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1-(Chloromethyl)-3-Fluoro-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
216391 |
| Chemical Formula | C8H5ClF4 |
| Molecular Weight | 212.57 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, but around 150 - 170 °C under normal pressure |
| Density | Approximately 1.3 - 1.5 g/cm³ |
| Solubility | Slightly soluble in water, soluble in many organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Caution: Flammable, flash point data may be around 40 - 60 °C |
| Stability | Stable under normal storage conditions, but may react with strong oxidizing agents |
As an accredited 1-(Chloromethyl)-3-Fluoro-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-3-fluoro-5-(trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 1-(Chloromethyl)-3-fluoro-5-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential reactions. |
| Shipping | 1-(Chloromethyl)-3-fluoro-5-(trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations ensures safe transport, considering its chemical nature. |
Competitive 1-(Chloromethyl)-3-Fluoro-5-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Chloromethyl)-3-Fluoro-5-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -3-fluoro-5- (trifluoromethyl) benzene?
1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene is a crucial raw material in the field of organic synthesis. It is widely used in the field of fine chemistry and plays a key role in the preparation of many complex organic compounds.
In the field of pharmaceutical synthesis, with its special chemical structure, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. Through ingenious chemical reactions, it can precisely build the core skeleton of drug molecules and lay the foundation for the development of new drugs.
In the field of materials science, it also shows unique value. It can be used as a basic unit for building high-performance materials. After specific polymerization reactions or chemical modifications, materials with special electrical, optical or mechanical properties can be prepared. For example, it is used to prepare organic semiconductor materials with excellent photoelectric properties, which is very useful in the field of organic light emitting diodes (OLEDs), organic solar cells and other optoelectronic devices.
Because its structure is rich in active groups such as cyanide groups, it can be functionalized through a series of chemical reactions, thereby expanding its application range in different fields. Chemists can make targeted modifications to it according to actual needs, giving it more unique properties and uses. Overall, 1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene, with its unique chemical structure, plays an important role in many scientific research and industrial production fields, promoting the continuous development and progress of related fields.
In the field of pharmaceutical synthesis, with its special chemical structure, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. Through ingenious chemical reactions, it can precisely build the core skeleton of drug molecules and lay the foundation for the development of new drugs.
In the field of materials science, it also shows unique value. It can be used as a basic unit for building high-performance materials. After specific polymerization reactions or chemical modifications, materials with special electrical, optical or mechanical properties can be prepared. For example, it is used to prepare organic semiconductor materials with excellent photoelectric properties, which is very useful in the field of organic light emitting diodes (OLEDs), organic solar cells and other optoelectronic devices.
Because its structure is rich in active groups such as cyanide groups, it can be functionalized through a series of chemical reactions, thereby expanding its application range in different fields. Chemists can make targeted modifications to it according to actual needs, giving it more unique properties and uses. Overall, 1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene, with its unique chemical structure, plays an important role in many scientific research and industrial production fields, promoting the continuous development and progress of related fields.
What are the physical properties of 1- (chloromethyl) -3-fluoro-5- (trifluoromethyl) benzene?
1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene is highly toxic and its physical properties are quite unique.
This compound often has a crystalline appearance and a fine texture. Its melting point is quite high, and a specific high temperature is required to melt it into a liquid state. The boiling point is even higher, and more severe conditions are required to make it boil and vaporize.
In terms of solubility, it is extremely difficult to dissolve in water. Due to the characteristics of its molecular structure, it is difficult to form an effective interaction with water molecules. However, in some organic solvents, such as dichloromethane and chloroform, it has certain solubility. This is because the molecular structure of these organic solvents is in some agreement with the molecular structure of 1- (cyanomethyl) -3-cyanomethyl-5- (tricyanomethyl) benzene, which can be dissolved through intermolecular forces.
Its density is higher than that of common organic compounds, and its sinking phenomenon can be observed when placed in some liquids. In addition, the substance has certain stability, and it is difficult to undergo significant chemical changes in a short period of time under conventional environmental conditions. However, it should be noted that because it contains many cyanide groups, its chemical activity cannot be underestimated under specific conditions. If a specific reagent or environmental factor changes, it may cause a chemical reaction, and because of its highly toxic nature, once the reaction occurs, the harm should not be underestimated. Therefore, when handling this substance, extreme caution is required and strict operating procedures are followed to prevent accidents.
This compound often has a crystalline appearance and a fine texture. Its melting point is quite high, and a specific high temperature is required to melt it into a liquid state. The boiling point is even higher, and more severe conditions are required to make it boil and vaporize.
In terms of solubility, it is extremely difficult to dissolve in water. Due to the characteristics of its molecular structure, it is difficult to form an effective interaction with water molecules. However, in some organic solvents, such as dichloromethane and chloroform, it has certain solubility. This is because the molecular structure of these organic solvents is in some agreement with the molecular structure of 1- (cyanomethyl) -3-cyanomethyl-5- (tricyanomethyl) benzene, which can be dissolved through intermolecular forces.
Its density is higher than that of common organic compounds, and its sinking phenomenon can be observed when placed in some liquids. In addition, the substance has certain stability, and it is difficult to undergo significant chemical changes in a short period of time under conventional environmental conditions. However, it should be noted that because it contains many cyanide groups, its chemical activity cannot be underestimated under specific conditions. If a specific reagent or environmental factor changes, it may cause a chemical reaction, and because of its highly toxic nature, once the reaction occurs, the harm should not be underestimated. Therefore, when handling this substance, extreme caution is required and strict operating procedures are followed to prevent accidents.
What are the synthesis methods of 1- (chloromethyl) -3-fluoro-5- (trifluoromethyl) benzene?
To prepare 1 - (methoxy) -3 - bromo - 5 - (trifluoromethoxy) benzene, there are various methods, let me tell you one by one.
First, 3 - bromo - 5 - hydroxyanisole. First, 3 - bromo - 5 - hydroxyanisole and suitable halogenated trifluoromethane reagents are reacted in the presence of bases in suitable solvents. Bases such as potassium carbonate, sodium carbonate, etc., the solvent can be N, N - dimethylformamide (DMF), acetonitrile, etc. During the reaction, the halogen atom of the halogenated trifluoromethane reagent is connected to the oxygen atom of the phenolic hydroxyl group, and through the nucleophilic substitution reaction, 1- (methoxy) -3-bromo-5- (trifluoromethoxy) benzene is obtained. This reaction needs to pay attention to the control of reaction temperature and time. If the temperature is too high or side reactions are caused, the reaction will be slow if it is too low. If the time is too long or the product is decomposed, the reaction will be incomplete if it is too short.
Second, 3-bromo-5-nitrobenzyl ether is used as the starting material. First, the nitro group is reduced to an amino group with a suitable reducing agent, such as iron filings and hydrochloric acid as reducing agents, or by catalytic hydrogenation, using palladium carbon as a catalyst, hydrogen is introduced to reduce to obtain 3-bromo-5-aminoanisole. Then the amino compound is reacted with a trifluoromethylation reagent, such as sodium trifluoromethanesulfonate, etc., through the diazotization-trifluoromethylation reaction process to obtain the target product 1- (methoxy) -3-bromo-5 - (trifluoromethoxy) benzene. In this process, the diazotization reaction needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the reagents used need to be strictly removed from water, because water will affect the reaction process.
Third, you can start with 3-bromo-5-halogenated anisole (the halogen atom can be chlorine, bromine, etc.). The halogen is reacted with reagents such as sodium trifluoromethoxide. Under suitable reaction conditions, the halogen atom is replaced by trifluoromethoxy to obtain 1- (methoxy) -3-bromo-5- (trifluoromethoxy) benzene. In this reaction, the preparation and storage of sodium trifluoromethoxide should be cautious, because it is easy to decompose in contact with water, and the anhydrous and oxygen-free environment of the reaction system is very critical, otherwise it is easy to cause side reactions and affect the yield and purity of the product.
First, 3 - bromo - 5 - hydroxyanisole. First, 3 - bromo - 5 - hydroxyanisole and suitable halogenated trifluoromethane reagents are reacted in the presence of bases in suitable solvents. Bases such as potassium carbonate, sodium carbonate, etc., the solvent can be N, N - dimethylformamide (DMF), acetonitrile, etc. During the reaction, the halogen atom of the halogenated trifluoromethane reagent is connected to the oxygen atom of the phenolic hydroxyl group, and through the nucleophilic substitution reaction, 1- (methoxy) -3-bromo-5- (trifluoromethoxy) benzene is obtained. This reaction needs to pay attention to the control of reaction temperature and time. If the temperature is too high or side reactions are caused, the reaction will be slow if it is too low. If the time is too long or the product is decomposed, the reaction will be incomplete if it is too short.
Second, 3-bromo-5-nitrobenzyl ether is used as the starting material. First, the nitro group is reduced to an amino group with a suitable reducing agent, such as iron filings and hydrochloric acid as reducing agents, or by catalytic hydrogenation, using palladium carbon as a catalyst, hydrogen is introduced to reduce to obtain 3-bromo-5-aminoanisole. Then the amino compound is reacted with a trifluoromethylation reagent, such as sodium trifluoromethanesulfonate, etc., through the diazotization-trifluoromethylation reaction process to obtain the target product 1- (methoxy) -3-bromo-5 - (trifluoromethoxy) benzene. In this process, the diazotization reaction needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the reagents used need to be strictly removed from water, because water will affect the reaction process.
Third, you can start with 3-bromo-5-halogenated anisole (the halogen atom can be chlorine, bromine, etc.). The halogen is reacted with reagents such as sodium trifluoromethoxide. Under suitable reaction conditions, the halogen atom is replaced by trifluoromethoxy to obtain 1- (methoxy) -3-bromo-5- (trifluoromethoxy) benzene. In this reaction, the preparation and storage of sodium trifluoromethoxide should be cautious, because it is easy to decompose in contact with water, and the anhydrous and oxygen-free environment of the reaction system is very critical, otherwise it is easy to cause side reactions and affect the yield and purity of the product.
What are the precautions for storing and transporting 1- (chloromethyl) -3-fluoro-5- (trifluoromethyl) benzene?
1 - (chloromethyl) - 3 - chloro - 5 - (trichloromethyl) pyridine is a chemical substance, and there are many precautions to be paid attention to during storage and transportation.
First storage conditions. It should be stored in a cool and well-ventilated place, away from fire and heat sources. Because it may be flammable, it is easy to cause combustion in case of open flames and hot topics, so extra care should be taken. The storage place should be equipped with suitable materials for containing leaks to prevent leakage from being handled in time and avoid causing greater harm.
Furthermore, make sure that the container is well sealed when storing. If this substance comes into contact with the air or deteriorates due to reaction with certain components in the air, its properties and uses will be affected. Sealed storage can effectively prevent such situations from happening.
When transporting, there are also many points. The transport vehicle must have the corresponding qualifications for transporting hazardous chemicals. The driver and escort personnel need to be professionally trained and familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is necessary to prevent the container from being damaged or leaking. In the event of a leak, emergency measures should be taken immediately to evacuate the surrounding personnel to avoid contact with the leaked material, and at the same time, it should be properly handled according to the leakage situation.
In addition, it is also necessary to pay attention to its compatibility with other substances. In storage and transportation, avoid mixing with oxidants, acids, bases and other substances, as they may react violently with these substances, causing danger.
In short, for the storage and transportation of 1- (chloromethyl) -3 -chloro-5- (trichloromethyl) pyridine, it is necessary to strictly follow the relevant regulations and operating procedures to ensure that personnel safety and the environment are not endangered.
First storage conditions. It should be stored in a cool and well-ventilated place, away from fire and heat sources. Because it may be flammable, it is easy to cause combustion in case of open flames and hot topics, so extra care should be taken. The storage place should be equipped with suitable materials for containing leaks to prevent leakage from being handled in time and avoid causing greater harm.
Furthermore, make sure that the container is well sealed when storing. If this substance comes into contact with the air or deteriorates due to reaction with certain components in the air, its properties and uses will be affected. Sealed storage can effectively prevent such situations from happening.
When transporting, there are also many points. The transport vehicle must have the corresponding qualifications for transporting hazardous chemicals. The driver and escort personnel need to be professionally trained and familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is necessary to prevent the container from being damaged or leaking. In the event of a leak, emergency measures should be taken immediately to evacuate the surrounding personnel to avoid contact with the leaked material, and at the same time, it should be properly handled according to the leakage situation.
In addition, it is also necessary to pay attention to its compatibility with other substances. In storage and transportation, avoid mixing with oxidants, acids, bases and other substances, as they may react violently with these substances, causing danger.
In short, for the storage and transportation of 1- (chloromethyl) -3 -chloro-5- (trichloromethyl) pyridine, it is necessary to strictly follow the relevant regulations and operating procedures to ensure that personnel safety and the environment are not endangered.
What are the environmental effects of 1- (chloromethyl) -3-fluoro-5- (trifluoromethyl) benzene?
Effects of 1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene on the environment
1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene, this is an organic compound. Its impact on the environment is quite complex, and it is summarized as follows:
1. Effects on soil
If the substance enters the soil, it is toxic because it contains cyanide groups. Cyanide groups can complex with metal ions in the soil, changing soil chemical properties. For example, form ferrocyanide with iron ions, which affects the absorption and utilization of iron by microorganisms in the soil. Soil microbial community structure may be impacted, causing disturbance to soil ecological processes such as decomposition of organic matter and nutrient cycling. Some cyanide-sensitive microorganisms die, causing soil fertility to decline and affecting plant growth.
Second, the impact on water bodies
Once it enters the water body, it will cause water quality to deteriorate. The substance dissolves in water and releases cyanide groups, which is significantly toxic to aquatic organisms. At low concentrations, it may affect the respiration and metabolism of aquatic organisms, and at high concentrations, it can cause acute poisoning and death. If fish come into contact with water containing this substance, the gill tissue is damaged, the gas exchange is blocked, and suffocation dies. And because it is difficult to degrade, it remains in the water body for a long time, enriches through the food chain, and threatens the health of higher organisms.
III. Effects on the atmosphere
If the substance volatilizes into the atmosphere, although the volatility may not be strong, some of it still enters the atmospheric environment. Cyanide-containing compounds photochemically react in the atmosphere to produce new pollutants, such as hydrogen cyanide gas. Not only irritates the human respiratory tract and eyes, but also damages human health, and participates in the atmospheric chemical cycle, affecting atmospheric composition and climate.
In summary, 1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene contains a cyanide group in its own chemical structure, which is potentially harmful to soil, water, atmosphere and other environmental factors. Strict control is required in all aspects of production, use and disposal to prevent it from entering the environment to ensure ecological and environmental safety.
1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene, this is an organic compound. Its impact on the environment is quite complex, and it is summarized as follows:
1. Effects on soil
If the substance enters the soil, it is toxic because it contains cyanide groups. Cyanide groups can complex with metal ions in the soil, changing soil chemical properties. For example, form ferrocyanide with iron ions, which affects the absorption and utilization of iron by microorganisms in the soil. Soil microbial community structure may be impacted, causing disturbance to soil ecological processes such as decomposition of organic matter and nutrient cycling. Some cyanide-sensitive microorganisms die, causing soil fertility to decline and affecting plant growth.
Second, the impact on water bodies
Once it enters the water body, it will cause water quality to deteriorate. The substance dissolves in water and releases cyanide groups, which is significantly toxic to aquatic organisms. At low concentrations, it may affect the respiration and metabolism of aquatic organisms, and at high concentrations, it can cause acute poisoning and death. If fish come into contact with water containing this substance, the gill tissue is damaged, the gas exchange is blocked, and suffocation dies. And because it is difficult to degrade, it remains in the water body for a long time, enriches through the food chain, and threatens the health of higher organisms.
III. Effects on the atmosphere
If the substance volatilizes into the atmosphere, although the volatility may not be strong, some of it still enters the atmospheric environment. Cyanide-containing compounds photochemically react in the atmosphere to produce new pollutants, such as hydrogen cyanide gas. Not only irritates the human respiratory tract and eyes, but also damages human health, and participates in the atmospheric chemical cycle, affecting atmospheric composition and climate.
In summary, 1 - (cyanomethyl) - 3 - cyanomethyl - 5 - (tricyanomethyl) benzene contains a cyanide group in its own chemical structure, which is potentially harmful to soil, water, atmosphere and other environmental factors. Strict control is required in all aspects of production, use and disposal to prevent it from entering the environment to ensure ecological and environmental safety.
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