Linshang Chemical
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1-(Chloromethyl)-2,3,4,5,6-Pentafluorobenzene
Linshang Chemical
|
HS Code |
787673 |
| Chemical Formula | C7H2ClF5 |
| Molar Mass | 214.535 g/mol |
| Appearance | Liquid (presumably, typical for such compounds) |
| Solubility In Water | Low (due to non - polar nature of fluorinated and chlorinated benzene ring) |
| Reactivity | Can undergo substitution reactions due to the presence of chloromethyl group |
As an accredited 1-(Chloromethyl)-2,3,4,5,6-Pentafluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 1-(chloromethyl)-2,3,4,5,6 - pentafluorobenzene. |
| Storage | 1-(Chloromethyl)-2,3,4,5,6 -pentafluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-2,3,4,5,6 - pentafluorobenzene is shipped in accordance with hazardous chemical regulations. Packed in specialized containers, it undergoes proper handling, storage, and transportation to ensure safety. |
Competitive 1-(Chloromethyl)-2,3,4,5,6-Pentafluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the main uses of 1- (chloromethyl) -2,3,4,5,6-pentafluorobenzene?
(1) 1 - (cyanomethyl) - 2, 3, 4, 5, 6 - pentabromobenzene is a commonly used intermediate in organic synthesis. It has multiple uses in the field of organic synthesis and can be used as a key building block for the construction of complex organic molecules.
(2) First, it can be used to prepare high-performance flame retardants. In modern materials science, flame retardant materials are widely required. This compound is used as a starting material, and a flame retardant with high bromine content can be prepared through a specific chemical reaction. This flame retardant is added to plastics, fibers and other materials. When exposed to fire, the bromine atoms in the molecule will undergo a series of reactions, such as generating non-flammable gases and diluting the oxygen concentration, thereby effectively inhibiting the spread of flames and improving the flame retardancy of the material.
(3) Second, in the field of medicinal chemistry, it may provide a unique structural unit for drug synthesis. Because the compound has a specific electron cloud distribution and spatial structure, it can be used as part of an active group or pharmacophore. After chemical modification and splicing with other compounds, it is expected to develop new drug molecules and provide new options for disease treatment.
(4) Third, it also has potential applications in material surface modification. Grafting it to the surface of the material through chemical reaction can change the surface chemical properties of the material, such as improving the surface polarity of the material, improving the wettability, etc., thereby improving the compatibility of the material with other substances and expanding the application range of the material.
(2) First, it can be used to prepare high-performance flame retardants. In modern materials science, flame retardant materials are widely required. This compound is used as a starting material, and a flame retardant with high bromine content can be prepared through a specific chemical reaction. This flame retardant is added to plastics, fibers and other materials. When exposed to fire, the bromine atoms in the molecule will undergo a series of reactions, such as generating non-flammable gases and diluting the oxygen concentration, thereby effectively inhibiting the spread of flames and improving the flame retardancy of the material.
(3) Second, in the field of medicinal chemistry, it may provide a unique structural unit for drug synthesis. Because the compound has a specific electron cloud distribution and spatial structure, it can be used as part of an active group or pharmacophore. After chemical modification and splicing with other compounds, it is expected to develop new drug molecules and provide new options for disease treatment.
(4) Third, it also has potential applications in material surface modification. Grafting it to the surface of the material through chemical reaction can change the surface chemical properties of the material, such as improving the surface polarity of the material, improving the wettability, etc., thereby improving the compatibility of the material with other substances and expanding the application range of the material.
What are the physical properties of 1- (chloromethyl) -2,3,4,5,6-pentafluorobenzene
1 - (cyanomethyl) - 2,3,4,5,6 - pentafluorobenzene, is an organic compound. Its physical properties are as follows:
- ** Appearance and Properties **: Under normal conditions, it is mostly colorless to light yellow liquid, and it is clear and transparent. This appearance feature is very important in practical application and observation, which can help to distinguish its physical state and purity.
- ** Melting Point and Boiling Point **: The melting point is low, about - [specific value] ℃, and the boiling point is about [specific value] ℃. The low melting point allows it to melt into a liquid state in a relatively low temperature environment; the specific boiling point makes it effective for distillation, separation and other operations according to this temperature characteristic.
- ** Density **: The density is different from that of water, about [X] g/cm ³. This density characteristic has a significant impact on processes involving liquid-liquid separation or distribution in different media, depending on its location and behavior in the system.
- ** Solubility **: In organic solvents such as dichloromethane, chloroform, ether, etc., it exhibits good solubility and can be miscible with these solvents in a certain proportion. However, in water, the solubility is very small. This difference in solubility is significant in chemical synthesis, extraction, etc., and can be used to select the appropriate solvent to achieve a specific reaction or separation goal.
- ** Volatility **: It is volatile to a certain extent. At room temperature and pressure, some molecules will escape into the air. Pay attention when using and storing, and place it in a well-ventilated place to prevent gas accumulation.
- ** Odor **: Usually has a special organic smell. Although the smell description of your mileage may vary, the smell, as one of its physical properties, can be used as a reference in identification and operation. It also reminds you to take good protection during operation and avoid inhalation.
- ** Appearance and Properties **: Under normal conditions, it is mostly colorless to light yellow liquid, and it is clear and transparent. This appearance feature is very important in practical application and observation, which can help to distinguish its physical state and purity.
- ** Melting Point and Boiling Point **: The melting point is low, about - [specific value] ℃, and the boiling point is about [specific value] ℃. The low melting point allows it to melt into a liquid state in a relatively low temperature environment; the specific boiling point makes it effective for distillation, separation and other operations according to this temperature characteristic.
- ** Density **: The density is different from that of water, about [X] g/cm ³. This density characteristic has a significant impact on processes involving liquid-liquid separation or distribution in different media, depending on its location and behavior in the system.
- ** Solubility **: In organic solvents such as dichloromethane, chloroform, ether, etc., it exhibits good solubility and can be miscible with these solvents in a certain proportion. However, in water, the solubility is very small. This difference in solubility is significant in chemical synthesis, extraction, etc., and can be used to select the appropriate solvent to achieve a specific reaction or separation goal.
- ** Volatility **: It is volatile to a certain extent. At room temperature and pressure, some molecules will escape into the air. Pay attention when using and storing, and place it in a well-ventilated place to prevent gas accumulation.
- ** Odor **: Usually has a special organic smell. Although the smell description of your mileage may vary, the smell, as one of its physical properties, can be used as a reference in identification and operation. It also reminds you to take good protection during operation and avoid inhalation.
Is the chemical properties of 1- (chloromethyl) -2,3,4,5,6-pentafluorobenzene stable?
The chemical properties of 1 - (methoxy) - 2,3,4,5,6 - pentafluorobenzene are determined. This is because the methoxy group has the effect of donating benzene, which can increase the density of benzene. The fluorine atom has a strong absorber effect. Because it is located on benzene, the interaction of methoxy groups is very important.
Generally speaking, the qualitative influence of the substituent on benzene compounds is very important. Methoxy donating benzene increases the density of benzene, making it more susceptible to attack. However, the absorber effect of fluorine atoms reduces the density of benzene to a certain extent and inhibits the reaction of benzene substitution.
Furthermore, the space resistance also affects the qualitative effect of benzene. The distribution of pentafluorine atoms on benzene makes the molecule empty and biochemical, and increases the space barrier. This space barrier effect can affect the reactance of benzene close to the degree of reactance, and affect the reactivity of benzene.
, 1- (methoxy) -2,3,4,5,6-pentafluorobenzene The reaction of the chemical phase is determined. Methoxy fluorine atoms check and balance each other, and the effect of space barrier makes the chemical compound biochemical reaction under normal conditions. However, in the presence of specific components, such as high temperature, acid, or specific catalysts, the qualitative of its chemical properties may also be changed, leading to the reaction of the chemical phase.
Generally speaking, the qualitative influence of the substituent on benzene compounds is very important. Methoxy donating benzene increases the density of benzene, making it more susceptible to attack. However, the absorber effect of fluorine atoms reduces the density of benzene to a certain extent and inhibits the reaction of benzene substitution.
Furthermore, the space resistance also affects the qualitative effect of benzene. The distribution of pentafluorine atoms on benzene makes the molecule empty and biochemical, and increases the space barrier. This space barrier effect can affect the reactance of benzene close to the degree of reactance, and affect the reactivity of benzene.
, 1- (methoxy) -2,3,4,5,6-pentafluorobenzene The reaction of the chemical phase is determined. Methoxy fluorine atoms check and balance each other, and the effect of space barrier makes the chemical compound biochemical reaction under normal conditions. However, in the presence of specific components, such as high temperature, acid, or specific catalysts, the qualitative of its chemical properties may also be changed, leading to the reaction of the chemical phase.
What are the synthesis methods of 1- (chloromethyl) -2,3,4,5,6-pentafluorobenzene?
To prepare 1 - (cyanomethyl) - 2,3,4,5,6 - pentabromobenzyl, there are many methods for synthesis, and several are common today.
First, the corresponding benzyl compound can be started. First, the benzyl compound interacts with a halogenating agent to introduce bromine atoms. The commonly used halogenating agent is bromine ($Br_2 $). Under suitable reaction conditions, such as in a suitable solvent (such as carbon tetrachloride, etc.), in the presence of light or initiator, bromine can undergo a radical substitution reaction with the benzyl compound, gradually replacing the hydrogen atom on the benzyl group with a bromine atom to obtain a bromine-containing benzyl intermediate. Subsequently, this intermediate is reacted with a cyanide-containing reagent to introduce cyanomethyl. For example, it can react with sodium cyanide in an appropriate solvent (such as dimethyl sulfoxide, etc.), and through nucleophilic substitution reaction, cyanomethyl can be added at a specific position of benzyl group to obtain the target product.
Second, benzaldehyde derivatives are used as raw materials. First, benzaldehyde derivatives are brominated, and bromine atoms are introduced at specific positions on their benzene rings. For this bromination process, suitable bromination reagents and reaction conditions can be selected according to positioning rules. If $N - $bromosuccinimide (NBS) is used, bromination at the benzyl position on the benzene ring can be achieved under the action of an initiator. After obtaining the polybrominated benzaldehyde derivative, the aldehyde group is converted into the corresponding alcohol hydroxyl group by reduction reaction, and then the alcohol hydroxyl group is halogenated to obtain the halogenated benzyl derivative. Finally, the halogenated benzyl derivative is reacted with a cyanide reagent to introduce cyanomethyl to complete the synthesis of 1- (cyanomethyl) -2,3,4,5,6-pentabromobenzyl.
Third, starting from benzocyclic compounds. First, the parent ring containing benzyl structure is constructed by cyclization reaction, and in the process of constructing the parent ring, the reaction can be cleverly designed so that the ring has functional groups that are easy to follow-up reactions. After that, the parent ring is modified by bromination and bromine atoms are introduced. Different bromination conditions can be used to control the position and quantity of bromine atoms introduced. After bromination is completed, cyanomethyl is introduced through an appropriate functional group conversion reaction. For example, by nucleophilic substitution or addition reaction with suitable cyanide reagents, 1- (cyanomethyl) -2,3,4,5,6-pentabromobenzyl is finally synthesized.
First, the corresponding benzyl compound can be started. First, the benzyl compound interacts with a halogenating agent to introduce bromine atoms. The commonly used halogenating agent is bromine ($Br_2 $). Under suitable reaction conditions, such as in a suitable solvent (such as carbon tetrachloride, etc.), in the presence of light or initiator, bromine can undergo a radical substitution reaction with the benzyl compound, gradually replacing the hydrogen atom on the benzyl group with a bromine atom to obtain a bromine-containing benzyl intermediate. Subsequently, this intermediate is reacted with a cyanide-containing reagent to introduce cyanomethyl. For example, it can react with sodium cyanide in an appropriate solvent (such as dimethyl sulfoxide, etc.), and through nucleophilic substitution reaction, cyanomethyl can be added at a specific position of benzyl group to obtain the target product.
Second, benzaldehyde derivatives are used as raw materials. First, benzaldehyde derivatives are brominated, and bromine atoms are introduced at specific positions on their benzene rings. For this bromination process, suitable bromination reagents and reaction conditions can be selected according to positioning rules. If $N - $bromosuccinimide (NBS) is used, bromination at the benzyl position on the benzene ring can be achieved under the action of an initiator. After obtaining the polybrominated benzaldehyde derivative, the aldehyde group is converted into the corresponding alcohol hydroxyl group by reduction reaction, and then the alcohol hydroxyl group is halogenated to obtain the halogenated benzyl derivative. Finally, the halogenated benzyl derivative is reacted with a cyanide reagent to introduce cyanomethyl to complete the synthesis of 1- (cyanomethyl) -2,3,4,5,6-pentabromobenzyl.
Third, starting from benzocyclic compounds. First, the parent ring containing benzyl structure is constructed by cyclization reaction, and in the process of constructing the parent ring, the reaction can be cleverly designed so that the ring has functional groups that are easy to follow-up reactions. After that, the parent ring is modified by bromination and bromine atoms are introduced. Different bromination conditions can be used to control the position and quantity of bromine atoms introduced. After bromination is completed, cyanomethyl is introduced through an appropriate functional group conversion reaction. For example, by nucleophilic substitution or addition reaction with suitable cyanide reagents, 1- (cyanomethyl) -2,3,4,5,6-pentabromobenzyl is finally synthesized.
What are the precautions for storing and transporting 1- (chloromethyl) -2,3,4,5,6-pentafluorobenzene?
1 - (cyanomethyl) - 2, 3, 4, 5, 6 - pentabromobenzene should pay attention to the following matters during storage and transportation:
First, because of its toxicity, contact can cause human damage, during storage and transportation, be sure to ensure that the packaging is tight to prevent leakage. Staff also need to take good protection, such as wearing gas masks, gloves and protective clothing, etc., to avoid direct contact.
Second, this substance may be harmful to the environment. If it leaks, it is likely to pollute soil and water sources. Therefore, the storage place should be selected away from water sources and residential areas, and there should be perfect leakage emergency treatment facilities and plans. Once a leak occurs, effective measures should be taken immediately to collect and clean up to prevent the spread of pollution.
Third, 1 - (cyanomethyl) - 2, 3, 4, 5, 6 - pentabromobenzene is flammable, in case of open flame, hot topic or cause combustion. When storing, it should be placed in a cool and well-ventilated place, away from fire and heat sources. At the same time, the transport vehicle should also be equipped with corresponding fire equipment, and fireworks are strictly prohibited during transportation.
Fourth, the storage and transportation of this substance must strictly follow relevant regulations and standards. Operators should be familiar with its characteristics and safety operating norms, and obvious warning signs should be set up in storage places and transport vehicles to remind people to pay attention to safety.
Fifth, avoid mixing and mixing with oxidizing substances, because the two contact or cause violent reactions, increasing safety risks. It should be stored separately from oxidizing substances in different areas and labeled accordingly.
First, because of its toxicity, contact can cause human damage, during storage and transportation, be sure to ensure that the packaging is tight to prevent leakage. Staff also need to take good protection, such as wearing gas masks, gloves and protective clothing, etc., to avoid direct contact.
Second, this substance may be harmful to the environment. If it leaks, it is likely to pollute soil and water sources. Therefore, the storage place should be selected away from water sources and residential areas, and there should be perfect leakage emergency treatment facilities and plans. Once a leak occurs, effective measures should be taken immediately to collect and clean up to prevent the spread of pollution.
Third, 1 - (cyanomethyl) - 2, 3, 4, 5, 6 - pentabromobenzene is flammable, in case of open flame, hot topic or cause combustion. When storing, it should be placed in a cool and well-ventilated place, away from fire and heat sources. At the same time, the transport vehicle should also be equipped with corresponding fire equipment, and fireworks are strictly prohibited during transportation.
Fourth, the storage and transportation of this substance must strictly follow relevant regulations and standards. Operators should be familiar with its characteristics and safety operating norms, and obvious warning signs should be set up in storage places and transport vehicles to remind people to pay attention to safety.
Fifth, avoid mixing and mixing with oxidizing substances, because the two contact or cause violent reactions, increasing safety risks. It should be stored separately from oxidizing substances in different areas and labeled accordingly.
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