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1-(Chloromethyl)-2,4-Difluorobenzene
Linshang Chemical
|
HS Code |
102754 |
| Chemical Formula | C7H5ClF2 |
| Molecular Weight | 162.56 |
| Appearance | Liquid (usually) |
| Color | Colorless to light - yellow |
| Odor | Characteristic organic odor |
| Boiling Point | Approx. 160 - 162 °C |
| Density | Approx. 1.33 - 1.35 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Approx. 52 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 1-(Chloromethyl)-2,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(chloromethyl)-2,4 - difluorobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 1-(Chloromethyl)-2,4 -difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions. Label the storage container clearly for easy identification. |
| Shipping | 1-(Chloromethyl)-2,4 -difluorobenzene is a chemical. Shipping requires proper containment in specialized, leak - proof containers. It must comply with hazardous material regulations, ensuring secure transport to prevent spills and environmental/health risks. |
Competitive 1-(Chloromethyl)-2,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-(Chloromethyl)-2,4-Difluorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Chloromethyl)-2,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1- (chloromethyl) -2,4-difluorobenzene?
1 - (chloromethyl) - 2,4 - difluorobenzene is also an organic compound. It has a wide range of uses and plays a significant role in the synthesis of medicine.
Because of the characteristics of halogen atoms and chloromethyl, it can be used as a key intermediate to create a variety of specific drugs. Taking antibacterial drugs as an example, by ingeniously integrating their structures through specific chemical reactions, they can increase the affinity between drugs and bacterial targets, strengthen antibacterial efficacy, and save patients from pain.
In the field of pesticide synthesis, it is also indispensable. After chemical transformation, efficient insecticides can be derived. Its unique structure can precisely act on the nervous system or physiological metabolism of pests, kill pests, protect the strong growth of crops, protect the hard work of farmers, and help a lot in agricultural harvest.
In addition, in the field of materials science, or through polymerization and other means, polymer materials with special properties can be prepared. For example, the synthesis of fluoropolymers gives the material excellent weather resistance and chemical stability, and is used in high-end fields such as aerospace and automobile manufacturing to improve material properties and quality.
In summary, although 1- (chloromethyl) -2,4-difluorobenzene is an organic compound, it has critical uses in many fields such as medicine, pesticides, and materials, and has far-reaching impact. It promotes the progress and development of related industries.
Because of the characteristics of halogen atoms and chloromethyl, it can be used as a key intermediate to create a variety of specific drugs. Taking antibacterial drugs as an example, by ingeniously integrating their structures through specific chemical reactions, they can increase the affinity between drugs and bacterial targets, strengthen antibacterial efficacy, and save patients from pain.
In the field of pesticide synthesis, it is also indispensable. After chemical transformation, efficient insecticides can be derived. Its unique structure can precisely act on the nervous system or physiological metabolism of pests, kill pests, protect the strong growth of crops, protect the hard work of farmers, and help a lot in agricultural harvest.
In addition, in the field of materials science, or through polymerization and other means, polymer materials with special properties can be prepared. For example, the synthesis of fluoropolymers gives the material excellent weather resistance and chemical stability, and is used in high-end fields such as aerospace and automobile manufacturing to improve material properties and quality.
In summary, although 1- (chloromethyl) -2,4-difluorobenzene is an organic compound, it has critical uses in many fields such as medicine, pesticides, and materials, and has far-reaching impact. It promotes the progress and development of related industries.
What are the physical properties of 1- (chloromethyl) -2,4-difluorobenzene
1- (chloromethyl) -2,4-difluorobenzene is an important compound in organic chemistry. The physical properties of this substance are unique and worth exploring.
Looking at its appearance, under normal circumstances, 1- (chloromethyl) -2,4-difluorobenzene is often a colorless to pale yellow transparent liquid. Its color is light, like morning mist, hidden in the sun, quiet and not public. Under the reflection of the light, it is slightly flooded, as if hiding endless mysteries.
Smell it, it has a pungent smell, like a sharp needle, touching the nasal cavity lightly, triggering a keen sense. Although this smell is not strong and pungent, it should not be underestimated, warning people to be cautious about it.
Talking about the boiling point, it is about 170-180 ° C. When the temperature rises gradually, the compound is like a bird that breaks free from the shackles, transforms from liquid light to gaseous state, and the attractive force between molecules gradually weakens, dancing freely in space. The characteristics of boiling point have a key guiding effect in many links such as separation, purification and chemical production.
In terms of melting point, it is about -40 ° C. When the temperature drops to this point, the molecular activity tends to slow down, just like a hibernation sleeping in winter, gradually solidifies, changing from a flowing state to a solid state, and the lattice structure gradually stabilizes.
Furthermore, its density is about 1.32 g/cm ³, which is heavier than water. If it is placed in one place with water, such as a stable stone sinking in a blue wave and slowly falling to the bottom, the boundary between the two is clearly demarcated.
In terms of solubility, 1- (chloromethyl) -2,4-difluorobenzene is slightly soluble in water, just like a drop of oil falling on the surface of a lake, and can only mix a little with water, most of which still exist independently. However, it is soluble in most organic solvents, such as ethanol, ether, etc., like a wanderer returning home, and blends well with organic solvents. In the field of organic synthesis, this solubility paves the way for many reactions.
The physical properties of this compound are of great significance in the fields of organic synthesis and drug development. Its unique state, taste, melting point and solubility provide chemists with precise tools to carve new substances in the microscopic world and open unknown scientific chapters.
Looking at its appearance, under normal circumstances, 1- (chloromethyl) -2,4-difluorobenzene is often a colorless to pale yellow transparent liquid. Its color is light, like morning mist, hidden in the sun, quiet and not public. Under the reflection of the light, it is slightly flooded, as if hiding endless mysteries.
Smell it, it has a pungent smell, like a sharp needle, touching the nasal cavity lightly, triggering a keen sense. Although this smell is not strong and pungent, it should not be underestimated, warning people to be cautious about it.
Talking about the boiling point, it is about 170-180 ° C. When the temperature rises gradually, the compound is like a bird that breaks free from the shackles, transforms from liquid light to gaseous state, and the attractive force between molecules gradually weakens, dancing freely in space. The characteristics of boiling point have a key guiding effect in many links such as separation, purification and chemical production.
In terms of melting point, it is about -40 ° C. When the temperature drops to this point, the molecular activity tends to slow down, just like a hibernation sleeping in winter, gradually solidifies, changing from a flowing state to a solid state, and the lattice structure gradually stabilizes.
Furthermore, its density is about 1.32 g/cm ³, which is heavier than water. If it is placed in one place with water, such as a stable stone sinking in a blue wave and slowly falling to the bottom, the boundary between the two is clearly demarcated.
In terms of solubility, 1- (chloromethyl) -2,4-difluorobenzene is slightly soluble in water, just like a drop of oil falling on the surface of a lake, and can only mix a little with water, most of which still exist independently. However, it is soluble in most organic solvents, such as ethanol, ether, etc., like a wanderer returning home, and blends well with organic solvents. In the field of organic synthesis, this solubility paves the way for many reactions.
The physical properties of this compound are of great significance in the fields of organic synthesis and drug development. Its unique state, taste, melting point and solubility provide chemists with precise tools to carve new substances in the microscopic world and open unknown scientific chapters.
Is 1- (chloromethyl) -2,4-difluorobenzene chemically stable?
1 - (chloromethyl) -2,4 -difluorobenzene is also an organic compound. The stability of its chemical properties depends on many factors and cannot be generalized.
From the structural point of view, the benzene ring has a conjugated system and usually has a certain stability. However, the benzene ring of this compound is connected with chloromethyl and difluoro substituents, and the fluorine atom is very electronegative, and the electron-absorbing effect is significant, which can reduce the electron cloud density of the benzene ring. The chlorine atom in chloromethyl also has electron-absorbing properties, and chloromethyl can undergo various reactions, which all affect its stability.
Under normal conditions, if the environment is relatively mild and there are no strong oxidizing agents, reducing agents, strong acids or strong bases, etc., 1- (chloromethyl) -2,4-difluorobenzene may maintain a relatively stable state. In case of high temperature, light and other conditions, it may initiate a reaction. If under light, the chlorine atom of chloromethyl can initiate a free radical reaction and cause structural changes in the compound.
In case of nucleophiles, the chlorine of chloromethyl can be easily replaced because the chlorine atom can be used as the leaving group. In case of strong oxidizing agents, benzene rings or side chains may also be oxidized. Therefore, in general, the chemical properties of 1- (chloromethyl) -2,4-difluorobenzene are not absolutely stable, but vary according to specific environmental conditions.
From the structural point of view, the benzene ring has a conjugated system and usually has a certain stability. However, the benzene ring of this compound is connected with chloromethyl and difluoro substituents, and the fluorine atom is very electronegative, and the electron-absorbing effect is significant, which can reduce the electron cloud density of the benzene ring. The chlorine atom in chloromethyl also has electron-absorbing properties, and chloromethyl can undergo various reactions, which all affect its stability.
Under normal conditions, if the environment is relatively mild and there are no strong oxidizing agents, reducing agents, strong acids or strong bases, etc., 1- (chloromethyl) -2,4-difluorobenzene may maintain a relatively stable state. In case of high temperature, light and other conditions, it may initiate a reaction. If under light, the chlorine atom of chloromethyl can initiate a free radical reaction and cause structural changes in the compound.
In case of nucleophiles, the chlorine of chloromethyl can be easily replaced because the chlorine atom can be used as the leaving group. In case of strong oxidizing agents, benzene rings or side chains may also be oxidized. Therefore, in general, the chemical properties of 1- (chloromethyl) -2,4-difluorobenzene are not absolutely stable, but vary according to specific environmental conditions.
What is the preparation method of 1- (chloromethyl) -2,4-difluorobenzene?
The preparation of 1- (chloromethyl) -2,4-difluorobenzene is an important topic in the field of organic synthesis. This compound is widely used in many fields such as medicine and pesticides, so it is of great significance to explore its effective preparation method.
Common methods for preparing 1- (chloromethyl) -2,4-difluorobenzene, one of which is to use 2,4-difluorotoluene as the starting material. Under suitable reaction conditions, 2,4-difluorotoluene is reacted with chlorine gas. This reaction needs to be carried out under the action of light or initiator. Light conditions can promote the homogenization of chlorine molecules to produce chlorine free radicals, and then react with the methyl group of 2,4-difluorotoluene to generate 1- (chloromethyl) -2,4-difluorobenzene. In this process, the reaction temperature, chlorine gas inlet and reaction time must be precisely controlled. If the temperature is too high, it is easy to cause polychlorination side reactions, resulting in a decrease in product purity; if the chlorine gas inlet is insufficient, the reaction will be incomplete and the yield will be poor.
The second method uses 2,4-difluorobenzoic acid as the raw material. First, 2,4-difluorobenzoic acid is reduced to 2,4-difluorobenzyl alcohol, and suitable reducing agents, such as sodium borohydride-zinc chloride system, can be selected. Then, 2,4-difluorobenzyl alcohol is reacted with chlorination reagents, commonly used chlorination reagents include thionyl chloride, phosphorus trichloride, etc. Taking thionyl chloride as an example, when it reacts with 2,4-difluorobenzyl alcohol, 1- (chloromethyl) -2,4-difluorobenzene is formed with sulfur dioxide and hydrogen chloride gas. This method has relatively many steps, but the reaction conditions of each step are easier to control, and the purity of the product is also easier to improve.
When preparing 1- (chloromethyl) -2,4-difluorobenzene, no matter what method is used, it is necessary to pay attention to the post-reaction process. After the reaction, the products are often separated and purified by means of extraction, distillation, column chromatography, etc., in order to obtain high-purity target products to meet the needs of subsequent applications.
Common methods for preparing 1- (chloromethyl) -2,4-difluorobenzene, one of which is to use 2,4-difluorotoluene as the starting material. Under suitable reaction conditions, 2,4-difluorotoluene is reacted with chlorine gas. This reaction needs to be carried out under the action of light or initiator. Light conditions can promote the homogenization of chlorine molecules to produce chlorine free radicals, and then react with the methyl group of 2,4-difluorotoluene to generate 1- (chloromethyl) -2,4-difluorobenzene. In this process, the reaction temperature, chlorine gas inlet and reaction time must be precisely controlled. If the temperature is too high, it is easy to cause polychlorination side reactions, resulting in a decrease in product purity; if the chlorine gas inlet is insufficient, the reaction will be incomplete and the yield will be poor.
The second method uses 2,4-difluorobenzoic acid as the raw material. First, 2,4-difluorobenzoic acid is reduced to 2,4-difluorobenzyl alcohol, and suitable reducing agents, such as sodium borohydride-zinc chloride system, can be selected. Then, 2,4-difluorobenzyl alcohol is reacted with chlorination reagents, commonly used chlorination reagents include thionyl chloride, phosphorus trichloride, etc. Taking thionyl chloride as an example, when it reacts with 2,4-difluorobenzyl alcohol, 1- (chloromethyl) -2,4-difluorobenzene is formed with sulfur dioxide and hydrogen chloride gas. This method has relatively many steps, but the reaction conditions of each step are easier to control, and the purity of the product is also easier to improve.
When preparing 1- (chloromethyl) -2,4-difluorobenzene, no matter what method is used, it is necessary to pay attention to the post-reaction process. After the reaction, the products are often separated and purified by means of extraction, distillation, column chromatography, etc., in order to obtain high-purity target products to meet the needs of subsequent applications.
What are the precautions for 1- (chloromethyl) -2,4-difluorobenzene in storage and transportation?
1 - (chloromethyl) - 2,4 - difluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause deterioration or cause chemical reactions. Therefore, the warehouse temperature should be controlled in a specific range to prevent accidents. And it must be kept away from fire and heat sources, because the material is flammable, in case of open flame, hot topic or risk of explosion.
Furthermore, when storing, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, in contact with such substances, it is easy to cause violent reactions and endanger safety. At the same time, the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage, and can be properly handled in a timely manner to avoid greater harm.
As for transportation, it should not be ignored. Before transportation, it is necessary to ensure that the container is well sealed to prevent leakage, collapse, fall and damage. During transportation, it is necessary to ensure that the container is not damaged, and the vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. When driving, it should be kept away from densely populated areas and traffic arteries to avoid accidents, resulting in major casualties and property losses. During transportation, escorts should always pay attention to the condition of the goods, and take timely measures if any abnormalities are found. When loading and unloading, the operator should be light and light, and it is strictly forbidden to drop and heavy pressure, so as not to damage the package and cause leakage. In this way, the 1 - (chloromethyl) - 2,4 - difluorobenzene is safe in storage and transportation.
First storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause deterioration or cause chemical reactions. Therefore, the warehouse temperature should be controlled in a specific range to prevent accidents. And it must be kept away from fire and heat sources, because the material is flammable, in case of open flame, hot topic or risk of explosion.
Furthermore, when storing, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, in contact with such substances, it is easy to cause violent reactions and endanger safety. At the same time, the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage, and can be properly handled in a timely manner to avoid greater harm.
As for transportation, it should not be ignored. Before transportation, it is necessary to ensure that the container is well sealed to prevent leakage, collapse, fall and damage. During transportation, it is necessary to ensure that the container is not damaged, and the vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. When driving, it should be kept away from densely populated areas and traffic arteries to avoid accidents, resulting in major casualties and property losses. During transportation, escorts should always pay attention to the condition of the goods, and take timely measures if any abnormalities are found. When loading and unloading, the operator should be light and light, and it is strictly forbidden to drop and heavy pressure, so as not to damage the package and cause leakage. In this way, the 1 - (chloromethyl) - 2,4 - difluorobenzene is safe in storage and transportation.
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