Linshang Chemical
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1-(Chloromethyl)-2,3,4,5-Tetrafluorobenzene
Linshang Chemical
|
HS Code |
362934 |
| Chemical Formula | C7H2ClF4 |
| Molar Mass | 198.538 g/mol |
| Appearance | colorless liquid |
| Boiling Point | 153 - 154 °C |
| Density | 1.49 g/cm³ |
| Flash Point | 48 °C |
| Solubility In Water | insoluble |
| Vapor Pressure | 1.33 kPa (25 °C) |
| Refractive Index | 1.434 |
| Stability | Stable under normal conditions |
As an accredited 1-(Chloromethyl)-2,3,4,5-Tetrafluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - (Chloromethyl)-2,3,4,5 - tetrafluorobenzene in 100 - mL glass bottle for quantity of 500 mL. |
| Storage | 1-(Chloromethyl)-2,3,4,5 - tetrafluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly to prevent misidentification and ensure proper handling. |
| Shipping | 1-(Chloromethyl)-2,3,4,5 - tetrafluorobenzene is shipped in sealed, corrosion - resistant containers. Strict safety protocols are followed to prevent leakage, ensuring safe transportation due to its chemical nature. |
Competitive 1-(Chloromethyl)-2,3,4,5-Tetrafluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What is the main use of 1- (chloromethyl) -2,3,4, 5-tetrafluorobenzene
1 - (chloromethyl) - 2, 3, 4, 5 - tetrafluorobenzene is also an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of chemical synthesis.
Because of the unique molecular structure of this compound, it contains chloromethyl and tetrafluorophenyl. This special structure gives it active chemical properties, so it can play an important role in organic synthesis reactions. For example, chloromethyl can participate in nucleophilic substitution reactions and can react with many nucleophilic reagents, such as alcohols and amines. With such reactions, chemists can construct more complex organic molecular structures, which are of great significance in the field of medicinal chemistry.
In the process of drug development, with the help of 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene as the starting material, through a series of chemical reactions, compounds with specific biological activities can be prepared, or potential drug candidates. In addition, in the field of materials science, this compound may be used to prepare high-performance organic materials. Because of its fluorine atom, it can improve the stability, corrosion resistance and thermal stability of the material.
And because of the fluorine atom in the structure, it can affect the intermolecular force and electron cloud distribution of the material, thus endowing the material with unique physical and chemical properties. For example, it can be used to prepare special coating materials, which can be used in aerospace, automobile manufacturing and other industries with strict material properties due to their corrosion resistance and stability.
Furthermore, in the study of organic synthesis methodology, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene is also a commonly used research object. By exploring the novel reaction pathways and reaction mechanisms involved in it, researchers can expand the methods and strategies of organic synthesis and promote the development of organic chemistry. In short, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene has important uses in many fields such as chemicals, drugs, materials, etc., providing a key material basis for research and development in related fields.
Because of the unique molecular structure of this compound, it contains chloromethyl and tetrafluorophenyl. This special structure gives it active chemical properties, so it can play an important role in organic synthesis reactions. For example, chloromethyl can participate in nucleophilic substitution reactions and can react with many nucleophilic reagents, such as alcohols and amines. With such reactions, chemists can construct more complex organic molecular structures, which are of great significance in the field of medicinal chemistry.
In the process of drug development, with the help of 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene as the starting material, through a series of chemical reactions, compounds with specific biological activities can be prepared, or potential drug candidates. In addition, in the field of materials science, this compound may be used to prepare high-performance organic materials. Because of its fluorine atom, it can improve the stability, corrosion resistance and thermal stability of the material.
And because of the fluorine atom in the structure, it can affect the intermolecular force and electron cloud distribution of the material, thus endowing the material with unique physical and chemical properties. For example, it can be used to prepare special coating materials, which can be used in aerospace, automobile manufacturing and other industries with strict material properties due to their corrosion resistance and stability.
Furthermore, in the study of organic synthesis methodology, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene is also a commonly used research object. By exploring the novel reaction pathways and reaction mechanisms involved in it, researchers can expand the methods and strategies of organic synthesis and promote the development of organic chemistry. In short, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene has important uses in many fields such as chemicals, drugs, materials, etc., providing a key material basis for research and development in related fields.
What are the physical properties of 1- (chloromethyl) -2,3,4, 5-tetrafluorobenzene
1 - (chloromethyl) - 2, 3, 4, 5 - tetrafluorobenzene, is a kind of organic compound. Its physical properties, let me tell them one by one.
First of all, its appearance, under normal conditions, or a colorless to light yellow transparent liquid, clear and with a specific luster, it looks like a flowing crystal liquid, shining.
As for its boiling point, it is about a certain temperature range. The value of this boiling point is closely related to the force between molecules. Because of its molecular structure, chloromethyl interacts with the tetrafluorobenzene ring, causing the attractive force between molecules to be different, so the boiling point depends on it. The characteristics of its boiling point are crucial in chemical operations such as separation and purification of substances, and are the key parameters for controlling the process.
Melting point is also one of its important physical properties. The melting point of the compound is affected by the regularity of molecular arrangement and interactions. The uniqueness of the molecular structure makes the molecules arranged in different degrees of order at low temperature, so it presents a specific melting point. The data of this melting point is of great significance for the study of its solid state properties and phase transition process.
In addition, its density also has a specific value. The density is related to the mass of the substance per unit volume. The density of 1 - (chloromethyl) -2,3,4,5 - tetrafluorobenzene reflects the compactness of its molecules. Due to the fixed type of atoms and connection mode in the molecule, the density is relatively stable, which can provide a basis for material metering and mixing operations in practical applications.
In terms of solubility, this compound exhibits a certain solubility in organic solvents. Due to the principle of similarity and phase dissolution, the polarity of its molecular structure is compatible with the polarity of the organic solvent, and it can be soluble in organic solvents such as some aromatics and halogenated hydrocarbons. However, in water, the solubility is poor, which is caused by the large difference between the polarity of the molecule and the polarity of water. This solubility property has a profound impact on the solvent selection and product separation of organic synthesis reactions.
Volatility cannot be ignored. Because the intermolecular force is not extremely strong, it has a certain volatility. In an open environment, it will slowly evaporate into the air. This volatility not only affects its storage stability, but also has certain requirements for the safety of the use environment. It needs to be properly protected to avoid the harm of volatile gases to the human body and the environment.
In summary, the physical properties of 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene have important reference value in many fields such as organic synthesis and chemical production, laying the foundation for related research and application.
First of all, its appearance, under normal conditions, or a colorless to light yellow transparent liquid, clear and with a specific luster, it looks like a flowing crystal liquid, shining.
As for its boiling point, it is about a certain temperature range. The value of this boiling point is closely related to the force between molecules. Because of its molecular structure, chloromethyl interacts with the tetrafluorobenzene ring, causing the attractive force between molecules to be different, so the boiling point depends on it. The characteristics of its boiling point are crucial in chemical operations such as separation and purification of substances, and are the key parameters for controlling the process.
Melting point is also one of its important physical properties. The melting point of the compound is affected by the regularity of molecular arrangement and interactions. The uniqueness of the molecular structure makes the molecules arranged in different degrees of order at low temperature, so it presents a specific melting point. The data of this melting point is of great significance for the study of its solid state properties and phase transition process.
In addition, its density also has a specific value. The density is related to the mass of the substance per unit volume. The density of 1 - (chloromethyl) -2,3,4,5 - tetrafluorobenzene reflects the compactness of its molecules. Due to the fixed type of atoms and connection mode in the molecule, the density is relatively stable, which can provide a basis for material metering and mixing operations in practical applications.
In terms of solubility, this compound exhibits a certain solubility in organic solvents. Due to the principle of similarity and phase dissolution, the polarity of its molecular structure is compatible with the polarity of the organic solvent, and it can be soluble in organic solvents such as some aromatics and halogenated hydrocarbons. However, in water, the solubility is poor, which is caused by the large difference between the polarity of the molecule and the polarity of water. This solubility property has a profound impact on the solvent selection and product separation of organic synthesis reactions.
Volatility cannot be ignored. Because the intermolecular force is not extremely strong, it has a certain volatility. In an open environment, it will slowly evaporate into the air. This volatility not only affects its storage stability, but also has certain requirements for the safety of the use environment. It needs to be properly protected to avoid the harm of volatile gases to the human body and the environment.
In summary, the physical properties of 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene have important reference value in many fields such as organic synthesis and chemical production, laying the foundation for related research and application.
What are the chemical properties of 1- (chloromethyl) -2,3,4, 5-tetrafluorobenzene
1 - (chloromethyl) - 2, 3, 4, 5 - tetrafluorobenzene, also an organic compound. It is active and has many unique chemical properties, and has a wide range of uses in the field of organic synthesis.
In terms of its chemical properties, the properties of halogenated hydrocarbons are highlighted. In the case of chloromethyl, the chlorine atom is quite active. In the case of nucleophiles, nucleophilic substitution often occurs. In the case of alcohol nucleophiles, under suitable conditions, the chlorine atom can be replaced by an alkoxy group and an ether-generating compound. This reaction may need to be catalyzed by alkali substances to promote the activity of nucleophiles and make the reaction more likely to occur.
Because of the fluorine atoms connected to the benzene ring, the fluorine atoms are very electronegative, which has a great impact on the electron cloud distribution of the benzene ring. The electron cloud density of the benzene ring decreases, which also changes the activity of the electrophilic substitution reaction. Compared with ordinary benzene derivatives, the electrophilic substitution reaction is more difficult to occur, and the reaction check point is also affected by the positioning effect of fluorine atoms. Generally speaking, fluorine atoms are adjacent and para-site locators, but the positioning effect is more complicated due to the joint action of multiple fluorine atoms.
In addition, the thermal stability of the compound also has characteristics. Because fluorine atoms are connected to the benzene ring, a stable C-F bond is formed, which has a high bond energy, so the thermal stability of the compound is enhanced to a certain extent. In a high temperature environment, it is more difficult to decompose than some fluorine-free similar compounds. However, when the temperature rises to a certain threshold, its structure will also change, triggering various thermal decomposition reactions.
In organic synthesis, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene is often used as a key intermediate. Through its chloromethyl reactivity, a variety of functional groups can be introduced to build complex organic molecules, providing an important raw material basis for research in pharmaceutical chemistry, materials science and other fields.
In terms of its chemical properties, the properties of halogenated hydrocarbons are highlighted. In the case of chloromethyl, the chlorine atom is quite active. In the case of nucleophiles, nucleophilic substitution often occurs. In the case of alcohol nucleophiles, under suitable conditions, the chlorine atom can be replaced by an alkoxy group and an ether-generating compound. This reaction may need to be catalyzed by alkali substances to promote the activity of nucleophiles and make the reaction more likely to occur.
Because of the fluorine atoms connected to the benzene ring, the fluorine atoms are very electronegative, which has a great impact on the electron cloud distribution of the benzene ring. The electron cloud density of the benzene ring decreases, which also changes the activity of the electrophilic substitution reaction. Compared with ordinary benzene derivatives, the electrophilic substitution reaction is more difficult to occur, and the reaction check point is also affected by the positioning effect of fluorine atoms. Generally speaking, fluorine atoms are adjacent and para-site locators, but the positioning effect is more complicated due to the joint action of multiple fluorine atoms.
In addition, the thermal stability of the compound also has characteristics. Because fluorine atoms are connected to the benzene ring, a stable C-F bond is formed, which has a high bond energy, so the thermal stability of the compound is enhanced to a certain extent. In a high temperature environment, it is more difficult to decompose than some fluorine-free similar compounds. However, when the temperature rises to a certain threshold, its structure will also change, triggering various thermal decomposition reactions.
In organic synthesis, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene is often used as a key intermediate. Through its chloromethyl reactivity, a variety of functional groups can be introduced to build complex organic molecules, providing an important raw material basis for research in pharmaceutical chemistry, materials science and other fields.
What are the preparation methods of 1- (chloromethyl) -2,3,4, 5-tetrafluorobenzene
There are several common methods for preparing 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene. One method is to use 2,3,4,5-tetrafluorobenzoic acid as the starting material. The acid is first heated with thionyl chloride, and the two are combined. The carboxyl group (-COOH) in the acid is converted into an acyl chloride group (-COCl) through this reaction, resulting in 2,3,4,5-tetrafluorobenzoyl chloride. The reaction is violent, temperature control is required to prevent accidents, and it is carried out in a well-ventilated place, because thionyl chloride is corrosive and irritating.
The resulting 2,3,4,5-tetrafluorobenzoyl chloride will be reduced with hydrogen in the presence of suitable catalysts such as palladium carbon (Pd/C). During this reduction process, the acid chloride group is reduced to methyl, but attention should be paid to controlling the reaction conditions, such as temperature, pressure and hydrogen flow. If the conditions are improper, side reactions such as excessive reduction may occur. Finally, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene can be obtained.
Another method is to use 2,3,4,5-tetrafluorobromobenzene as the starting material. First, 2,3,4,5-tetrafluorobromobenzene is reacted with metal magnesium to make Grignard reagent. This reaction is carried out in anhydrous ether or tetrahydrofuran and other solvents. The anhydrous environment is very critical, otherwise Grignard reagent is easy to decompose. The prepared Grignard reagent, then reacted with formaldehyde, can introduce hydroxymethyl groups, and then react with chlorinated reagents such as thionyl chloride to convert hydroxymethyl groups to chloromethyl groups, and the target product can also be obtained 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene. When preparing
, the reaction conditions at each step need to be carefully regulated, from the purity of the raw materials, reaction temperature, time, and even the type and amount of solvent and catalyst used, all of which affect the yield and purity of the product. And many reactions involve toxic, flammable or corrosive reagents. When operating, safety procedures should be strictly followed to ensure the safety of the experimenter and the smooth operation of the experiment.
The resulting 2,3,4,5-tetrafluorobenzoyl chloride will be reduced with hydrogen in the presence of suitable catalysts such as palladium carbon (Pd/C). During this reduction process, the acid chloride group is reduced to methyl, but attention should be paid to controlling the reaction conditions, such as temperature, pressure and hydrogen flow. If the conditions are improper, side reactions such as excessive reduction may occur. Finally, 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene can be obtained.
Another method is to use 2,3,4,5-tetrafluorobromobenzene as the starting material. First, 2,3,4,5-tetrafluorobromobenzene is reacted with metal magnesium to make Grignard reagent. This reaction is carried out in anhydrous ether or tetrahydrofuran and other solvents. The anhydrous environment is very critical, otherwise Grignard reagent is easy to decompose. The prepared Grignard reagent, then reacted with formaldehyde, can introduce hydroxymethyl groups, and then react with chlorinated reagents such as thionyl chloride to convert hydroxymethyl groups to chloromethyl groups, and the target product can also be obtained 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene. When preparing
, the reaction conditions at each step need to be carefully regulated, from the purity of the raw materials, reaction temperature, time, and even the type and amount of solvent and catalyst used, all of which affect the yield and purity of the product. And many reactions involve toxic, flammable or corrosive reagents. When operating, safety procedures should be strictly followed to ensure the safety of the experimenter and the smooth operation of the experiment.
1- (chloromethyl) -2, 3, 4, 5-tetrafluorobenzene What are the precautions during use?
1 - (chloromethyl) - 2,3,4,5 - tetrafluorobenzene is one of the organic compounds. During use, all precautions should not be ignored.
First safety protection. This compound is dangerous to a certain extent, or it may be irritating or even toxic to the human body. Therefore, users must wear complete protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent it from coming into contact with the skin and eyes, and to prevent it from entering the body through the respiratory tract.
Second words operating environment. It is suitable for a well-ventilated place. It is best to have a local ventilation device to quickly disperse the vapor or dust that may escape, reduce its concentration in the air, and reduce the risk of harm. And the operation place should be kept away from fire and heat sources, because it may be flammable, in case of open flame, hot topic, it may cause combustion or even explosion.
Furthermore, it is related to storage. When stored in a cool, dry and well-ventilated place, and sealed to avoid it from contact with air and moisture to cause deterioration. It also needs to be placed separately from oxidants, strong alkalis and other substances to prevent violent chemical reactions.
When taking it, you must also be cautious. Follow the method of accurate measurement, use the utensils, and wash them immediately to avoid residual pollution. If you accidentally come into contact with this object during operation and touch the skin, rinse with a large amount of water as soon as possible, and then seek medical attention; if it enters the eyes, it should not be delayed. Immediately rinse with flowing water or normal saline, and also seek medical treatment as soon as possible.
In short, with 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene, be sure to strictly abide by safety procedures and operate with caution to ensure personal safety and environmental harmlessness.
First safety protection. This compound is dangerous to a certain extent, or it may be irritating or even toxic to the human body. Therefore, users must wear complete protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent it from coming into contact with the skin and eyes, and to prevent it from entering the body through the respiratory tract.
Second words operating environment. It is suitable for a well-ventilated place. It is best to have a local ventilation device to quickly disperse the vapor or dust that may escape, reduce its concentration in the air, and reduce the risk of harm. And the operation place should be kept away from fire and heat sources, because it may be flammable, in case of open flame, hot topic, it may cause combustion or even explosion.
Furthermore, it is related to storage. When stored in a cool, dry and well-ventilated place, and sealed to avoid it from contact with air and moisture to cause deterioration. It also needs to be placed separately from oxidants, strong alkalis and other substances to prevent violent chemical reactions.
When taking it, you must also be cautious. Follow the method of accurate measurement, use the utensils, and wash them immediately to avoid residual pollution. If you accidentally come into contact with this object during operation and touch the skin, rinse with a large amount of water as soon as possible, and then seek medical attention; if it enters the eyes, it should not be delayed. Immediately rinse with flowing water or normal saline, and also seek medical treatment as soon as possible.
In short, with 1- (chloromethyl) -2,3,4,5-tetrafluorobenzene, be sure to strictly abide by safety procedures and operate with caution to ensure personal safety and environmental harmlessness.
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