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1-Chloromethyl-2,5-Dimethylbenzene
Linshang Chemical
|
HS Code |
446615 |
| Chemical Formula | C9H11Cl |
| Molar Mass | 154.64 g/mol |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| Odor | Pungent odor |
| Density | 1.004 g/cm³ |
| Boiling Point | 201 - 203 °C |
| Melting Point | -45 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 77 °C |
| Vapor Pressure | 0.16 mmHg (25 °C) |
As an accredited 1-Chloromethyl-2,5-Dimethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - chloromethyl - 2,5 - dimethylbenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 1 - Chloromethyl - 2,5 - dimethylbenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames due to its flammability risk. It should be kept in a tightly - sealed container to prevent vapor release. Store it separately from oxidizing agents, bases, and reactive substances. Use appropriate storage cabinets or areas compliant with safety regulations for handling hazardous chemicals. |
| Shipping | 1 - Chloromethyl - 2,5 - dimethylbenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper labeling and handling to prevent spills and environmental or safety risks. |
Competitive 1-Chloromethyl-2,5-Dimethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 1-chloromethyl-2,5-dimethylbenzene?
1-Chloromethyl-2,5-dimethylbenzene is 1-chloromethyl-2,5-dimethylbenzene, and its main uses are as follows.
This substance has important applications in the field of organic synthesis. First, it can be used as a key intermediate for the synthesis of a wide range of organic compounds. For example, through nucleophilic substitution reactions, chlorine atoms on chloromethyl groups are highly active and easily replaced by many nucleophiles. When they meet with nitrogen-containing nucleophiles, such as amine compounds, new nitrogen-containing organic compounds can be formed. Such compounds often exhibit unique biological activities in the field of medicinal chemistry, or can be used as potential drug molecule precursors for the development of drugs to treat specific diseases.
Furthermore, in the field of materials science, 1-chloromethyl-2,5-dimethylbenzene is also useful. Through appropriate reactions, it can be introduced into the structure of polymer materials, thereby changing the properties of the materials. For example, it can participate in the polymerization reaction, become part of the polymer chain, endow the polymer with specific functions, such as improving the solubility and thermal stability of the material or endowing it with special optical properties, etc., and play an important role in the preparation of high-performance functional materials.
In addition, this compound is often regarded as an important starting material in the preparation of fine chemical products. After a series of chemical reactions, it can be converted into fine chemicals with specific functions, such as special fragrances, dye intermediates, etc. Through structural modification and transformation, it can meet the diverse needs of different industries for fine chemicals and provide a key material basis for the development of the fine chemical industry.
This substance has important applications in the field of organic synthesis. First, it can be used as a key intermediate for the synthesis of a wide range of organic compounds. For example, through nucleophilic substitution reactions, chlorine atoms on chloromethyl groups are highly active and easily replaced by many nucleophiles. When they meet with nitrogen-containing nucleophiles, such as amine compounds, new nitrogen-containing organic compounds can be formed. Such compounds often exhibit unique biological activities in the field of medicinal chemistry, or can be used as potential drug molecule precursors for the development of drugs to treat specific diseases.
Furthermore, in the field of materials science, 1-chloromethyl-2,5-dimethylbenzene is also useful. Through appropriate reactions, it can be introduced into the structure of polymer materials, thereby changing the properties of the materials. For example, it can participate in the polymerization reaction, become part of the polymer chain, endow the polymer with specific functions, such as improving the solubility and thermal stability of the material or endowing it with special optical properties, etc., and play an important role in the preparation of high-performance functional materials.
In addition, this compound is often regarded as an important starting material in the preparation of fine chemical products. After a series of chemical reactions, it can be converted into fine chemicals with specific functions, such as special fragrances, dye intermediates, etc. Through structural modification and transformation, it can meet the diverse needs of different industries for fine chemicals and provide a key material basis for the development of the fine chemical industry.
What are the physical properties of 1-chloromethyl-2,5-dimethylbenzene
1-Chloromethyl-2,5-dimethylbenzene, that is, 1-chloromethyl-2,5-dimethylbenzene, is an organic compound. Its physical properties are as follows:
At room temperature, it may be a colorless to light yellow liquid with a special odor. This odor may be irritating, and it can be known by smelling. Its volatility is more significant, and it is volatile in the air, such as the dissipation of fog, and the molecules escape from the surrounding environment.
Considering its solubility, it is slightly soluble in water, just like oil floating on water, and the two are difficult to dissolve. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc., just like salt melted in water, and can be uniformly mixed with organic solvents.
When it comes to density, the density is slightly greater than that of water. If it is poured into water, it will sink to the bottom like a stone and live under the water layer.
In terms of boiling point, due to factors such as intermolecular forces, the boiling point is within a certain range. The specific value is subject to accurate measurement. When heated to the corresponding temperature, it will change from liquid to gaseous state, such as boiling water in a kettle to boiling point and vaporization.
The melting point is also a specific value. When cooled below the melting point, it will solidify from liquid to solid state, and the morphology will change, like water condensing into ice.
These physical properties of 1-chloromethyl-2,5-dimethylbenzene have far-reaching effects on its application and treatment in chemical production, scientific research experiments and other fields. It needs to be properly used and stored according to its characteristics.
At room temperature, it may be a colorless to light yellow liquid with a special odor. This odor may be irritating, and it can be known by smelling. Its volatility is more significant, and it is volatile in the air, such as the dissipation of fog, and the molecules escape from the surrounding environment.
Considering its solubility, it is slightly soluble in water, just like oil floating on water, and the two are difficult to dissolve. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc., just like salt melted in water, and can be uniformly mixed with organic solvents.
When it comes to density, the density is slightly greater than that of water. If it is poured into water, it will sink to the bottom like a stone and live under the water layer.
In terms of boiling point, due to factors such as intermolecular forces, the boiling point is within a certain range. The specific value is subject to accurate measurement. When heated to the corresponding temperature, it will change from liquid to gaseous state, such as boiling water in a kettle to boiling point and vaporization.
The melting point is also a specific value. When cooled below the melting point, it will solidify from liquid to solid state, and the morphology will change, like water condensing into ice.
These physical properties of 1-chloromethyl-2,5-dimethylbenzene have far-reaching effects on its application and treatment in chemical production, scientific research experiments and other fields. It needs to be properly used and stored according to its characteristics.
What are the chemical properties of 1-chloromethyl-2,5-dimethylbenzene?
1-Chloromethyl-2,5-dimethylbenzene is 1-chloromethyl-2,5-dimethylbenzene. The chemical properties of this substance are as follows:
It has two kinds of properties: aromatics and halogenated hydrocarbons. In the aromatic hydrocarbon part, the methyl group on the benzene ring can be oxidized. In case of strong oxidants such as potassium permanganate, under appropriate conditions, the methyl group can be oxidized to the carboxyl group to obtain the corresponding benzoic acid derivative. This is due to the influence of the benzene ring on the side chain. The side chain methyl activity is enhanced.
The benzene ring also has electrophilic substitution reactivity. Because the methyl group is the power supply, the electron cloud density of the benzene ring can be increased, and it is more In the halogenation reaction, under the catalysis of light or Lewis acid, the chlorine atom can replace the hydrogen on the benzene ring, mainly replacing the methyl o-and para-position hydrogen atoms. If it reacts with chlorine under the catalysis of ferric chloride, the chlorine atom will preferentially replace the methyl o-and para-position to generate the corresponding halogenated product.
As a halogenated hydrocarbon, its chloromethyl group is partially active. In the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophilic reagents. The chlorine atom is replaced by a hydroxyl group to form 1-hydroxymethyl-2,5-dimethylbenzene; when reacted with sodium alcohol, the chlorine atom is replaced by an alkoxy group to obtain the corresponding ether compound; when reacted with sodium cyanide, nitriles are formed by nucleophilic substitution, and nitriles can be further hydrolyzed to obtain carboxylic acids.
In addition, the chloromethyl group in 1-chloromethyl-2,5-dimethylbenzene can also undergo elimination reaction. In a strong alkali alcohol solution, the chlorine atom and the hydrogen atom on the adjacent carbon atom dehydrochloride when heated to form an unsaturated compound containing carbon-carbon double bonds.
It is rich in chemical properties and can be used to construct organic compounds with different structures through various reactions in the field of organic synthesis, which is of important application value.
It has two kinds of properties: aromatics and halogenated hydrocarbons. In the aromatic hydrocarbon part, the methyl group on the benzene ring can be oxidized. In case of strong oxidants such as potassium permanganate, under appropriate conditions, the methyl group can be oxidized to the carboxyl group to obtain the corresponding benzoic acid derivative. This is due to the influence of the benzene ring on the side chain. The side chain methyl activity is enhanced.
The benzene ring also has electrophilic substitution reactivity. Because the methyl group is the power supply, the electron cloud density of the benzene ring can be increased, and it is more In the halogenation reaction, under the catalysis of light or Lewis acid, the chlorine atom can replace the hydrogen on the benzene ring, mainly replacing the methyl o-and para-position hydrogen atoms. If it reacts with chlorine under the catalysis of ferric chloride, the chlorine atom will preferentially replace the methyl o-and para-position to generate the corresponding halogenated product.
As a halogenated hydrocarbon, its chloromethyl group is partially active. In the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophilic reagents. The chlorine atom is replaced by a hydroxyl group to form 1-hydroxymethyl-2,5-dimethylbenzene; when reacted with sodium alcohol, the chlorine atom is replaced by an alkoxy group to obtain the corresponding ether compound; when reacted with sodium cyanide, nitriles are formed by nucleophilic substitution, and nitriles can be further hydrolyzed to obtain carboxylic acids.
In addition, the chloromethyl group in 1-chloromethyl-2,5-dimethylbenzene can also undergo elimination reaction. In a strong alkali alcohol solution, the chlorine atom and the hydrogen atom on the adjacent carbon atom dehydrochloride when heated to form an unsaturated compound containing carbon-carbon double bonds.
It is rich in chemical properties and can be used to construct organic compounds with different structures through various reactions in the field of organic synthesis, which is of important application value.
What are the synthesis methods of 1-chloromethyl-2,5-dimethylbenzene?
1-Chloromethyl-2,5-dimethylbenzene is also an important intermediate in organic synthesis. There are several common methods for its synthesis.
First, 2,5-dimethyltoluene is used as the starting material and can be obtained by chloromethylation. This reaction is often carried out with paraformaldehyde and hydrogen chloride as chloromethylation reagents, catalyzed by Lewis acids such as anhydrous zinc chloride. In the reaction system, paraformaldehyde is first hydrolyzed to produce formaldehyde, and formaldehyde reacts with hydrogen chloride to produce chloromethanol, which is then electrophilically substituted with 2,5-dimethyltoluene, and chloromethyl is introduced to obtain 1-chloromethyl-2,5-dimethylbenzene.
Second, 2,5-dimethylbenzoic acid is used as the starting material. First, it is reduced to 2,5-dimethylbenzyl alcohol, and strong reducing agents such as lithium aluminum hydride can be used to achieve this step. Then, 2,5-dimethylbenzyl alcohol reacts with chlorinated reagents such as thionyl chloride and phosphorus trichloride, and the hydroxyl group is replaced by chlorine atoms to obtain the target product 1-chloromethyl-2,5-dimethylbenzene.
Third, 2,5-dimethylbenzoyl chloride is used as the starting material. It is first reduced by Rosenmund to obtain 2,5-dimethylbenzaldehyde. Then 2,5-dimethylbenzaldehyde is reacted with chloromethylation reagents, such as chloromethyl methyl ether, under alkali catalysis to produce 1-chloromethyl-2,5-dimethylbenzene.
The above synthesis methods have their own advantages and disadvantages. The chloromethylation reaction raw materials are easy to obtain, the operation is relatively simple, but there are many side reactions; the method of making halogenated hydrocarbons from alcohol has relatively mild reaction conditions and relatively high product purity; while the method starting from aldehyde, although the steps are slightly complicated, can be synthesized under special conditions. In the practice of organic synthesis, the advantages and disadvantages of each method can be weighed according to actual needs, and the best method can be selected.
First, 2,5-dimethyltoluene is used as the starting material and can be obtained by chloromethylation. This reaction is often carried out with paraformaldehyde and hydrogen chloride as chloromethylation reagents, catalyzed by Lewis acids such as anhydrous zinc chloride. In the reaction system, paraformaldehyde is first hydrolyzed to produce formaldehyde, and formaldehyde reacts with hydrogen chloride to produce chloromethanol, which is then electrophilically substituted with 2,5-dimethyltoluene, and chloromethyl is introduced to obtain 1-chloromethyl-2,5-dimethylbenzene.
Second, 2,5-dimethylbenzoic acid is used as the starting material. First, it is reduced to 2,5-dimethylbenzyl alcohol, and strong reducing agents such as lithium aluminum hydride can be used to achieve this step. Then, 2,5-dimethylbenzyl alcohol reacts with chlorinated reagents such as thionyl chloride and phosphorus trichloride, and the hydroxyl group is replaced by chlorine atoms to obtain the target product 1-chloromethyl-2,5-dimethylbenzene.
Third, 2,5-dimethylbenzoyl chloride is used as the starting material. It is first reduced by Rosenmund to obtain 2,5-dimethylbenzaldehyde. Then 2,5-dimethylbenzaldehyde is reacted with chloromethylation reagents, such as chloromethyl methyl ether, under alkali catalysis to produce 1-chloromethyl-2,5-dimethylbenzene.
The above synthesis methods have their own advantages and disadvantages. The chloromethylation reaction raw materials are easy to obtain, the operation is relatively simple, but there are many side reactions; the method of making halogenated hydrocarbons from alcohol has relatively mild reaction conditions and relatively high product purity; while the method starting from aldehyde, although the steps are slightly complicated, can be synthesized under special conditions. In the practice of organic synthesis, the advantages and disadvantages of each method can be weighed according to actual needs, and the best method can be selected.
What are the precautions for 1-chloromethyl-2,5-dimethylbenzene in storage and transportation?
1-Chloromethyl-2,5-dimethylbenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First, let's talk about storage. First, you must find a cool, dry and well-ventilated place. Cover because of its heat is prone to danger, humid environment or promote its chemical reaction, resulting in quality damage, or even cause safety accidents. Second, you must keep away from fires and heat sources. This compound is flammable, in case of open flame, hot topic, or there is a risk of combustion and explosion, so the storage place is strictly prohibited from fireworks, and electrical equipment should also be explosion-proof type. Third, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Because of its active chemical properties, contact with the above substances, or a violent reaction, endangering safety. Fourth, the storage container must be well sealed to prevent volatilization from escaping, polluting the environment, and if the volatilized gas reaches a certain concentration, it may form an explosive mixture in the air.
As for transportation, there are also many details. First, the transport vehicle must have the corresponding qualifications, and be equipped with necessary emergency treatment equipment and protective equipment. Drivers and escorts should also be familiar with the characteristics of the transported goods and emergency treatment methods. Second, during transportation, it should be ensured that the container does not leak, collapse, fall, or damage. Driving should be stable, and violent actions such as sudden braking and sharp turning should be avoided to prevent packaging damage. Third, when transporting, you should follow the specified route and do not stop in densely populated areas and prosperous areas. In case of leakage, it is extremely harmful in densely populated areas. Fourth, in summer, transportation should be selected in the morning and evening to avoid high temperature at noon. High temperature will increase the volatilization of compounds and increase safety risks.
All of these are for the storage and transportation of 1-chloromethyl-2,5-dimethylbenzene. If there is a slight carelessness or serious consequences, it must be treated with caution.
First, let's talk about storage. First, you must find a cool, dry and well-ventilated place. Cover because of its heat is prone to danger, humid environment or promote its chemical reaction, resulting in quality damage, or even cause safety accidents. Second, you must keep away from fires and heat sources. This compound is flammable, in case of open flame, hot topic, or there is a risk of combustion and explosion, so the storage place is strictly prohibited from fireworks, and electrical equipment should also be explosion-proof type. Third, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Because of its active chemical properties, contact with the above substances, or a violent reaction, endangering safety. Fourth, the storage container must be well sealed to prevent volatilization from escaping, polluting the environment, and if the volatilized gas reaches a certain concentration, it may form an explosive mixture in the air.
As for transportation, there are also many details. First, the transport vehicle must have the corresponding qualifications, and be equipped with necessary emergency treatment equipment and protective equipment. Drivers and escorts should also be familiar with the characteristics of the transported goods and emergency treatment methods. Second, during transportation, it should be ensured that the container does not leak, collapse, fall, or damage. Driving should be stable, and violent actions such as sudden braking and sharp turning should be avoided to prevent packaging damage. Third, when transporting, you should follow the specified route and do not stop in densely populated areas and prosperous areas. In case of leakage, it is extremely harmful in densely populated areas. Fourth, in summer, transportation should be selected in the morning and evening to avoid high temperature at noon. High temperature will increase the volatilization of compounds and increase safety risks.
All of these are for the storage and transportation of 1-chloromethyl-2,5-dimethylbenzene. If there is a slight carelessness or serious consequences, it must be treated with caution.
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