Linshang Chemical
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1-(Chloromethyl)-2,4,5-Trifluorobenzene
Linshang Chemical
|
HS Code |
277667 |
| Chemical Formula | C7H3ClF3 |
| Molecular Weight | 182.547 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 150 - 160 °C |
| Density | Around 1.4 g/cm³ (estimated for similar chlorofluorobenzene derivatives) |
| Solubility In Water | Insoluble (hydrophobic due to non - polar benzene ring and halogen groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low at room temperature (due to relatively high boiling point) |
As an accredited 1-(Chloromethyl)-2,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottles of 1-(chloromethyl)-2,4,5 - trifluorobenzene with secure chemical - grade packaging. |
| Storage | 1-(Chloromethyl)-2,4,5 -trifluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially lead to chemical reactions. |
| Shipping | 1-(Chloromethyl)-2,4,5 -trifluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring safe transport to prevent spills and environmental or safety risks. |
Competitive 1-(Chloromethyl)-2,4,5-Trifluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-(Chloromethyl)-2,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -2,4,5-trifluorobenzene?
1 - (cyanomethyl) - 2,4,5 -trifluorobenzene, which is widely used.
In the field of medicinal chemistry, it is often a key intermediate. Based on this, a variety of specific drugs can be prepared through a series of chemical reactions. For example, in the development of antidepressant drugs, with its special chemical structure, specific functional groups can be ingeniously introduced to change the binding mode of drug molecules and receptors, thereby enhancing the efficacy of drugs and improving the therapeutic effect on neurological diseases. At the same time, in the creation of antibacterial drugs, it also plays an important role in the construction of new compounds with unique antibacterial mechanisms, providing new ways to deal with the increasingly complex problem of bacterial drug resistance.
In the field of materials science, 1- (cyanomethyl) -2,4,5-trifluorobenzene can participate in the synthesis of high-performance polymer materials. During the polymerization process, its unique chemical activity can precisely regulate the molecular structure and properties of polymers. Such as the preparation of special engineering plastics with excellent heat resistance and chemical corrosion resistance, such materials are widely used in high-end fields such as aerospace and electronic information. In the aerospace field, it can be used to manufacture structural components of aircraft to reduce weight while ensuring structural strength; in the field of electronic information, it can be used as an integrated circuit packaging material to improve the stability and reliability of electronic devices.
In the research and development of pesticides, it is also an important raw material. Through rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be synthesized. These pesticides can precisely act on the physiological targets of specific pests or pathogens, improve the control effect, reduce the impact on non-target organisms, and help the sustainable development of agriculture. For example, in the development of new insecticides, the compounds synthesized by it can interfere with the normal function of the nervous system of pests and achieve the purpose of efficient extermination.
In the field of medicinal chemistry, it is often a key intermediate. Based on this, a variety of specific drugs can be prepared through a series of chemical reactions. For example, in the development of antidepressant drugs, with its special chemical structure, specific functional groups can be ingeniously introduced to change the binding mode of drug molecules and receptors, thereby enhancing the efficacy of drugs and improving the therapeutic effect on neurological diseases. At the same time, in the creation of antibacterial drugs, it also plays an important role in the construction of new compounds with unique antibacterial mechanisms, providing new ways to deal with the increasingly complex problem of bacterial drug resistance.
In the field of materials science, 1- (cyanomethyl) -2,4,5-trifluorobenzene can participate in the synthesis of high-performance polymer materials. During the polymerization process, its unique chemical activity can precisely regulate the molecular structure and properties of polymers. Such as the preparation of special engineering plastics with excellent heat resistance and chemical corrosion resistance, such materials are widely used in high-end fields such as aerospace and electronic information. In the aerospace field, it can be used to manufacture structural components of aircraft to reduce weight while ensuring structural strength; in the field of electronic information, it can be used as an integrated circuit packaging material to improve the stability and reliability of electronic devices.
In the research and development of pesticides, it is also an important raw material. Through rational design and modification, new pesticides with high efficiency, low toxicity and environmental friendliness can be synthesized. These pesticides can precisely act on the physiological targets of specific pests or pathogens, improve the control effect, reduce the impact on non-target organisms, and help the sustainable development of agriculture. For example, in the development of new insecticides, the compounds synthesized by it can interfere with the normal function of the nervous system of pests and achieve the purpose of efficient extermination.
What are the physical properties of 1- (chloromethyl) -2,4,5-trifluorobenzene?
(Monoformyl) - 2,4,5 -trimethoxybenzene is a synthetic substance, and its physical properties are quite unique. They are described as follows:
- ** Appearance and Properties **: This substance is usually in the state of white to off-white crystalline powder, with a fine texture. It looks like the first snow in winter, pure and soft, flickering slightly under the light, as if hiding a fine light.
- ** Melting Point and Boiling Point **: The melting point is about a specific temperature range. This temperature is the key node of its transition from solid to liquid, just like a quiet reconstruction of the internal order of matter. As for the boiling point, it is also in the corresponding range. When the temperature rises to this point, the binding between molecules is greatly weakened, and the substance will break free from the shackles of the liquid state and become gaseous.
- ** Solubility **: In organic solvents, such as ethanol, acetone, etc., its solubility is quite good, like a fish entering water, it can blend with solvent molecules and disperse evenly. However, the solubility in water is very small, and the two seem to be distinct and difficult to blend, which is determined by the hydrophobicity of its molecular structure.
- ** Density **: With a certain density, this property determines its "sense of weight" in the material world, reflecting the amount of substances contained in a unit volume, just like a scale for measuring the weight it occupies in space.
- ** Stability **: Under normal conditions, this object is relatively stable, and the molecular structure is like a solid fortress, which is not easy to change. However, if it encounters extreme environments such as high temperature, strong acid, and strong alkali, its structure may be damaged, just like the fortress collapses under heavy storms and artillery fire, which in turn causes changes in physical properties.
- ** Appearance and Properties **: This substance is usually in the state of white to off-white crystalline powder, with a fine texture. It looks like the first snow in winter, pure and soft, flickering slightly under the light, as if hiding a fine light.
- ** Melting Point and Boiling Point **: The melting point is about a specific temperature range. This temperature is the key node of its transition from solid to liquid, just like a quiet reconstruction of the internal order of matter. As for the boiling point, it is also in the corresponding range. When the temperature rises to this point, the binding between molecules is greatly weakened, and the substance will break free from the shackles of the liquid state and become gaseous.
- ** Solubility **: In organic solvents, such as ethanol, acetone, etc., its solubility is quite good, like a fish entering water, it can blend with solvent molecules and disperse evenly. However, the solubility in water is very small, and the two seem to be distinct and difficult to blend, which is determined by the hydrophobicity of its molecular structure.
- ** Density **: With a certain density, this property determines its "sense of weight" in the material world, reflecting the amount of substances contained in a unit volume, just like a scale for measuring the weight it occupies in space.
- ** Stability **: Under normal conditions, this object is relatively stable, and the molecular structure is like a solid fortress, which is not easy to change. However, if it encounters extreme environments such as high temperature, strong acid, and strong alkali, its structure may be damaged, just like the fortress collapses under heavy storms and artillery fire, which in turn causes changes in physical properties.
Is the chemical property of 1- (chloromethyl) -2,4,5-trifluorobenzene stable?
(1 - (methoxy) -2,4,5 -tribromobenzene) This physical property is still stable.
Looking at the structure of this compound, the methoxy group has the effect of a electron conductor, which can increase the electron cloud density of the benzene ring and enhance its stability to a certain extent. Although the bromine atom has an electron-absorbing induction effect, its conjugation effect cannot be ignored. The interaction between the two affects the overall stability.
From the perspective of the spatial structure, the substitution of methoxy and bromine atoms on the benzene ring results in a specific molecular spatial arrangement, and the interaction between the atoms also contributes to the stability. The methoxy group can form a certain steric barrier with the ortho and para-bromine atoms, and this spatial effect will change the distribution of electron clouds in the molecule and the interaction between atoms, thereby affecting its stability.
Furthermore, from the perspective of chemical reaction, under generally mild conditions, if there are no extreme reaction conditions such as strong oxidants, strong acids, and strong bases, the compound can maintain a relatively stable state. However, in a strong oxidizing environment, the oxygen atoms in the methoxy group may be oxidized; if the bromine atoms may undergo reactions such as substitution and elimination under high temperature, high pressure and the presence of specific catalysts, the stability will be affected.
Overall, under common conventional environments and general chemical operating conditions, the chemical properties of 1- (methoxy) -2,4,5-tribromobenzene are relatively stable, but under certain extreme conditions, its stability will be broken and corresponding chemical changes will occur.
Looking at the structure of this compound, the methoxy group has the effect of a electron conductor, which can increase the electron cloud density of the benzene ring and enhance its stability to a certain extent. Although the bromine atom has an electron-absorbing induction effect, its conjugation effect cannot be ignored. The interaction between the two affects the overall stability.
From the perspective of the spatial structure, the substitution of methoxy and bromine atoms on the benzene ring results in a specific molecular spatial arrangement, and the interaction between the atoms also contributes to the stability. The methoxy group can form a certain steric barrier with the ortho and para-bromine atoms, and this spatial effect will change the distribution of electron clouds in the molecule and the interaction between atoms, thereby affecting its stability.
Furthermore, from the perspective of chemical reaction, under generally mild conditions, if there are no extreme reaction conditions such as strong oxidants, strong acids, and strong bases, the compound can maintain a relatively stable state. However, in a strong oxidizing environment, the oxygen atoms in the methoxy group may be oxidized; if the bromine atoms may undergo reactions such as substitution and elimination under high temperature, high pressure and the presence of specific catalysts, the stability will be affected.
Overall, under common conventional environments and general chemical operating conditions, the chemical properties of 1- (methoxy) -2,4,5-tribromobenzene are relatively stable, but under certain extreme conditions, its stability will be broken and corresponding chemical changes will occur.
What are the synthesis methods of 1- (chloromethyl) -2,4,5-trifluorobenzene?
To prepare 1 - (cyanomethyl) - 2,4,5 - tribromobenzene, there are many ways to synthesize it, and several common ones are outlined below.
First, it can be started with 2,4,5 - tribromobenzoic acid. First, 2,4,5 - tribromobenzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to form methyl 2,4,5 - tribromobenzoate. This process requires temperature control to ensure a smooth reaction. Then, 2,4,5 - tribromobenzyl alcohol can be obtained by reducing methyl 2,4,5 - tribromobenzoate with lithium aluminum hydride. This reduction reaction needs to be carefully handled in an inert solvent such as anhydrous ether to prevent severe reaction of lithium aluminum hydride with water. Next, 2,4,5-tribromobenzyl alcohol is reacted with hydrobromic acid or phosphorus tribromide, and the hydroxyl group is replaced with a bromine atom to obtain 2,4,5-tribromobenzyl. Finally, 2,4,5-tribromobenzyl is reacted with sodium cyanide or potassium cyanide in a suitable solvent (such as N, N-dimethylformamide), and nucleophilic substitution is used to obtain 1- (cyanomethyl) -2,4,5-tribromobenzene.
Second, 2,4,5-tribromotoluene is used as a raw material. First, 2,4,5-tribromotoluene is subjected to a free radical substitution reaction with bromine under the action of light or an initiator, and bromine atoms are introduced on the methyl group to generate 2,4,5-tribromobenzyl. The subsequent steps are the same as those described above after preparing 2,4,5-tribromobenzyl with 2,4,5-tribromobenzoic acid as a starting material, that is, reacting with sodium cyanide or potassium cyanide to obtain the target product 1- (cyanomethyl) -2,4,5-tribromobenzene.
Third, if 2,4,5-tribromoaniline is used as the starting material. First, 2,4,5-tribromoaniline is reacted with sodium nitrite and an acid (such as hydrochloric acid) at low temperature through diazotization to form a diazonium salt. Subsequently, the diazonium salt is reacted with cuprous bromide and hydrobromic acid, and the Sandmeier reaction occurs, and the amino group is replaced with a bromine atom to obtain 2,4,5-tribromobenzene. Then through the Fu-gram alkylation reaction, the chloromethyl cyanide is used as the alkylation reagent, and under the catalysis of Lewis acid such as anhydrous aluminum trichloride, cyanomethyl is introduced into the benzene ring to obtain 1- (cyanomethyl) -2,4,5-tribromobenzene. This synthesis route has many steps, and the reaction conditions of each step need to be carefully controlled to improve the yield and purity.
First, it can be started with 2,4,5 - tribromobenzoic acid. First, 2,4,5 - tribromobenzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to form methyl 2,4,5 - tribromobenzoate. This process requires temperature control to ensure a smooth reaction. Then, 2,4,5 - tribromobenzyl alcohol can be obtained by reducing methyl 2,4,5 - tribromobenzoate with lithium aluminum hydride. This reduction reaction needs to be carefully handled in an inert solvent such as anhydrous ether to prevent severe reaction of lithium aluminum hydride with water. Next, 2,4,5-tribromobenzyl alcohol is reacted with hydrobromic acid or phosphorus tribromide, and the hydroxyl group is replaced with a bromine atom to obtain 2,4,5-tribromobenzyl. Finally, 2,4,5-tribromobenzyl is reacted with sodium cyanide or potassium cyanide in a suitable solvent (such as N, N-dimethylformamide), and nucleophilic substitution is used to obtain 1- (cyanomethyl) -2,4,5-tribromobenzene.
Second, 2,4,5-tribromotoluene is used as a raw material. First, 2,4,5-tribromotoluene is subjected to a free radical substitution reaction with bromine under the action of light or an initiator, and bromine atoms are introduced on the methyl group to generate 2,4,5-tribromobenzyl. The subsequent steps are the same as those described above after preparing 2,4,5-tribromobenzyl with 2,4,5-tribromobenzoic acid as a starting material, that is, reacting with sodium cyanide or potassium cyanide to obtain the target product 1- (cyanomethyl) -2,4,5-tribromobenzene.
Third, if 2,4,5-tribromoaniline is used as the starting material. First, 2,4,5-tribromoaniline is reacted with sodium nitrite and an acid (such as hydrochloric acid) at low temperature through diazotization to form a diazonium salt. Subsequently, the diazonium salt is reacted with cuprous bromide and hydrobromic acid, and the Sandmeier reaction occurs, and the amino group is replaced with a bromine atom to obtain 2,4,5-tribromobenzene. Then through the Fu-gram alkylation reaction, the chloromethyl cyanide is used as the alkylation reagent, and under the catalysis of Lewis acid such as anhydrous aluminum trichloride, cyanomethyl is introduced into the benzene ring to obtain 1- (cyanomethyl) -2,4,5-tribromobenzene. This synthesis route has many steps, and the reaction conditions of each step need to be carefully controlled to improve the yield and purity.
What are the precautions for storing and transporting 1- (chloromethyl) -2,4,5-trifluorobenzene?
1 - (Cyanomethyl) - 2, 4, 5 - tribromobenzene, when storing and transporting, there are a number of important items to be paid attention to.
First, this compound is toxic and irritating, and safety procedures must be strictly followed during handling. Those involved should wear complete protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent the compound from coming into contact with the skin, eyes, or being inhaled into the body, causing damage to the body.
Second, because of its active chemical properties, when storing, it should be placed in a cool, dry and well-ventilated place. Keep away from fire, heat sources, and avoid direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to prevent dangerous chemical reactions from occurring, causing fires, explosions and other disasters.
Third, when transporting, relevant regulations and standards must also be followed. Packaging must be tight and stable to ensure that there is no leakage during transportation. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Route planning should also be careful to avoid densely populated areas and important places.
Fourth, for storage and transportation places, there should be obvious warning signs to remind personnel to pay attention to its danger. In addition, the site needs to be equipped with complete emergency treatment facilities and plans. In the event of an unexpected situation such as a leak, it can be responded to quickly and effectively to minimize the harm. In short, whether it is storing or transporting 1- (cyanomethyl) -2,4,5-tribromobenzene, we must attach great importance to safety issues and must not be slack in the slightest.
First, this compound is toxic and irritating, and safety procedures must be strictly followed during handling. Those involved should wear complete protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent the compound from coming into contact with the skin, eyes, or being inhaled into the body, causing damage to the body.
Second, because of its active chemical properties, when storing, it should be placed in a cool, dry and well-ventilated place. Keep away from fire, heat sources, and avoid direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to prevent dangerous chemical reactions from occurring, causing fires, explosions and other disasters.
Third, when transporting, relevant regulations and standards must also be followed. Packaging must be tight and stable to ensure that there is no leakage during transportation. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Route planning should also be careful to avoid densely populated areas and important places.
Fourth, for storage and transportation places, there should be obvious warning signs to remind personnel to pay attention to its danger. In addition, the site needs to be equipped with complete emergency treatment facilities and plans. In the event of an unexpected situation such as a leak, it can be responded to quickly and effectively to minimize the harm. In short, whether it is storing or transporting 1- (cyanomethyl) -2,4,5-tribromobenzene, we must attach great importance to safety issues and must not be slack in the slightest.
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