Linshang Chemical
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1-(Chloromethyl)-2-Iodobenzene
Linshang Chemical
|
HS Code |
830538 |
| Chemical Formula | C7H6ClI |
| Molar Mass | 254.48 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 245 - 247 °C |
| Solubility | Slightly soluble in water, soluble in organic solvents like ether, chloroform |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but reactive towards nucleophiles due to the presence of chloro and iodo groups |
As an accredited 1-(Chloromethyl)-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1-(chloromethyl)-2-iodobenzene packaged in a sealed glass bottle. |
| Storage | 1-(Chloromethyl)-2-iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Due to its chemical nature, store it separately from oxidizing agents, bases, and reactive compounds to prevent unwanted reactions. |
| Shipping | 1-(Chloromethyl)-2-iodobenzene is shipped in sealed, corrosion - resistant containers. Compliance with chemical shipping regulations is ensured, with proper labeling indicating its hazardous nature, and temperature - controlled transport if required. |
Competitive 1-(Chloromethyl)-2-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-(Chloromethyl)-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -2-iodobenzene?
1 - (chloromethyl) -2 -iodobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in pharmaceutical chemistry, a series of chemical reactions can be used to introduce specific functional groups to construct molecular structures with specific pharmacological activities, paving the way for the creation of new drugs. Drug developers often use the unique structure of this compound to ingeniously build complex molecular frameworks, hoping to obtain drugs with better efficacy and fewer side effects.
Second, in the field of materials science, can participate in the preparation of special materials. For example, polymerization with other monomers can generate polymer materials with special properties, or excellent photoelectric properties, or excellent mechanical properties, which can be applied to electronic devices, optical materials and other fields to promote the progress of related technologies.
Third, in the fine chemical industry, it is also an important raw material. It is used to synthesize various fine chemicals, such as fragrances, dyes, etc. Through its participation in the reaction, it can endow the product with unique color and fragrance characteristics, and improve the quality and added value of the product.
1 - (chloromethyl) -2 - iodobenzene plays a key role in organic synthesis, drug research and development, material preparation and fine chemicals, and has made great contributions to the development of chemical science and the progress of related industries.
First, in pharmaceutical chemistry, a series of chemical reactions can be used to introduce specific functional groups to construct molecular structures with specific pharmacological activities, paving the way for the creation of new drugs. Drug developers often use the unique structure of this compound to ingeniously build complex molecular frameworks, hoping to obtain drugs with better efficacy and fewer side effects.
Second, in the field of materials science, can participate in the preparation of special materials. For example, polymerization with other monomers can generate polymer materials with special properties, or excellent photoelectric properties, or excellent mechanical properties, which can be applied to electronic devices, optical materials and other fields to promote the progress of related technologies.
Third, in the fine chemical industry, it is also an important raw material. It is used to synthesize various fine chemicals, such as fragrances, dyes, etc. Through its participation in the reaction, it can endow the product with unique color and fragrance characteristics, and improve the quality and added value of the product.
1 - (chloromethyl) -2 - iodobenzene plays a key role in organic synthesis, drug research and development, material preparation and fine chemicals, and has made great contributions to the development of chemical science and the progress of related industries.
What are the synthesis methods of 1- (chloromethyl) -2-iodobenzene?
The synthesis method of 1- (chloromethyl) -2 -iodobenzene has been followed by ancient methods. First, it can be started from o-iodotoluene. First, chlorine gas is used as a halogenating agent. Under the action of light or initiator, the hydrogen atom on the methyl group is replaced by the chlorine atom, which is a free radical substitution reaction. Cover light or initiator can promote the homogenization of chlorine gas into chlorine radicals, and then interact with the methyl group of o-iodotoluene to generate 1- (chloromethyl) -2 -iodobenzene. However, the selectivity of this reaction is not good, or by-products such as dichloro substitutes are formed.
Furthermore, the Grignard reagent method can be used. First, the Grignard reagent is prepared by reacting o-iodobromobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other inert solvents. Then, the Grignard reagent is reacted with formaldehyde to form an alcohol intermediate, and then treated with a chlorination reagent, such as dichlorosulfoxide or phosphorus trichloride, to convert the hydroxyl group into a chlorine atom, and finally obtain 1- (chloromethyl) -2 -iodobenzene. This method step is slightly complicated, but the control of the reaction conditions is quite high. The anhydrous and anaerobic environment is very important, otherwise the Grignard reagent is easy to decompose.
There are also those who use o-iodobenzoic acid as the starting material. First, it is reduced to o-iodobenzanol. Then the target product can be obtained by treating o-iodobenzyl alcohol with a chlorination reagent. In this approach, the reduction step requires careful operation. Lithium aluminum hydride has very high activity and reacts violently in contact with water, so the reaction environment needs to be strictly anhydrous.
The above synthesis methods have their own advantages and disadvantages. In practical application, the choice should be weighed according to factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
Furthermore, the Grignard reagent method can be used. First, the Grignard reagent is prepared by reacting o-iodobromobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other inert solvents. Then, the Grignard reagent is reacted with formaldehyde to form an alcohol intermediate, and then treated with a chlorination reagent, such as dichlorosulfoxide or phosphorus trichloride, to convert the hydroxyl group into a chlorine atom, and finally obtain 1- (chloromethyl) -2 -iodobenzene. This method step is slightly complicated, but the control of the reaction conditions is quite high. The anhydrous and anaerobic environment is very important, otherwise the Grignard reagent is easy to decompose.
There are also those who use o-iodobenzoic acid as the starting material. First, it is reduced to o-iodobenzanol. Then the target product can be obtained by treating o-iodobenzyl alcohol with a chlorination reagent. In this approach, the reduction step requires careful operation. Lithium aluminum hydride has very high activity and reacts violently in contact with water, so the reaction environment needs to be strictly anhydrous.
The above synthesis methods have their own advantages and disadvantages. In practical application, the choice should be weighed according to factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
What are the physical properties of 1- (chloromethyl) -2-iodobenzene?
1- (chloromethyl) -2 -iodobenzene is one of the organic compounds. Its physical properties are quite important, as listed in detail:
Looking at its properties, under room temperature, 1- (chloromethyl) -2 -iodobenzene is probably colorless to light yellow liquid. This color feature can be one of the aids in identifying this substance.
In terms of its boiling point, it is about a certain temperature range. Due to factors such as intermolecular forces, it needs to reach a certain temperature before it can change from liquid to gaseous. According to many experimental measurements, its boiling point is around [specific boiling point value], which is a key parameter in the separation and purification of substances.
As for the melting point, there is also a specific value. When the temperature drops to a certain extent, the compound will solidify from liquid to solid, and its melting point is about [specific melting point value]. Determination of melting point is very useful in identifying the purity of a substance. If the substance is pure, the melting point is often fixed; if it contains impurities, the melting point may change.
The density of 1- (chloromethyl) -2 -iodobenzene is also an important physical property. Its density is about [specific density value], which is related to the phase distribution of the substance when mixed with other substances. For example, in liquid-liquid mixed systems, density differences can affect their stratification.
In terms of solubility, 1- (chloromethyl) -2 -iodobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. However, in water, the solubility is not good. The difference in solubility is due to the difference in its molecular structure and the forces between water molecules and organic solvent molecules. The forces between organic solvent molecules and 1- (chloromethyl) -2 -iodobenzene molecules, or the forces between water molecules and the compound molecules, cause them to dissolve differently in different solvents. This solubility property has important guiding significance in the selection of solvents for organic synthesis reactions.
Looking at its properties, under room temperature, 1- (chloromethyl) -2 -iodobenzene is probably colorless to light yellow liquid. This color feature can be one of the aids in identifying this substance.
In terms of its boiling point, it is about a certain temperature range. Due to factors such as intermolecular forces, it needs to reach a certain temperature before it can change from liquid to gaseous. According to many experimental measurements, its boiling point is around [specific boiling point value], which is a key parameter in the separation and purification of substances.
As for the melting point, there is also a specific value. When the temperature drops to a certain extent, the compound will solidify from liquid to solid, and its melting point is about [specific melting point value]. Determination of melting point is very useful in identifying the purity of a substance. If the substance is pure, the melting point is often fixed; if it contains impurities, the melting point may change.
The density of 1- (chloromethyl) -2 -iodobenzene is also an important physical property. Its density is about [specific density value], which is related to the phase distribution of the substance when mixed with other substances. For example, in liquid-liquid mixed systems, density differences can affect their stratification.
In terms of solubility, 1- (chloromethyl) -2 -iodobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. However, in water, the solubility is not good. The difference in solubility is due to the difference in its molecular structure and the forces between water molecules and organic solvent molecules. The forces between organic solvent molecules and 1- (chloromethyl) -2 -iodobenzene molecules, or the forces between water molecules and the compound molecules, cause them to dissolve differently in different solvents. This solubility property has important guiding significance in the selection of solvents for organic synthesis reactions.
What are the chemical properties of 1- (chloromethyl) -2-iodobenzene?
1 - (chloromethyl) - 2 - iodobenzene, this is an organic compound with unique chemical properties. It has strong chemical activity due to the presence of chloromethyl and iodine atoms.
First, the nucleophilic substitution reaction, the chlorine atom in the chlorine methyl group, due to the strong electronegativity of chlorine, makes the C-Cl bond polar, and the carbon is partially positively charged, which is vulnerable to attack by nucleophiles. Nucleophiles such as alcohols, amines, mercaptans, etc., can react with them. Taking alcohol as an example, under the catalysis of alkali, the oxygen-negative ions of the alcohol attack the chloromethyl carbon, and the chlorine atoms leave to form ether compounds. In organic synthesis, this reaction is often an important means to construct carbon-oxygen bonds. It can produce a variety of compounds containing ether structures and is widely used in the fields of medicine and materials.
Looking at the halogen atom reaction, the iodine atom of 2-iodobenzene, although the carbon-iodine bond energy is relatively small, makes the iodine atom more active. Under the catalysis of metals, it can participate in many coupling reactions, such as the Suzuki coupling reaction catalyzed by palladium. Under the action of palladium catalyst and base, iodobenzene and compounds containing borate esters cross-couple to form new carbon-carbon bonds and construct complex aromatic compound structures. This reaction is an important method for the synthesis of polyaryl compounds, which is of great significance in the fields of drug development and materials science. It can prepare materials with special photoelectric properties or bioactive drug molecules.
In addition, the chloromethyl and iodine atoms of 1- (chloromethyl) -2 -iodobenzene can initiate intramolecular reactions. When there are appropriate nucleophilic check points in the molecule, under suitable conditions, cyclization can occur to generate compounds with specific cyclic structures. This reaction is an effective strategy for constructing cyclic compounds, enriching the structural diversity of organic compounds, and is widely used in the total synthesis of natural products and the development of new drugs.
In summary, 1- (chloromethyl) -2 -iodobenzene plays an important role in the field of organic synthesis due to its properties of chloromethyl and iodine atoms. It provides possibilities for the preparation of various organic compounds through various reactions, and has important application value in many fields such as medicine and materials.
First, the nucleophilic substitution reaction, the chlorine atom in the chlorine methyl group, due to the strong electronegativity of chlorine, makes the C-Cl bond polar, and the carbon is partially positively charged, which is vulnerable to attack by nucleophiles. Nucleophiles such as alcohols, amines, mercaptans, etc., can react with them. Taking alcohol as an example, under the catalysis of alkali, the oxygen-negative ions of the alcohol attack the chloromethyl carbon, and the chlorine atoms leave to form ether compounds. In organic synthesis, this reaction is often an important means to construct carbon-oxygen bonds. It can produce a variety of compounds containing ether structures and is widely used in the fields of medicine and materials.
Looking at the halogen atom reaction, the iodine atom of 2-iodobenzene, although the carbon-iodine bond energy is relatively small, makes the iodine atom more active. Under the catalysis of metals, it can participate in many coupling reactions, such as the Suzuki coupling reaction catalyzed by palladium. Under the action of palladium catalyst and base, iodobenzene and compounds containing borate esters cross-couple to form new carbon-carbon bonds and construct complex aromatic compound structures. This reaction is an important method for the synthesis of polyaryl compounds, which is of great significance in the fields of drug development and materials science. It can prepare materials with special photoelectric properties or bioactive drug molecules.
In addition, the chloromethyl and iodine atoms of 1- (chloromethyl) -2 -iodobenzene can initiate intramolecular reactions. When there are appropriate nucleophilic check points in the molecule, under suitable conditions, cyclization can occur to generate compounds with specific cyclic structures. This reaction is an effective strategy for constructing cyclic compounds, enriching the structural diversity of organic compounds, and is widely used in the total synthesis of natural products and the development of new drugs.
In summary, 1- (chloromethyl) -2 -iodobenzene plays an important role in the field of organic synthesis due to its properties of chloromethyl and iodine atoms. It provides possibilities for the preparation of various organic compounds through various reactions, and has important application value in many fields such as medicine and materials.
What are the precautions for 1- (chloromethyl) -2-iodobenzene during storage and transportation?
For 1 - (chloromethyl) -2 -iodobenzene, there are several ends that should be taken care of during storage and transportation.
First, this substance is chemically active. When storing, it must be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, and risk deterioration due to light or promoting its chemical reaction. Temperature should also be carefully checked. Excessive temperature can increase its reactivity or cause safety problems. Too low temperature, although it may reduce its activity, may have changes in crystallization and solidification, which will affect the use.
Second, its packaging must be tight. 1 - (chloromethyl) - 2 - iodobenzene is sensitive to air and water vapor. If the packaging is not strict, air and water vapor will invade, or neutralize or hydrolyze with it, which will damage its quality. Therefore, the packaging material should have good barrier properties, such as glass containers, which need to be well sealed; plastic packaging, which must also be corrosion-resistant and reliable.
When transporting, there are also many important rules. It should be shipped separately with oxidizing agents, strong alkalis, strong acids and other chemicals, and cover 1- (chloromethyl) - 2 - iodobenzene with it, which is prone to violent reactions, causing dangers such as combustion and explosion. Transportation vehicles should be equipped with fire extinguishing and leakage emergency treatment equipment to be prepared. And during driving, avoid bumps, shocks, and prevent material leakage caused by damaged packaging.
Furthermore, operators must undergo professional training to be familiar with the nature of this object and safe operation methods. When handling, load lightly and unload lightly, so as not to damage the packaging. If there is a leak, immediately isolate the scene, evacuate personnel, and take appropriate cleaning measures according to the amount of leakage. Small leaks can be adsorbed by inert materials such as sand and vermiculite; large leaks need to be contained and collected and handled by professional institutions.
In general, the storage and transportation of 1- (chloromethyl) -2-iodobenzene must strictly follow the relevant procedures and pay attention to all details to ensure the safety of the process and the quality of the material.
First, this substance is chemically active. When storing, it must be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, and risk deterioration due to light or promoting its chemical reaction. Temperature should also be carefully checked. Excessive temperature can increase its reactivity or cause safety problems. Too low temperature, although it may reduce its activity, may have changes in crystallization and solidification, which will affect the use.
Second, its packaging must be tight. 1 - (chloromethyl) - 2 - iodobenzene is sensitive to air and water vapor. If the packaging is not strict, air and water vapor will invade, or neutralize or hydrolyze with it, which will damage its quality. Therefore, the packaging material should have good barrier properties, such as glass containers, which need to be well sealed; plastic packaging, which must also be corrosion-resistant and reliable.
When transporting, there are also many important rules. It should be shipped separately with oxidizing agents, strong alkalis, strong acids and other chemicals, and cover 1- (chloromethyl) - 2 - iodobenzene with it, which is prone to violent reactions, causing dangers such as combustion and explosion. Transportation vehicles should be equipped with fire extinguishing and leakage emergency treatment equipment to be prepared. And during driving, avoid bumps, shocks, and prevent material leakage caused by damaged packaging.
Furthermore, operators must undergo professional training to be familiar with the nature of this object and safe operation methods. When handling, load lightly and unload lightly, so as not to damage the packaging. If there is a leak, immediately isolate the scene, evacuate personnel, and take appropriate cleaning measures according to the amount of leakage. Small leaks can be adsorbed by inert materials such as sand and vermiculite; large leaks need to be contained and collected and handled by professional institutions.
In general, the storage and transportation of 1- (chloromethyl) -2-iodobenzene must strictly follow the relevant procedures and pay attention to all details to ensure the safety of the process and the quality of the material.
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