Linshang Chemical
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1-(Chloromethyl)-2,4-Bis(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
856607 |
| Chemical Formula | C9H5ClF6 |
| Molecular Weight | 260.58 |
| Appearance | Typically a colorless to pale - yellow liquid |
| Boiling Point | Around 157 - 159 °C |
| Density | Data may vary, but in the range of approximately 1.4 - 1.5 g/cm³ |
| Solubility | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Relatively low, but data depends on temperature |
| Stability | Stable under normal conditions, but can react with strong oxidizing agents |
As an accredited 1-(Chloromethyl)-2,4-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-2,4-bis(trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 1-(Chloromethyl)-2,4-bis(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-2,4-bis(trifluoromethyl)benzene is shipped in specialized, sealed containers compliant with chemical transport regulations. These containers prevent leakage and ensure safe transit, following strict handling protocols for hazardous chemicals. |
Competitive 1-(Chloromethyl)-2,4-Bis(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 1-(Chloromethyl)-2,4-Bis(Trifluoromethyl)Benzene in China?
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Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Chloromethyl)-2,4-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -2,4-bis (trifluoromethyl) benzene?
1 - (cyanomethyl) - 2,4 - bis (trifluoromethyl) benzene, which is widely used. In the field of medicinal chemistry, it is a key intermediate that helps to create many special drugs. Due to its unique electronic effect and hydrophobicity, trifluoromethyl can significantly improve the affinity of drugs with specific targets and optimize pharmacokinetic properties. For example, in the development of antiviral drugs, intermediates containing this structure can effectively enhance the inhibitory activity of drugs against viral proteases, opening up new avenues for antiviral therapy.
In the field of materials science, it is also an important synthetic raw material. With its special structure, polymer materials with excellent properties can be synthesized. Taking the preparation of high-performance engineering plastics as an example, the introduction of this structure can greatly improve the thermal stability, chemical stability and mechanical properties of plastics, making it useful in fields such as aerospace and automobile manufacturing that require strict material properties.
In agricultural chemistry, this compound is of great significance for the development of new pesticides. It can be used to synthesize insecticides and herbicides with high efficiency, low toxicity and broad-spectrum characteristics. For example, insecticides designed with the help of their structural characteristics can precisely act on specific physiological targets of pests, effectively killing pests while reducing the impact on the environment and non-target organisms, providing strong support for sustainable agricultural development.
In the field of materials science, it is also an important synthetic raw material. With its special structure, polymer materials with excellent properties can be synthesized. Taking the preparation of high-performance engineering plastics as an example, the introduction of this structure can greatly improve the thermal stability, chemical stability and mechanical properties of plastics, making it useful in fields such as aerospace and automobile manufacturing that require strict material properties.
In agricultural chemistry, this compound is of great significance for the development of new pesticides. It can be used to synthesize insecticides and herbicides with high efficiency, low toxicity and broad-spectrum characteristics. For example, insecticides designed with the help of their structural characteristics can precisely act on specific physiological targets of pests, effectively killing pests while reducing the impact on the environment and non-target organisms, providing strong support for sustainable agricultural development.
What are the physical properties of 1- (chloromethyl) -2,4-bis (trifluoromethyl) benzene?
1 - (methoxy) - 2,4 - bis (trifluoromethoxy) benzene, this substance has the following physical properties:
Appearance is mostly colorless to slightly yellow transparent liquid, stable at room temperature and pressure. Its boiling point is in a specific range, which is closely related to its intermolecular forces and structure. Due to the presence of functional groups such as methoxy and trifluoromethoxy in the molecule, the intermolecular forces present a unique pattern, which in turn determines the boiling point characteristics. Accurate knowledge of the boiling point is of great significance in separating and purifying the substance, and can be used to choose the appropriate distillation temperature and conditions.
Melting point is also an important physical parameter, which reflects the temperature node when the substance transitions from solid to liquid. The melting point of this substance is formed by the interaction of its lattice energy and molecular thermal motion, which is of great significance for the study of the morphological changes and storage conditions of this substance in a low temperature environment.
Density, as one of the physical properties, refers to the mass of the substance per unit volume. This value is closely related to the molecular structure and arrangement. For the use of this substance in a solution system or in scenarios such as liquid-liquid mixing, the density parameters can help determine the dosage and mixing ratio of the substance.
In terms of solubility, 1- (methoxy) -2,4-bis (trifluoromethoxy) benzene has different solubility in common organic solvents. It has good solubility in some polar organic solvents, which is due to the interaction between the polarity of some functional groups in the molecule and the solvent molecules. For example, polar solvents such as acetone can achieve better dissolution through dipole-dipole interaction. However, in non-polar solvents, the solubility is limited, which is mainly affected by the overall polarity of the molecule and the weak force between it and the non-polar solvent. Understanding the solubility is helpful to choose a suitable solvent for chemical reactions, recrystallization and other operations.
In addition, the refractive index of the substance also has a specific value. The refractive index is closely related to the electron cloud distribution and molecular structure of the molecule, which can be used as one of the basis for judging the purity of the substance. The refractive index of the substance with different purity will be slightly different.
Appearance is mostly colorless to slightly yellow transparent liquid, stable at room temperature and pressure. Its boiling point is in a specific range, which is closely related to its intermolecular forces and structure. Due to the presence of functional groups such as methoxy and trifluoromethoxy in the molecule, the intermolecular forces present a unique pattern, which in turn determines the boiling point characteristics. Accurate knowledge of the boiling point is of great significance in separating and purifying the substance, and can be used to choose the appropriate distillation temperature and conditions.
Melting point is also an important physical parameter, which reflects the temperature node when the substance transitions from solid to liquid. The melting point of this substance is formed by the interaction of its lattice energy and molecular thermal motion, which is of great significance for the study of the morphological changes and storage conditions of this substance in a low temperature environment.
Density, as one of the physical properties, refers to the mass of the substance per unit volume. This value is closely related to the molecular structure and arrangement. For the use of this substance in a solution system or in scenarios such as liquid-liquid mixing, the density parameters can help determine the dosage and mixing ratio of the substance.
In terms of solubility, 1- (methoxy) -2,4-bis (trifluoromethoxy) benzene has different solubility in common organic solvents. It has good solubility in some polar organic solvents, which is due to the interaction between the polarity of some functional groups in the molecule and the solvent molecules. For example, polar solvents such as acetone can achieve better dissolution through dipole-dipole interaction. However, in non-polar solvents, the solubility is limited, which is mainly affected by the overall polarity of the molecule and the weak force between it and the non-polar solvent. Understanding the solubility is helpful to choose a suitable solvent for chemical reactions, recrystallization and other operations.
In addition, the refractive index of the substance also has a specific value. The refractive index is closely related to the electron cloud distribution and molecular structure of the molecule, which can be used as one of the basis for judging the purity of the substance. The refractive index of the substance with different purity will be slightly different.
What is the synthesis method of 1- (chloromethyl) -2,4-bis (trifluoromethyl) benzene?
To prepare 1 - (methoxy) - 2,4 - bis (trimethylmethoxy) benzene, the following ancient method can be used.
First take an appropriate amount of phenol, react with halomethane, and when at a suitable temperature and in the presence of a catalyst, the phenolic hydroxyl group undergoes a nucleophilic substitution reaction with halomethane to obtain methoxylated phenol derivatives. In this step, attention should be paid to the precise control of the reaction conditions. Too high or too low temperature can cause fluctuations in the reaction yield, and the choice and dosage of catalyst also affect the rate and effect of the reaction.
React the obtained product with trimethylchlorosilane in an alkaline environment. Alkaline reagents can promote the deprotonation of phenolic hydroxyl groups and enhance their nucleophilicity, so that the substitution reaction with trimethylchlorosilane can occur smoothly, and trimethoxy groups are introduced at specific positions in the benzene ring. In this process, the strength and dosage of alkaline reagents need to be carefully weighed. Excessive alkalinity may cause side reactions, resulting in impure products. At the same time, the anhydrous environment of the reaction system is also crucial, otherwise trimethylchlorosilane is easy to hydrolyze and affect the reaction process.
After the reaction is completed, the target product is separated from the reaction mixture by conventional separation and purification methods, such as extraction, distillation, column chromatography, etc., and impurities are carefully removed to obtain pure 1- (methoxy) -2,4-bis (trimethoxy) benzene. Each step of the operation needs to be rigorous and meticulous in order to make the entire synthesis process smooth and achieve the desired target product synthesis.
First take an appropriate amount of phenol, react with halomethane, and when at a suitable temperature and in the presence of a catalyst, the phenolic hydroxyl group undergoes a nucleophilic substitution reaction with halomethane to obtain methoxylated phenol derivatives. In this step, attention should be paid to the precise control of the reaction conditions. Too high or too low temperature can cause fluctuations in the reaction yield, and the choice and dosage of catalyst also affect the rate and effect of the reaction.
React the obtained product with trimethylchlorosilane in an alkaline environment. Alkaline reagents can promote the deprotonation of phenolic hydroxyl groups and enhance their nucleophilicity, so that the substitution reaction with trimethylchlorosilane can occur smoothly, and trimethoxy groups are introduced at specific positions in the benzene ring. In this process, the strength and dosage of alkaline reagents need to be carefully weighed. Excessive alkalinity may cause side reactions, resulting in impure products. At the same time, the anhydrous environment of the reaction system is also crucial, otherwise trimethylchlorosilane is easy to hydrolyze and affect the reaction process.
After the reaction is completed, the target product is separated from the reaction mixture by conventional separation and purification methods, such as extraction, distillation, column chromatography, etc., and impurities are carefully removed to obtain pure 1- (methoxy) -2,4-bis (trimethoxy) benzene. Each step of the operation needs to be rigorous and meticulous in order to make the entire synthesis process smooth and achieve the desired target product synthesis.
What are the precautions for storing and transporting 1- (chloromethyl) -2,4-bis (trifluoromethyl) benzene?
1-% (cyanomethyl) -2,4-bis (trifluoromethyl) benzene should pay attention to the following matters during storage and transportation:
First, storage. This substance should be stored in a cool, dry and well-ventilated place. Because the compound may be more sensitive to heat, high temperature environments can easily cause chemical changes such as decomposition, which in turn affects quality and stability. Be sure to keep away from fires and heat sources to prevent fires and even explosions caused by open flames. Storage should be separated from oxidants, acids, bases, etc., to avoid mixed storage to prevent danger due to mutual reaction. At the same time, the storage area should be equipped with suitable containment materials so that it can be collected in time in the event of leakage and prevent the spread of pollution.
Second, transportation. Before transportation, it is necessary to ensure that the packaging is complete and well sealed to prevent leakage during transportation. During transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals, and select transportation personnel and vehicles with professional qualifications. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When driving, avoid sun and rain, and try to choose a smooth route to prevent bumps from causing damage to the packaging. Moreover, during transportation, it is not allowed to stop near densely populated areas and important places to prevent accidents from causing serious harm to the surrounding area. In addition, transportation personnel must be familiar with the nature of the substance and emergency treatment methods. In the event of an emergency, they can respond quickly and properly to ensure transportation safety.
First, storage. This substance should be stored in a cool, dry and well-ventilated place. Because the compound may be more sensitive to heat, high temperature environments can easily cause chemical changes such as decomposition, which in turn affects quality and stability. Be sure to keep away from fires and heat sources to prevent fires and even explosions caused by open flames. Storage should be separated from oxidants, acids, bases, etc., to avoid mixed storage to prevent danger due to mutual reaction. At the same time, the storage area should be equipped with suitable containment materials so that it can be collected in time in the event of leakage and prevent the spread of pollution.
Second, transportation. Before transportation, it is necessary to ensure that the packaging is complete and well sealed to prevent leakage during transportation. During transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals, and select transportation personnel and vehicles with professional qualifications. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When driving, avoid sun and rain, and try to choose a smooth route to prevent bumps from causing damage to the packaging. Moreover, during transportation, it is not allowed to stop near densely populated areas and important places to prevent accidents from causing serious harm to the surrounding area. In addition, transportation personnel must be familiar with the nature of the substance and emergency treatment methods. In the event of an emergency, they can respond quickly and properly to ensure transportation safety.
What are the effects of 1- (chloromethyl) -2,4-bis (trifluoromethyl) benzene on the environment and human health?
1 - (cyanomethyl) - 2,4 - bis (trifluoromethyl) benzene, which has an impact on both the environment and human health.
In terms of the environment, such fluorine-containing and cyanide-group chemicals, if they are not properly treated and enter the environment, are difficult to degrade naturally due to their stable structure, or persist in the environment for a long time, accumulating in ecological media such as soil and water bodies. For example, they flow into the soil, or change the physical and chemical properties of the soil, affecting the structure and function of soil microbial communities, thereby destroying the balance of soil ecosystems and hindering the normal growth of plants. After entering the water body, it will affect the survival of aquatic organisms. Because of its certain toxicity, or causing abnormal behavior of aquatic organisms, damage to physiological functions, or even death, it seriously destroys the biodiversity of aquatic ecosystems.
As far as human health is concerned, if the human body comes into contact with or ingests the environmental medium containing the substance, it may be harmful to health. Contact through skin may cause skin irritation, allergies and other symptoms, such as skin redness, swelling and itching. If inhaled, the volatile gas in the air will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term exposure or ingestion, the substance accumulates in the body, or affects human metabolism and physiological functions. The cyanide group it contains is highly toxic, or interferes with cell respiration, which is life-threatening in severe cases; the existence of fluorine atoms may also affect the normal development and function of human bones, teeth and other tissues. Therefore, the production, use and discharge of such chemical substances should be strictly controlled to reduce their harm to the environment and human health.
In terms of the environment, such fluorine-containing and cyanide-group chemicals, if they are not properly treated and enter the environment, are difficult to degrade naturally due to their stable structure, or persist in the environment for a long time, accumulating in ecological media such as soil and water bodies. For example, they flow into the soil, or change the physical and chemical properties of the soil, affecting the structure and function of soil microbial communities, thereby destroying the balance of soil ecosystems and hindering the normal growth of plants. After entering the water body, it will affect the survival of aquatic organisms. Because of its certain toxicity, or causing abnormal behavior of aquatic organisms, damage to physiological functions, or even death, it seriously destroys the biodiversity of aquatic ecosystems.
As far as human health is concerned, if the human body comes into contact with or ingests the environmental medium containing the substance, it may be harmful to health. Contact through skin may cause skin irritation, allergies and other symptoms, such as skin redness, swelling and itching. If inhaled, the volatile gas in the air will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term exposure or ingestion, the substance accumulates in the body, or affects human metabolism and physiological functions. The cyanide group it contains is highly toxic, or interferes with cell respiration, which is life-threatening in severe cases; the existence of fluorine atoms may also affect the normal development and function of human bones, teeth and other tissues. Therefore, the production, use and discharge of such chemical substances should be strictly controlled to reduce their harm to the environment and human health.
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