloro-4-trifluoromethoxy benzene can be used to prepare polymer materials with special properties. By introducing it into the polymer chain, it endows the material with excellent characteristics such as chemical corrosion resistance and high temperature resistance, expanding the application range of the material, and has potential application value in high-end fields such as aerospace and electronics.
What are the physical properties of 1-chloro-4-trifluoromethxybenzene?
1-Chloro-4-trifluoromethoxy benzene, this is an organic compound, its physical properties are unique, as follows:
- ** Properties **: Under normal temperature and pressure, 1-chloro-4-trifluoromethoxy benzene is a colorless to light yellow transparent liquid. It is clear and pure, with no visible impurities. Its color may vary slightly due to purity and trace impurities.
- ** Melting point and boiling point **: The melting point is about -10 ° C, and the boiling point is between 160-162 ° C. The melting point indicates that the substance gradually melts from a solid state to a liquid state at -10 ° C; the boiling point indicates that in an atmospheric pressure environment, the temperature rises to 160-162 ° C, and the substance is violently vaporized from a liquid state to a gaseous state. This melting boiling point characteristic allows it to maintain a liquid state in a specific temperature range, which is easy to handle and use in chemical operations.
- ** Density **: The density is about 1.38g/cm ³, which is relatively dense compared to the density of water. If mixed with water, it will sink to the bottom. This density property is of great significance in the separation and mixing process, and a suitable separation method can be selected according to this characteristic.
- ** Solubility **: Slightly soluble in water, but can be miscible with various organic solvents such as ethanol, ether, acetone, etc. Due to the hydrophobic group in its molecular structure, it is difficult to dissolve in water; and it is compatible with the force between the organic solvent molecules. This solubility is extremely critical in organic synthesis, so the appropriate solvent can be selected accordingly to promote the smooth progress of the reaction.
- ** Volatility and odor **: It has a certain volatility and can evaporate slowly in the air. The odor is unique, although it is difficult to describe accurately, it is usually regarded as irritating, inhalation or irritation to the respiratory tract. It is necessary to ensure good ventilation during operation to protect the safety of operators.
- ** Stability **: Under normal conditions, 1-chloro-4-trifluoromethoxy benzene is quite stable and is not prone to spontaneous chemical reactions. However, in case of open flames, hot topics or strong oxidants, or cause dangerous conditions such as combustion and explosion. Therefore, when storing and using, be sure to keep away from such dangerous items to ensure safety.
- ** Properties **: Under normal temperature and pressure, 1-chloro-4-trifluoromethoxy benzene is a colorless to light yellow transparent liquid. It is clear and pure, with no visible impurities. Its color may vary slightly due to purity and trace impurities.
- ** Melting point and boiling point **: The melting point is about -10 ° C, and the boiling point is between 160-162 ° C. The melting point indicates that the substance gradually melts from a solid state to a liquid state at -10 ° C; the boiling point indicates that in an atmospheric pressure environment, the temperature rises to 160-162 ° C, and the substance is violently vaporized from a liquid state to a gaseous state. This melting boiling point characteristic allows it to maintain a liquid state in a specific temperature range, which is easy to handle and use in chemical operations.
- ** Density **: The density is about 1.38g/cm ³, which is relatively dense compared to the density of water. If mixed with water, it will sink to the bottom. This density property is of great significance in the separation and mixing process, and a suitable separation method can be selected according to this characteristic.
- ** Solubility **: Slightly soluble in water, but can be miscible with various organic solvents such as ethanol, ether, acetone, etc. Due to the hydrophobic group in its molecular structure, it is difficult to dissolve in water; and it is compatible with the force between the organic solvent molecules. This solubility is extremely critical in organic synthesis, so the appropriate solvent can be selected accordingly to promote the smooth progress of the reaction.
- ** Volatility and odor **: It has a certain volatility and can evaporate slowly in the air. The odor is unique, although it is difficult to describe accurately, it is usually regarded as irritating, inhalation or irritation to the respiratory tract. It is necessary to ensure good ventilation during operation to protect the safety of operators.
- ** Stability **: Under normal conditions, 1-chloro-4-trifluoromethoxy benzene is quite stable and is not prone to spontaneous chemical reactions. However, in case of open flames, hot topics or strong oxidants, or cause dangerous conditions such as combustion and explosion. Therefore, when storing and using, be sure to keep away from such dangerous items to ensure safety.
What is the chemistry of 1-chloro-4-trifluoromethxybenzene?
1-Chloro-4-trifluoromethoxy benzene, which is one of the organic compounds. This substance has unique chemical properties, which are related to its reactivity, stability and other characteristics.
Let's talk about the reactivity first. Due to the presence of chlorine atoms and trifluoromethoxy groups on the benzene ring, it is endowed with special electronic effects. The chlorine atom is an electron-withdrawing group. Although its lone pair of electrons can be conjugated with the benzene ring, the induced effect is mainly electron-withdrawing, which reduces the electron cloud density of the benzene ring. Trifluoromethoxy is also a strong electron-withdrawing group, which further weakens the electron cloud density of the benzene ring. The synergistic effect of the two results in a decrease in the electrophilic substitution of the benzene ring. And the substitution position is affected by the localization effect of the two. The chlorine atom is an ortho-para-site locator, and the trifluoromethoxy group is an meta-site locator. Under the synthesis, the new substituent mainly enters the ortho-site of the chlorine atom and the intersite of the trifluoromethoxy group.
In terms of stability, the C-Cl bond and C-O bond in 1-chloro-4-trifluoromethoxy benzene have certain strength. However, the fluorine atom in the trifluoromethoxy group is extremely electronegative, which has a strong attraction to the electron cloud of the C-O bond, so that the bond has a certain polarity. Under certain conditions, in case of strong nucleophiles, the C-O bond may
Furthermore, the trifluoromethyl group in this compound makes the molecule have a certain lipid solubility. In organic synthesis, it can be used to construct molecules with special physical and chemical properties. It is widely used in the field of organic synthesis and can be used as a key intermediate to participate in many reactions, such as reacting with Grignard reagents to construct more complex organic molecular structures.
In short, 1-chloro-4-trifluoromethoxyphenyl has a unique structure and unique chemical properties. It is of great value in organic synthesis and related fields. In-depth understanding of its properties will help to better apply to various chemical processes.
Let's talk about the reactivity first. Due to the presence of chlorine atoms and trifluoromethoxy groups on the benzene ring, it is endowed with special electronic effects. The chlorine atom is an electron-withdrawing group. Although its lone pair of electrons can be conjugated with the benzene ring, the induced effect is mainly electron-withdrawing, which reduces the electron cloud density of the benzene ring. Trifluoromethoxy is also a strong electron-withdrawing group, which further weakens the electron cloud density of the benzene ring. The synergistic effect of the two results in a decrease in the electrophilic substitution of the benzene ring. And the substitution position is affected by the localization effect of the two. The chlorine atom is an ortho-para-site locator, and the trifluoromethoxy group is an meta-site locator. Under the synthesis, the new substituent mainly enters the ortho-site of the chlorine atom and the intersite of the trifluoromethoxy group.
In terms of stability, the C-Cl bond and C-O bond in 1-chloro-4-trifluoromethoxy benzene have certain strength. However, the fluorine atom in the trifluoromethoxy group is extremely electronegative, which has a strong attraction to the electron cloud of the C-O bond, so that the bond has a certain polarity. Under certain conditions, in case of strong nucleophiles, the C-O bond may
Furthermore, the trifluoromethyl group in this compound makes the molecule have a certain lipid solubility. In organic synthesis, it can be used to construct molecules with special physical and chemical properties. It is widely used in the field of organic synthesis and can be used as a key intermediate to participate in many reactions, such as reacting with Grignard reagents to construct more complex organic molecular structures.
In short, 1-chloro-4-trifluoromethoxyphenyl has a unique structure and unique chemical properties. It is of great value in organic synthesis and related fields. In-depth understanding of its properties will help to better apply to various chemical processes.
What are 1-chloro-4-trifluoromethxybenzene synthesis methods?
The common methods for synthesizing 1-chloro-4-trifluoromethoxybenzene are as follows.
First, p-chlorophenol is used as the starting material. Mix p-chlorophenol with potassium carbonate and other bases, in an appropriate solvent such as N, N-dimethylformamide (DMF), heat and stir, and then slowly add trifluoromethyl halides such as trifluoromethyl iodine or trifluoromethyl bromide. In this reaction process, the alkali acts on the phenolic hydroxyl group of p-chlorophenol to form phenoxy anions, which enhances its nucleophilicity, and then undergoes nucleophilic substitution reaction with trifluoromethyl halide to obtain the target product 1-chloro-4-trifluoromethoxybenzene. The reaction needs to pay attention to temperature control. Excessive temperature may trigger side reactions, resulting in lower yield.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline is converted into diazonium salts by diazotization reaction, such as reaction with sodium nitrite and hydrochloric acid at low temperature. The diazonium salt has a high activity, and then it interacts with trifluoromethoxy reagents, such as trifluoromethoxy copper, etc., to react that the diazonium group is replaced by the trifluoromethoxy group, so as to obtain 1-chloro-4-trifluoromethoxy benzene. In this process, the diazotization reaction needs to be strictly controlled at low temperature to prevent the decomposition of diazonium salts, and the preparation and use of trifluoromethoxy copper also need to be carefully handled to ensure the smooth progress of the reaction.
Third, p-chlorobenzoic acid is used as the starting material. First, the p-chlorobenzoic acid is converted into the corresponding acid chloride, and reagents such as thionyl chloride can be used. The acid chloride reacts with trifluoromethanol under alkali catalysis to obtain the target product. In this reaction, the preparation of acid chloride requires an anhydrous environment to prevent hydrolysis, and the amount and type of alkali need to be precisely controlled to optimize the reaction process and yield.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be selected according to the availability of raw materials, cost, reaction conditions and product purity.
First, p-chlorophenol is used as the starting material. Mix p-chlorophenol with potassium carbonate and other bases, in an appropriate solvent such as N, N-dimethylformamide (DMF), heat and stir, and then slowly add trifluoromethyl halides such as trifluoromethyl iodine or trifluoromethyl bromide. In this reaction process, the alkali acts on the phenolic hydroxyl group of p-chlorophenol to form phenoxy anions, which enhances its nucleophilicity, and then undergoes nucleophilic substitution reaction with trifluoromethyl halide to obtain the target product 1-chloro-4-trifluoromethoxybenzene. The reaction needs to pay attention to temperature control. Excessive temperature may trigger side reactions, resulting in lower yield.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline is converted into diazonium salts by diazotization reaction, such as reaction with sodium nitrite and hydrochloric acid at low temperature. The diazonium salt has a high activity, and then it interacts with trifluoromethoxy reagents, such as trifluoromethoxy copper, etc., to react that the diazonium group is replaced by the trifluoromethoxy group, so as to obtain 1-chloro-4-trifluoromethoxy benzene. In this process, the diazotization reaction needs to be strictly controlled at low temperature to prevent the decomposition of diazonium salts, and the preparation and use of trifluoromethoxy copper also need to be carefully handled to ensure the smooth progress of the reaction.
Third, p-chlorobenzoic acid is used as the starting material. First, the p-chlorobenzoic acid is converted into the corresponding acid chloride, and reagents such as thionyl chloride can be used. The acid chloride reacts with trifluoromethanol under alkali catalysis to obtain the target product. In this reaction, the preparation of acid chloride requires an anhydrous environment to prevent hydrolysis, and the amount and type of alkali need to be precisely controlled to optimize the reaction process and yield.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be selected according to the availability of raw materials, cost, reaction conditions and product purity.
What are the precautions in storage and transportation of 1-chloro-4-trifluoromethxybenzene?
1-Chloro-4-trifluoromethoxybenzene is an organic compound. When storing and transporting, many things need to be paid attention to.
Store first. This compound should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause it to decompose or cause chemical reactions, so it is necessary to keep away from fire and heat sources, such as heating pipes and heating equipment. And because it may be volatile to a certain extent, if the storage environment is poorly ventilated, its volatile gas will accumulate, or cause danger. Good ventilation is essential.
Furthermore, it should be stored separately from oxidants, acids, bases, etc. 1-Chloro-4-trifluoromethoxy benzene is chemically active, meets with oxidants, or has a violent oxidation reaction, even triggering combustion and explosion; coexisting with acids and bases, chemical reactions may also occur, causing deterioration of substances, so separate storage can effectively avoid such risks.
The choice of storage containers cannot be ignored, and corrosion-resistant materials such as glass and specific plastics should be used. Because 1-chloro-4-trifluoromethoxy benzene may be corrosive, ordinary material containers may be corroded, resulting in leakage, and suitable materials can ensure safe storage.
As for transportation, ensure that the packaging is complete and sealed. If the packaging is damaged and the compound leaks during transportation, it will not only pollute the environment, but also pose a threat to the safety of the transportation personnel. During transportation, it is also necessary to keep away from fire and heat sources to avoid sunlight exposure. The choice of transportation tools should also be cautious. Vehicles or ships that meet relevant safety standards should be selected, and the transportation personnel must be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
If a leak occurs during transportation, do not panic. The surrounding personnel should be evacuated immediately, the leakage area should be isolated, and the fire should not be approached. Depending on the amount of leakage, appropriate measures should be taken. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if a large amount leaks, it is necessary to build a dike or dig a pit for containment, and then transfer it to a special container with an explosion-proof pump for proper disposal.
In conclusion, the storage and transportation of 1-chloro-4-trifluoromethoxylbenzene must strictly follow relevant norms and requirements to ensure safety.
Store first. This compound should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause it to decompose or cause chemical reactions, so it is necessary to keep away from fire and heat sources, such as heating pipes and heating equipment. And because it may be volatile to a certain extent, if the storage environment is poorly ventilated, its volatile gas will accumulate, or cause danger. Good ventilation is essential.
Furthermore, it should be stored separately from oxidants, acids, bases, etc. 1-Chloro-4-trifluoromethoxy benzene is chemically active, meets with oxidants, or has a violent oxidation reaction, even triggering combustion and explosion; coexisting with acids and bases, chemical reactions may also occur, causing deterioration of substances, so separate storage can effectively avoid such risks.
The choice of storage containers cannot be ignored, and corrosion-resistant materials such as glass and specific plastics should be used. Because 1-chloro-4-trifluoromethoxy benzene may be corrosive, ordinary material containers may be corroded, resulting in leakage, and suitable materials can ensure safe storage.
As for transportation, ensure that the packaging is complete and sealed. If the packaging is damaged and the compound leaks during transportation, it will not only pollute the environment, but also pose a threat to the safety of the transportation personnel. During transportation, it is also necessary to keep away from fire and heat sources to avoid sunlight exposure. The choice of transportation tools should also be cautious. Vehicles or ships that meet relevant safety standards should be selected, and the transportation personnel must be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
If a leak occurs during transportation, do not panic. The surrounding personnel should be evacuated immediately, the leakage area should be isolated, and the fire should not be approached. Depending on the amount of leakage, appropriate measures should be taken. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if a large amount leaks, it is necessary to build a dike or dig a pit for containment, and then transfer it to a special container with an explosion-proof pump for proper disposal.
In conclusion, the storage and transportation of 1-chloro-4-trifluoromethoxylbenzene must strictly follow relevant norms and requirements to ensure safety.
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