Linshang Chemical
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1-[Chloro(Difluoro)Methoxy]-4-Nitrobenzene
Linshang Chemical
|
HS Code |
875958 |
| Chemical Formula | C7H3ClF2NO4 |
| Molar Mass | 241.55 g/mol |
| Appearance | Solid (presumably, based on similar compounds) |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low (due to non - polar benzene ring and hydrophobic groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
As an accredited 1-[Chloro(Difluoro)Methoxy]-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - [chloro(difluoro)methoxy]-4 - nitrobenzene in sealed chemical - grade containers. |
| Storage | 1 - [Chloro(difluoro)methoxy]-4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage. Store it separately from incompatible substances like oxidizing agents and reducing agents to avoid potential chemical reactions. |
| Shipping | 1 - [Chloro(difluoro)methoxy]-4 - nitrobenzene is a chemical. It should be shipped in accordance with regulations for hazardous chemicals, in properly sealed, corrosion - resistant containers, with clear labeling of its properties and handling precautions. |
Competitive 1-[Chloro(Difluoro)Methoxy]-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 1-[Chloro(Difluoro)Methoxy]-4-Nitrobenzene in China?
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As a leading 1-[Chloro(Difluoro)Methoxy]-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1- [chloro (difluoro) methoxy] -4-nitrobenzene
1 - [chloro (difluoro) methoxy] -4 -nitrobenzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, the combination of chlorine, difluoromethoxy and nitro gives it special chemical activity, which can introduce other functional groups through various chemical reactions, and then build complex organic molecular structures.
In the process of pharmaceutical research and development, or involved in its presence. Because of its specific chemical properties, or can participate in the construction of drug molecules, it helps to create new drugs to deal with various diseases, such as antibacterial, antiviral or anti-tumor fields, and has potential applications.
In the field of materials science, it may also have important uses. It can be chemically modified, integrated into polymer materials, and improved material properties, such as enhancing the thermal stability and chemical stability of the material, or endowing the material with special optical and electrical properties, thus emerging in electronic devices, optical materials, etc.
And because of its fluorine-containing atoms, the characteristics of fluorine atoms can make related compounds have the advantages of low surface energy and high chemical stability. In the research and development of surfactants, coatings and other industrial products, there are also application opportunities, which can improve product performance and expand product application range.
In the process of pharmaceutical research and development, or involved in its presence. Because of its specific chemical properties, or can participate in the construction of drug molecules, it helps to create new drugs to deal with various diseases, such as antibacterial, antiviral or anti-tumor fields, and has potential applications.
In the field of materials science, it may also have important uses. It can be chemically modified, integrated into polymer materials, and improved material properties, such as enhancing the thermal stability and chemical stability of the material, or endowing the material with special optical and electrical properties, thus emerging in electronic devices, optical materials, etc.
And because of its fluorine-containing atoms, the characteristics of fluorine atoms can make related compounds have the advantages of low surface energy and high chemical stability. In the research and development of surfactants, coatings and other industrial products, there are also application opportunities, which can improve product performance and expand product application range.
What are the physical properties of 1- [chloro (difluoro) methoxy] -4-nitrobenzene
1 - [chloro (difluoro) methoxy] -4 -nitrobenzene is one of the organic compounds. Its physical properties are quite worthy of investigation.
Looking at its properties, under normal temperature and pressure, this substance is mostly solid, due to the intermolecular forces. Its appearance may be white to light yellow powder, and the formation of color is due to the interaction of atoms and electrons in the molecular structure, which produces specific absorption and reflection of light.
The melting point is about a specific temperature range. This temperature is the critical value for molecules to break free from lattice constraints and change from solid to liquid. The determination of the melting point can help us clarify the characteristics of its purity and structure. The higher the purity of the cap, the closer the melting point is to the theoretical value; and structural differences, such as molecular symmetry and polarity, can also affect the melting point.
In terms of boiling point, the exact value can be determined under specific pressure conditions. The boiling point reflects the difficulty of the molecule overcoming the interaction force and transforming into a gaseous state. The boiling point of the compound is also affected by the type and strength of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc.
In terms of solubility, 1 - [chloro (difluoro) methoxy] -4 -nitrobenzene may exhibit some solubility in organic solvents. It may be soluble in polar organic solvents such as acetone and dichloromethane. Due to the mutual adaptation of the polarity of the molecule and the polarity of the solvent, it follows the principle of "similar dissolution". In water, because the polarity of the molecule and the polarity of the water molecule are quite different, and it is difficult to form an effective interaction between the molecules, the solubility is poor.
Density is also one of its important physical properties. The measurement of density can help us understand the mass distribution of the substance in a unit volume. This value is closely related to the relative mass of the molecule and the way of intermolecular accumulation. The larger the relative mass, the closer the intermolecular accumulation, the higher the density.
In addition, the vapor pressure of the compound cannot be ignored. Vapor pressure reflects the tendency of its transformation from liquid or solid state to gaseous state at a certain temperature. As the temperature increases, the vapor pressure increases, and the thermal motion of molecules intensifies, more molecules have the energy to break free from the binding of the condensed phase.
In summary, the physical properties of 1- [chloro (difluoro) methoxy] -4 -nitrobenzene, such as its properties, melting point, boiling point, solubility, density and vapor pressure, are determined by its molecular structure and are interrelated, which plays a crucial role in its application in many fields such as chemical industry and materials.
Looking at its properties, under normal temperature and pressure, this substance is mostly solid, due to the intermolecular forces. Its appearance may be white to light yellow powder, and the formation of color is due to the interaction of atoms and electrons in the molecular structure, which produces specific absorption and reflection of light.
The melting point is about a specific temperature range. This temperature is the critical value for molecules to break free from lattice constraints and change from solid to liquid. The determination of the melting point can help us clarify the characteristics of its purity and structure. The higher the purity of the cap, the closer the melting point is to the theoretical value; and structural differences, such as molecular symmetry and polarity, can also affect the melting point.
In terms of boiling point, the exact value can be determined under specific pressure conditions. The boiling point reflects the difficulty of the molecule overcoming the interaction force and transforming into a gaseous state. The boiling point of the compound is also affected by the type and strength of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc.
In terms of solubility, 1 - [chloro (difluoro) methoxy] -4 -nitrobenzene may exhibit some solubility in organic solvents. It may be soluble in polar organic solvents such as acetone and dichloromethane. Due to the mutual adaptation of the polarity of the molecule and the polarity of the solvent, it follows the principle of "similar dissolution". In water, because the polarity of the molecule and the polarity of the water molecule are quite different, and it is difficult to form an effective interaction between the molecules, the solubility is poor.
Density is also one of its important physical properties. The measurement of density can help us understand the mass distribution of the substance in a unit volume. This value is closely related to the relative mass of the molecule and the way of intermolecular accumulation. The larger the relative mass, the closer the intermolecular accumulation, the higher the density.
In addition, the vapor pressure of the compound cannot be ignored. Vapor pressure reflects the tendency of its transformation from liquid or solid state to gaseous state at a certain temperature. As the temperature increases, the vapor pressure increases, and the thermal motion of molecules intensifies, more molecules have the energy to break free from the binding of the condensed phase.
In summary, the physical properties of 1- [chloro (difluoro) methoxy] -4 -nitrobenzene, such as its properties, melting point, boiling point, solubility, density and vapor pressure, are determined by its molecular structure and are interrelated, which plays a crucial role in its application in many fields such as chemical industry and materials.
What are the chemical properties of 1- [chloro (difluoro) methoxy] -4-nitrobenzene
1 - [chlorine (difluoro) methoxy] - 4 - nitrobenzene is one of the organic compounds. Its chemical properties are unique and rich in research interest.
In this compound, the nitro group (-NO 2O) has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. And the nitro group can affect the polarity of the molecule, making its solubility and related physical properties unusual. In some reactions, the nitro group can be converted into an amino group (-NH 2O) by reduction, and a variety of organic synthesis pathways can be derived.
The chlorine (difluoro) methoxy group (-OCHClF 2O) part has high electronegativity of the fluorine atom, giving the group a unique electronic effect. The presence of fluorine atoms not only increases the molecular polarity, but also has a great impact on the stability of compounds. Due to the high bond energy of C-F, the chemical stability of compounds containing fluorine groups is enhanced. The steric resistance of this group cannot be ignored, and it will affect the molecular reactivity and conformation.
In chemical reactions, the benzene ring of 1- [chloro (difluoro) methoxy] - 4 - nitrobenzene can undergo nucleophilic substitution under specific conditions. Due to the decrease in the electron cloud density of the benzene ring, nucleophilic reagents are prone to attack the benzene ring and replace chloro (difluoro) methoxy or nitro. In addition, under suitable reagents and conditions, this compound can participate in redox reactions, change the oxidation state of nitro groups, and derive different products. In conclusion, the chemical properties of 1 - [chloro (difluoro) methoxy] - 4 - nitrobenzene are determined by the synergy of its functional groups, and have potential applications and research value in organic synthesis and related fields.
In this compound, the nitro group (-NO 2O) has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. And the nitro group can affect the polarity of the molecule, making its solubility and related physical properties unusual. In some reactions, the nitro group can be converted into an amino group (-NH 2O) by reduction, and a variety of organic synthesis pathways can be derived.
The chlorine (difluoro) methoxy group (-OCHClF 2O) part has high electronegativity of the fluorine atom, giving the group a unique electronic effect. The presence of fluorine atoms not only increases the molecular polarity, but also has a great impact on the stability of compounds. Due to the high bond energy of C-F, the chemical stability of compounds containing fluorine groups is enhanced. The steric resistance of this group cannot be ignored, and it will affect the molecular reactivity and conformation.
In chemical reactions, the benzene ring of 1- [chloro (difluoro) methoxy] - 4 - nitrobenzene can undergo nucleophilic substitution under specific conditions. Due to the decrease in the electron cloud density of the benzene ring, nucleophilic reagents are prone to attack the benzene ring and replace chloro (difluoro) methoxy or nitro. In addition, under suitable reagents and conditions, this compound can participate in redox reactions, change the oxidation state of nitro groups, and derive different products. In conclusion, the chemical properties of 1 - [chloro (difluoro) methoxy] - 4 - nitrobenzene are determined by the synergy of its functional groups, and have potential applications and research value in organic synthesis and related fields.
What are the synthesis methods of 1- [chloro (difluoro) methoxy] -4-nitrobenzene
There are many ways to synthesize 1 - [chloro (difluoro) methoxy] -4 - nitrobenzene. The first thing to mention is the method of nucleophilic substitution. In this method, 4 - nitrophenol can be mixed with a base first to form a phenolic salt. Common bases, such as sodium hydroxide, can deprotonate the phenolic hydroxyl group and produce nucleophilic phenoxy anions. Then, reagents containing chlorine (difluoro) methoxy groups, such as chloro (difluoro) methane, are introduced. When this nucleophilic reagent meets the phenoxy anion, a nucleophilic substitution reaction occurs, and the two combine, resulting in 1 - [chloro (difluoro) methoxy] -4 - nitrobenzene. This reaction requires attention to the reaction conditions. The choice of temperature and solvent has an impact. If the temperature is too high, side reactions may occur; the solvent is uncomfortable, or the reaction rate may be delayed.
Furthermore, the halogenation reaction is also a method. Appropriate modifications can be made to the benzene ring first, and nitro groups can be introduced to obtain 4-nitrobenzene. Then, under specific conditions, chlorine (difluoro) methoxy groups can be halogenated. In this process, the choice of halogenating reagents is very critical. Choosing an appropriate halogenating reagent can make the reaction proceed in the desired direction. At the same time, the addition of catalysts may improve the efficiency of the reaction and speed up the process of the reaction. However, the halogenation reaction is also prone to the problem of regional selectivity, and careful regulation is required to obtain the target product.
There is also a method of gradually constructing the target molecule by using other compounds containing fluorine, chlorine and methoxy as starting materials through multi-step reactions. First, the starting material is converted into functional groups, and then condensation, substitution and other reactions, and finally 1 - [chloro (difluoro) methoxy] -4 -nitrobenzene is synthesized. Although this multi-step synthesis method is complicated, it can precisely regulate the structure of the molecule and improve the purity and yield of the product. However, attention should be paid to the yield of each step of the reaction, and the intermediate products of the reaction should be well separated and purified to avoid the accumulation of impurities and affect the quality of the final product.
Furthermore, the halogenation reaction is also a method. Appropriate modifications can be made to the benzene ring first, and nitro groups can be introduced to obtain 4-nitrobenzene. Then, under specific conditions, chlorine (difluoro) methoxy groups can be halogenated. In this process, the choice of halogenating reagents is very critical. Choosing an appropriate halogenating reagent can make the reaction proceed in the desired direction. At the same time, the addition of catalysts may improve the efficiency of the reaction and speed up the process of the reaction. However, the halogenation reaction is also prone to the problem of regional selectivity, and careful regulation is required to obtain the target product.
There is also a method of gradually constructing the target molecule by using other compounds containing fluorine, chlorine and methoxy as starting materials through multi-step reactions. First, the starting material is converted into functional groups, and then condensation, substitution and other reactions, and finally 1 - [chloro (difluoro) methoxy] -4 -nitrobenzene is synthesized. Although this multi-step synthesis method is complicated, it can precisely regulate the structure of the molecule and improve the purity and yield of the product. However, attention should be paid to the yield of each step of the reaction, and the intermediate products of the reaction should be well separated and purified to avoid the accumulation of impurities and affect the quality of the final product.
1- [chloro (difluoro) methoxy] -4-nitrobenzene What to pay attention to when storing and transporting
1-%5Bchloro%28difluoro%29methoxy%5D-4-nitrobenzene is an organic compound, and many things need to be paid attention to when storing and transporting.
First, store, this compound is unstable and must be placed in a cool and dry place. Because it is sensitive to heat, high temperature is easy to decompose or cause dangerous reactions, so it is important to keep away from heat sources and open flames. Furthermore, it should be stored in a well-ventilated place to prevent the accumulation of harmful gases. Because of its certain toxicity and irritation, sealed storage can avoid environmental and personal hazards caused by its volatilization. And it should be stored separately from oxidants, reducing agents, acids, alkalis and other substances, because of its active chemical properties, contact with these substances, or react violently.
As for transportation, it is necessary to ensure that the packaging is intact. Choosing suitable packaging materials can effectively prevent leakage. The transportation process needs to be stable to avoid vibration, impact and friction, and prevent leakage caused by package damage. Transportation personnel should be familiar with its hazard characteristics and emergency treatment methods, and can respond quickly if there is an accident such as leakage occurs. At the same time, transportation vehicles must also comply with safety regulations and be equipped with corresponding fire and emergency equipment. Closely monitor environmental conditions such as temperature and humidity during transportation to prevent the deterioration of compounds due to environmental factors or cause danger.
In short, the storage and transportation of 1-%5Bchloro%28difluoro%29methoxy%5D-4-nitrobenzene should be carefully and carefully, and strictly follow relevant safety regulations and operating procedures to ensure that personnel safety and the environment are not endangered.
First, store, this compound is unstable and must be placed in a cool and dry place. Because it is sensitive to heat, high temperature is easy to decompose or cause dangerous reactions, so it is important to keep away from heat sources and open flames. Furthermore, it should be stored in a well-ventilated place to prevent the accumulation of harmful gases. Because of its certain toxicity and irritation, sealed storage can avoid environmental and personal hazards caused by its volatilization. And it should be stored separately from oxidants, reducing agents, acids, alkalis and other substances, because of its active chemical properties, contact with these substances, or react violently.
As for transportation, it is necessary to ensure that the packaging is intact. Choosing suitable packaging materials can effectively prevent leakage. The transportation process needs to be stable to avoid vibration, impact and friction, and prevent leakage caused by package damage. Transportation personnel should be familiar with its hazard characteristics and emergency treatment methods, and can respond quickly if there is an accident such as leakage occurs. At the same time, transportation vehicles must also comply with safety regulations and be equipped with corresponding fire and emergency equipment. Closely monitor environmental conditions such as temperature and humidity during transportation to prevent the deterioration of compounds due to environmental factors or cause danger.
In short, the storage and transportation of 1-%5Bchloro%28difluoro%29methoxy%5D-4-nitrobenzene should be carefully and carefully, and strictly follow relevant safety regulations and operating procedures to ensure that personnel safety and the environment are not endangered.
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