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1-(Chloromethyl)-2-Nitrobenzene
Linshang Chemical
|
HS Code |
972536 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Yellow - to - brown liquid |
| Boiling Point | 261 - 262 °C |
| Melting Point | 15 - 16 °C |
| Density | 1.345 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 118 °C |
| Vapor Pressure | Low |
| Odor | Pungent |
As an accredited 1-(Chloromethyl)-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - (Chloromethyl)-2 - nitrobenzene: Packed in 5 - kg containers for secure storage and transport. |
| Storage | 1-(Chloromethyl)-2-nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents, reducing agents, and bases due to potential reactivity. Use proper storage cabinets or areas designated for hazardous chemicals. |
| Shipping | 1-(Chloromethyl)-2 - nitrobenzene is a hazardous chemical. Shipping requires compliance with strict regulations. It must be properly packaged, labeled, and transported by carriers authorized for such chemicals to ensure safety during transit. |
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What are the main uses of 1- (chloromethyl) -2-nitrobenzene?
(1) Cyanomethyl
cyanomethyl has important uses in organic synthesis. First, it can participate in many reactions as a nucleophilic reagent. For example, in some nucleophilic substitution reactions, the carbon atoms in cyanomethyl are nucleophilic and can attack substrate molecules with suitable leaving groups, such as halogenated hydrocarbons, to form new carbon-carbon bonds, which is of great significance for the growth of carbon chains and the construction of complex organic molecular frameworks. Second, cyanofunctional groups can undergo various subsequent transformations. Cyanyl groups can be hydrolyzed to form carboxyl groups. After hydrolysis, cyanomethyl groups are converted into carboxyl-containing structures under suitable reaction conditions, which is very critical in the synthesis of organic compounds with acidic functional groups. For example, the introduction of carboxyl groups in some drug molecules and natural products sometimes relies on the conversion of cyanomethyl groups. Third, cyanyl groups can also undergo reduction reactions to generate other functional groups such as amino groups, which enriches the diversity of functional groups in organic compounds and provides possibilities for the synthesis of different types of organic molecules.
(di) benzyl chloride
Benzyl chloride is mainly used for a wide range of purposes. In the field of organic synthesis, it is an important benzylation reagent. Because of its high reactivity, chlorine atoms are easily replaced by nucleophiles. For example, the reaction with alcohols can realize the benzylation of alcohols to generate benzyl ether compounds. These benzyl ethers are often used as protective groups in organic synthesis to protect the alcohol hydroxyl group from being destroyed under some reaction conditions. After the reaction, the benzyl group is removed by a suitable method and the alcohol hydroxyl group is restored. In drug synthesis, benzyl chloride can be used to introduce benzyl structure. The existence of benzyl structure may change the lipid solubility, spatial structure and other properties of drug molecules, which in turn affects the activity and pharmacokinetic properties of drugs. At the same time, in the field of materials science, the reactions involving benzyl chloride can be used to prepare some polymer materials with special structures and properties. For example, by reacting with a monomer containing a specific functional group, the benzyl structure is introduced into the polymer chain to change the solubility and thermal stability of the polymer material.
cyanomethyl has important uses in organic synthesis. First, it can participate in many reactions as a nucleophilic reagent. For example, in some nucleophilic substitution reactions, the carbon atoms in cyanomethyl are nucleophilic and can attack substrate molecules with suitable leaving groups, such as halogenated hydrocarbons, to form new carbon-carbon bonds, which is of great significance for the growth of carbon chains and the construction of complex organic molecular frameworks. Second, cyanofunctional groups can undergo various subsequent transformations. Cyanyl groups can be hydrolyzed to form carboxyl groups. After hydrolysis, cyanomethyl groups are converted into carboxyl-containing structures under suitable reaction conditions, which is very critical in the synthesis of organic compounds with acidic functional groups. For example, the introduction of carboxyl groups in some drug molecules and natural products sometimes relies on the conversion of cyanomethyl groups. Third, cyanyl groups can also undergo reduction reactions to generate other functional groups such as amino groups, which enriches the diversity of functional groups in organic compounds and provides possibilities for the synthesis of different types of organic molecules.
(di) benzyl chloride
Benzyl chloride is mainly used for a wide range of purposes. In the field of organic synthesis, it is an important benzylation reagent. Because of its high reactivity, chlorine atoms are easily replaced by nucleophiles. For example, the reaction with alcohols can realize the benzylation of alcohols to generate benzyl ether compounds. These benzyl ethers are often used as protective groups in organic synthesis to protect the alcohol hydroxyl group from being destroyed under some reaction conditions. After the reaction, the benzyl group is removed by a suitable method and the alcohol hydroxyl group is restored. In drug synthesis, benzyl chloride can be used to introduce benzyl structure. The existence of benzyl structure may change the lipid solubility, spatial structure and other properties of drug molecules, which in turn affects the activity and pharmacokinetic properties of drugs. At the same time, in the field of materials science, the reactions involving benzyl chloride can be used to prepare some polymer materials with special structures and properties. For example, by reacting with a monomer containing a specific functional group, the benzyl structure is introduced into the polymer chain to change the solubility and thermal stability of the polymer material.
What are the physical properties of 1- (chloromethyl) -2-nitrobenzene?
(1) Halomethyl-2 -furanyl ketone, the physical properties of this substance are as follows:
Halomethyl-2 -furanyl ketone, when viewed at room temperature, is mostly in a liquid state, but it also depends on the type of halogen atom and the state of the substituent. Its color state is usually a colorless to light yellow transparent liquid, with a clear appearance, resembling the condensation of morning dew, and it also has a sparkling luster under light.
Smell it, its smell is unique, with a certain irritation, but it is not pungent and intolerable, just like the smell of faint medicinal incense mixed with light chemical agents, lingering in the nose, which is quite impressive.
As for its boiling point, it is usually in a specific range due to the influence of halogen atoms and methyl groups. If the halogen atom is chlorine, under normal pressure, the boiling point or hovers around hundreds of degrees Celsius, the specific value also varies due to the exact structure. The characteristics of this boiling point make it possible to separate and purify the experimental operation according to the difference in boiling points between it and others, and to analyze it by distillation or other methods.
Its density is also considerable compared to water. Generally speaking, it is slightly larger than water. If it is co-placed with water, it can be seen that it slowly sinks to the bottom of the water, like a pearl falling into the abyss. The two are clearly defined and never mix.
In terms of solubility, halomethyl-2-furanyl ketone exhibits good solubility in organic solvents, such as ethanol, ether, etc., and can be mutually soluble with one to one, just like water emulsion blending, seamless. However, in water, the solubility is relatively limited and only slightly soluble. This property is of great significance in the process of phase transfer catalysis in organic synthesis. A suitable reaction system can be designed accordingly to promote the smooth progress of the reaction.
And halomethyl-2-furanyl ketones have strong molecular polarity due to the existence of halogen atoms, carbonyl groups and furan rings in the molecule, which in turn affects their interaction with other substances. Whether it is physical adsorption or chemical reaction, they are very different from non-polar or weakly polar substances, laying a solid foundation for their wide application in the field of organic chemistry.
Halomethyl-2 -furanyl ketone, when viewed at room temperature, is mostly in a liquid state, but it also depends on the type of halogen atom and the state of the substituent. Its color state is usually a colorless to light yellow transparent liquid, with a clear appearance, resembling the condensation of morning dew, and it also has a sparkling luster under light.
Smell it, its smell is unique, with a certain irritation, but it is not pungent and intolerable, just like the smell of faint medicinal incense mixed with light chemical agents, lingering in the nose, which is quite impressive.
As for its boiling point, it is usually in a specific range due to the influence of halogen atoms and methyl groups. If the halogen atom is chlorine, under normal pressure, the boiling point or hovers around hundreds of degrees Celsius, the specific value also varies due to the exact structure. The characteristics of this boiling point make it possible to separate and purify the experimental operation according to the difference in boiling points between it and others, and to analyze it by distillation or other methods.
Its density is also considerable compared to water. Generally speaking, it is slightly larger than water. If it is co-placed with water, it can be seen that it slowly sinks to the bottom of the water, like a pearl falling into the abyss. The two are clearly defined and never mix.
In terms of solubility, halomethyl-2-furanyl ketone exhibits good solubility in organic solvents, such as ethanol, ether, etc., and can be mutually soluble with one to one, just like water emulsion blending, seamless. However, in water, the solubility is relatively limited and only slightly soluble. This property is of great significance in the process of phase transfer catalysis in organic synthesis. A suitable reaction system can be designed accordingly to promote the smooth progress of the reaction.
And halomethyl-2-furanyl ketones have strong molecular polarity due to the existence of halogen atoms, carbonyl groups and furan rings in the molecule, which in turn affects their interaction with other substances. Whether it is physical adsorption or chemical reaction, they are very different from non-polar or weakly polar substances, laying a solid foundation for their wide application in the field of organic chemistry.
What are the chemical properties of 1- (chloromethyl) -2-nitrobenzene?
(Monomethoxy) -2 -carbonyl indole, this is an organic compound. Its chemical properties are unique and it has attracted much attention in the field of organic synthesis.
Structurally, in this compound, methoxy and carbonyl are respectively connected to specific positions of the indole ring. As a power supply group, methoxy will affect the electron cloud density distribution of the indole ring and enhance its electron cloud density, especially in the ortho and para-positions. This makes the ortho and para-positions of the indole ring more likely to become the reaction check point in the electrophilic substitution reaction, and it is easier to react with electrophilic reagents.
Carbonyl groups have strong electron-withdrawing properties, which not only make carbonyl carbon atoms partially positively charged and vulnerable to nucleophilic reagents, but also further affect the electron cloud density distribution of indole rings through conjugation effects and induction effects, so that the electron cloud density of carbon atoms connected to carbonyl groups decreases.
In chemical reactions, the methoxy group of (monomethoxy) -2 -carbonyl indole can participate in nucleophilic substitution reactions. When encountering suitable nucleophilic reagents, methoxy groups may be replaced to generate new derivatives. Carbonyl groups can undergo many reactions, such as acetalylation with alcohols. Under acidic conditions, carbonyl groups react with alcohols to form acetal structures; nucleophilic addition reactions can occur with amines to form imines and other products. In addition, due to the existence of the conjugate system of indole rings, the compound may also undergo oxidation reactions and reduction reactions on the ring. Under the action of suitable oxidants, indole rings may be oxidized to form products with different oxidation states; under the action of reducing agents, partial unsaturated bonds can be reduced. In short, (monomethoxy) -2 -carbonyl indoles have rich and diverse chemical reaction activities due to their special structures, providing a broad space for organic synthesis and related fields research.
Structurally, in this compound, methoxy and carbonyl are respectively connected to specific positions of the indole ring. As a power supply group, methoxy will affect the electron cloud density distribution of the indole ring and enhance its electron cloud density, especially in the ortho and para-positions. This makes the ortho and para-positions of the indole ring more likely to become the reaction check point in the electrophilic substitution reaction, and it is easier to react with electrophilic reagents.
Carbonyl groups have strong electron-withdrawing properties, which not only make carbonyl carbon atoms partially positively charged and vulnerable to nucleophilic reagents, but also further affect the electron cloud density distribution of indole rings through conjugation effects and induction effects, so that the electron cloud density of carbon atoms connected to carbonyl groups decreases.
In chemical reactions, the methoxy group of (monomethoxy) -2 -carbonyl indole can participate in nucleophilic substitution reactions. When encountering suitable nucleophilic reagents, methoxy groups may be replaced to generate new derivatives. Carbonyl groups can undergo many reactions, such as acetalylation with alcohols. Under acidic conditions, carbonyl groups react with alcohols to form acetal structures; nucleophilic addition reactions can occur with amines to form imines and other products. In addition, due to the existence of the conjugate system of indole rings, the compound may also undergo oxidation reactions and reduction reactions on the ring. Under the action of suitable oxidants, indole rings may be oxidized to form products with different oxidation states; under the action of reducing agents, partial unsaturated bonds can be reduced. In short, (monomethoxy) -2 -carbonyl indoles have rich and diverse chemical reaction activities due to their special structures, providing a broad space for organic synthesis and related fields research.
What are the preparation methods of 1- (chloromethyl) -2-nitrobenzene?
To prepare (cyanomethyl) -2 -furanyl ketone, there are several methods as follows:
First, furanaldehyde is used as the starting material. First, furanaldehyde reacts with ethyl chloroacetate under alkaline conditions, which is the application of the ginseng reaction. Ethyl chloroacetate under the action of alkali generates carbon negative ions, which carry out nucleophilic addition to the carbonyl group of furanaldehyde, and then cyclize to form glycidyl ester intermediates. Subsequent steps such as hydrolysis and decarboxylation can obtain the target product (cyanomethyl) -2 -furanyl ketone. In this process, the control of the reaction conditions is extremely critical. Factors such as the type, dosage, and reaction temperature of the base will all affect the yield and selectivity of the reaction. For example, the alkali is too alkaline, which may lead to more side reactions and reduce the purity of the product; and the reaction temperature is too high or too low, which will also make the reaction process deviate from expectations.
Second, compounds containing cyanide groups can be used to react with 2-furanone derivatives. For example, select a suitable halogenated cyanomethyl compound and 2-furanone in the presence of a basic catalyst to undergo nucleophilic substitution. The basic catalyst can activate the halogen atom in the halogenated cyanomethyl compound, making it more susceptible to attack by the activity check point in the 2-furanyl ketone derivative, so as to realize the synthesis of (cyanomethyl) -2-furanyl ketone. However, in this reaction, the activity and selectivity of the halogenated cyanomethyl compound need to be carefully considered, otherwise it is prone to side reactions such as multiple substitutions, which interfere with the formation of the target product. At the same time, the solvent selection in the reaction system cannot be ignored, and the properties such as the polarity of different solvents will change the reaction rate and equilibrium.
Third, it can also be prepared by the reaction involving organometallic reagents. For example, the reaction between the furanyl lithium reagent and the electrophilic reagent containing cyan Lithium furanyl reagents have strong nucleophilicity and can perform nucleophilic addition to electrophilic reagents containing cyanomethyl groups. However, organometallic reagents are usually more active and have strict requirements on the reaction environment. They need to be operated under anhydrous and anaerobic conditions to avoid reaction with moisture and oxygen in the air, resulting in the inactivation of the reagent and affecting the reaction progress. In addition, the feeding sequence and reaction time in the reaction process also need to be carefully controlled to obtain the ideal product yield and purity.
First, furanaldehyde is used as the starting material. First, furanaldehyde reacts with ethyl chloroacetate under alkaline conditions, which is the application of the ginseng reaction. Ethyl chloroacetate under the action of alkali generates carbon negative ions, which carry out nucleophilic addition to the carbonyl group of furanaldehyde, and then cyclize to form glycidyl ester intermediates. Subsequent steps such as hydrolysis and decarboxylation can obtain the target product (cyanomethyl) -2 -furanyl ketone. In this process, the control of the reaction conditions is extremely critical. Factors such as the type, dosage, and reaction temperature of the base will all affect the yield and selectivity of the reaction. For example, the alkali is too alkaline, which may lead to more side reactions and reduce the purity of the product; and the reaction temperature is too high or too low, which will also make the reaction process deviate from expectations.
Second, compounds containing cyanide groups can be used to react with 2-furanone derivatives. For example, select a suitable halogenated cyanomethyl compound and 2-furanone in the presence of a basic catalyst to undergo nucleophilic substitution. The basic catalyst can activate the halogen atom in the halogenated cyanomethyl compound, making it more susceptible to attack by the activity check point in the 2-furanyl ketone derivative, so as to realize the synthesis of (cyanomethyl) -2-furanyl ketone. However, in this reaction, the activity and selectivity of the halogenated cyanomethyl compound need to be carefully considered, otherwise it is prone to side reactions such as multiple substitutions, which interfere with the formation of the target product. At the same time, the solvent selection in the reaction system cannot be ignored, and the properties such as the polarity of different solvents will change the reaction rate and equilibrium.
Third, it can also be prepared by the reaction involving organometallic reagents. For example, the reaction between the furanyl lithium reagent and the electrophilic reagent containing cyan Lithium furanyl reagents have strong nucleophilicity and can perform nucleophilic addition to electrophilic reagents containing cyanomethyl groups. However, organometallic reagents are usually more active and have strict requirements on the reaction environment. They need to be operated under anhydrous and anaerobic conditions to avoid reaction with moisture and oxygen in the air, resulting in the inactivation of the reagent and affecting the reaction progress. In addition, the feeding sequence and reaction time in the reaction process also need to be carefully controlled to obtain the ideal product yield and purity.
What are the precautions for using 1- (chloromethyl) -2-nitrobenzene?
Halomethyl and hydroxymethyl do have many things to pay attention to during use.
Let's talk about halomethyl first, its chemical activity is quite high, and it is often used as a reactive substituent group in many chemical reactions. However, when using, it is necessary to pay great attention to its toxicity and irritation. Halomethyl compounds are mostly harmful to the human body, or can irritate the skin, eyes and respiratory tract, and some are even carcinogenic. When operating, be sure to carry out it in a well-ventilated environment, preferably in a fume hood, and wear appropriate protective equipment, such as gloves, goggles and gas masks, to prevent direct contact with the human body or inhalation. In addition, the reactivity of halomethyl compounds makes their chemical properties unstable and prone to side reactions. Therefore, when designing the reaction, it is necessary to precisely control the reaction conditions, such as temperature, reaction time and the ratio of reactants, so that the reaction proceeds in the desired direction.
Besides hydroxymethyl, although hydroxymethyl is slightly more stable than halomethyl, there are also points to be paid attention to. First, hydroxymethyl is prone to dehydration, especially under acidic or high temperature conditions, it is easy to dehydrate molecules to form carbonyl compounds. Therefore, when storing and using hydroxymethyl-related compounds, attention should be paid to controlling the ambient humidity and temperature to avoid dehydration due to improper conditions. Second, hydroxymethyl is highly hydrophilic, which will affect the solubility of the compound in organic solvents. When selecting the reaction solvent, the influence of hydroxymethyl on solubility should be fully considered, and the appropriate solvent system should be selected to ensure the smooth progress of the reaction. Moreover, during the organic synthesis reaction, hydroxymethyl may participate in a variety of reaction paths. According to the specific reaction requirements, the protective group should be reasonably selected to protect and deprotect the hydroxymethyl group to ensure the selectivity and yield of the reaction.
When using halomethyl and hydroxymethyl, full attention should be paid to their chemical properties, toxicity and requirements for reaction conditions to ensure the safety and efficiency of the experiment or production process.
Let's talk about halomethyl first, its chemical activity is quite high, and it is often used as a reactive substituent group in many chemical reactions. However, when using, it is necessary to pay great attention to its toxicity and irritation. Halomethyl compounds are mostly harmful to the human body, or can irritate the skin, eyes and respiratory tract, and some are even carcinogenic. When operating, be sure to carry out it in a well-ventilated environment, preferably in a fume hood, and wear appropriate protective equipment, such as gloves, goggles and gas masks, to prevent direct contact with the human body or inhalation. In addition, the reactivity of halomethyl compounds makes their chemical properties unstable and prone to side reactions. Therefore, when designing the reaction, it is necessary to precisely control the reaction conditions, such as temperature, reaction time and the ratio of reactants, so that the reaction proceeds in the desired direction.
Besides hydroxymethyl, although hydroxymethyl is slightly more stable than halomethyl, there are also points to be paid attention to. First, hydroxymethyl is prone to dehydration, especially under acidic or high temperature conditions, it is easy to dehydrate molecules to form carbonyl compounds. Therefore, when storing and using hydroxymethyl-related compounds, attention should be paid to controlling the ambient humidity and temperature to avoid dehydration due to improper conditions. Second, hydroxymethyl is highly hydrophilic, which will affect the solubility of the compound in organic solvents. When selecting the reaction solvent, the influence of hydroxymethyl on solubility should be fully considered, and the appropriate solvent system should be selected to ensure the smooth progress of the reaction. Moreover, during the organic synthesis reaction, hydroxymethyl may participate in a variety of reaction paths. According to the specific reaction requirements, the protective group should be reasonably selected to protect and deprotect the hydroxymethyl group to ensure the selectivity and yield of the reaction.
When using halomethyl and hydroxymethyl, full attention should be paid to their chemical properties, toxicity and requirements for reaction conditions to ensure the safety and efficiency of the experiment or production process.
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