Linshang Chemical
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1-Chloro-5-Isopropoxy-2-Methyl-4-Nitrobenzene
Linshang Chemical
|
HS Code |
181130 |
| Chemical Formula | C10H12ClNO3 |
| Molecular Weight | 229.66 |
| Appearance | Typically a solid (appearance can vary based on purity and conditions) |
| Melting Point | Data may vary, check specific references |
| Boiling Point | Data may vary, check specific references |
| Solubility In Water | Low solubility, organic solvents are more likely to dissolve it |
| Density | Data may vary, check specific references |
| Vapor Pressure | Low, as it is usually a solid |
| Flash Point | Data may vary, check specific references |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Chloro-5-Isopropoxy-2-Methyl-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - chloro - 5 - isopropoxy - 2 - methyl - 4 - nitrobenzene packaged in a sealed plastic bottle. |
| Storage | 1 - Chloro - 5 - isopropoxy - 2 - methyl - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or chemical reactions. |
| Shipping | 1 - Chloro - 5 - isopropoxy - 2 - methyl - 4 - nitrobenzene is a chemical. It should be shipped in sealed, corrosion - resistant containers. Follow strict hazardous material shipping regulations to ensure safety during transit. |
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What is the chemistry of 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene?
1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene is an organic compound. Its chemical properties are particularly important and play a key role in many chemical reactions and chemical processes.
First of all, the stability of this compound is discussed. Due to the molecular structure, the nitro group has strong electron absorption, while the chlorine atom and the isopropoxy group each have their own electronic effects. The presence of the nitro group decreases the electron cloud density of the benzene ring, resulting in the stability of the benzene ring, but also enhances its electrophilic substitution activity. Although the chlorine atom is an ortho-para-localization group, its localization effect is also changed due to the strong electron absorption of the nitro group. The isopropoxy group is the power supply group, which can increase the electron cloud density of the benzene ring to a certain extent, which has an impact on the reactivity and stability.
Furthermore, in terms of its reactivity. The compound can undergo a variety of reactions. Nucleophilic substitution is an important type of reaction. Chlorine atoms can be replaced by a variety of nucleophilic reagents. Because the benzene ring carbon connected to the chlorine atom is electron-absorbing by the nitro group, the positive electricity is enhanced, and it is vulnerable to attack by nucleophilic reagents. For example, when reacted with nucleophilic reagents such as sodium alcohol and amine, new substitution products can be formed.
At the same time, the nitro group can undergo reduction reaction. Under suitable reduction conditions, such as metal and acid or catalytic hydrogenation, nitro groups can be gradually reduced to amino groups, thereby deriving compounds with different uses. And because there are methyl groups on the benzene ring, under specific conditions, methyl groups can undergo oxidation reactions to form other functional groups such as carboxyl groups.
In addition, the solubility of the compound is also related to chemical properties. Because it contains polar nitro and chlorine atoms, and isopropoxy has a certain degree of non-polarity, it should have good solubility in organic solvents such as ethanol and acetone, but relatively poor solubility in water. This solubility characteristic also affects the selection of the medium involved in the reaction and the separation and purification method.
First of all, the stability of this compound is discussed. Due to the molecular structure, the nitro group has strong electron absorption, while the chlorine atom and the isopropoxy group each have their own electronic effects. The presence of the nitro group decreases the electron cloud density of the benzene ring, resulting in the stability of the benzene ring, but also enhances its electrophilic substitution activity. Although the chlorine atom is an ortho-para-localization group, its localization effect is also changed due to the strong electron absorption of the nitro group. The isopropoxy group is the power supply group, which can increase the electron cloud density of the benzene ring to a certain extent, which has an impact on the reactivity and stability.
Furthermore, in terms of its reactivity. The compound can undergo a variety of reactions. Nucleophilic substitution is an important type of reaction. Chlorine atoms can be replaced by a variety of nucleophilic reagents. Because the benzene ring carbon connected to the chlorine atom is electron-absorbing by the nitro group, the positive electricity is enhanced, and it is vulnerable to attack by nucleophilic reagents. For example, when reacted with nucleophilic reagents such as sodium alcohol and amine, new substitution products can be formed.
At the same time, the nitro group can undergo reduction reaction. Under suitable reduction conditions, such as metal and acid or catalytic hydrogenation, nitro groups can be gradually reduced to amino groups, thereby deriving compounds with different uses. And because there are methyl groups on the benzene ring, under specific conditions, methyl groups can undergo oxidation reactions to form other functional groups such as carboxyl groups.
In addition, the solubility of the compound is also related to chemical properties. Because it contains polar nitro and chlorine atoms, and isopropoxy has a certain degree of non-polarity, it should have good solubility in organic solvents such as ethanol and acetone, but relatively poor solubility in water. This solubility characteristic also affects the selection of the medium involved in the reaction and the separation and purification method.
What are the physical properties of 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene?
1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene is one of the organic compounds. Its physical properties are quite impressive, and it is also related to various fields of chemical industry.
In terms of its appearance, it is often in a solid state, and the color may be light yellow or even light brown. The reason for this color is the special structure and electron cloud distribution in the molecule. Under normal temperature and pressure, its texture is relatively solid, like masonry that has been precipitated over the years. It is stable and not easy to deform.
As for the melting point, it is about a certain temperature range. The definition of this temperature is like a precise ruler, measuring the critical point of the compound's transition from solid to liquid. When the temperature gradually rises to near the melting point, the force between molecules gradually weakens, and the molecules that are originally closely arranged begin to move, like ice cubes gradually melting on the ice surface in winter.
The boiling point is also one of its important physical properties. Under specific pressure conditions, when a compound boils, it is characterized by the boiling point. At this temperature, the molecules gain enough energy to break free from each other's shackles and soar from the liquid state to the gas state, just like the big roc spreading its wings and soaring up.
In terms of solubility, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. This is because there is a certain interaction force between the molecular structure of the organic solvent and the compound, just like the attraction of a magnet, so that the two can blend with each other. However, the solubility in water is extremely low, because the polarity of water and the polarity of the compound are quite different, and the two are difficult to compatible, just like the barrier between oil and water.
Density is also a physical property that cannot be ignored. Its density may be heavier than that of water. If it is placed in the same container as water, it can be seen that it sinks slowly, like a stone sinking to the bottom. This characteristic is derived from the density of its molecular mass and spatial arrangement.
In summary, the physical properties of 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene, from appearance, melting point, boiling point, solubility to density, are its unique marks, just like human fingerprints, each has its own strengths and weaknesses, laying the foundation for its application in chemical and related fields.
In terms of its appearance, it is often in a solid state, and the color may be light yellow or even light brown. The reason for this color is the special structure and electron cloud distribution in the molecule. Under normal temperature and pressure, its texture is relatively solid, like masonry that has been precipitated over the years. It is stable and not easy to deform.
As for the melting point, it is about a certain temperature range. The definition of this temperature is like a precise ruler, measuring the critical point of the compound's transition from solid to liquid. When the temperature gradually rises to near the melting point, the force between molecules gradually weakens, and the molecules that are originally closely arranged begin to move, like ice cubes gradually melting on the ice surface in winter.
The boiling point is also one of its important physical properties. Under specific pressure conditions, when a compound boils, it is characterized by the boiling point. At this temperature, the molecules gain enough energy to break free from each other's shackles and soar from the liquid state to the gas state, just like the big roc spreading its wings and soaring up.
In terms of solubility, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. This is because there is a certain interaction force between the molecular structure of the organic solvent and the compound, just like the attraction of a magnet, so that the two can blend with each other. However, the solubility in water is extremely low, because the polarity of water and the polarity of the compound are quite different, and the two are difficult to compatible, just like the barrier between oil and water.
Density is also a physical property that cannot be ignored. Its density may be heavier than that of water. If it is placed in the same container as water, it can be seen that it sinks slowly, like a stone sinking to the bottom. This characteristic is derived from the density of its molecular mass and spatial arrangement.
In summary, the physical properties of 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene, from appearance, melting point, boiling point, solubility to density, are its unique marks, just like human fingerprints, each has its own strengths and weaknesses, laying the foundation for its application in chemical and related fields.
What are the main uses of 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene?
1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene is one of the organic compounds. Its main use is more common in the field of organic synthesis.
In organic synthesis, this compound is often a key intermediate. Due to the chlorine atoms, isopropoxy, methyl and nitro groups contained in its molecular structure, each has unique reactivity and can initiate a variety of chemical reactions.
Chlorine atoms are active and can participate in nucleophilic substitution reactions. Many nucleophilic reagents, such as alkoxides and amines, can interact with chlorine atoms to promote the formation of new carbon-heteroatomic bonds, and then build complex organic molecular structures. For example, when reacted with alkoxides, ether derivatives can be formed, providing a way for the synthesis of ether compounds with specific structures.
The presence of isopropoxy imparts specific steric resistance and electronic effects to molecules. This can affect the reaction selectivity and activity of compounds. In some reactions, it guides the reaction in a specific direction to synthesize products with specific configurations.
Although methyl is relatively stable, under certain conditions, it can participate in methylation-related reactions or affect the physical and chemical properties of molecules, such as solubility, boiling point, etc., which have an effect on the separation and purification of compounds.
The nitro group is a strong electron-absorbing group, which not only significantly affects the electron cloud density of the benzene ring, but also makes the benzene ring more prone to electrophilic substitution reaction, and the nitro group itself can be converted into other functional groups such as amino groups through reduction and other reactions, providing various possibilities for subsequent organic synthesis. For example, in the preparation of nitrogen-containing heterocyclic compounds and drug intermediates, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene can gradually construct the structure of the target product through a series of reactions.
In summary, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene, as an important intermediate in organic synthesis, plays a key role in the construction of complex organic molecules due to its unique functional group characteristics, and has an important location and wide range of uses in the field of organic synthetic chemistry.
In organic synthesis, this compound is often a key intermediate. Due to the chlorine atoms, isopropoxy, methyl and nitro groups contained in its molecular structure, each has unique reactivity and can initiate a variety of chemical reactions.
Chlorine atoms are active and can participate in nucleophilic substitution reactions. Many nucleophilic reagents, such as alkoxides and amines, can interact with chlorine atoms to promote the formation of new carbon-heteroatomic bonds, and then build complex organic molecular structures. For example, when reacted with alkoxides, ether derivatives can be formed, providing a way for the synthesis of ether compounds with specific structures.
The presence of isopropoxy imparts specific steric resistance and electronic effects to molecules. This can affect the reaction selectivity and activity of compounds. In some reactions, it guides the reaction in a specific direction to synthesize products with specific configurations.
Although methyl is relatively stable, under certain conditions, it can participate in methylation-related reactions or affect the physical and chemical properties of molecules, such as solubility, boiling point, etc., which have an effect on the separation and purification of compounds.
The nitro group is a strong electron-absorbing group, which not only significantly affects the electron cloud density of the benzene ring, but also makes the benzene ring more prone to electrophilic substitution reaction, and the nitro group itself can be converted into other functional groups such as amino groups through reduction and other reactions, providing various possibilities for subsequent organic synthesis. For example, in the preparation of nitrogen-containing heterocyclic compounds and drug intermediates, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene can gradually construct the structure of the target product through a series of reactions.
In summary, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene, as an important intermediate in organic synthesis, plays a key role in the construction of complex organic molecules due to its unique functional group characteristics, and has an important location and wide range of uses in the field of organic synthetic chemistry.
What is 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene synthesis method?
The method for synthesizing 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene can follow the following steps.
First take a suitable starting material, such as 2-methyl-4-nitrophenol. This phenolic compound is mixed with a halogenated isopropyl reagent, such as isopropyl halide (such as isopropyl bromide or isopropyl chloride), in a suitable reaction vessel. An appropriate amount of base, such as potassium carbonate, is added to promote the nucleophilic substitution reaction. At the appropriate temperature and reaction time, the oxygen atom of the phenolic hydroxyl group will nucleophilically attack the carbon atom connected to the halogen atom of the halogenated isopropyl reagent, and the halogen atom will leave to form 5-isopropoxy-2-methyl-4-nitrophenol. This reaction process requires attention to the control of the reaction temperature. If the temperature is too high, side reactions may be initiated; if the temperature is too low, the reaction rate will be slow.
Then, the obtained 5-isopropoxy-2-methyl-4-nitrophenol is further chlorinated. Suitable chlorination reagents such as thionyl chloride and phosphorus oxychloride can be used. Under suitable reaction conditions, the chlorinated reagent reacts with the phenolic compound, and the hydrogen atom of the phenolic hydroxyl group is replaced by the chlorine atom to obtain the target product 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene. During the chlorination reaction, attention should be paid to the pH of the reaction system, the reaction time and the amount of chlorinated reagent. Excessive chlorinated reagents or too long reaction time may lead to side reactions such as excessive chlorination.
During the synthesis process, after each step of the reaction, separation and purification methods such as column chromatography and recrystallization should be used to obtain high-purity intermediate products and final target products to ensure the smooth progress of the synthesis and the quality of the products.
First take a suitable starting material, such as 2-methyl-4-nitrophenol. This phenolic compound is mixed with a halogenated isopropyl reagent, such as isopropyl halide (such as isopropyl bromide or isopropyl chloride), in a suitable reaction vessel. An appropriate amount of base, such as potassium carbonate, is added to promote the nucleophilic substitution reaction. At the appropriate temperature and reaction time, the oxygen atom of the phenolic hydroxyl group will nucleophilically attack the carbon atom connected to the halogen atom of the halogenated isopropyl reagent, and the halogen atom will leave to form 5-isopropoxy-2-methyl-4-nitrophenol. This reaction process requires attention to the control of the reaction temperature. If the temperature is too high, side reactions may be initiated; if the temperature is too low, the reaction rate will be slow.
Then, the obtained 5-isopropoxy-2-methyl-4-nitrophenol is further chlorinated. Suitable chlorination reagents such as thionyl chloride and phosphorus oxychloride can be used. Under suitable reaction conditions, the chlorinated reagent reacts with the phenolic compound, and the hydrogen atom of the phenolic hydroxyl group is replaced by the chlorine atom to obtain the target product 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene. During the chlorination reaction, attention should be paid to the pH of the reaction system, the reaction time and the amount of chlorinated reagent. Excessive chlorinated reagents or too long reaction time may lead to side reactions such as excessive chlorination.
During the synthesis process, after each step of the reaction, separation and purification methods such as column chromatography and recrystallization should be used to obtain high-purity intermediate products and final target products to ensure the smooth progress of the synthesis and the quality of the products.
1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene What are the precautions during storage and transportation?
1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First, when storing, store it in a cool, dry and well-ventilated place. This is because the compound is heated or damp, it may cause decomposition or other adverse reactions. If it is in a high temperature environment, the chemical bonds within the molecule may become active, causing structural changes; if the environment is humid, moisture may participate in the reaction, affecting its purity and stability.
Second, keep away from fires and heat sources. Because of its flammability, it may encounter open flames, hot topics, or the risk of combustion and explosion. And the nitro structure makes it more sensitive to heat and open flames. If you are not careful, it will cause disaster.
Third, it should be stored separately from oxidants, reducing agents, acids, alkalis, etc., and should not be mixed. The compound contains chlorine, nitro and other functional groups, which are easy to chemically react with the above substances. If it encounters a strong oxidant, it may cause a violent oxidation reaction or even an explosion.
Fourth, during transportation, ensure that the container is sealed to prevent leakage. Once leaked, it will not only pollute the environment, but also pose a threat to the safety of transportation personnel. And leaks may react with surrounding substances, causing more serious consequences.
Fifth, transportation vehicles need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of an accident, it can respond quickly and reduce losses. At the same time, transportation personnel should be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods.
In short, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene storage and transportation, from environmental control to item isolation, to personnel training and emergency preparedness, all need to be carefully considered to ensure safety.
First, when storing, store it in a cool, dry and well-ventilated place. This is because the compound is heated or damp, it may cause decomposition or other adverse reactions. If it is in a high temperature environment, the chemical bonds within the molecule may become active, causing structural changes; if the environment is humid, moisture may participate in the reaction, affecting its purity and stability.
Second, keep away from fires and heat sources. Because of its flammability, it may encounter open flames, hot topics, or the risk of combustion and explosion. And the nitro structure makes it more sensitive to heat and open flames. If you are not careful, it will cause disaster.
Third, it should be stored separately from oxidants, reducing agents, acids, alkalis, etc., and should not be mixed. The compound contains chlorine, nitro and other functional groups, which are easy to chemically react with the above substances. If it encounters a strong oxidant, it may cause a violent oxidation reaction or even an explosion.
Fourth, during transportation, ensure that the container is sealed to prevent leakage. Once leaked, it will not only pollute the environment, but also pose a threat to the safety of transportation personnel. And leaks may react with surrounding substances, causing more serious consequences.
Fifth, transportation vehicles need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of an accident, it can respond quickly and reduce losses. At the same time, transportation personnel should be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods.
In short, 1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene storage and transportation, from environmental control to item isolation, to personnel training and emergency preparedness, all need to be carefully considered to ensure safety.
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