Linshang Chemical
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1-(Chloro-Difluoro-Methoxy)-4-Nitro-Benzene
Linshang Chemical
|
HS Code |
384955 |
| Chemical Formula | C7H3ClF2NO3 |
| Molar Mass | 223.55 g/mol |
| Appearance | Solid (predicted) |
| Solubility In Water | Low solubility (predicted due to non - polar nature of benzene ring and fluorine substitution) |
| Vapor Pressure | Low (predicted due to relatively large molar mass and solid state) |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-(Chloro-Difluoro-Methoxy)-4-Nitro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(chloro - difluoro - methoxy)-4 - nitro - benzene in sealed chemical - grade containers. |
| Storage | 1-(Chloro - difluoro - methoxy)-4 - nitro - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances like strong oxidizers. Store in a tightly closed container, preferably in a cabinet dedicated to chemicals, to prevent leakage and potential exposure. Label clearly for easy identification and safety. |
| Shipping | 1-(Chloro - difluoro - methoxy)-4 - nitro - benzene, a chemical, should be shipped in accordance with hazardous materials regulations. Use appropriate, sealed containers to prevent leakage during transportation. |
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What is the main use of 1- (chloro-difluoro-methoxy) -4-nitro-benzene?
1 - (chloro-difluoro-methoxy) -4 -nitro-benzene, this substance has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique chemical structure, various organic compounds can be derived through various chemical reactions.
In the creation of pesticides, this is used as a starting material to synthesize pesticides with high insecticidal, bactericidal or herbicidal properties. For example, through specific reaction steps, the corresponding functional groups are introduced to construct molecular structures that are in line with specific targets in pests or weeds, and by interfering with their physiological metabolism, the effect of control is achieved.
In the field of pharmaceutical research and development, it also has important functions. It can be used as a basic structural unit for the synthesis of certain drug molecules. Through chemical modification, it is endowed with pharmacological activity to deal with specific diseases. For example, for biological targets related to certain diseases, the design and synthesis of compounds that interact with them are expected to develop new therapeutic drugs.
In addition, in the field of materials science, materials with special properties can be prepared through specific synthesis pathways. Or because of its structure, the material is endowed with unique electrical, optical or thermal properties, which can be used in fields such as electronic devices and optical materials. In conclusion, 1- (chloro-difluoro-methoxy) -4-nitro-benzene plays an indispensable role in many fields such as organic synthesis, pesticides, medicine, and materials science, promoting the development and innovation of various fields.
In the creation of pesticides, this is used as a starting material to synthesize pesticides with high insecticidal, bactericidal or herbicidal properties. For example, through specific reaction steps, the corresponding functional groups are introduced to construct molecular structures that are in line with specific targets in pests or weeds, and by interfering with their physiological metabolism, the effect of control is achieved.
In the field of pharmaceutical research and development, it also has important functions. It can be used as a basic structural unit for the synthesis of certain drug molecules. Through chemical modification, it is endowed with pharmacological activity to deal with specific diseases. For example, for biological targets related to certain diseases, the design and synthesis of compounds that interact with them are expected to develop new therapeutic drugs.
In addition, in the field of materials science, materials with special properties can be prepared through specific synthesis pathways. Or because of its structure, the material is endowed with unique electrical, optical or thermal properties, which can be used in fields such as electronic devices and optical materials. In conclusion, 1- (chloro-difluoro-methoxy) -4-nitro-benzene plays an indispensable role in many fields such as organic synthesis, pesticides, medicine, and materials science, promoting the development and innovation of various fields.
What are the physical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene
1 - (chloro-difluoro-methoxy) - 4 - nitro-benzene, is a kind of organic compound. Its physical properties are particularly important, and it is related to the use and related reactions of this compound.
Looking at its appearance, under room temperature and pressure, it is mostly in a solid state, usually white to light yellow crystalline powder. This color state is convenient for preliminary identification, and in actual operation, it is easy to distinguish its state changes.
When it comes to the melting point, it is within a certain range. This value has a significant impact on the thermal stability and phase transition of the compound. When heated, the melting point changes from solid to liquid state. This property is of great significance in the separation and purification process of chemical production, and can be separated by the difference in melting point.
Its boiling point is also a key physical property. Although the exact value varies slightly according to specific conditions, it is roughly determined. The boiling point reflects the volatility of the compound. The boiling point of this substance is related to the difficulty of vaporization during heating and has a great impact on operations such as distillation.
Furthermore, solubility is also one of its important physical properties. In organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents, there is a certain solubility. This property allows the compound to be uniformly mixed in organic synthesis reactions with suitable solvents and promotes the smooth progress of the reaction. However, in water, the solubility is very small, which is related to the polarity of the compound. Its molecular structure makes the polarity mismatch with water, so it is difficult to dissolve in water.
Density is also a key consideration. Under certain conditions, the value of density is stable. This parameter has reference value in chemical design for reactor volume calculation, material transportation, etc. According to its density, the material ratio and equipment parameters can be reasonably planned.
In summary, the physical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene, such as appearance, melting point, boiling point, solubility and density, are widely used in chemical production, organic synthesis and related fields. In-depth understanding of it lays a foundation for the rational use of this compound.
Looking at its appearance, under room temperature and pressure, it is mostly in a solid state, usually white to light yellow crystalline powder. This color state is convenient for preliminary identification, and in actual operation, it is easy to distinguish its state changes.
When it comes to the melting point, it is within a certain range. This value has a significant impact on the thermal stability and phase transition of the compound. When heated, the melting point changes from solid to liquid state. This property is of great significance in the separation and purification process of chemical production, and can be separated by the difference in melting point.
Its boiling point is also a key physical property. Although the exact value varies slightly according to specific conditions, it is roughly determined. The boiling point reflects the volatility of the compound. The boiling point of this substance is related to the difficulty of vaporization during heating and has a great impact on operations such as distillation.
Furthermore, solubility is also one of its important physical properties. In organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents, there is a certain solubility. This property allows the compound to be uniformly mixed in organic synthesis reactions with suitable solvents and promotes the smooth progress of the reaction. However, in water, the solubility is very small, which is related to the polarity of the compound. Its molecular structure makes the polarity mismatch with water, so it is difficult to dissolve in water.
Density is also a key consideration. Under certain conditions, the value of density is stable. This parameter has reference value in chemical design for reactor volume calculation, material transportation, etc. According to its density, the material ratio and equipment parameters can be reasonably planned.
In summary, the physical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene, such as appearance, melting point, boiling point, solubility and density, are widely used in chemical production, organic synthesis and related fields. In-depth understanding of it lays a foundation for the rational use of this compound.
What are the chemical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene
1 - (chlorine-difluoro-methoxy) - 4 -nitro-benzene, this is an organic compound with unique chemical properties.
From the perspective of reactivity, because the benzene ring is connected with nitro groups and chlorine-containing and fluorine-containing methoxy groups, and the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reactivity of the benzene ring is decreased. However, under certain conditions, nucleophilic substitution reactions can still occur. Because the carbon connected to the chlorine atom is affected by the difluoromethoxy group and the nitro group, the electron cloud is offset, so that the chlorine atom has a certain tendency to leave. When encountering nucleophilic reagents, the chlorine atom can be replaced
In terms of physical properties, it is a solid or a liquid, depending on the specific conditions. Because the molecule contains polar groups, nitro and difluoromethoxy make the molecule have a certain polarity, and its solubility in organic solvents is better than in water. Containing fluorine and chlorine atoms makes it chemically stable to a certain extent, and may affect its melting point, boiling point and other physical parameters.
In terms of thermal stability, nitro-containing compounds are heated or decomposed. When 1- (chlorine-difluoro-methoxy) -4-nitro-benzene is heated, the nitro group may decompose, releasing heat and even causing danger. Therefore, pay attention to temperature conditions when storing and using.
Its chemical properties are also affected by the surrounding environment, such as acidity and alkalinity. Under acidic or alkaline conditions, different reactions may occur. In alkaline environments, nucleophilic substitution reactions may be easier to carry out, because alkaline reagents can enhance the activity of nucleophilic reagents.
In short, the chemical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene are complex, and they may have potential applications in organic synthesis, materials science and other fields. Its properties and reaction conditions need to be fully considered when studying and using.
From the perspective of reactivity, because the benzene ring is connected with nitro groups and chlorine-containing and fluorine-containing methoxy groups, and the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reactivity of the benzene ring is decreased. However, under certain conditions, nucleophilic substitution reactions can still occur. Because the carbon connected to the chlorine atom is affected by the difluoromethoxy group and the nitro group, the electron cloud is offset, so that the chlorine atom has a certain tendency to leave. When encountering nucleophilic reagents, the chlorine atom can be replaced
In terms of physical properties, it is a solid or a liquid, depending on the specific conditions. Because the molecule contains polar groups, nitro and difluoromethoxy make the molecule have a certain polarity, and its solubility in organic solvents is better than in water. Containing fluorine and chlorine atoms makes it chemically stable to a certain extent, and may affect its melting point, boiling point and other physical parameters.
In terms of thermal stability, nitro-containing compounds are heated or decomposed. When 1- (chlorine-difluoro-methoxy) -4-nitro-benzene is heated, the nitro group may decompose, releasing heat and even causing danger. Therefore, pay attention to temperature conditions when storing and using.
Its chemical properties are also affected by the surrounding environment, such as acidity and alkalinity. Under acidic or alkaline conditions, different reactions may occur. In alkaline environments, nucleophilic substitution reactions may be easier to carry out, because alkaline reagents can enhance the activity of nucleophilic reagents.
In short, the chemical properties of 1- (chloro-difluoro-methoxy) -4-nitro-benzene are complex, and they may have potential applications in organic synthesis, materials science and other fields. Its properties and reaction conditions need to be fully considered when studying and using.
What is the preparation method of 1- (chloro-difluoro-methoxy) -4-nitro-benzene
The method of preparing 1- (chloro-difluoro-methoxy) -4-nitro-benzene usually follows the following route.
First, p-nitrophenol is used as the starting material, which is easily available. In a suitable reaction vessel, p-nitrophenol is first added, followed by an appropriate amount of basic substances, such as sodium hydroxide or potassium carbonate, etc. The function of basic substances is to deprotonate the hydroxyl group of p-nitrophenol to form a phenoxy anion, which has higher nucleophilicity.
Then, chlorodifluoromethane is slowly introduced into the reaction system. In chlorodifluoromethane, the carbon atoms connected to the chlorine atoms are partially positive and vulnerable to the nucleophilic attack of phenoxy negative ions. When the two meet, the phenoxy negative ions attack the carbon atoms of chlorodifluoromethane, and the chlorine atoms leave as the leaving group, forming a carbon-oxygen bond and forming the target product 1- (chlorine-difluoro-methoxy) -4-nitro-benzene.
During the reaction process, temperature control is extremely important. If the temperature is too low, the reaction rate is slow and takes a long time; if the temperature is too high, side reactions may occur, resulting in a decrease in the purity of the product. In general, the reaction temperature is usually maintained in a moderate range, such as between 40 and 60 degrees Celsius, which is fine-tuned according to the specific reaction conditions and the solvent used.
The choice of solvent is also critical. Commonly used polar aprotic solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO). Such solvents can not only dissolve p-nitrophenol and its basic salts, but also have a certain solubility to chlorodifluoromethane, and can promote nucleophilic substitution reactions.
After the reaction is completed, the product is often obtained by conventional post-treatment methods. The reaction liquid is first poured into an appropriate amount of water to dilute the unreacted raw materials and by-products. The product is hydrophobic or precipitated and stratified. The extraction operation is carried out again, with a suitable organic solvent, such as dichloromethane or ethyl acetate, extracted several times to merge the organic phases. After that, the water in the organic phase is removed with a desiccant such as anhydrous sodium sulfate. Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product is further purified by column chromatography or recrystallization to obtain pure 1- (chloro-difluoro-methoxy) -4-nitro-benzene.
First, p-nitrophenol is used as the starting material, which is easily available. In a suitable reaction vessel, p-nitrophenol is first added, followed by an appropriate amount of basic substances, such as sodium hydroxide or potassium carbonate, etc. The function of basic substances is to deprotonate the hydroxyl group of p-nitrophenol to form a phenoxy anion, which has higher nucleophilicity.
Then, chlorodifluoromethane is slowly introduced into the reaction system. In chlorodifluoromethane, the carbon atoms connected to the chlorine atoms are partially positive and vulnerable to the nucleophilic attack of phenoxy negative ions. When the two meet, the phenoxy negative ions attack the carbon atoms of chlorodifluoromethane, and the chlorine atoms leave as the leaving group, forming a carbon-oxygen bond and forming the target product 1- (chlorine-difluoro-methoxy) -4-nitro-benzene.
During the reaction process, temperature control is extremely important. If the temperature is too low, the reaction rate is slow and takes a long time; if the temperature is too high, side reactions may occur, resulting in a decrease in the purity of the product. In general, the reaction temperature is usually maintained in a moderate range, such as between 40 and 60 degrees Celsius, which is fine-tuned according to the specific reaction conditions and the solvent used.
The choice of solvent is also critical. Commonly used polar aprotic solvents, such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO). Such solvents can not only dissolve p-nitrophenol and its basic salts, but also have a certain solubility to chlorodifluoromethane, and can promote nucleophilic substitution reactions.
After the reaction is completed, the product is often obtained by conventional post-treatment methods. The reaction liquid is first poured into an appropriate amount of water to dilute the unreacted raw materials and by-products. The product is hydrophobic or precipitated and stratified. The extraction operation is carried out again, with a suitable organic solvent, such as dichloromethane or ethyl acetate, extracted several times to merge the organic phases. After that, the water in the organic phase is removed with a desiccant such as anhydrous sodium sulfate. Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product is further purified by column chromatography or recrystallization to obtain pure 1- (chloro-difluoro-methoxy) -4-nitro-benzene.
What are the precautions for 1- (chloro-difluoro-methoxy) -4-nitro-benzene during use?
1 - (chloro-difluoro-methoxy) - 4 - nitro-benzene is also an organic compound. When using, many matters need to be paid attention to.
First, this compound is toxic to a certain extent, and caution must be taken when exposed. It may be absorbed, inhaled or ingested through the skin, causing damage to human health. Therefore, when operating, it is necessary to wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to prevent contact with it.
Furthermore, this compound may be harmful to the environment. When disposing of its waste, it must not be discarded at will, and it must be properly disposed of in accordance with relevant regulations to prevent pollution of soil, water sources, etc.
Repeat, 1- (chlorine-difluoro-methoxy) -4-nitro-benzene is chemically active and may react under certain conditions. When storing, place in a cool, dry and well-ventilated place, away from fire, heat and oxidants, etc., to avoid danger.
Also, if you accidentally touch the skin or eyes during use, rinse with plenty of water immediately and seek medical attention in time. In case of inhalation, quickly move to a fresh air place and perform first aid measures such as artificial respiration if necessary.
When handling this compound, the experimental site should have good ventilation equipment to reduce the concentration in the air and reduce the harm. And the operator must be professionally trained and familiar with its properties and operating specifications to ensure the safety of the use process.
First, this compound is toxic to a certain extent, and caution must be taken when exposed. It may be absorbed, inhaled or ingested through the skin, causing damage to human health. Therefore, when operating, it is necessary to wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to prevent contact with it.
Furthermore, this compound may be harmful to the environment. When disposing of its waste, it must not be discarded at will, and it must be properly disposed of in accordance with relevant regulations to prevent pollution of soil, water sources, etc.
Repeat, 1- (chlorine-difluoro-methoxy) -4-nitro-benzene is chemically active and may react under certain conditions. When storing, place in a cool, dry and well-ventilated place, away from fire, heat and oxidants, etc., to avoid danger.
Also, if you accidentally touch the skin or eyes during use, rinse with plenty of water immediately and seek medical attention in time. In case of inhalation, quickly move to a fresh air place and perform first aid measures such as artificial respiration if necessary.
When handling this compound, the experimental site should have good ventilation equipment to reduce the concentration in the air and reduce the harm. And the operator must be professionally trained and familiar with its properties and operating specifications to ensure the safety of the use process.
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