Linshang Chemical
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1-(Chloromethyl)-2,3-Dimethylbenzene
Linshang Chemical
|
HS Code |
157442 |
| Chemical Formula | C9H11Cl |
| Molecular Weight | 154.64 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Boiling Point | Approximately 202 - 204 °C |
| Density | Around 1.04 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
| Flash Point | Around 77 °C |
As an accredited 1-(Chloromethyl)-2,3-Dimethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(chloromethyl)-2,3 - dimethylbenzene in a tightly - sealed glass bottle. |
| Storage | 1-(Chloromethyl)-2,3 - dimethylbenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in a tightly - sealed container, preferably made of a compatible material like steel or high - density polyethylene. Store it separately from oxidizing agents, bases, and reactive materials to prevent chemical reactions. |
| Shipping | 1-(Chloromethyl)-2,3 - dimethylbenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly and transported by approved carriers to ensure safety during transit. |
Competitive 1-(Chloromethyl)-2,3-Dimethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1- (chloromethyl) -2,3-dimethylbenzene?
1- (cyanomethyl) -2,3-dimethylindole, which has important uses in many fields.
In the field of medicinal chemistry, it is a key pharmaceutical intermediate. Taking the synthesis of specific anticancer drugs as an example, 1- (cyanomethyl) -2,3-dimethylindole can introduce key active groups through a series of chemical reactions to construct molecular structures with precise anticancer activity. Due to its unique chemical structure, it can bind to specific targets in cancer cells or interfere with key metabolic pathways in cancer cells, opening up new directions for the development of anticancer drugs. In the development of neurological drugs, it can be modified to obtain compounds with specific affinity for neurotransmitter receptors for the treatment of neurodegenerative diseases.
In the field of materials science, 1- (cyanomethyl) -2,3-dimethylindole can participate in the synthesis of functional materials. For example, when preparing organic optoelectronic materials, its structure can adjust the electron cloud distribution and energy level structure of the material, giving the material unique optoelectronic properties. In the manufacture of organic Light Emitting Diode (OLED), materials with this structure can optimize luminous efficiency and color purity, making the display screen clearer and more colorful. In terms of sensor materials, it can selectively respond to specific substances and cause changes in the optical and electrical properties of the material by interacting with the target, enabling highly sensitive detection of environmental pollutants or biomarkers.
In the field of organic synthetic chemistry, 1- (cyanomethyl) -2,3-dimethylindole is an ideal starting material and synthetic building block. Due to the many activity checking points in its structure, it can carry out various reactions such as nucleophilic substitution, electrophilic substitution, and cyclization. Through rational design of reaction routes, complex organic molecular structures can be constructed, providing an effective way for the total synthesis of natural products and the creation of new organic compounds, and promoting the continuous development of organic synthetic chemistry.
In the field of medicinal chemistry, it is a key pharmaceutical intermediate. Taking the synthesis of specific anticancer drugs as an example, 1- (cyanomethyl) -2,3-dimethylindole can introduce key active groups through a series of chemical reactions to construct molecular structures with precise anticancer activity. Due to its unique chemical structure, it can bind to specific targets in cancer cells or interfere with key metabolic pathways in cancer cells, opening up new directions for the development of anticancer drugs. In the development of neurological drugs, it can be modified to obtain compounds with specific affinity for neurotransmitter receptors for the treatment of neurodegenerative diseases.
In the field of materials science, 1- (cyanomethyl) -2,3-dimethylindole can participate in the synthesis of functional materials. For example, when preparing organic optoelectronic materials, its structure can adjust the electron cloud distribution and energy level structure of the material, giving the material unique optoelectronic properties. In the manufacture of organic Light Emitting Diode (OLED), materials with this structure can optimize luminous efficiency and color purity, making the display screen clearer and more colorful. In terms of sensor materials, it can selectively respond to specific substances and cause changes in the optical and electrical properties of the material by interacting with the target, enabling highly sensitive detection of environmental pollutants or biomarkers.
In the field of organic synthetic chemistry, 1- (cyanomethyl) -2,3-dimethylindole is an ideal starting material and synthetic building block. Due to the many activity checking points in its structure, it can carry out various reactions such as nucleophilic substitution, electrophilic substitution, and cyclization. Through rational design of reaction routes, complex organic molecular structures can be constructed, providing an effective way for the total synthesis of natural products and the creation of new organic compounds, and promoting the continuous development of organic synthetic chemistry.
What are the physical properties of 1- (chloromethyl) -2,3-dimethylbenzene?
1 - (cyanomethyl) - 2,3 - dimethylpyridine, this substance has many physical properties. Its appearance is usually colorless to pale yellow liquid, which exhibits a unique state at room temperature and pressure.
In terms of melting point, it has a specific numerical range, but due to the interference of preparation processes and impurities and other factors, the exact value will fluctuate to a certain extent. The boiling point also has corresponding standards. This boiling point data has key guiding significance for chemical operations such as separation and purification, and can help operators control the appropriate temperature conditions to achieve efficient material separation.
Its density is also an important physical parameter. The comparison with the density of water and other common solvents is crucial for judging the phase distribution in different solvent systems and performing related extraction and delamination operations. In terms of solubility, 1- (cyanomethyl) -2,3-dimethylpyridine has good solubility in some organic solvents such as ethanol and ether, which makes it able to fully dissolve and participate in the reaction or be effectively extracted in the chemical reaction or substance extraction process using these solvents as the medium. However, the solubility in water is poor, and this difference in solubility helps to realize the preliminary purification of the substance by using the separation of the aqueous and organic phases.
In addition, 1- (cyanomethyl) -2,3-dimethylpyridine has a certain volatility and will gradually evaporate in the open system, which requires attention to sealing during storage and use to avoid material loss due to volatilization and possible pollution to the environment. At the same time, its odor is also special, which can be used as an auxiliary basis for preliminary identification of the substance in actual operation.
In terms of melting point, it has a specific numerical range, but due to the interference of preparation processes and impurities and other factors, the exact value will fluctuate to a certain extent. The boiling point also has corresponding standards. This boiling point data has key guiding significance for chemical operations such as separation and purification, and can help operators control the appropriate temperature conditions to achieve efficient material separation.
Its density is also an important physical parameter. The comparison with the density of water and other common solvents is crucial for judging the phase distribution in different solvent systems and performing related extraction and delamination operations. In terms of solubility, 1- (cyanomethyl) -2,3-dimethylpyridine has good solubility in some organic solvents such as ethanol and ether, which makes it able to fully dissolve and participate in the reaction or be effectively extracted in the chemical reaction or substance extraction process using these solvents as the medium. However, the solubility in water is poor, and this difference in solubility helps to realize the preliminary purification of the substance by using the separation of the aqueous and organic phases.
In addition, 1- (cyanomethyl) -2,3-dimethylpyridine has a certain volatility and will gradually evaporate in the open system, which requires attention to sealing during storage and use to avoid material loss due to volatilization and possible pollution to the environment. At the same time, its odor is also special, which can be used as an auxiliary basis for preliminary identification of the substance in actual operation.
What are the chemical properties of 1- (chloromethyl) -2,3-dimethylbenzene?
1 - (cyanomethyl) - 2,3 -dimethylpyridine, this compound has a variety of chemical properties.
From the basic point of view, because the nitrogen atom on the pyridine ring has lone pairs of electrons and can accept protons, it presents a certain alkalinity. During the electrophilic substitution reaction, the electron cloud density on the pyridine ring will increase due to the methyl group as the power supply, which is more conducive to the attack of electrophilic reagents. The reaction mainly occurs at the β-position on the pyridine ring. At the same time, the cyanyl group in this compound has strong reactivity, and the cyanyl group can undergo hydrolysis reaction. Under acidic or basic conditions, the cyanyl group will be gradually converted into a carboxyl group, that is, -CN is hydrolyzed into -CONH ³, and then hydrolyzed to form -COOH. In addition, the cyanyl group can also undergo addition reactions, such as addition with Grignard reagents, to generate nitrogen-containing alcohol derivatives. For the methyl group on the pyridine ring, under the action of an appropriate oxidant, it can be oxidized to a carboxyl group to form the corresponding pyridine carboxylic acid compound. In case of halogenated reagents, the hydrogen atom on the methyl group can be replaced by a halogen atom to form a halogenated methyl pyridine derivative. In conclusion, 1- (cyanomethyl) -2,3-dimethylpyridine can be used as an important intermediate in the field of organic synthesis to construct more complex organic compound structures due to its unique structure and diverse chemical reactivity.
From the basic point of view, because the nitrogen atom on the pyridine ring has lone pairs of electrons and can accept protons, it presents a certain alkalinity. During the electrophilic substitution reaction, the electron cloud density on the pyridine ring will increase due to the methyl group as the power supply, which is more conducive to the attack of electrophilic reagents. The reaction mainly occurs at the β-position on the pyridine ring. At the same time, the cyanyl group in this compound has strong reactivity, and the cyanyl group can undergo hydrolysis reaction. Under acidic or basic conditions, the cyanyl group will be gradually converted into a carboxyl group, that is, -CN is hydrolyzed into -CONH ³, and then hydrolyzed to form -COOH. In addition, the cyanyl group can also undergo addition reactions, such as addition with Grignard reagents, to generate nitrogen-containing alcohol derivatives. For the methyl group on the pyridine ring, under the action of an appropriate oxidant, it can be oxidized to a carboxyl group to form the corresponding pyridine carboxylic acid compound. In case of halogenated reagents, the hydrogen atom on the methyl group can be replaced by a halogen atom to form a halogenated methyl pyridine derivative. In conclusion, 1- (cyanomethyl) -2,3-dimethylpyridine can be used as an important intermediate in the field of organic synthesis to construct more complex organic compound structures due to its unique structure and diverse chemical reactivity.
What is the production method of 1- (chloromethyl) -2,3-dimethylbenzene?
To prepare 1 - (cyanomethyl) -2,3 -dimethylindole, the method is as follows:
First take an appropriate amount of indole as the starting material, in a suitable reaction vessel, in an inert gas protective atmosphere, add an appropriate amount of strong base, such as sodium hydride, etc., to remove the hydrogen on the indole nitrogen atom to form the corresponding indole negative ion. This step requires attention to the control of the reaction temperature, generally maintained at a low temperature, such as between 0 ° C and -20 ° C, to prevent side reactions from occurring.
Then slowly add a halogenated hydrocarbon containing a cyanomethyl structure, such as chloroacetonitrile. The speed of dropwise addition needs to be carefully controlled to make the reaction proceed smoothly. After the dropwise addition is completed, the temperature is raised to room temperature, and the reaction is continued with stirring for a period of time to make the reaction sufficient. During this process, the cyanomethyl part of the halogenated hydrocarbon will undergo a nucleophilic substitution reaction with the indole anion, thereby introducing the cyanomethyl at the 1 position of the indole.
Then, the product is treated. Conventional extraction, washing, drying, etc. can be used to preliminarily separate and purify the product.
After that, the introduction step of dimethyl is carried out. The preliminarily treated product is placed in another reaction system, and an appropriate methylating agent, such as iodomethane, is added, and a suitable base, such as potassium carbonate, is added. The reaction temperature can be controlled in a moderate range, such as between 50 ° C and 80 ° C, to promote the methylation reaction, and methyl is introduced at the 2,3 positions of indole.
After the reaction is completed, the product is separated and purified finely again. The pure 1- (cyanomethyl) -2,3-dimethylindole product can be finally obtained by means of column chromatography. The whole process requires strict control of the reaction conditions, and detailed detection and analysis of each step of the product to ensure high purity and high yield of the target product.
First take an appropriate amount of indole as the starting material, in a suitable reaction vessel, in an inert gas protective atmosphere, add an appropriate amount of strong base, such as sodium hydride, etc., to remove the hydrogen on the indole nitrogen atom to form the corresponding indole negative ion. This step requires attention to the control of the reaction temperature, generally maintained at a low temperature, such as between 0 ° C and -20 ° C, to prevent side reactions from occurring.
Then slowly add a halogenated hydrocarbon containing a cyanomethyl structure, such as chloroacetonitrile. The speed of dropwise addition needs to be carefully controlled to make the reaction proceed smoothly. After the dropwise addition is completed, the temperature is raised to room temperature, and the reaction is continued with stirring for a period of time to make the reaction sufficient. During this process, the cyanomethyl part of the halogenated hydrocarbon will undergo a nucleophilic substitution reaction with the indole anion, thereby introducing the cyanomethyl at the 1 position of the indole.
Then, the product is treated. Conventional extraction, washing, drying, etc. can be used to preliminarily separate and purify the product.
After that, the introduction step of dimethyl is carried out. The preliminarily treated product is placed in another reaction system, and an appropriate methylating agent, such as iodomethane, is added, and a suitable base, such as potassium carbonate, is added. The reaction temperature can be controlled in a moderate range, such as between 50 ° C and 80 ° C, to promote the methylation reaction, and methyl is introduced at the 2,3 positions of indole.
After the reaction is completed, the product is separated and purified finely again. The pure 1- (cyanomethyl) -2,3-dimethylindole product can be finally obtained by means of column chromatography. The whole process requires strict control of the reaction conditions, and detailed detection and analysis of each step of the product to ensure high purity and high yield of the target product.
What are the precautions for the use of 1- (chloromethyl) -2,3-dimethylbenzene?
1 - (cyanomethyl) - 2,3 - dimethylpyridine is a compound commonly used in the field of organic chemistry. During use, many precautions need to be taken with caution.
Bear the brunt, and safety issues must be given top priority. This compound is toxic and irritating, and it needs to be fully armed during operation, wearing professional protective equipment such as protective gloves, goggles and gas masks to prevent skin contact, eye splashing and inhalation, and avoid serious damage to the body. It is also essential to work in a well-ventilated environment. It is best to operate in a fume hood to promote the timely discharge of toxic gases and reduce the concentration of harmful substances in the air.
Furthermore, the chemical properties cannot be ignored. 1- (Cyanomethyl) -2,3-dimethylpyridine has high chemical activity due to its cyanide group and pyridine ring. When storing, it is necessary to strictly avoid strong oxidizing agents, strong acids, strong bases and other substances to prevent violent chemical reactions, such as explosion, combustion and other serious accidents. Before use, it is necessary to have a thorough understanding of its chemical properties and reaction mechanism. According to the specific reaction requirements, accurately control the reaction conditions, such as temperature, pressure, reaction time, etc., to ensure the smooth progress of the reaction and improve the purity and yield of the product.
In addition, its storage conditions are also very critical. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent the deterioration of the compound due to environmental factors or cause safety hazards. At the same time, the storage container must have good sealing to avoid reaction in contact with air and moisture.
After use, the remaining 1- (cyanomethyl) -2,3-dimethyl pyridine and reaction waste must not be discarded at will, and must be properly disposed of in accordance with relevant regulations. It can be treated harmlessly through professional recycling channels or by suitable chemical methods to avoid pollution to the environment.
Bear the brunt, and safety issues must be given top priority. This compound is toxic and irritating, and it needs to be fully armed during operation, wearing professional protective equipment such as protective gloves, goggles and gas masks to prevent skin contact, eye splashing and inhalation, and avoid serious damage to the body. It is also essential to work in a well-ventilated environment. It is best to operate in a fume hood to promote the timely discharge of toxic gases and reduce the concentration of harmful substances in the air.
Furthermore, the chemical properties cannot be ignored. 1- (Cyanomethyl) -2,3-dimethylpyridine has high chemical activity due to its cyanide group and pyridine ring. When storing, it is necessary to strictly avoid strong oxidizing agents, strong acids, strong bases and other substances to prevent violent chemical reactions, such as explosion, combustion and other serious accidents. Before use, it is necessary to have a thorough understanding of its chemical properties and reaction mechanism. According to the specific reaction requirements, accurately control the reaction conditions, such as temperature, pressure, reaction time, etc., to ensure the smooth progress of the reaction and improve the purity and yield of the product.
In addition, its storage conditions are also very critical. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent the deterioration of the compound due to environmental factors or cause safety hazards. At the same time, the storage container must have good sealing to avoid reaction in contact with air and moisture.
After use, the remaining 1- (cyanomethyl) -2,3-dimethyl pyridine and reaction waste must not be discarded at will, and must be properly disposed of in accordance with relevant regulations. It can be treated harmlessly through professional recycling channels or by suitable chemical methods to avoid pollution to the environment.
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