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1-(Chloromethyl)-2-Fluoro-4-Methoxybenzene
Linshang Chemical
|
HS Code |
851642 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.6 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, but around 200 - 220 °C |
| Density | Estimated around 1.2 - 1.3 g/cm³ |
| Solubility In Water | Low solubility, hydrophobic due to non - polar benzene ring |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Flash Point | Should be determined experimentally, but may be around 80 - 90 °C |
| Vapor Pressure | Relatively low at room temperature, increases with temperature |
As an accredited 1-(Chloromethyl)-2-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-2-fluoro-4-methoxybenzene in a sealed chemical - grade bottle. |
| Storage | 1-(Chloromethyl)-2-fluoro-4-methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. This helps prevent decomposition, evaporation, and potential reactions that could pose safety risks. |
| Shipping | 1-(Chloromethyl)-2-fluoro-4-methoxybenzene is shipped in properly sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring safe transport to prevent any leakage or environmental hazard. |
Competitive 1-(Chloromethyl)-2-Fluoro-4-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Chloromethyl)-2-Fluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1- (chloromethyl) -2-fluoro-4-methoxybenzene?
(1) The properties of this substance are related to its composition. (1 - (cyanomethyl) - 2 - cyanogen - 4 - methoxy phenyl ether), its molecular structure contains a specific atomic combination, which gives it its unique physical properties.
Looking at its physical state, under room temperature, it is mostly in the shape of a solid state. Its texture is relatively solid, just like the solid of gold and stone. When you touch it, you can feel its fine texture and no loose state.
When it comes to the melting point, due to the force between molecules, its melting point is quite high. A considerable amount of heat needs to be applied to make the solid state into a liquid state. This process is similar to the melting of ice and snow in the warm sun. The boiling point is also not low. If you want to change it from liquid to gaseous state, you need to put in more heat energy, such as boiling water over a stove fire. If the firepower is insufficient, the water will be difficult to boil.
In terms of solubility, it is soluble in common organic solvents such as ethanol and ether. Like salt entering water, it gradually melts, but it is difficult to dissolve in water, just like oil floating in water, and it does not blend with each other. This is due to the difference in the matching of molecular polarity and solvent polarity.
The density is larger than that of ordinary water. If it is placed in water, such as a stone sinking in the abyss, it sinks directly. This is the manifestation of its density characteristics.
(2) The root of its physical properties lies in the molecular structure. Cyanyl, methoxy and other functional groups in the molecule are located in their respective positions and interact with each other. Cyanyl groups have strong electron-absorbing properties, which affect the charge distribution of molecules; methoxy groups give electrons, and the two cooperate to shape the overall polarity of the molecule, and then affect its solubility, melting point and other physical properties. And the van der Waals forces between molecules are also strong or weak due to their structure, which are manifested in terms of physical state and density. In short, the physical properties of (1- (cyanomethyl) -2 -cyano- 4 -methoxy phenyl ether) are characterized outside the molecular microstructure, and the two are closely related and inseparable.
Looking at its physical state, under room temperature, it is mostly in the shape of a solid state. Its texture is relatively solid, just like the solid of gold and stone. When you touch it, you can feel its fine texture and no loose state.
When it comes to the melting point, due to the force between molecules, its melting point is quite high. A considerable amount of heat needs to be applied to make the solid state into a liquid state. This process is similar to the melting of ice and snow in the warm sun. The boiling point is also not low. If you want to change it from liquid to gaseous state, you need to put in more heat energy, such as boiling water over a stove fire. If the firepower is insufficient, the water will be difficult to boil.
In terms of solubility, it is soluble in common organic solvents such as ethanol and ether. Like salt entering water, it gradually melts, but it is difficult to dissolve in water, just like oil floating in water, and it does not blend with each other. This is due to the difference in the matching of molecular polarity and solvent polarity.
The density is larger than that of ordinary water. If it is placed in water, such as a stone sinking in the abyss, it sinks directly. This is the manifestation of its density characteristics.
(2) The root of its physical properties lies in the molecular structure. Cyanyl, methoxy and other functional groups in the molecule are located in their respective positions and interact with each other. Cyanyl groups have strong electron-absorbing properties, which affect the charge distribution of molecules; methoxy groups give electrons, and the two cooperate to shape the overall polarity of the molecule, and then affect its solubility, melting point and other physical properties. And the van der Waals forces between molecules are also strong or weak due to their structure, which are manifested in terms of physical state and density. In short, the physical properties of (1- (cyanomethyl) -2 -cyano- 4 -methoxy phenyl ether) are characterized outside the molecular microstructure, and the two are closely related and inseparable.
What are the chemical properties of 1- (chloromethyl) -2-fluoro-4-methoxybenzene?
"Tiangong Kaiwu" is written by Song Yingxing in the Ming Dynasty, which is the culmination of ancient science and technology. Yu Si asked "the chemical properties of (1- (methoxy) -2-chloro-4-methoxy benzaldehyde) ", and it was stated in ancient Chinese, and I tried to solve it for you.
This (1- (methoxy) -2-chloro-4-methoxy benzaldehyde), which has the property of aldehyde group, aldehyde group, and active functional group. It can interact with weak oxidants, such as Torun reagent and Feilin reagent. When encountering Torun's reagent, the aldehyde group is oxidized to a carboxyl group, and a silver mirror is formed at the same time. This is the famous silver mirror reaction. Although the ancients did not know the mechanism of its atoms and molecules in detail, the phenomenon shows the wonders of its changes. When encountering Ferlin's reagent, the aldehyde group is oxidized, and the copper ion is reduced from divalent to monovalent, resulting in a brick-red cuprous oxide precipitation.
Furthermore, it contains methoxy. Methoxy is the power supply group, which can affect the electron cloud density of the benzene ring. Therefore, the electrophilic substitution reaction activity on the benzene ring is affected by it. The electron cloud density of the adjacent and para-position of the benzene ring is relatively high, and the electrophilic reagent is Although the chlorine atom is also connected to the benzene ring, its electron-withdrawing induction effect coexists with the electron conjugation effect, and generally speaking, it also has a certain impact on the reactivity and substitution position of the benzene ring.
And because it has chlorine atoms, nucleophilic substitution reactions can occur. In case of nucleophilic reagents, chlorine atoms can be replaced to form new compounds. And the groups in the molecule interact with each other, resulting in rich and complex chemical properties of this compound. Although the ancient people could not accurately analyze it today, it can be seen that it has various changes under different conditions, which can provide many clues for the research and application of chemistry.
This (1- (methoxy) -2-chloro-4-methoxy benzaldehyde), which has the property of aldehyde group, aldehyde group, and active functional group. It can interact with weak oxidants, such as Torun reagent and Feilin reagent. When encountering Torun's reagent, the aldehyde group is oxidized to a carboxyl group, and a silver mirror is formed at the same time. This is the famous silver mirror reaction. Although the ancients did not know the mechanism of its atoms and molecules in detail, the phenomenon shows the wonders of its changes. When encountering Ferlin's reagent, the aldehyde group is oxidized, and the copper ion is reduced from divalent to monovalent, resulting in a brick-red cuprous oxide precipitation.
Furthermore, it contains methoxy. Methoxy is the power supply group, which can affect the electron cloud density of the benzene ring. Therefore, the electrophilic substitution reaction activity on the benzene ring is affected by it. The electron cloud density of the adjacent and para-position of the benzene ring is relatively high, and the electrophilic reagent is Although the chlorine atom is also connected to the benzene ring, its electron-withdrawing induction effect coexists with the electron conjugation effect, and generally speaking, it also has a certain impact on the reactivity and substitution position of the benzene ring.
And because it has chlorine atoms, nucleophilic substitution reactions can occur. In case of nucleophilic reagents, chlorine atoms can be replaced to form new compounds. And the groups in the molecule interact with each other, resulting in rich and complex chemical properties of this compound. Although the ancient people could not accurately analyze it today, it can be seen that it has various changes under different conditions, which can provide many clues for the research and application of chemistry.
What are the main uses of 1- (chloromethyl) -2-fluoro-4-methoxybenzene?
(1 - (cyanomethyl) - 2 - cyano- 4 - methoxyphenylnaphthalene, this substance is mainly used for a wide range of purposes. In the field of pharmaceutical synthesis, it can be used as a key intermediate. For example, in the preparation of some drugs with specific curative effects, 1- (cyanomethyl) - 2 - cyano- 4 - methoxyphenylnaphthalene can be converted into pharmaceutical active ingredients through a series of chemical reactions due to its unique chemical structure, which can then play a therapeutic role in specific diseases.
In the field of materials science, it also shows important value. Due to the special chemical properties of this substance, it can be used to develop new functional materials. For example, in the field of optical materials, specific processes can endow materials with unique optical properties, such as the absorption and emission characteristics of specific wavelengths of light, which can be applied to optical display, optical communication and many other aspects.
In organic synthetic chemistry, it can participate in the construction of many complex organic compounds as an important raw material. Chemists can use various organic synthesis methods to introduce different functional groups, expand molecular structures, and synthesize organic compounds with novel structures and properties according to their structural characteristics, providing rich materials for the research and development of organic chemistry.
In conclusion, 1 - (cyanomethyl) - 2 - cyanogen - 4 - methoxyphenylnaphthalene plays a key role in many fields such as medicine, materials and organic synthesis, and plays an indispensable role in promoting scientific and technological progress and development in related fields.)
In the field of materials science, it also shows important value. Due to the special chemical properties of this substance, it can be used to develop new functional materials. For example, in the field of optical materials, specific processes can endow materials with unique optical properties, such as the absorption and emission characteristics of specific wavelengths of light, which can be applied to optical display, optical communication and many other aspects.
In organic synthetic chemistry, it can participate in the construction of many complex organic compounds as an important raw material. Chemists can use various organic synthesis methods to introduce different functional groups, expand molecular structures, and synthesize organic compounds with novel structures and properties according to their structural characteristics, providing rich materials for the research and development of organic chemistry.
In conclusion, 1 - (cyanomethyl) - 2 - cyanogen - 4 - methoxyphenylnaphthalene plays a key role in many fields such as medicine, materials and organic synthesis, and plays an indispensable role in promoting scientific and technological progress and development in related fields.)
What are the synthesis methods of 1- (chloromethyl) -2-fluoro-4-methoxybenzene?
To prepare 1 - (methoxy) - 2 - chloro - 4 - methoxy phenyl ether, the synthesis method is as follows:
First, the corresponding phenolic compound is used as the starting material. First, the phenol is reacted with halomethane under alkaline conditions, and the methoxy group can be introduced. For example, the phenol is dissolved in a suitable organic solvent such as N, N - dimethylformamide (DMF), a base such as potassium carbonate is added, and then the halomethane is added dropwise, and the reaction is heated and stirred for a period of time. After separation and purification, the methoxylated phenolic intermediate can be obtained.
Second, the methoxylated phenolic intermediate is chlorinated. Suitable chlorination reagents can be selected, such as thionyl chloride, phosphorus oxychloride, etc. Taking thionyl chloride as an example, methoxylated phenols are placed in a reaction vessel, an appropriate amount of catalyst such as pyridine is added, and thionyl chloride is slowly added dropwise to react at a certain temperature. After the reaction, excess reagents and by-products are removed by distillation, extraction, etc., to obtain a chlorine-containing intermediate.
Third, the chlorine-containing intermediate is etherified with another methoxy-containing alcohol compound or phenolic compound. In an alkaline environment, such as using an alcohol solution of sodium hydroxide or potassium hydroxide, the nucleophilic substitution reaction occurs between the two to generate the target product 1- (methoxy) -2 -chloro-4 -methoxy phenyl ether. After the reaction is completed, the product is further purified by washing with water, drying, column chromatography, etc. to improve its purity.
This synthesis process requires attention to the control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., which have a great impact on the reaction yield and product purity. After each step of the reaction, careful separation and purification operations must be carried out to ensure the smooth progress of subsequent reactions and the quality of the final product.
First, the corresponding phenolic compound is used as the starting material. First, the phenol is reacted with halomethane under alkaline conditions, and the methoxy group can be introduced. For example, the phenol is dissolved in a suitable organic solvent such as N, N - dimethylformamide (DMF), a base such as potassium carbonate is added, and then the halomethane is added dropwise, and the reaction is heated and stirred for a period of time. After separation and purification, the methoxylated phenolic intermediate can be obtained.
Second, the methoxylated phenolic intermediate is chlorinated. Suitable chlorination reagents can be selected, such as thionyl chloride, phosphorus oxychloride, etc. Taking thionyl chloride as an example, methoxylated phenols are placed in a reaction vessel, an appropriate amount of catalyst such as pyridine is added, and thionyl chloride is slowly added dropwise to react at a certain temperature. After the reaction, excess reagents and by-products are removed by distillation, extraction, etc., to obtain a chlorine-containing intermediate.
Third, the chlorine-containing intermediate is etherified with another methoxy-containing alcohol compound or phenolic compound. In an alkaline environment, such as using an alcohol solution of sodium hydroxide or potassium hydroxide, the nucleophilic substitution reaction occurs between the two to generate the target product 1- (methoxy) -2 -chloro-4 -methoxy phenyl ether. After the reaction is completed, the product is further purified by washing with water, drying, column chromatography, etc. to improve its purity.
This synthesis process requires attention to the control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., which have a great impact on the reaction yield and product purity. After each step of the reaction, careful separation and purification operations must be carried out to ensure the smooth progress of subsequent reactions and the quality of the final product.
What are the precautions for storing and transporting 1- (chloromethyl) -2-fluoro-4-methoxybenzene?
(1 - (Cyanomethyl) -2 - Cyanogen-4 - Methoxybenzonitrile requires attention to many matters during storage and transportation.)
First, because of its certain chemical activity, the storage place must be dry and cool, away from fire and heat sources. Humid environment is prone to chemical reactions, affecting quality; high temperature may cause dangerous reactions, such as accelerated decomposition, and may even lead to serious consequences such as combustion and explosion.
Second, when storing, it should be stored separately from oxidants, acids, bases and other substances. This compound has special chemical properties, and contact with the above substances can easily trigger violent chemical reactions, generate dangerous products, and endanger the safety of personnel and the environment.
Third, the transportation process must strictly follow the relevant regulations, and the packaging must be tight and stable. Make sure that the packaging will not be damaged during transportation bumps to prevent leakage. Once leaked, not only pollute the environment, but also pose a threat to the health of the contact personnel, such as through inhalation, skin contact and other means, causing health problems such as poisoning.
Fourth, the transportation and storage site should be equipped with corresponding emergency treatment equipment and protective equipment. In the event of an accident, such as leakage, fire, etc., the staff can take effective measures quickly. For example, equipped with suitable adsorption materials to deal with leaks, and ready fire extinguishing equipment to deal with fires. At the same time, the staff should receive professional training and be familiar with the characteristics of the substance and emergency treatment methods to ensure the safety of operation.
First, because of its certain chemical activity, the storage place must be dry and cool, away from fire and heat sources. Humid environment is prone to chemical reactions, affecting quality; high temperature may cause dangerous reactions, such as accelerated decomposition, and may even lead to serious consequences such as combustion and explosion.
Second, when storing, it should be stored separately from oxidants, acids, bases and other substances. This compound has special chemical properties, and contact with the above substances can easily trigger violent chemical reactions, generate dangerous products, and endanger the safety of personnel and the environment.
Third, the transportation process must strictly follow the relevant regulations, and the packaging must be tight and stable. Make sure that the packaging will not be damaged during transportation bumps to prevent leakage. Once leaked, not only pollute the environment, but also pose a threat to the health of the contact personnel, such as through inhalation, skin contact and other means, causing health problems such as poisoning.
Fourth, the transportation and storage site should be equipped with corresponding emergency treatment equipment and protective equipment. In the event of an accident, such as leakage, fire, etc., the staff can take effective measures quickly. For example, equipped with suitable adsorption materials to deal with leaks, and ready fire extinguishing equipment to deal with fires. At the same time, the staff should receive professional training and be familiar with the characteristics of the substance and emergency treatment methods to ensure the safety of operation.
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