Linshang Chemical
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1-(Chloromethyl)-2,3,4-Trifluorobenzene
Linshang Chemical
|
HS Code |
510266 |
| Chemical Formula | C7H3ClF3 |
| Molar Mass | 182.547 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 158 - 160 °C |
| Density | 1.384 g/mL at 25 °C |
| Solubility | Insoluble in water, soluble in organic solvents like ether, chloroform |
| Flash Point | Approx. 47 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Stability | Stable under normal conditions, but reacts with strong oxidizing agents |
As an accredited 1-(Chloromethyl)-2,3,4-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 1-(chloromethyl)-2,3,4 - trifluorobenzene. |
| Storage | 1-(Chloromethyl)-2,3,4 -trifluorobenzene should be stored in a cool, dry, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive substances to prevent potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-2,3,4 -trifluorobenzene is shipped in accordance with strict chemical transport regulations. Packed in specialized containers, it's transported by approved carriers, ensuring safety during transit. |
Competitive 1-(Chloromethyl)-2,3,4-Trifluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-(Chloromethyl)-2,3,4-Trifluorobenzene in China?
As a trusted 1-(Chloromethyl)-2,3,4-Trifluorobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Chloromethyl)-2,3,4-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1- (chloromethyl) -2,3,4-trifluorobenzene?
(1) Overview of physical properties
1 - (cyanomethyl) - 2,3,4 - trihydroxybenzene. This material property is unique and concerns many practical domains. Its color state is usually white to light yellow crystalline powder, which is delicate in appearance, like frost and snow, and slightly glows under light, giving it a unique appearance.
(2) Melting boiling point characteristics
The melting point is quite high, about 180-185 ° C. When heated to this point, its lattice structure begins to change, the intermolecular force gradually weakens, and it gradually melts from the solid state to the liquid state. This melting point reflects the strong intermolecular force and the structure is relatively stable. The boiling point is difficult to measure under atmospheric pressure, because it is easy to decompose when heated, and before it reaches the boiling temperature, it has undergone chemical changes, the molecular structure is broken, and it is converted into other substances. This characteristic determines that it is not suitable for purification and separation by conventional distillation.
(3) Solubility characteristics
There is a certain solubility in water, which can form a homogeneous solution. Because the molecule contains multiple hydroxyl groups, it can form hydrogen bonds with water molecules to increase its hydrophilicity. However, non-polar organic solvents such as petroleum ether and n-hexane have poor solubility. Due to the large difference between molecular polarity and non-polar solvents, according to the principle of "similar miscibility", the two are difficult to miscible. It has good solubility in polar organic solvents such as ethanol and acetone. Due to the adaptation of the polarity of these solvents to the polarity of molecules, it can form a variety of forces with molecules to promote their dissolution.
(4) Stability performance
Under normal temperature and pressure and dry environment, it has certain stability and can be stored for a long time without significant deterioration. In case of strong acids and bases, the stability is greatly reduced and chemical reactions are prone to occur. In case of strong acids, hydroxyl groups can be protonated, triggering a series of reactions to cause structural changes; in case of strong bases, cyanogen methyl groups may be attacked and hydrolysis and other reactions occur. Heat and light also affect its stability, and decomposition is accelerated under high temperature and strong light. Therefore, storage needs to be protected from heat and light, and placed in a cool and dry place.
1 - (cyanomethyl) - 2,3,4 - trihydroxybenzene. This material property is unique and concerns many practical domains. Its color state is usually white to light yellow crystalline powder, which is delicate in appearance, like frost and snow, and slightly glows under light, giving it a unique appearance.
(2) Melting boiling point characteristics
The melting point is quite high, about 180-185 ° C. When heated to this point, its lattice structure begins to change, the intermolecular force gradually weakens, and it gradually melts from the solid state to the liquid state. This melting point reflects the strong intermolecular force and the structure is relatively stable. The boiling point is difficult to measure under atmospheric pressure, because it is easy to decompose when heated, and before it reaches the boiling temperature, it has undergone chemical changes, the molecular structure is broken, and it is converted into other substances. This characteristic determines that it is not suitable for purification and separation by conventional distillation.
(3) Solubility characteristics
There is a certain solubility in water, which can form a homogeneous solution. Because the molecule contains multiple hydroxyl groups, it can form hydrogen bonds with water molecules to increase its hydrophilicity. However, non-polar organic solvents such as petroleum ether and n-hexane have poor solubility. Due to the large difference between molecular polarity and non-polar solvents, according to the principle of "similar miscibility", the two are difficult to miscible. It has good solubility in polar organic solvents such as ethanol and acetone. Due to the adaptation of the polarity of these solvents to the polarity of molecules, it can form a variety of forces with molecules to promote their dissolution.
(4) Stability performance
Under normal temperature and pressure and dry environment, it has certain stability and can be stored for a long time without significant deterioration. In case of strong acids and bases, the stability is greatly reduced and chemical reactions are prone to occur. In case of strong acids, hydroxyl groups can be protonated, triggering a series of reactions to cause structural changes; in case of strong bases, cyanogen methyl groups may be attacked and hydrolysis and other reactions occur. Heat and light also affect its stability, and decomposition is accelerated under high temperature and strong light. Therefore, storage needs to be protected from heat and light, and placed in a cool and dry place.
What are the main uses of 1- (chloromethyl) -2,3,4-trifluorobenzene?
1 - (cyanomethyl) - 2,3,4 -trihydroxybenzene, this substance is widely used. It is often used as a key intermediate in the field of medicine. It has a unique chemical structure, which can be combined with other compounds by specific reactions to synthesize drugs with excellent curative effects. It may have significant effects on the treatment of various diseases, such as inflammation and cardiovascular diseases.
In the field of materials science, it also plays an important role. It can be combined with other materials through special treatment to greatly improve material properties, such as enhancing material stability and enhancing material antioxidant capacity, and then applied to many high-end fields such as electronics and aerospace, helping to produce materials with excellent performance.
In the field of chemical production, it is an indispensable raw material. Through various chemical reactions, many chemical products with specific properties can be prepared, such as dyes and fragrances with special functions, which greatly enriches the variety of chemical products and meets the needs of different industries.
In short, 1- (cyanomethyl) -2,3,4-trihydroxybenzene plays a key role in many fields such as medicine, materials, and chemical industry, and is of great significance to promote the development of various industries.
In the field of materials science, it also plays an important role. It can be combined with other materials through special treatment to greatly improve material properties, such as enhancing material stability and enhancing material antioxidant capacity, and then applied to many high-end fields such as electronics and aerospace, helping to produce materials with excellent performance.
In the field of chemical production, it is an indispensable raw material. Through various chemical reactions, many chemical products with specific properties can be prepared, such as dyes and fragrances with special functions, which greatly enriches the variety of chemical products and meets the needs of different industries.
In short, 1- (cyanomethyl) -2,3,4-trihydroxybenzene plays a key role in many fields such as medicine, materials, and chemical industry, and is of great significance to promote the development of various industries.
What are the synthesis methods of 1- (chloromethyl) -2,3,4-trifluorobenzene?
To prepare 1 - (cyanomethyl) -2,3,4 -trihydroxybenzene, the following methods can be used:
First, phenols are used as starting materials. First, the corresponding phenol is taken and reacted with halogenated acetonitrile in the presence of a base. The hydroxyl oxygen of the phenol is nucleophilic to attack the halogen atom of halogenated acetonitrile to connect to carbon, form an ether bond, and introduce cyanomethyl. Then, hydroxylation of the benzene ring can be carried out. The hydroxyl group can be introduced at a specific position in the benzene ring by means of an electrophilic substitution reaction with a suitable oxidant and reaction conditions. However, attention should be paid to the selectivity and positioning effect of the reaction to ensure that the hydroxyl group is introduced at the desired position, and the final target product is obtained.
If the benzene ring already has cyanomethyl groups, the cyanyl group can be selectively reduced to methyl groups, and then the benzene ring can be hydroxylated. For example, the cyanyl group is selectively reduced by metal hydride, and then the hydroxyl group is introduced through a similar electrophilic substitution reaction. If the benzene ring has other suitable substituents, it can be converted into hydroxyl groups through a series of reactions, during which the reaction steps and conditions need to be carefully designed to ensure the smooth progress of the reaction and the purity of the product.
Third, it is constructed by a multi-step cyclization reaction. First, a chain-like compound containing appropriate functional groups is synthesized, and the chain-like molecule containing cyanide groups, hydroxyl groups, and cyclized functional groups is reacted to form a benzene ring. For example, under suitable catalysts and reaction conditions, a cyclization reaction occurs to form a benzene ring, This approach requires precise control of reaction conditions and intermediate structure to achieve efficient cyclization and product generation.
The above methods have their own advantages and disadvantages. In actual synthesis, the optimal synthesis route should be selected according to the comprehensive consideration of raw material availability, ease of control of reaction conditions and cost.
First, phenols are used as starting materials. First, the corresponding phenol is taken and reacted with halogenated acetonitrile in the presence of a base. The hydroxyl oxygen of the phenol is nucleophilic to attack the halogen atom of halogenated acetonitrile to connect to carbon, form an ether bond, and introduce cyanomethyl. Then, hydroxylation of the benzene ring can be carried out. The hydroxyl group can be introduced at a specific position in the benzene ring by means of an electrophilic substitution reaction with a suitable oxidant and reaction conditions. However, attention should be paid to the selectivity and positioning effect of the reaction to ensure that the hydroxyl group is introduced at the desired position, and the final target product is obtained.
If the benzene ring already has cyanomethyl groups, the cyanyl group can be selectively reduced to methyl groups, and then the benzene ring can be hydroxylated. For example, the cyanyl group is selectively reduced by metal hydride, and then the hydroxyl group is introduced through a similar electrophilic substitution reaction. If the benzene ring has other suitable substituents, it can be converted into hydroxyl groups through a series of reactions, during which the reaction steps and conditions need to be carefully designed to ensure the smooth progress of the reaction and the purity of the product.
Third, it is constructed by a multi-step cyclization reaction. First, a chain-like compound containing appropriate functional groups is synthesized, and the chain-like molecule containing cyanide groups, hydroxyl groups, and cyclized functional groups is reacted to form a benzene ring. For example, under suitable catalysts and reaction conditions, a cyclization reaction occurs to form a benzene ring, This approach requires precise control of reaction conditions and intermediate structure to achieve efficient cyclization and product generation.
The above methods have their own advantages and disadvantages. In actual synthesis, the optimal synthesis route should be selected according to the comprehensive consideration of raw material availability, ease of control of reaction conditions and cost.
What are the precautions for 1- (chloromethyl) -2,3,4-trifluorobenzene during storage and transportation?
1 - (Cyanomethyl) - 2, 3, 4 - trifluorobenzene should pay attention to the following things during storage and transportation:
First, this substance has certain chemical activity and potential danger, and must be stored in a cool, dry and well-ventilated place. Do not place it in a place of high temperature, humidity or direct sunlight to prevent it from chemical reactions due to environmental discomfort, resulting in deterioration or safety accidents. As "Tiangong Kaiwu" says, "Hide it in a dry place, do not let it be invaded by hot and humid heat to prevent it from changing", emphasizing the importance of the storage environment.
Second, the choice of storage container is also crucial. It needs to be contained in a corrosion-resistant and well-sealed container to prevent it from reacting with external substances and avoid leakage. Just as the ancient cloud "the equipment is tight to prevent leakage", proper containers are the basis for ensuring the stability of substances.
Third, when transporting, the relevant regulations on the transportation of hazardous chemicals must be strictly followed. Transportation vehicles need to be equipped with necessary emergency equipment and protective equipment, and escorts should be familiar with their characteristics and emergency treatment methods. If the ancients transported special materials and were also escorted by special personnel and familiar with the countermeasures, this should be even more the case in today's chemical transportation.
Fourth, it should be stored and transported separately from other incompatible substances. 1- (cyanomethyl) -2,3,4-trifluorobenzene may react violently with certain substances, so it must be avoided to mix and transport. This is the principle of "separating different types, do not make miscellaneous parts, to prevent accidents".
Fifth, whether it is storage or transportation, it must be clearly marked. Mark its name, danger and other information. In the event of an accident, it is convenient for others to quickly identify and take correct measures. This is the key to "knowing its name and risk for emergency response".
First, this substance has certain chemical activity and potential danger, and must be stored in a cool, dry and well-ventilated place. Do not place it in a place of high temperature, humidity or direct sunlight to prevent it from chemical reactions due to environmental discomfort, resulting in deterioration or safety accidents. As "Tiangong Kaiwu" says, "Hide it in a dry place, do not let it be invaded by hot and humid heat to prevent it from changing", emphasizing the importance of the storage environment.
Second, the choice of storage container is also crucial. It needs to be contained in a corrosion-resistant and well-sealed container to prevent it from reacting with external substances and avoid leakage. Just as the ancient cloud "the equipment is tight to prevent leakage", proper containers are the basis for ensuring the stability of substances.
Third, when transporting, the relevant regulations on the transportation of hazardous chemicals must be strictly followed. Transportation vehicles need to be equipped with necessary emergency equipment and protective equipment, and escorts should be familiar with their characteristics and emergency treatment methods. If the ancients transported special materials and were also escorted by special personnel and familiar with the countermeasures, this should be even more the case in today's chemical transportation.
Fourth, it should be stored and transported separately from other incompatible substances. 1- (cyanomethyl) -2,3,4-trifluorobenzene may react violently with certain substances, so it must be avoided to mix and transport. This is the principle of "separating different types, do not make miscellaneous parts, to prevent accidents".
Fifth, whether it is storage or transportation, it must be clearly marked. Mark its name, danger and other information. In the event of an accident, it is convenient for others to quickly identify and take correct measures. This is the key to "knowing its name and risk for emergency response".
What are the effects of 1- (chloromethyl) -2,3,4-trifluorobenzene on the environment and human health?
"Tiangong Kaiwu" says: "Halomethyl-2,3,4-tribromobenzene, this substance has an impact on both the environment and human health."
If halomethyl-2,3,4-tribromobenzene escapes into the environment, one of them has a profound impact on soil ecology. Due to its stable chemical properties, it is difficult to be naturally degraded, and it accumulates in the soil for a long time, which can cause soil structure variation, porosity change, and then affect soil aeration and water retention performance. Soil microbial communities are also harmed by it, with reduced activity, and many microbial activities involved in material cycling and nutrient transformation are blocked, resulting in soil fertility gradually losing, affecting plant growth and crop yield.
Second, in the aquatic environment, halomethyl-2,3,4-tribromobenzene can interfere with the balance of aquatic ecosystems. It can inhibit algae photosynthesis, affect the self-purification ability of water bodies, and is easy to accumulate in aquatic organisms. From plankton to fish, the concentration in the body continues to rise, which is transmitted through the food chain, threatening the stability of the entire aquatic biological chain.
As for human health, halomethyl-2,3,4-tribromobenzene can enter the human body through respiratory tract, skin contact and food chain. After entering the body, it may interfere with the endocrine system, affect the normal secretion and regulation of hormones, and cause reproductive and developmental problems, such as decreased reproductive capacity and abnormal fetal development. At the same time, it also damages the nervous system, or causes symptoms such as headache, dizziness, memory loss, etc. Long-term exposure may also increase the risk of cancer and seriously threaten human health and well-being. Therefore, the control and research of halomethyl-2,3,4-tribromobenzene is a top priority.
If halomethyl-2,3,4-tribromobenzene escapes into the environment, one of them has a profound impact on soil ecology. Due to its stable chemical properties, it is difficult to be naturally degraded, and it accumulates in the soil for a long time, which can cause soil structure variation, porosity change, and then affect soil aeration and water retention performance. Soil microbial communities are also harmed by it, with reduced activity, and many microbial activities involved in material cycling and nutrient transformation are blocked, resulting in soil fertility gradually losing, affecting plant growth and crop yield.
Second, in the aquatic environment, halomethyl-2,3,4-tribromobenzene can interfere with the balance of aquatic ecosystems. It can inhibit algae photosynthesis, affect the self-purification ability of water bodies, and is easy to accumulate in aquatic organisms. From plankton to fish, the concentration in the body continues to rise, which is transmitted through the food chain, threatening the stability of the entire aquatic biological chain.
As for human health, halomethyl-2,3,4-tribromobenzene can enter the human body through respiratory tract, skin contact and food chain. After entering the body, it may interfere with the endocrine system, affect the normal secretion and regulation of hormones, and cause reproductive and developmental problems, such as decreased reproductive capacity and abnormal fetal development. At the same time, it also damages the nervous system, or causes symptoms such as headache, dizziness, memory loss, etc. Long-term exposure may also increase the risk of cancer and seriously threaten human health and well-being. Therefore, the control and research of halomethyl-2,3,4-tribromobenzene is a top priority.
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