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1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene
Linshang Chemical
|
HS Code |
113250 |
| Chemical Formula | C7H5ClFNO3 |
| Molar Mass | 207.57 g/mol |
| Appearance | Solid (usually a pale - colored solid) |
| Physical State At Room Temperature | Solid |
| Boiling Point | Data may vary, estimated around high temperature due to its aromatic and substituted nature |
| Melting Point | Data specific to this compound needed for exact value |
| Solubility In Water | Low solubility in water, being an organic aromatic compound with non - polar and polar substituents |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data specific to this compound required for accurate value |
| Odor | May have a characteristic organic chemical odor |
As an accredited 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene packaged in sealed containers. |
| Storage | 1 - Chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and leakage. It's crucial to store it separately from incompatible substances to avoid potential chemical reactions. |
| Shipping | 1 - Chloro - 5 - fluoro - 2 - methoxy - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent spills and maintain product integrity during transit. |
Competitive 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Chloro-5-Fluoro-2-Methoxy-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene?
1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene is an organic compound. Its chemical properties are very important and are related to the process of many chemical changes.
In this compound, chlorine atoms and fluorine atoms have their own characteristics. Chlorine has a certain nucleophilic substitution activity and can interact with nucleophilic reagents to undergo substitution reactions. Fluorine atoms, because of their high electronegativity, affect the electron cloud distribution of molecules, resulting in special molecular polarities, and in some reactions, can affect the selectivity and rate of reactions. The electron cloud density of the benzene ring can be increased by the methoxy group, which makes the benzene ring more prone to electrophilic substitution reaction, and has an impact on the reaction localization, often guiding electrophilic reagents into its ortho and para-sites. The nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, which not only increases the difficulty of electrophilic substitution reaction, but also activates the reactivity of other substituents on the benzene ring. Under reduction conditions, the nitro group can be reduced to other groups such as amino groups.
The synergistic effect of the above substituents of 1-chloro-5-fluoro-2-methoxy-4-nitrophenyl is widely used in the field of organic synthesis. Or as an intermediary for the preparation of complex organic molecules, it can be converted into compounds with different functions through various reactions, and has potential value in many industries such as medicine, pesticides, and materials.
In this compound, chlorine atoms and fluorine atoms have their own characteristics. Chlorine has a certain nucleophilic substitution activity and can interact with nucleophilic reagents to undergo substitution reactions. Fluorine atoms, because of their high electronegativity, affect the electron cloud distribution of molecules, resulting in special molecular polarities, and in some reactions, can affect the selectivity and rate of reactions. The electron cloud density of the benzene ring can be increased by the methoxy group, which makes the benzene ring more prone to electrophilic substitution reaction, and has an impact on the reaction localization, often guiding electrophilic reagents into its ortho and para-sites. The nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, which not only increases the difficulty of electrophilic substitution reaction, but also activates the reactivity of other substituents on the benzene ring. Under reduction conditions, the nitro group can be reduced to other groups such as amino groups.
The synergistic effect of the above substituents of 1-chloro-5-fluoro-2-methoxy-4-nitrophenyl is widely used in the field of organic synthesis. Or as an intermediary for the preparation of complex organic molecules, it can be converted into compounds with different functions through various reactions, and has potential value in many industries such as medicine, pesticides, and materials.
What are the common uses of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene?
1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene is also an organic compound. Its common use, due to its unique structure, is very important in the field of organic synthesis.
First, it is often a key intermediate in pharmaceutical synthesis. In the process of pharmaceutical preparation, chlorine, fluorine, methoxy and nitro groups can be introduced into the target molecule through a series of reactions to construct compounds with specific pharmacological activities. For example, by means of nucleophilic substitution reactions, chlorine atoms or fluorine atoms can be replaced by suitable nucleophiles to form complex and therapeutic drug molecules.
Second, it is also involved in the field of materials science. Because it contains a variety of functional groups, it can participate in the synthesis of polymer materials. By polymerization reaction, it is introduced into the main chain or side chain of the polymer to impart specific electrical, optical or thermal properties to the material. Such as the preparation of organic semiconductor materials with special optoelectronic properties, or functional polymers that enhance the chemical stability of materials.
Third, it also plays a role in pesticide synthesis. After rational design and reaction, it is converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. By its structure interacting with targets in vivo, it interferes with the physiological processes of pests, pathogens or weeds to achieve the purpose of control. In conclusion, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene, with its unique structure, is used in many fields such as medicine, materials, and pesticides. It provides important starting materials and intermediates for the preparation of compounds and materials with specific properties and functions through various organic reactions, and is of great significance in the chemical industry and related industries.
First, it is often a key intermediate in pharmaceutical synthesis. In the process of pharmaceutical preparation, chlorine, fluorine, methoxy and nitro groups can be introduced into the target molecule through a series of reactions to construct compounds with specific pharmacological activities. For example, by means of nucleophilic substitution reactions, chlorine atoms or fluorine atoms can be replaced by suitable nucleophiles to form complex and therapeutic drug molecules.
Second, it is also involved in the field of materials science. Because it contains a variety of functional groups, it can participate in the synthesis of polymer materials. By polymerization reaction, it is introduced into the main chain or side chain of the polymer to impart specific electrical, optical or thermal properties to the material. Such as the preparation of organic semiconductor materials with special optoelectronic properties, or functional polymers that enhance the chemical stability of materials.
Third, it also plays a role in pesticide synthesis. After rational design and reaction, it is converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. By its structure interacting with targets in vivo, it interferes with the physiological processes of pests, pathogens or weeds to achieve the purpose of control. In conclusion, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene, with its unique structure, is used in many fields such as medicine, materials, and pesticides. It provides important starting materials and intermediates for the preparation of compounds and materials with specific properties and functions through various organic reactions, and is of great significance in the chemical industry and related industries.
What are 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene synthesis methods?
There are several methods for the synthesis of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene. One method can also be prepared by multi-step reaction from suitable aromatic starting materials.
First take a benzene ring compound with a suitable substituent group, such as a benzene derivative containing methoxy group. First nitrate it to introduce nitro groups. This step requires selecting a suitable nitrifying reagent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, and controlling the reaction temperature, time and other conditions, so that nitro groups can be introduced into the target position accurately to generate benzene derivatives containing methoxy groups and nitro groups.
Then, a halogen atom is introduced into the resulting product. Halogenation reagents can be selected, such as reagents containing chlorine and fluorine. When introducing chlorine atoms, suitable chlorination reagents can be selected according to specific circumstances, such as thionyl chloride, etc., and chlorine atoms can be substituted for hydrogen atoms at specific positions on the benzene ring under catalysts or specific reaction conditions. When introducing fluorine atoms, fluorine-containing reagents, such as potassium fluoride, etc., are often used under the action of phase transfer catalysts and other auxiliaries to complete the fluorination reaction, and then the target product containing methoxy, nitro, chlorine atoms and fluorine atoms is obtained.
Another method can first construct the structure of the benzene ring containing some substituents, and then gradually add the remaining substituents. For example, benzene derivatives containing chlorine and fluorine are first synthesized, and then methoxylated, methoxy is introduced, and then nitrification is carried out, and nitro In this process, each step of the reaction requires fine regulation of the reaction conditions, such as temperature, pH, and the ratio of reactants, to ensure the smooth progress of the reaction and improve the yield and purity of the product.
In short, the synthesis of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene requires careful selection of appropriate synthesis paths and reaction conditions according to the characteristics of the starting material, the controllability of the reaction conditions and the requirements of the target product, in order to achieve effective synthesis.
First take a benzene ring compound with a suitable substituent group, such as a benzene derivative containing methoxy group. First nitrate it to introduce nitro groups. This step requires selecting a suitable nitrifying reagent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, and controlling the reaction temperature, time and other conditions, so that nitro groups can be introduced into the target position accurately to generate benzene derivatives containing methoxy groups and nitro groups.
Then, a halogen atom is introduced into the resulting product. Halogenation reagents can be selected, such as reagents containing chlorine and fluorine. When introducing chlorine atoms, suitable chlorination reagents can be selected according to specific circumstances, such as thionyl chloride, etc., and chlorine atoms can be substituted for hydrogen atoms at specific positions on the benzene ring under catalysts or specific reaction conditions. When introducing fluorine atoms, fluorine-containing reagents, such as potassium fluoride, etc., are often used under the action of phase transfer catalysts and other auxiliaries to complete the fluorination reaction, and then the target product containing methoxy, nitro, chlorine atoms and fluorine atoms is obtained.
Another method can first construct the structure of the benzene ring containing some substituents, and then gradually add the remaining substituents. For example, benzene derivatives containing chlorine and fluorine are first synthesized, and then methoxylated, methoxy is introduced, and then nitrification is carried out, and nitro In this process, each step of the reaction requires fine regulation of the reaction conditions, such as temperature, pH, and the ratio of reactants, to ensure the smooth progress of the reaction and improve the yield and purity of the product.
In short, the synthesis of 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene requires careful selection of appropriate synthesis paths and reaction conditions according to the characteristics of the starting material, the controllability of the reaction conditions and the requirements of the target product, in order to achieve effective synthesis.
1-chloro-5-fluoro-2-methoxy-4-nitrobenzene need to pay attention to when storing?
1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene is also an organic compound. When storing it, many matters must not be ignored.
The first thing to pay attention to is the temperature and humidity of the environment. The nature of this compound may change due to the change of temperature and humidity, so it should be stored in a cool and dry place. If the temperature is too high, it may increase its volatilization, or even cause chemical reactions; if the humidity is too high, it is easy to cause it to get damp and affect the quality. Generally speaking, the temperature should be controlled below 20 ° C, and the humidity should be kept below 60%.
The second time is related to the storage container. It is necessary to use a corrosion-resistant container to hold it, because the compound contains chlorine, fluorine, nitro and other groups, or reacts with ordinary materials. Glass containers are the best choice, because of their stable chemical properties, it is not easy to interact with them. And the container must be tightly sealed to prevent it from coming into contact with the air. Cover the oxygen, water vapor, etc. in the air, or react with the compound such as oxidation and hydrolysis.
In addition, this compound has certain toxicity and danger, and the storage place must be kept away from fire and heat sources, and must not be mixed with flammable and explosive substances. It should also be stored separately from oxidizing agents and reducing agents, etc., because they may react violently with each other, endangering safety.
In addition, the storage place should have obvious warning signs to inform everyone of its danger. Management personnel should be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other accidents, they can be properly disposed of in time to avoid greater harm. In short, when storing 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene, care should be taken in terms of temperature and humidity, containers, mixtures, safety labels and personnel preparation to ensure its safety and quality.
The first thing to pay attention to is the temperature and humidity of the environment. The nature of this compound may change due to the change of temperature and humidity, so it should be stored in a cool and dry place. If the temperature is too high, it may increase its volatilization, or even cause chemical reactions; if the humidity is too high, it is easy to cause it to get damp and affect the quality. Generally speaking, the temperature should be controlled below 20 ° C, and the humidity should be kept below 60%.
The second time is related to the storage container. It is necessary to use a corrosion-resistant container to hold it, because the compound contains chlorine, fluorine, nitro and other groups, or reacts with ordinary materials. Glass containers are the best choice, because of their stable chemical properties, it is not easy to interact with them. And the container must be tightly sealed to prevent it from coming into contact with the air. Cover the oxygen, water vapor, etc. in the air, or react with the compound such as oxidation and hydrolysis.
In addition, this compound has certain toxicity and danger, and the storage place must be kept away from fire and heat sources, and must not be mixed with flammable and explosive substances. It should also be stored separately from oxidizing agents and reducing agents, etc., because they may react violently with each other, endangering safety.
In addition, the storage place should have obvious warning signs to inform everyone of its danger. Management personnel should be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other accidents, they can be properly disposed of in time to avoid greater harm. In short, when storing 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene, care should be taken in terms of temperature and humidity, containers, mixtures, safety labels and personnel preparation to ensure its safety and quality.
What impact does 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene have on the environment?
1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene is an organic compound. Its impact on the environment cannot be ignored.
This substance may be toxic. If released in the environment, it may be harmful to organisms. In aquatic ecosystems, or as the culprit, aquatic animals and plants are poisoned by it. It may affect the photosynthesis of algae, causing their growth to be trapped, and then disturbing the balance of the food chain. If aquatic organisms such as fish are exposed to this substance, they may have abnormal physiological functions, such as respiratory disorders and reproduction, and in the long run, the population may decrease.
In the soil environment, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene may be refractory to degradation and gradually accumulate in the soil. It may affect the community structure and function of soil microorganisms, damage soil fertility, hinder plant root uptake of nutrients, and cause poor plant growth.
And if this substance escapes in the atmosphere through volatilization and other pathways, or participates in photochemical reactions, it affects air quality. It may interact with other pollutants to produce more harmful secondary pollutants, endangering human beings and the ecological environment.
Because of its chlorine, fluorine, nitro and other groups, the chemical properties are active, and complex transformations may occur in the environment, generating toxic or stronger and more mobile derivatives, increasing environmental risks.
Therefore, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene has multiple effects on the environment, and it needs to be handled with caution to prevent its wanton spread to ensure the safety of the ecological environment.
This substance may be toxic. If released in the environment, it may be harmful to organisms. In aquatic ecosystems, or as the culprit, aquatic animals and plants are poisoned by it. It may affect the photosynthesis of algae, causing their growth to be trapped, and then disturbing the balance of the food chain. If aquatic organisms such as fish are exposed to this substance, they may have abnormal physiological functions, such as respiratory disorders and reproduction, and in the long run, the population may decrease.
In the soil environment, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene may be refractory to degradation and gradually accumulate in the soil. It may affect the community structure and function of soil microorganisms, damage soil fertility, hinder plant root uptake of nutrients, and cause poor plant growth.
And if this substance escapes in the atmosphere through volatilization and other pathways, or participates in photochemical reactions, it affects air quality. It may interact with other pollutants to produce more harmful secondary pollutants, endangering human beings and the ecological environment.
Because of its chlorine, fluorine, nitro and other groups, the chemical properties are active, and complex transformations may occur in the environment, generating toxic or stronger and more mobile derivatives, increasing environmental risks.
Therefore, 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene has multiple effects on the environment, and it needs to be handled with caution to prevent its wanton spread to ensure the safety of the ecological environment.
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