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1-(Chloromethyl)-3,5-Difluorobenzene
Linshang Chemical
|
HS Code |
821062 |
| Chemical Formula | C7H5ClF2 |
| Molar Mass | 162.564 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 160 - 162 °C |
| Melting Point | N/A |
| Density | 1.299 g/cm³ |
| Flash Point | 52 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | N/A |
| Odor | Pungent |
As an accredited 1-(Chloromethyl)-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL of 1-(chloromethyl)-3,5 -difluorobenzene in a sealed, chemical - resistant bottle. |
| Storage | 1-(Chloromethyl)-3,5-difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or specific plastics. Store it separately from oxidizing agents, bases, and other reactive chemicals to prevent hazardous reactions. |
| Shipping | 1-(Chloromethyl)-3,5 -difluorobenzene is a chemical. Shipping should comply with relevant hazardous materials regulations. It must be properly packaged to prevent leakage, with clear labels indicating its nature and handling precautions. |
Competitive 1-(Chloromethyl)-3,5-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted 1-(Chloromethyl)-3,5-Difluorobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Chloromethyl)-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -3,5-difluorobenzene?
1- (cyanomethyl) -3,5-dibromobenzene has many main uses. This compound is a key raw material in the field of organic synthesis.
In the field of pharmaceutical synthesis, its role is significant. It can be converted into pharmaceutical intermediates with specific pharmacological activities through a series of delicate chemical reactions. With its unique chemical structure, it can participate in the construction of complex drug molecular structures, paving the way for the development of new drugs. For example, in the creation of antibacterial drugs, 1- (cyanomethyl) -3,5-dibromobenzene can be used as a starting material to gradually build molecular entities with antibacterial efficacy through reactions such as nucleophilic substitution and cyclization with other specific reagents.
In the field of materials science, it also has important uses. Due to the presence of bromine atoms and cyanomethyl groups in its structure, it is endowed with special electronic properties and reactivity. It can be used to prepare functional polymer materials, such as by polymerizing with monomers containing specific functional groups to generate polymers with unique electrical and optical properties. These polymers can be used in frontier materials such as organic Light Emitting Diode (OLED) and solar cells to improve the performance and efficiency of materials.
In the synthesis of pesticides, 1- (cyanomethyl) -3,5-dibromobenzene can also play an important role. It can be used as a key intermediate for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and reaction modification, pesticide products with high selective killing effect on crop pests can be created, which contributes to the sustainable development of agriculture.
In short, 1- (cyanomethyl) -3,5-dibromobenzene has shown indispensable uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure. It is of great significance to promote scientific research and industrial development in related fields.
In the field of pharmaceutical synthesis, its role is significant. It can be converted into pharmaceutical intermediates with specific pharmacological activities through a series of delicate chemical reactions. With its unique chemical structure, it can participate in the construction of complex drug molecular structures, paving the way for the development of new drugs. For example, in the creation of antibacterial drugs, 1- (cyanomethyl) -3,5-dibromobenzene can be used as a starting material to gradually build molecular entities with antibacterial efficacy through reactions such as nucleophilic substitution and cyclization with other specific reagents.
In the field of materials science, it also has important uses. Due to the presence of bromine atoms and cyanomethyl groups in its structure, it is endowed with special electronic properties and reactivity. It can be used to prepare functional polymer materials, such as by polymerizing with monomers containing specific functional groups to generate polymers with unique electrical and optical properties. These polymers can be used in frontier materials such as organic Light Emitting Diode (OLED) and solar cells to improve the performance and efficiency of materials.
In the synthesis of pesticides, 1- (cyanomethyl) -3,5-dibromobenzene can also play an important role. It can be used as a key intermediate for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and reaction modification, pesticide products with high selective killing effect on crop pests can be created, which contributes to the sustainable development of agriculture.
In short, 1- (cyanomethyl) -3,5-dibromobenzene has shown indispensable uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure. It is of great significance to promote scientific research and industrial development in related fields.
What are the physical properties of 1- (chloromethyl) -3,5-difluorobenzene?
1 - (cyanomethyl) -3,5 -dibromobenzene, which is an organic compound. Its physical properties are as follows:
In terms of color state, it is mostly white to light yellow crystalline powder at room temperature. This color and morphology are quite common among organic compounds, and its appearance characteristics are conducive to preliminary identification and distinction.
Melting point is within a certain range. The specific value may vary slightly due to factors such as preparation purity, but it is roughly in a specific range. Melting point, as one of the important physical parameters of organic compounds, is of great significance for its identification, separation and purity judgment. By means of melting point determination, the purity and type of the substance can be preliminarily determined.
In terms of solubility, it exhibits some solubility in common organic solvents such as ethanol, ether, and dichloromethane, while it has little solubility in water. This difference in solubility provides a theoretical basis for its chemical synthesis, separation and purification operations. According to the principle of similar miscibility, a suitable solvent can be selected to realize the dissolution, reaction or separation of the substance.
In addition, 1- (cyanomethyl) -3,5-dibromobenzene has certain stability, but it can also undergo chemical reactions under specific conditions such as high temperature, strong acid-base environment, or when encountering specific chemical reagents. Understanding its stability and reactivity is crucial during storage, transportation, and use. It can effectively avoid latent risks and ensure the safety of operation and the smooth progress of experiments and production.
In terms of color state, it is mostly white to light yellow crystalline powder at room temperature. This color and morphology are quite common among organic compounds, and its appearance characteristics are conducive to preliminary identification and distinction.
Melting point is within a certain range. The specific value may vary slightly due to factors such as preparation purity, but it is roughly in a specific range. Melting point, as one of the important physical parameters of organic compounds, is of great significance for its identification, separation and purity judgment. By means of melting point determination, the purity and type of the substance can be preliminarily determined.
In terms of solubility, it exhibits some solubility in common organic solvents such as ethanol, ether, and dichloromethane, while it has little solubility in water. This difference in solubility provides a theoretical basis for its chemical synthesis, separation and purification operations. According to the principle of similar miscibility, a suitable solvent can be selected to realize the dissolution, reaction or separation of the substance.
In addition, 1- (cyanomethyl) -3,5-dibromobenzene has certain stability, but it can also undergo chemical reactions under specific conditions such as high temperature, strong acid-base environment, or when encountering specific chemical reagents. Understanding its stability and reactivity is crucial during storage, transportation, and use. It can effectively avoid latent risks and ensure the safety of operation and the smooth progress of experiments and production.
Is 1- (chloromethyl) -3,5-difluorobenzene chemically stable?
The chemical properties of 1 - (methoxy) -3,5 -dibromobenzene are still stable. In its structure, the benzene ring is a stable hexamembered cyclic conjugate system, which endows the compound with certain stability. Methoxy (-OCH) is a power supply group, which can increase the electron cloud density of the benzene ring through p-π conjugation effect, enhance the stability of the benzene ring, and can affect the activity and positional selectivity of the electrophilic substitution reaction on the benzene ring.
Although the bromine atom (-Br) is an electron-withdrawing group, it has lone pairs of electrons, which can be p-π conjugated with the benzene ring, stabilizing the benzene ring to a certain extent. At the same time, due to the electronegativity of the bromine atom, the electron cloud density of the benzene ring will decrease, which will affect the electrophilic substitution reaction.
Furthermore, the spatial structure of 1- (methoxy) -3,5-dibromobenzene also contributes to its stability. The distribution of methoxy and bromine atoms at specific positions on the benzene ring makes the intramolecular interaction reach a certain equilibrium, reducing the intramolecular tension and enhancing the overall stability. This structural characteristic makes the compound less prone to structural changes or chemical reactions under normal conditions. Even in the face of common chemical environmental changes, its stable structure can maintain its relatively stable chemical properties.
Although the bromine atom (-Br) is an electron-withdrawing group, it has lone pairs of electrons, which can be p-π conjugated with the benzene ring, stabilizing the benzene ring to a certain extent. At the same time, due to the electronegativity of the bromine atom, the electron cloud density of the benzene ring will decrease, which will affect the electrophilic substitution reaction.
Furthermore, the spatial structure of 1- (methoxy) -3,5-dibromobenzene also contributes to its stability. The distribution of methoxy and bromine atoms at specific positions on the benzene ring makes the intramolecular interaction reach a certain equilibrium, reducing the intramolecular tension and enhancing the overall stability. This structural characteristic makes the compound less prone to structural changes or chemical reactions under normal conditions. Even in the face of common chemical environmental changes, its stable structure can maintain its relatively stable chemical properties.
What are the synthesis methods of 1- (chloromethyl) -3,5-difluorobenzene?
To prepare 1 - (cyanomethyl) -3,5 - dibromobenzene, the method is as follows:
First, the halogenation method. Starting with benzene, first with bromine and an appropriate catalyst, such as iron or iron tribromide, through electrophilic substitution, bromobenzene can be obtained. Then bromobenzene is allowed to react with magnesium under specific conditions, such as in an ether environment, to produce Grignard reagent magnesium bromide. Subsequently, it is reacted with carbon dioxide and then acidified to obtain benzoic acid. Benzoic acid is brominated, and under suitable catalysts and conditions, bromine atoms can be introduced into the meta-position, and then through a series of reactions, such as reduction, halogenation, etc., to achieve the purpose of introducing cyanomethyl and another bromine atom, and finally obtain 1- (cyanomethyl) -3,5-dibromobenzene. The second is the method of introducing cyanomethyl. It can first be based on 3,5-dibromobenzene, and it can be combined with a suitable halogenated alkane, such as bromoacetonitrile, under the catalysis of a base, through a nucleophilic substitution reaction, so that the cyanomethyl is connected to the benzene ring In this process, the choice of base is very critical, and it needs to be carefully selected according to the reaction conditions and the characteristics of the substrate. For example, potassium carbonate, sodium hydroxide, etc. can be candidates to promote the smooth progress of the reaction.
There are also methods to use other compounds as starting materials. For example, suitable compounds containing cyanide groups and bromine atoms can be found, and appropriate rearrangements and substitutions can be made to construct the structure of the target molecule. Or first prepare benzene-containing rings and one side chain has functional groups that can be converted into cyanomethyl and bromine atoms, and then gradually convert them to precisely regulate the reaction conditions, so that the functional groups can be converted in sequence to achieve the purpose of preparing 1- (cyanomethyl) -3,5 -dibromobenzene. There are various ways of preparation, and it is necessary to consider the availability of raw materials, the difficulty of reaction and the yield, etc. according to the actual situation, and choose the optimal method.
First, the halogenation method. Starting with benzene, first with bromine and an appropriate catalyst, such as iron or iron tribromide, through electrophilic substitution, bromobenzene can be obtained. Then bromobenzene is allowed to react with magnesium under specific conditions, such as in an ether environment, to produce Grignard reagent magnesium bromide. Subsequently, it is reacted with carbon dioxide and then acidified to obtain benzoic acid. Benzoic acid is brominated, and under suitable catalysts and conditions, bromine atoms can be introduced into the meta-position, and then through a series of reactions, such as reduction, halogenation, etc., to achieve the purpose of introducing cyanomethyl and another bromine atom, and finally obtain 1- (cyanomethyl) -3,5-dibromobenzene. The second is the method of introducing cyanomethyl. It can first be based on 3,5-dibromobenzene, and it can be combined with a suitable halogenated alkane, such as bromoacetonitrile, under the catalysis of a base, through a nucleophilic substitution reaction, so that the cyanomethyl is connected to the benzene ring In this process, the choice of base is very critical, and it needs to be carefully selected according to the reaction conditions and the characteristics of the substrate. For example, potassium carbonate, sodium hydroxide, etc. can be candidates to promote the smooth progress of the reaction.
There are also methods to use other compounds as starting materials. For example, suitable compounds containing cyanide groups and bromine atoms can be found, and appropriate rearrangements and substitutions can be made to construct the structure of the target molecule. Or first prepare benzene-containing rings and one side chain has functional groups that can be converted into cyanomethyl and bromine atoms, and then gradually convert them to precisely regulate the reaction conditions, so that the functional groups can be converted in sequence to achieve the purpose of preparing 1- (cyanomethyl) -3,5 -dibromobenzene. There are various ways of preparation, and it is necessary to consider the availability of raw materials, the difficulty of reaction and the yield, etc. according to the actual situation, and choose the optimal method.
What should be paid attention to when storing and transporting 1- (chloromethyl) -3,5-difluorobenzene?
1-% (cyanomethyl) -3,5-dibromobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to to ensure safety.
Primary storage environment. This compound should be placed in a cool, dry and well-ventilated place. Avoid high temperature and humidity, where high temperature may increase its chemical reactivity, and humidity may cause it to deteriorate. For example, in summer heat, if the warehouse temperature is too high, it is potentially dangerous; and in humid places such as basements, it should not be stored.
This is the second way to pack. Packaging must be tight to prevent leakage. It is often packed in a sealed container to ensure that there is no leakage. If the package is damaged, this compound can escape, or endanger the surrounding environment and personal safety. If the package is damaged during transportation, it may pollute the environment and endanger others after leakage.
Furthermore, isolation requirements. It should be stored separately from oxidants, acids and other substances. Due to its chemical properties, contact with the above substances, or trigger violent chemical reactions, resulting in serious accidents such as fire and explosion. For example, oxidants are mixed with the compound, or cause intense oxidation reactions.
When transporting, caution is also required. When selecting compliance transportation tools, transporters should be familiar with their characteristics and emergency treatment methods. Avoid collisions and vibrations during transportation to prevent packaging damage. And transportation route planning should avoid crowded and environmentally sensitive areas. If it is unfortunate to leak, it can reduce harm.
When storing and transporting 1-% (cyanomethyl) -3,5-dibromobenzene, attention must be paid to all aspects of the environment, packaging, isolation and transportation, so as to be safe.
Primary storage environment. This compound should be placed in a cool, dry and well-ventilated place. Avoid high temperature and humidity, where high temperature may increase its chemical reactivity, and humidity may cause it to deteriorate. For example, in summer heat, if the warehouse temperature is too high, it is potentially dangerous; and in humid places such as basements, it should not be stored.
This is the second way to pack. Packaging must be tight to prevent leakage. It is often packed in a sealed container to ensure that there is no leakage. If the package is damaged, this compound can escape, or endanger the surrounding environment and personal safety. If the package is damaged during transportation, it may pollute the environment and endanger others after leakage.
Furthermore, isolation requirements. It should be stored separately from oxidants, acids and other substances. Due to its chemical properties, contact with the above substances, or trigger violent chemical reactions, resulting in serious accidents such as fire and explosion. For example, oxidants are mixed with the compound, or cause intense oxidation reactions.
When transporting, caution is also required. When selecting compliance transportation tools, transporters should be familiar with their characteristics and emergency treatment methods. Avoid collisions and vibrations during transportation to prevent packaging damage. And transportation route planning should avoid crowded and environmentally sensitive areas. If it is unfortunate to leak, it can reduce harm.
When storing and transporting 1-% (cyanomethyl) -3,5-dibromobenzene, attention must be paid to all aspects of the environment, packaging, isolation and transportation, so as to be safe.
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